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Ngm Biopharmaceuticals - NGM STOCK NEWS

Welcome to our dedicated page for Ngm Biopharmaceuticals news (Ticker: NGM), a resource for investors and traders seeking the latest updates and insights on Ngm Biopharmaceuticals stock.

Overview of NGM Biopharmaceuticals

NGM Biopharmaceuticals is a research-driven, clinical stage biopharmaceutical company dedicated to the discovery and development of first-in-class biologic drug candidates. With a strong foundation in understanding complex biological mechanisms, including the intricate interplay between hormones, cell receptors, and ligands, the company employs a comprehensive drug discovery platform that integrates advanced protein and antibody engineering techniques. Keywords such as "drug discovery", "biologics", and "clinical stage" are central to its business model, ensuring that its research is not only innovative but also precisely aligned with unmet medical needs in diverse therapeutic areas.

Core Business and Research Focus

At the heart of NGM Biopharmaceuticals lies its commitment to elucidating the fundamental biology of disease. The company initially concentrated its efforts on cardio-metabolic and liver diseases, leveraging deep insights into protein structure and function to design targeted therapeutic candidates. This biology-centric approach facilitates the identification of novel mechanisms that underpin disease pathology, thereby enabling the generation of optimized therapeutics with a potential first-in-class profile. Beyond its initial focus areas, the company’s research platform is inherently adaptable, allowing for the exploration of additional domains, such as oncology, where scientific advances can translate into transformative therapeutic options.

Innovative Drug Discovery Platform

NGM Biopharmaceuticals distinguishes itself with a unique drug discovery engine that emphasizes an integrated approach. By combining intricate biological interrogation with precision protein engineering, the company is capable of developing biologic candidates tailored to specific molecular targets. This methodical process not only streamlines candidate identification and optimization but also ensures that the resulting therapeutics possess refined pharmacologic profiles. Such an approach exemplifies a commitment to quality and innovation that is critical in today’s competitive biopharma landscape.

Operational Excellence and Research Integration

The operational framework of NGM Biopharmaceuticals is marked by a synergy between scientific discovery and clinical application. The company has nurtured an environment where deep research insights and advanced biochemical techniques converge, fostering a pipeline built entirely on in-house discovery efforts. Its systematic strategy involves extensive preclinical studies that decode disease mechanisms, followed by rigorous candidate validation to rapidly transition promising molecules into proof-of-concept studies. This seamless integration of research and development underlines the company’s dedication to advancing a rich portfolio of therapeutic candidates based on robust scientific evidence.

Competitive Landscape and Distinct Value Proposition

Within the competitive biopharmaceutical industry, NGM Biopharmaceuticals holds a distinctive position due to its rigorous, biology-centric approach. Unlike traditional models that often rely solely on empirical data or incremental improvements, NGM Bio combines fundamental biological research with advanced engineering, creating a platform that is both adaptable and deeply scientific. This differentiation is especially valuable in areas where conventional therapies have fallen short, such as certain oncology indications and complex metabolic disorders. By targeting interrelated mechanisms of human biology, the company not only enhances its chances of clinical success but also addresses critical gaps in current treatment paradigms.

Robust Research and Development Pipeline

The company’s pipeline is a testament to its commitment to pioneering drug discovery. Every therapeutic candidate is generated through its in-house discovery platform, ensuring that development is grounded in a solid understanding of molecular biology and disease pathology. This pipeline, while spanning multiple therapeutic areas, is unified by an emphasis on novel biological insights and targeted engineering. This comprehensive strategy positions NGM Biopharmaceuticals as a formidable research engine within the biopharmaceutical industry, continuously exploring new avenues for innovation while remaining anchored in scientific rigor.

Commitment to Scientific Excellence

NGM Biopharmaceuticals’ operations are deeply embedded in a culture of scientific excellence, where each discovery is approached with methodical detail and a relentless pursuit of innovation. The company’s research efforts extend beyond the mere generation of drug candidates; they represent a broader quest to understand and harness the complex mechanisms that govern human health. This commitment is reflected in its ongoing efforts to dissect the relationships between protein structure and function, ultimately contributing to its ability to design therapies that are both novel and precisely targeted.

