NanoString Highlights Spatial Biology Research at the 2022 American Association of Cancer Research (AACR) Conference
NanoString Technologies (NASDAQ: NSTG) highlighted over 125 studies at the 2022 AACR meeting showcasing the adoption of its platforms in cancer research. With over 110 posters and 15 oral presentations, this marks a record for the company. Key studies utilized the GeoMx Digital Spatial Profiler and CosMx Spatial Molecular Imager, focusing on spatial biology and gene expression. The research includes innovative approaches such as high-plex protein imaging and multi-omic analyses, illustrating the growing importance of spatial profiling in developing cancer therapeutics.
- Over 125 studies presented at AACR 2022, illustrating strong adoption of NanoString technologies.
- Record number of posters and presentations (110 posters, 15 oral) indicating increased research engagement.
- Highlight on spatial biology technology, including GeoMx DSP and CosMx SMI, emphasizing innovation.
- Research contributions enhance understanding of cancer, potentially leading to better treatment options.
- None.
Researchers Present Over 125 Studies Enabled by NanoString Platforms, including the new GeoMx Spatial Proteogenomic Workflow and 108-plex Protein Imaging on CosMx
At AACR 2022, over 110 posters and 15 oral presentations will showcase unique biological insights generated using
“NanoString customers continue to make tremendous contributions to our understanding of cancer and the development of cures,” said
Several studies and presentations that feature the use of NanoString’s spatial biology platforms are highlighted below.
Poster: Multi-omic dissection of immunotherapy response in groups in non-small cell lung cancer
Arutha Kulasinghe, Ph.D., NHMRC Research Fellow,
This study utilized spatial transcriptomics methods, including the GeoMx DSP and multiplex IHC, to define the tumor/stroma compartment specific proteome and transcriptome from a cohort of 2nd line immunotherapy treated non-small cell lung cancer patients.
Poster: Development of a custom high-plex GeoMx digital spatial profiler breast cancer protein biomarker assay
This study's goal was to develop a high-plex assay to simultaneously quantitate 27 established and novel breast cancer (BC)-related immune protein and phosphoprotein biomarkers using the GeoMx DSP. The custom assay performance was compared to standard, immunohistochemistry-based clinical BC biomarker assays (e.g., ER, PR, HER2) across the spectrum of BC subtypes and in multiple laboratories with statistically significant concordance.
Poster: A single-cell, spatial multi-omics atlas and cellular interactome of all major skin cancer types
Alongside other multi-omics tools, CosMx SMI was used to generate the first spatial single-cell atlas and cellular interactome of all major skin cancer types (squamous cell carcinoma, basal cell carcinoma, and melanoma). Spatial transcriptomics with CosMx SMI reveals cell-type organization into distinct functional tissue layers and identifies cancer-, patient-, and region-specific differences in cell-cell interaction.
Poster: Subcellular characterization of over 100 proteins in FFPE tumor biopsies with CosMx Spatial Molecular Imager
108 proteins were imaged in a breast cancer biopsy using the CosMx Spatial Molecular Imager, representing one of the highest-plex protein imaging studies. CosMx encoding and chemistry enable high-throughput, short-turnaround protein imaging studies on the same instrument as the CosMx single-molecule RNA assay.
Poster: Multi-omic analysis of whole transcriptome and high plex protein assays on a single FFPE slide
The newly developed GeoMx Spatial Proteogenomic workflow enables the co-detection of protein (>100-plex) and RNA (up to 21,000-plex) from a single FFPE slide. The performance of the Proteogenomic workflow has been confirmed on various cell pellets and tissue types.
Oral:
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Vice President, Investor Relations & Corporate Communications
dfarrell@nanostring.com
Phone: 206-602-1768
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