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Ngm Biopharmaceuticals - NGM STOCK NEWS

Welcome to our dedicated page for Ngm Biopharmaceuticals news (Ticker: NGM), a resource for investors and traders seeking the latest updates and insights on Ngm Biopharmaceuticals stock.

Overview of NGM Biopharmaceuticals

NGM Biopharmaceuticals is a research-driven, clinical stage biopharmaceutical company dedicated to the discovery and development of first-in-class biologic drug candidates. With a strong foundation in understanding complex biological mechanisms, including the intricate interplay between hormones, cell receptors, and ligands, the company employs a comprehensive drug discovery platform that integrates advanced protein and antibody engineering techniques. Keywords such as "drug discovery", "biologics", and "clinical stage" are central to its business model, ensuring that its research is not only innovative but also precisely aligned with unmet medical needs in diverse therapeutic areas.

Core Business and Research Focus

At the heart of NGM Biopharmaceuticals lies its commitment to elucidating the fundamental biology of disease. The company initially concentrated its efforts on cardio-metabolic and liver diseases, leveraging deep insights into protein structure and function to design targeted therapeutic candidates. This biology-centric approach facilitates the identification of novel mechanisms that underpin disease pathology, thereby enabling the generation of optimized therapeutics with a potential first-in-class profile. Beyond its initial focus areas, the company’s research platform is inherently adaptable, allowing for the exploration of additional domains, such as oncology, where scientific advances can translate into transformative therapeutic options.

Innovative Drug Discovery Platform

NGM Biopharmaceuticals distinguishes itself with a unique drug discovery engine that emphasizes an integrated approach. By combining intricate biological interrogation with precision protein engineering, the company is capable of developing biologic candidates tailored to specific molecular targets. This methodical process not only streamlines candidate identification and optimization but also ensures that the resulting therapeutics possess refined pharmacologic profiles. Such an approach exemplifies a commitment to quality and innovation that is critical in today’s competitive biopharma landscape.

Operational Excellence and Research Integration

The operational framework of NGM Biopharmaceuticals is marked by a synergy between scientific discovery and clinical application. The company has nurtured an environment where deep research insights and advanced biochemical techniques converge, fostering a pipeline built entirely on in-house discovery efforts. Its systematic strategy involves extensive preclinical studies that decode disease mechanisms, followed by rigorous candidate validation to rapidly transition promising molecules into proof-of-concept studies. This seamless integration of research and development underlines the company’s dedication to advancing a rich portfolio of therapeutic candidates based on robust scientific evidence.

Competitive Landscape and Distinct Value Proposition

Within the competitive biopharmaceutical industry, NGM Biopharmaceuticals holds a distinctive position due to its rigorous, biology-centric approach. Unlike traditional models that often rely solely on empirical data or incremental improvements, NGM Bio combines fundamental biological research with advanced engineering, creating a platform that is both adaptable and deeply scientific. This differentiation is especially valuable in areas where conventional therapies have fallen short, such as certain oncology indications and complex metabolic disorders. By targeting interrelated mechanisms of human biology, the company not only enhances its chances of clinical success but also addresses critical gaps in current treatment paradigms.

Robust Research and Development Pipeline

The company’s pipeline is a testament to its commitment to pioneering drug discovery. Every therapeutic candidate is generated through its in-house discovery platform, ensuring that development is grounded in a solid understanding of molecular biology and disease pathology. This pipeline, while spanning multiple therapeutic areas, is unified by an emphasis on novel biological insights and targeted engineering. This comprehensive strategy positions NGM Biopharmaceuticals as a formidable research engine within the biopharmaceutical industry, continuously exploring new avenues for innovation while remaining anchored in scientific rigor.

