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Mural Oncology to Present Clinical and Preclinical Data at the 39th Annual Meeting of the Society for Immunotherapy of Cancer (SITC)

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Mural Oncology plc (Nasdaq: MURA) announced three upcoming poster presentations at the 39th Annual Meeting of the Society for Immunotherapy of Cancer (SITC) from November 6-10, 2024, in Houston. The presentations will cover:

1. Tumor microenvironment pharmacodynamic data from the phase 1/2 ARTISTRY-3 study, evaluating less frequent dosing of nemvaleukin, Mural's engineered interleukin-2 (IL-2).

2. Preclinical efficacy and immune activity data for half-life extended IL-18 fusion proteins.

3. Modulation of IL-12p70 exposure and activity following sequential administration of tumor-targeted self-assembling split IL-12 subunits.

These presentations showcase Mural's progress in developing novel engineered cytokine therapies for cancer treatment, including their IL-2, IL-18, and IL-12 research programs.

Mural Oncology plc (Nasdaq: MURA) ha annunciato tre prossime presentazioni di poster al 39° Congresso Annuale della Society for Immunotherapy of Cancer (SITC), che si terrà dal 6 al 10 novembre 2024 a Houston. Le presentazioni tratteranno:

1. Dati farmacodinamici del microambiente tumorale dallo studio di fase 1/2 ARTISTRY-3, che valuta dosaggi meno frequenti di nemvaleukin, l'interleuchina-2 (IL-2) ingegnerizzata di Mural.

2. Dati di efficacia preclinica e attività immunitaria per le proteine fusione IL-18 a vita media estesa.

3. Modulazione dell'esposizione e dell'attività di IL-12p70 a seguito dell'amministrazione sequenziale di subunità IL-12 split autoassemblanti mirati al tumore.

Queste presentazioni mostrano i progressi di Mural nello sviluppo di nuove terapie con citochine ingegnerizzate per il trattamento del cancro, compresi i loro programmi di ricerca su IL-2, IL-18 e IL-12.

Mural Oncology plc (Nasdaq: MURA) anunció tres próximas presentaciones de carteles en el 39º Congreso Anual de la Society for Immunotherapy of Cancer (SITC), que se llevará a cabo del 6 al 10 de noviembre de 2024 en Houston. Las presentaciones cubrirán:

1. Datos farmacodinámicos del microambiente tumoral del estudio de fase 1/2 ARTISTRY-3, que evalúa dosificaciones menos frecuentes de nemvaleukin, la interleucina-2 (IL-2) diseñada de Mural.

2. Datos de eficacia preclínica y actividad inmune para proteínas de fusión de IL-18 con vida media extendida.

3. Modulación de la exposición y la actividad de IL-12p70 tras la administración secuencial de subunidades IL-12 autoensambladas dirigidas al tumor.

Estas presentaciones destacan los avances de Mural en el desarrollo de nuevas terapias de citoquinas diseñadas para el tratamiento del cáncer, incluidos sus programas de investigación sobre IL-2, IL-18 e IL-12.

Mural Oncology plc (Nasdaq: MURA)는 2024년 11월 6일부터 10일까지 휴스턴에서 열리는 제39회 암 면역요법 학회(SITC) 연례 회의에서 세 가지 포스터 발표를 예정하고 있다고 발표했습니다. 발표 내용은 다음과 같습니다:

1. Mural의 엔지니어링된 인터루킨-2(IL-2)인 념발류킨의 덜 잦은 투여를 평가하는 임상 1/2 ARTISTRY-3 연구에서의 종양 미세환경 약리역학 데이터.

2. 반감기 연장 IL-18 융합 단백질의 전임상 효능 및 면역 활성을 위한 데이터.

3. 종양을 표적으로 하는 자가 조립 분할 IL-12 서브유닛의 순차적 투여 후 IL-12p70 노출 및 활성 조절.

이 발표들은 암 치료를 위한 새로운 엔지니어링된 사이토카인 치료법 개발에서 Mural의 진행 상황을 보여주며, IL-2, IL-18 및 IL-12 연구 프로그램을 포함하고 있습니다.

Mural Oncology plc (Nasdaq: MURA) a annoncé trois prochaines présentations de poster lors du 39ème Congrès Annuel de la Society for Immunotherapy of Cancer (SITC), qui se tiendra du 6 au 10 novembre 2024 à Houston. Les présentations porteront sur :

1. Données pharmacodynamiques du microenvironnement tumoral issues de l'étude de phase 1/2 ARTISTRY-3, évaluant des dosages moins fréquents de nemvaleukin, l'interleukine-2 (IL-2) ingénierie de Mural.

2. Données d'efficacité préclinique et d'activité immunitaire pour les protéines de fusion IL-18 à demi-vie prolongée.

3. Modulation de l'exposition et de l'activité de l'IL-12p70 après administration séquentielle de sous-unités IL-12 auto-assemblantes ciblant la tumeur.

