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Mural Oncology plc Ordinary Shares - MURA STOCK NEWS

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Mural Oncology plc (Nasdaq: MURA) is a clinical-stage immuno-oncology company focused on the discovery and development of innovative immunotherapies to significantly improve the lives of cancer patients. The company specializes in immune cell modulation and protein engineering to create novel cytokine therapies that address areas of unmet need.

Mural's leading product candidate, nemvaleukin alfa (nemvaleukin), is an engineered interleukin-2 (IL-2) cytokine designed to capture and expand the therapeutic benefits of high-dose recombinant human IL-2 while reducing toxicities. Nemvaleukin is currently in two potentially registrational trials: one for mucosal melanoma and another for platinum-resistant ovarian cancer (PROC), both with results expected in 1Q 2025. Additionally, nemvaleukin is being evaluated in a less frequent dosing regimen in cutaneous melanoma.

Beyond nemvaleukin, Mural Oncology is advancing discovery-stage programs targeting interleukin-18 (IL-18) and interleukin-12 (IL-12), with plans to nominate development candidates for each in 2024. These programs leverage Mural's expertise in cytokine biology and protein engineering to create therapies that could potentially overcome the limitations of existing immunotherapies.

Formed as a spin-out from Alkermes plc in November 2023, Mural Oncology started with $275 million in committed funding, providing financial stability projected into 4Q 2025. The company is led by a team of seasoned oncology experts and utilizes its innovative approaches to protein engineering to push the boundaries of cancer treatment.

For more information, visit Mural Oncology’s website at www.muraloncology.com and follow them on LinkedIn and X.

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Mural Oncology plc (Nasdaq: MURA) has announced its first Virtual Investor Day, scheduled for September 26, 2024, at 10 a.m. ET. The event will provide clinical insights and updates on the company's late-stage candidate, nemvaleukin alfa, an engineered IL-2 therapy. Mural remains on track to deliver key data readouts from potentially registrational trials in platinum-resistant ovarian cancer and mucosal melanoma in 1H 2025.

The Investor Day will feature presentations from Mural's leadership, including CEO Caroline Loew and CMO Vicki Goodman, as well as expert clinicians. They will discuss the trial design, clinical proof of concept, and unmet needs in target cancer types. Additionally, Mural will provide an overview of its IL-18 pipeline program.

The event aims to showcase Mural's progress in developing novel, engineered cytokine therapies for various cancers. Interested parties can register for the webcast at ir.muraloncology.com/events-and-presentations.

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Mural Oncology plc (Nasdaq: MURA), a clinical-stage immuno-oncology company, has granted stock options and restricted stock units to a newly hired employee. The company issued non-statutory stock options to purchase 21,500 ordinary shares and restricted stock units for 11,500 ordinary shares. These grants were made under Mural's 2024 Inducement Stock Option and Incentive Plan, in compliance with Nasdaq Listing Rule 5635(c)(4).

The stock options have an exercise price of $3.16 per share, equal to the closing price on September 3, 2024. They have a ten-year term and vest over four years, with 25% vesting after one year and 6.25% quarterly thereafter. The restricted stock units also vest over four years, with 25% vesting annually. Both grants are subject to continued employment and specific award agreements.

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Mural Oncology plc (Nasdaq: MURA), a clinical-stage immuno-oncology company, has announced its participation in two upcoming investor conferences. The company, which develops novel engineered cytokine therapies for cancer patients, will be represented by key management team members at these events:

1. Morgan Stanley 22nd Annual Global Healthcare Conference on September 6 at 1:50 p.m. ET, featuring a fireside chat with CEO Caroline Loew, Ph.D., Chief Medical Officer Vicki Goodman, MD, and CFO Adam Cutler.

2. H.C. Wainwright 26th Annual Global Investment Conference on September 11 at 9:30 a.m. ET, where CEO Caroline Loew, Ph.D. will give a presentation.

Webcasts of both presentations will be available on the company's investor relations website. The management team will also be available for one-on-one meetings during these conferences.

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Mural Oncology (Nasdaq: MURA) reported Q2 2024 financial results and provided a pipeline update. Key highlights include:

Financial Position: Cash, cash equivalents, and marketable securities stood at $204.7 million as of June 30, 2024. The company reaffirms its cash runway into Q4 2025.

Pipeline Progress: Mural is on track to report readouts from two late-stage clinical trials of its lead asset, nemvaleukin alfa, in 1H 2025. The company presented data on less frequent dosing of nemvaleukin at ASCO in June. Candidate nominations for IL-18 and IL-12 programs are expected later this year.

Financial Results: R&D expenses decreased to $27.5 million in Q2 2024 from $42.5 million in Q2 2023. G&A expenses increased to $6.7 million from $4.7 million. Net loss narrowed to $31.6 million from $50.2 million year-over-year.

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Mural Oncology plc (Nasdaq: MURA), a clinical-stage immuno-oncology company, announced on August 2, 2024, that it granted stock options and restricted stock units to a newly hired employee on August 1. The grants include:

1. Non-statutory stock options to purchase 13,000 ordinary shares
2. Restricted stock units for 7,000 ordinary shares

These grants were made under the company's 2024 Inducement Stock Option and Incentive Plan, in accordance with Nasdaq Listing Rule 5635(c)(4). The stock options have an exercise price of $3.48 per share, equal to the closing price on August 1, 2024. They have a ten-year term and vest over four years. The restricted stock units also vest over four years, with 25% vesting annually.