Commitment to Scientific Excellence

NGM Biopharmaceuticals’ operations are deeply embedded in a culture of scientific excellence, where each discovery is approached with methodical detail and a relentless pursuit of innovation. The company’s research efforts extend beyond the mere generation of drug candidates; they represent a broader quest to understand and harness the complex mechanisms that govern human health. This commitment is reflected in its ongoing efforts to dissect the relationships between protein structure and function, ultimately contributing to its ability to design therapies that are both novel and precisely targeted.

Conclusion

In summary, NGM Biopharmaceuticals is characterized by its comprehensive, science-driven approach to drug discovery and development. By integrating advanced biochemical techniques with deep biological insights, the company continues to expand its portfolio of novel therapeutic candidates across a range of critical disease areas. Its meticulous research methodology and commitment to innovation make it an intriguing subject for further study, particularly for those interested in the intersection of cutting-edge science and therapeutic discovery.

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NGM Biopharmaceuticals, Inc. (NGM) has priced an underwritten public offering of 4,629,630 shares of its common stock at $27.00 per share, aiming for approximately $125 million in gross proceeds. The offering is set to close on or about January 8, 2021, pending customary conditions. There is a 30-day option for underwriters to purchase an additional 694,444 shares. Goldman Sachs, Citigroup, and Cowen are joint book-running managers, with Raymond James and B. Riley Securities as lead managers. The offering is registered under an effective shelf registration statement with the SEC.

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NGM Biopharmaceuticals, Inc. (NGM) has announced a public offering of $100 million in common stock, with an additional $15 million option for underwriters. All shares will be sold by NGM, which is subject to market conditions. Goldman Sachs, Citigroup, and Cowen are managing the offering. The shares will be offered under a previously filed shelf registration statement with the SEC. NGM focuses on developing therapeutics for liver diseases, metabolic disorders, retinal diseases, and cancer.

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NGM Biopharmaceuticals has introduced NGM438, a new antibody candidate targeting LAIR1, during its inaugural R&D Day. LAIR1 is implicated in tumor-associated immune suppression. The company aims to initiate first-in-human trials for NGM438 in Q4 2021. NGM438 is designed to enhance anti-tumor immunity by disrupting LAIR1-collagen interactions, which may improve responses to current immunotherapies. Alongside NGM438, NGM707 and NGM120 are part of its oncology pipeline, focusing on reversing immune suppression.

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NGM Biopharmaceuticals will host a virtual R&D Day on December 9, 2020 at 12:00 pm ET, showcasing its multi-therapeutic pipeline. The event will highlight key drug candidates addressing unmet patient needs in liver and metabolic diseases, retinal diseases, and cancer, including aldafermin and MK-3655, NGM621, NGM120, and NGM707. Notable speakers include distinguished industry physicians and executives from Merck. The event will be streamed live, with a replay available on the NGM website for one year.

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NGM Biopharmaceuticals reported positive results from its Phase 1 study of NGM621, an anti-complement C3 antibody for geographic atrophy. The treatment showed a favorable safety profile, with no serious adverse events or intraocular inflammation. The serum pharmacokinetics were linear and dose-proportional, supporting a potential dosing regimen of every eight weeks. The ongoing Phase 2 CATALINA study has begun enrollment, with the first patient dosed in July 2020. NGM621 may offer significant advantages in treating this progressive retinal disease.

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NGM Biopharmaceuticals (NGM) reported significant advances in its therapeutic pipeline as of September 30, 2020. The company initiated a Phase 2 clinical trial for NGM621 targeting geographic atrophy and expanded its oncology portfolio with NGM707, an immuno-oncology candidate. Financially, NGM reported a net loss of $29.8 million, up from $10.9 million in 2019, while research and development expenses surged to $47 million. NGM's cash reserves stood at $287.9 million, down from $344.5 million at year-end 2019, emphasizing ongoing investments in its expanding pipeline.