Ces présentations mettent en avant les progrès de Mural dans le développement de nouvelles thérapies basées sur des cytokines ingénieries pour le traitement du cancer, y compris leurs programmes de recherche sur l'IL-2, l'IL-18 et l'IL-12.

Mural Oncology plc (Nasdaq: MURA) gab bekannt, dass während des 39. Jahreskongresses der Society for Immunotherapy of Cancer (SITC) vom 6. bis 10. November 2024 in Houston drei bevorstehende Posterpräsentationen stattfinden werden. Die Präsentationen werden folgende Themen behandeln:

1. Pharmakodynamische Daten aus dem Tumormikroumfeld der Phase 1/2-Studie ARTISTRY-3, die weniger häufige Dosierungen von Nemvaleukin, Murals ingeniehrtem Interleukin-2 (IL-2), evaluiert.

2. Präklinische Wirksamkeit und Immunaktivitätsdaten für IL-18-Fusionsproteine mit verlängerter Halbwertszeit.

3. Modulation der Exposition und Aktivität von IL-12p70 nach sequentieller Verabreichung von tumorgerichteten selbstassemblierenden IL-12-Split-Subeinheiten.

Diese Präsentationen zeigen Murals Fortschritte bei der Entwicklung neuartiger ingeniehrter Zytokinterapien zur Krebsbehandlung, einschließlich ihrer Forschungsprogramme zu IL-2, IL-18 und IL-12.

Positive
  • Mural Oncology will present data from three research programs at a major oncology conference
  • The company is advancing multiple cytokine-based therapies for cancer treatment
  • Presentation of phase 1/2 clinical data for nemvaleukin (IL-2 therapy)
  • New preclinical efficacy data for IL-18 program to be shared
Negative
  • None.

WALTHAM, Mass and DUBLIN, Oct. 07, 2024 (GLOBE NEWSWIRE) -- Mural Oncology plc (Nasdaq: MURA), a clinical-stage immuno-oncology company developing novel, investigational engineered cytokine therapies designed to address areas of unmet need for patients with a variety of cancers, today announced three upcoming poster presentations at the 39th Annual Meeting of the Society for Immunotherapy of Cancer (SITC) taking place November 6-10, 2024 in Houston.

The company will present tumor microenvironment pharmacodynamic data from the phase 1/2 ARTISTRY-3 study, an evaluation of less frequent dosing of nemvaleukin, Mural’s engineered interleukin-2 (IL-2). Additionally, Mural will share data from its two preclinical research programs in IL-18 and IL-12, including new preclinical efficacy data for IL-18. The details are as follows.

Title: Tumor microenvironment pharmacodynamic effect of nemvaleukin less frequent intravenous dosing in multiple solid tumors: results from the phase 1/2 ARTISTRY-3 study
Abstract Number: 217
Presentation Date: Friday, Nov. 8

Title: Preclinical efficacy and immune activity of half-life extended IL-18 fusion proteins resistant to IL-18BP suppression
Abstract Number: 1340
Presentation Date: Saturday, Nov. 9

Title: Modulation of IL-12p70 exposure and activity following sequential administration of tumor targeted self-assembling split IL-12 subunits
Abstract Number: 1300
Presentation Date: Saturday, Nov. 9

About Mural Oncology
Mural Oncology is leveraging its novel protein engineering platform to develop cytokine-based immunotherapies for the treatment of cancer. By combining our expertise in cytokine biology and immune cell modulation and our protein engineering platform, we are developing medicines to deliver meaningful and clinical benefits to people living with cancer. Our mission is to broaden the potential, and reach, of cytokine-based immunotherapies to improve the lives of patients. Our lead candidate, nemvaleukin, is currently in potentially registrational trials in platinum-resistant ovarian cancer and mucosal melanoma reading out in the first half of 2025. Mural Oncology has its registered office in Dublin, Ireland, and its primary facilities in Waltham, Mass. For more information, visit Mural Oncology’s website at www.muraloncology.com and follow us on LinkedIn and X

About Nemvaleukin
Nemvaleukin alfa (nemvaleukin) is a novel, engineered cytokine designed to leverage antitumor effects of the IL-2 pathway while mitigating the hallmark toxicities that limit its use. Nemvaleukin selectively binds to the intermediate-affinity IL-2 receptor (IL-2R) and is sterically occluded from binding to the high-affinity IL-2R. Because of this molecular design, nemvaleukin treatment leads to preferential expansion of antitumor CD8+ T cells and natural killer cells, with minimal expansion of immunosuppressive regulatory T cells. Nemvaleukin is currently being evaluated in two potentially registrational late-stage trials.