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Mural Oncology plc (Nasdaq: MURA) has appointed George Golumbeski, Ph.D., to its board of directors effective July 30, 2024. Dr. Golumbeski brings 30 years of leadership in business development, with extensive experience in strategic collaborations, M&A, licensing, and alliance management. He currently serves as a partner at DROIA Ventures and has held key positions at GRAIL, Celgene, Nabriva Therapeutics, Novartis Oncology, and Elan Biopharmaceuticals.

Mural Oncology, a clinical-stage immuno-oncology company, is developing engineered cytokine therapies for cancer treatment. The company has two potentially registrational studies reading out in the first half of 2025 and two preclinical programs approaching candidate nomination later this year. Dr. Golumbeski's appointment is expected to bring valuable expertise as Mural advances its current programs and explores potential partnerships.

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Mural Oncology, a clinical-stage immuno-oncology company, announced on July 1, 2024, the granting of non-statutory stock options and restricted stock units under its 2024 Inducement Stock Option and Incentive Plan. The grants were made as inducements for four newly hired employees under Nasdaq Listing Rule 5635(c)(4). The stock options cover 15,470 ordinary shares at an exercise price of $3.11, with a ten-year term and a vesting schedule of four years. The restricted stock units cover 8,330 ordinary shares, also vesting over four years. Both grants are subject to the terms of respective award agreements and the company's 2024 Inducement Plan.

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Mural Oncology (Nasdaq: MURA), a clinical-stage immuno-oncology company, announced that CEO Caroline Loew, Ph.D., will present at the 14th Annual East Coast IDEAS Investor Conference on June 13 at 9:15 a.m. EST.

The company focuses on developing engineered cytokine therapies to address unmet needs in cancer treatment. A webcast of the presentation will be available at www.threepartadvisors.com/east-coast and ir.muraloncology.com.

Mural will also host one-on-one investor meetings during the conference.

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Mural Oncology, a clinical-stage immuno-oncology company listed on Nasdaq under the ticker MURA, announced the granting of inducement stock options and restricted stock units to two new employees.

On June 3, 2024, the company awarded non-statutory stock options to purchase 7,995 ordinary shares and restricted stock units for 4,305 ordinary shares under the company's 2024 Inducement Stock Option and Incentive Plan. The options have an exercise price of $3.41 per share, matching the closing price on June 3, 2024, a ten-year term, and vest over four years with 25% vesting after the first year and 6.25% vesting quarterly thereafter. The restricted stock units vest at 25% annually over four years.

These grants were made as an inducement for the employees' new roles, complying with Nasdaq Listing Rule 5635(c)(4).

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Mural Oncology presented data from its ARTISTRY-3 trial at the ASCO annual meeting, showing that less frequent dosing of nemvaleukin alfa (nemvaleukin), an engineered IL-2 cytokine, is well-tolerated and effective.

The trial shifted from five daily infusions to two infusions per three-week cycle, both as a single agent and in combination with pembrolizumab. Nemvaleukin showed promising pharmacodynamic effects, such as expansion of immune-stimulating CD8+ T cells and NK cells, with minimal expansion of immunosuppressive Tregs, and no new safety issues.

Preliminary data from ARTISTRY-6 cohorts are expected in 2025.

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FAQ

What is the current stock price of Mural Oncology plc Ordinary Shares (MURA)?

The current stock price of Mural Oncology plc Ordinary Shares (MURA) is $3.18 as of December 20, 2024.

What is the market cap of Mural Oncology plc Ordinary Shares (MURA)?

The market cap of Mural Oncology plc Ordinary Shares (MURA) is approximately 54.8M.

What is Mural Oncology's primary business focus?

Mural Oncology is focused on discovering and developing innovative immunotherapies to improve the lives of cancer patients, leveraging its expertise in immune cell modulation and protein engineering.

What is nemvaleukin alfa?

Nemvaleukin alfa is Mural Oncology's lead product candidate. It is an engineered interleukin-2 (IL-2) cytokine designed to capture the therapeutic benefits of high-dose recombinant human IL-2 while mitigating its toxicities.

What are the current clinical trials for nemvaleukin?

Nemvaleukin is being evaluated in two potentially registrational trials for mucosal melanoma and platinum-resistant ovarian cancer. Additionally, it is being tested in a less frequent dosing regimen in cutaneous melanoma.

What other programs is Mural Oncology developing?

Mural Oncology is advancing discovery-stage programs targeting interleukin-18 (IL-18) and interleukin-12 (IL-12), with plans to nominate development candidates for each in 2024.

Where is Mural Oncology headquartered?

Mural Oncology's registered office is in Dublin, Ireland, and its primary facilities are located in Waltham, Massachusetts.

How was Mural Oncology formed?

Mural Oncology was spun out from Alkermes plc in November 2023 with $275 million in committed funding.

Who is leading Mural Oncology?

Mural Oncology is led by a team of seasoned oncology experts, including CEO Caroline Loew, Ph.D.

What financial runway does Mural Oncology have?

Mural Oncology's initial funding of $275 million is expected to support its operations through 4Q 2025.

What sets Mural Oncology apart in the field of immuno-oncology?

Mural Oncology's unique approach to protein engineering and immune cell modulation allows it to develop cytokine therapies that potentially overcome the limitations of existing cancer immunotherapies.

How can I get more information about Mural Oncology?

For more information, visit Mural Oncology’s website at www.muraloncology.com and follow them on LinkedIn and X.

Mural Oncology plc Ordinary Shares

Nasdaq:MURA

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