Conclusion

In summary, NGM Biopharmaceuticals is characterized by its comprehensive, science-driven approach to drug discovery and development. By integrating advanced biochemical techniques with deep biological insights, the company continues to expand its portfolio of novel therapeutic candidates across a range of critical disease areas. Its meticulous research methodology and commitment to innovation make it an intriguing subject for further study, particularly for those interested in the intersection of cutting-edge science and therapeutic discovery.

Rhea-AI Summary

NGM Biopharmaceuticals (NGM) announced that CEO David J. Woodhouse, Ph.D., will present a company overview at the 40th Annual J.P. Morgan Healthcare Conference on January 13, 2022, at 7:30 AM PST/10:30 AM EST. The presentation will be available via a live audio webcast on NGM’s website, with an archived version accessible for 30 days post-event. NGM focuses on developing innovative therapeutics for retinal diseases, cancer, and metabolic conditions, currently advancing seven programs including four in Phase 2/2b studies.

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NGM has entered a clinical trial collaboration with Merck to evaluate NGM707 in combination with KEYTRUDA for treating advanced solid tumors. This trial aims to assess the dual antagonist's potential to enhance immune response against tumors expressing ILT2 and ILT4. Currently, the Phase 1/2 trial is enrolling patients, focusing on how NGM707 might reverse immune suppression in tumors. Initial preclinical studies suggest that combining NGM707 with KEYTRUDA could amplify T-cell activation and cytokine secretion, offering hope for improved cancer therapies.

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NGM Biopharmaceuticals, Inc. (NGM) announced CEO David J. Woodhouse, Ph.D. will present at several upcoming virtual investor conferences. The Stifel 2021 Virtual Healthcare Conference will take place on November 15, 2021, at 2:40 p.m. ET. The Jefferies London Healthcare Conference is scheduled for November 18-19, with an on-demand presentation starting November 18 at 3:00 a.m. ET. The Piper Sandler Healthcare Conference occurs from November 30 to December 2, 2021, with an on-demand presentation available November 22, and the Evercore ISI Healthcare Conference on December 1 at 1:25 p.m. ET.

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NGM Biopharmaceuticals reported promising progress in its oncology portfolio during Q3 2021, showcasing preliminary data from NGM120 trials at ESMO 2021. Notably, all evaluable metastatic pancreatic cancer patients showed disease control at 16 weeks. The company initiated clinical studies for NGM707 and disclosed NGM831 as part of its pipeline. Financially, NGM reported a net loss of $28.9 million, a slight decrease from $29.8 million a year ago. Cash reserves improved to $383.4 million, compared to $295.2 million at the end of 2020, highlighting a strong liquidity position.

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NGM Biopharmaceuticals announced preliminary findings from its Phase 1a/1b study of NGM120, a GFRAL antagonist antibody aimed at treating advanced solid tumors, particularly metastatic pancreatic cancer. The study demonstrated that NGM120 was well tolerated without dose-limiting toxicities. In the Phase 1b cohort, all six evaluable patients showed disease control at 16 weeks, with three partial responses and three stable disease outcomes. Four patients continued to exhibit responses beyond 36 weeks. NGM plans to report final results post-completion of treatment.

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NGM Biopharmaceuticals announced the discovery of ILT3's functional ligand, fibronectin, which could form a stromal checkpoint suppressing myeloid cell function and inhibiting antitumor immunity. Their new candidate, NGM831, is designed to block ILT3's interactions with fibronectin and other ligands. First-in-human testing of NGM831 is planned for the first half of 2022.

NGM's oncology portfolio now includes four candidates targeting ILT2/ILT4, ILT3, and LAIR1, aimed at enhancing antitumor immunity.