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NGM Biopharmaceuticals (NGM) announced that CEO David J. Woodhouse, Ph.D., will present at three investor conferences. The presentations are scheduled for:

  • November 18, 2020: Jefferies Virtual London Healthcare Conference at 12:00 PM ET
  • November 18, 2020: Stifel Virtual Healthcare Conference at 2:40 PM ET
  • November 23, 2020: 32nd Annual Piper Sandler Virtual Healthcare Conference at 12:00 PM ET

A live webcast will be available on the NGM website, and a replay of the presentation will be archived for 90 days.

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NGM Biopharmaceuticals announced the upcoming poster presentation of its Phase 1 study on NGM621, a monoclonal antibody targeting complement C3, at the American Academy of Ophthalmology (AAO) 2020 Virtual event. The study focuses on its safety, tolerability, and pharmacokinetics in patients with geographic atrophy (GA). The presentation is scheduled for Nov. 13, 2020. NGM621 is engineered for potential extended dosing and aims to address issues arising from complement system dysregulation. The company is committed to advancing innovative therapeutics in retinal diseases and other conditions.

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NGM Biopharmaceuticals, Inc. (Nasdaq: NGM) announced multiple presentations of aldafermin at AASLD’s The Liver Meeting, scheduled for Nov. 13-16, 2020. A late-breaking oral presentation will showcase results from the 24-week Phase 2 study on aldafermin in patients with non-alcoholic steatohepatitis (NASH). The study's findings indicate significant anti-fibrotic responses in patients with advanced fibrosis. Additional presentations will cover lipid management and improvements in non-invasive measures related to NASH. Aldafermin aims to address liver disease by targeting multiple pathways, demonstrating promising clinical efficacy.

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NGM Biopharmaceuticals (NGM) announced the expansion of its oncology portfolio with NGM707, a novel dual antagonist antibody targeting ILT2 and ILT4, which may enhance anti-tumor immune responses. First-in-human testing is planned for mid-2021. NGM707 aims to combat myeloid cell immune suppression implicated in immune evasion by tumors. This new candidate complements NGM120, currently in clinical trials. NGM's R&D Day is scheduled for December 9, 2020, to showcase its pipeline, which addresses various diseases, including cancer.

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FAQ

What is the market cap of Ngm Biopharmaceuticals (NGM)?

The market cap of Ngm Biopharmaceuticals (NGM) is approximately 128.5M.

What is the primary focus of NGM Biopharmaceuticals?

NGM Biopharmaceuticals is primarily focused on discovering and developing first-in-class biologic drug candidates through an integrated, biology-centric drug discovery platform.

Which therapeutic areas does NGM Bio currently emphasize?

The company initially targets cardio-metabolic and liver diseases, with research expanding into additional areas such as oncology, driven by its deep understanding of human biology.

How does NGM Bio generate its drug candidates?

NGM Bio utilizes a research-driven platform combining detailed biological analysis with advanced protein and antibody engineering to systematically generate and optimize potential therapeutic candidates.

What distinguishes NGM Biopharmaceuticals from other biopharma companies?

Its unique integration of fundamental biological research with precision engineering sets it apart; the company prioritizes deep molecular insights to develop novel therapeutics addressing unmet medical needs.

How is clinical development incorporated into the company’s strategy?

Clinical development is seamlessly integrated into the company’s operations, with an in-house discovery engine paving the way for rigorous preclinical studies and proof-of-concept trials for each candidate.

What role does protein engineering play in NGM Bio's operations?

Protein and antibody engineering are central components of its strategy, enabling the team to design molecules with optimized pharmacologic profiles that are precisely targeted to specific biological mechanisms.

How does NGM Biopharmaceuticals maintain its commitment to scientific excellence?

The company fosters a culture of meticulous research, where each candidate is developed from validated biological insights, ensuring that its therapeutic innovations are grounded in robust scientific evidence.
Ngm Biopharmaceuticals

Nasdaq:NGM

NGM Rankings

NGM Stock Data

128.53M
64.29M
21.08%
54.16%
2.01%
Biotechnology
Healthcare
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United States
South San Francisco