About Mural Oncology’s IL-18 Program        
IL-18 is a potent immune-stimulating cytokine, but its efficacy is blunted by IL-18 binding protein (IL-18BP), a high affinity decoy receptor that binds to, and neutralizes, IL-18, thereby rendering it ineffective. Native IL-18’s potency is also limited by its short half-life. Mural Oncology’s novel approach to protein engineering is designed to mitigate these issues. First, Mural introduced mutations to IL-18 that eliminate binding to IL-18BP while minimally impacting the native IL-18 structure. Second, it fused IL-18 to protein scaffolds which extend the half-life and increase IL-18’s exposure. Together, these have demonstrated more durable immunological effect in preclinical studies. Mural intends to nominate a development candidate for its IL-18 program by the end of this year and file an IND submission by the end of 2025.

About Mural Oncology’s IL-12 Program
Native IL-12 is a highly potent pro-inflammatory cytokine, but because of its very narrow therapeutic index, it can also be toxic with systemic exposure. To mitigate this hallmark toxicity, Mural, through its novel approach to protein engineering, split the IL-12p70 heterodimer into two inactive monomers: IL12p35 and IL-12p40. These individual subunits are then separately fused to antibody fragments and sequentially injected, which deliver and concentrate IL-12 specifically in the tumor microenvironment to limit systemic exposure. In preclinical studies, Mural’s engineered IL-12 achieved the desired reduction in serum while maintaining tumor concentrations providing the potential to reduce systemic toxicities. Mural intends to nominate a development candidate for its IL-12 program by the end of this year.

Forward-Looking Statements
Statements contained in this press release regarding matters that are not historical facts are “forward-looking statements” within the meaning of the Private Securities Litigation Reform Act of 1995. Because such statements are subject to risks and uncertainties, actual results may differ materially from those expressed or implied by such forward-looking statements. Such statements include, but are not limited to, statements regarding: the company’s pipeline and development programs, including the expected timing of clinical updates from the ARTISTRY-6 and ARTISTRY-7 trials, the expected timing of preclinical updates, candidate nomination, and IND submission, including with respect to the Company’s IL-18 and IL-12 programs, the potential of the company’s product candidates and programs to address unmet medical needs, and the continued progress of its pipeline and programs. Any forward-looking statements in this press release are based on management’s current expectations of future events and are subject to a number of risks and uncertainties that could cause actual results to differ materially and adversely from those set forth in or implied by such forward-looking statements. Risks that contribute to the uncertain nature of the forward-looking statements include, among others, the inherent risks and uncertainties associated with competitive developments, preclinical development, clinical trials, recruitment of patients, product development activities and regulatory approval requirements; that preclinical or interim results and data from ongoing clinical studies of the company’s cytokine programs and product candidates may not be predictive of future or final results from such studies, results of future clinical studies or real-world results; future clinical trials or future stages of ongoing clinical trials may not be initiated or completed on time or at all; the company’s product candidates, including nemvaleukin, could be shown to be unsafe or ineffective; changes in the cost, scope and duration of development activities; the U.S. Food and Drug Administration may make adverse decisions regarding the company’s product candidates; and those other risks and uncertainties set forth in the company’s filings with the Securities and Exchange Commission (“SEC”), including its Quarterly Report on Form 10-Q for the quarterly period ended June 30, 2024 and in subsequent filings the company may make with the SEC. All forward-looking statements contained in this press release speak only as of the date of this press release. The company anticipates that subsequent events and developments will cause its views to change. However, the company undertakes no obligation to update such forward-looking statements to reflect events that occur or circumstances that exist after the date of this press release, except as required by law.

Contact:
Katie Sullivan
katie.sullivan@muraloncology.com


FAQ

What data will Mural Oncology (MURA) present at the 39th SITC Annual Meeting?

Mural Oncology will present tumor microenvironment pharmacodynamic data from the phase 1/2 ARTISTRY-3 study of nemvaleukin, preclinical efficacy data for IL-18 fusion proteins, and data on IL-12p70 modulation using self-assembling split IL-12 subunits.

When and where will Mural Oncology (MURA) present at the SITC Annual Meeting?

Mural Oncology will present at the 39th Annual Meeting of the Society for Immunotherapy of Cancer (SITC) taking place November 6-10, 2024 in Houston.

What is nemvaleukin and what will Mural Oncology (MURA) present about it?

Nemvaleukin is Mural's engineered interleukin-2 (IL-2) therapy. The company will present tumor microenvironment pharmacodynamic data from the phase 1/2 ARTISTRY-3 study, evaluating less frequent dosing of nemvaleukin in multiple solid tumors.

What preclinical data will Mural Oncology (MURA) present at SITC 2024?

Mural Oncology will present preclinical efficacy and immune activity data for half-life extended IL-18 fusion proteins, and data on modulation of IL-12p70 exposure and activity using tumor-targeted self-assembling split IL-12 subunits.

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