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NGM Biopharmaceuticals (NGM) has completed enrollment in the 320-patient Phase 2 CATALINA study of NGM621 for geographic atrophy, with topline data expected in late 2022. The company initiated a Phase 1/2 trial of NGM707 for solid tumors and amended its collaboration with Merck to focus on retinal and cardiovascular diseases. NGM reported a net loss of $36.7 million for Q2 2021, a rise from $25.6 million in 2020, with an increase in R&D expenses to $43.6 million. NGM's cash and equivalents stood at $390.6 million as of June 30, 2021, up from $295.2 million at year-end 2020.

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NGM Biopharmaceuticals has completed enrollment in the Phase 2 CATALINA study evaluating NGM621 for treating geographic atrophy associated with age-related macular degeneration. This monoclonal antibody targets complement C3 to slow disease progression, with enrollment exceeding the initial estimate of 240 patients, now totaling 320. The trial will assess the efficacy and safety of NGM621, with topline data expected in the second half of 2022. Geographic atrophy currently has no approved treatments, impacting about 1 million patients in the U.S. and 5 million globally.

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NGM Biopharmaceuticals, Inc. (NGM) has initiated a Phase 1/2 study for NGM707, a dual antagonistic antibody targeting ILT2 and ILT4, designed to enhance anti-tumor immune responses. The study will evaluate NGM707 as a monotherapy and combined with KEYTRUDA® (pembrolizumab) in approximately 180 patients with elevated ILT2 and ILT4 expressions across various advanced solid tumors. Preliminary efficacy signals will also be assessed, focusing on safety and tolerability. This marks NGM's second oncology candidate in clinical trials, following NGM120.

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NGM Biopharmaceuticals and Merck have amended their collaboration to focus on retinal and cardiovascular diseases through March 2024. Merck will continue funding NGM with approximately $120 million for research and development. NGM retains rights to its oncology portfolio and other undisclosed assets, allowing for greater independence in advancing its programs. This collaboration revision supports ongoing clinical trials for NGM621 and MK-3655 while allowing NGM to explore new opportunities in therapeutics. Merck’s option to license NGM’s developed assets remains intact.

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FAQ

What is the market cap of Ngm Biopharmaceuticals (NGM)?

The market cap of Ngm Biopharmaceuticals (NGM) is approximately 128.5M.

What is the primary focus of NGM Biopharmaceuticals?

NGM Biopharmaceuticals is primarily focused on discovering and developing first-in-class biologic drug candidates through an integrated, biology-centric drug discovery platform.

Which therapeutic areas does NGM Bio currently emphasize?

The company initially targets cardio-metabolic and liver diseases, with research expanding into additional areas such as oncology, driven by its deep understanding of human biology.

How does NGM Bio generate its drug candidates?

NGM Bio utilizes a research-driven platform combining detailed biological analysis with advanced protein and antibody engineering to systematically generate and optimize potential therapeutic candidates.

What distinguishes NGM Biopharmaceuticals from other biopharma companies?

Its unique integration of fundamental biological research with precision engineering sets it apart; the company prioritizes deep molecular insights to develop novel therapeutics addressing unmet medical needs.

How is clinical development incorporated into the company’s strategy?

Clinical development is seamlessly integrated into the company’s operations, with an in-house discovery engine paving the way for rigorous preclinical studies and proof-of-concept trials for each candidate.

What role does protein engineering play in NGM Bio's operations?

Protein and antibody engineering are central components of its strategy, enabling the team to design molecules with optimized pharmacologic profiles that are precisely targeted to specific biological mechanisms.

How does NGM Biopharmaceuticals maintain its commitment to scientific excellence?

The company fosters a culture of meticulous research, where each candidate is developed from validated biological insights, ensuring that its therapeutic innovations are grounded in robust scientific evidence.
Ngm Biopharmaceuticals

Nasdaq:NGM

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NGM Stock Data

128.53M
64.29M
21.08%
54.16%
2.01%
Biotechnology
Healthcare
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United States
South San Francisco