Marvel Biosciences Shares Positive Results of MB204 in the Oprm1 Model of Autism
Rhea-AI Summary
Marvel Biosciences Corp. (TSXV: MRVL) (OTCQB: MBCOF) has reported positive results from a study on MB204 in the Oprm1 mouse model of autism. The research, conducted by Drs. Julie Le Merrer and Jerome Becker, showed that a single oral dose of MB204 successfully reversed social behavior deficits typically seen in the model within one hour of administration.
Key findings include:
- A high dose (2.5 mg/kg) of MB204 significantly restored social behavior in all measured endpoints (p<0.0001)
- A lower dose (1 mg/kg) also reversed nearly all social behavior deficits
- The higher dose even outperformed normal (non-autistic) mice on several endpoints
The researchers noted that MB204 showed more improvement and a hyper-social effect compared to previously tested drugs. Marvel is now testing MB204 in other autism spectrum disorder models, including Rett syndrome (Mecp2) and Fragile X syndrome (Fmr1).
Positive
- MB204 successfully reversed social behavior deficits in the Oprm1 mouse model of autism
- High dose (2.5 mg/kg) of MB204 significantly restored social behavior in all measured endpoints (p<0.0001)
- Lower dose (1 mg/kg) of MB204 also reversed nearly all social behavior deficits
- MB204 outperformed normal (non-autistic) mice on several endpoints, demonstrating a potent pro-social effect
- MB204 showed more improvement and a hyper-social effect compared to previously tested drugs like Istradefylline
Negative
- None.
News Market Reaction
On the day this news was published, MBCOF declined 9.08%, reflecting a notable negative market reaction.
Data tracked by StockTitan Argus on the day of publication.
Calgary, Alberta--(Newsfile Corp. - October 10, 2024) - Marvel Biosciences Corp. (TSXV: MRVL) (OTCQB: MBCOF), and its wholly owned subsidiary, Marvel Biotechnology Inc. (collectively the "Company" or "Marvel"), today shared promising results from a recent study on MB204. The research was conducted by Drs. Julie Le Merrer and Jerome Becker of the iBraiN Institute in Tours, France, to investigate the impact of MB204 in the Oprm1 mouse model of autism (widely used to study social behavior deficits). Marvel is pleased to report that just one hour after administering a single oral dose of MB204, the drug successfully reversed the social behaviour deficits typically seen in the model.
Key Highlights:
- A high dose of MB204 (2.5 mg/kg) significantly restored social behaviour in all measured endpoints (p<0.0001). Improvements were seen in social interaction behaviours including, the number and duration of nose contacts, the number and duration of paw contacts, and time spent self-grooming, amongst others.
- A lower dose of MB204 (1 mg/kg) also reversed nearly all social behaviour deficits, showing a clear connection between dose and response.
- The higher dose of MB204 not only improved/restored social interactions in Oprm1 (autistic) mice, but even outperformed the social interactions of normal (non-autistic) mice on several endpoints, demonstrating MB204's potent pro-social effect.
"These results are very encouraging," said Drs. Le Merrer and Becker, "MB204, at both doses, nearly reversed all the social deficits/endpoints in our autism model, and in some cases, the Oprm1 animals appeared to be more sociable than normal animals. We have previously tested Istradefylline (an off-patent approved drug similar to MB204), in multiple models of autism such as Oprm1, Mecp2, and Fmr1 but we have not seen this level of improvement or the hyper-social effect before."
Currently, Drs. Le Merrer and Becker are now testing MB204 in another chronic Rett syndrome model (Mecp2) and are looking forward to seeing how it performs 'head-to-head' against the approved drug Trofinetide.
"We are very pleased with these findings for MB204 and intend to publish them in a peer reviewed journal," said Marvel's Chief Science Officer, Dr. Mark Williams. "MB204 is currently being tested in two very clinically relevant autism spectrum disorder models of Rett syndrome (Mecp2) and Fragile X syndrome (Fmr1), the latter is in collaboration with the Fraxa Research Foundation, and we look forward to reviewing the results."
About Marvel Biosciences Corp.
Marvel Biosciences Corp., and its wholly owned subsidiary, Marvel Biotechnology Inc., is a Calgary-based pre-clinical stage pharmaceutical development biotechnology company that utilizes a "drug redevelopment" approach to drug development. Historically, when a new class of drug is developed, it is optimized for a particular target, but typically only approved for a specific disease. Often, a new disease is identified which involves the same target, however, pending the remaining patent life, the originally approved drug may not have sufficient time left for it to be commercially viable to be developed for the new disease indication. Marvel develops new synthetic chemical derivatives of the original approved drug for the new disease indication. Patent protection is sought, as the new potential asset is developed by the Company. The Company believes the business model results in significantly less risk, cost and time to develop its assets compared to traditional biotechnology companies.
Marvel Biotechnology Inc. has currently developed several new chemical entities, using synthetic chemical derivatives of known, off-patent drugs, that inhibit the A2a adenosine receptor with application to neurological diseases (depression & anxiety, Alzheimer's, ADHD), and the non-neurological conditions of cancer and non-alcoholic steatohepatitis. Marvel is also exploring additional undisclosed targets to expand its asset pipeline.
Contact Information
Marvel Biosciences Corp.
J. Roderick (Rod) Matheson, Chief Executive Officer or
Dr. Mark Williams, President and Chief Science Officer
Tel: 403 770 2469
Neither the TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in the policies of the TSXV) accepts responsibility for the adequacy or accuracy of this press release.
All information contained in this news release with respect to the Company and its subsidiary, (collectively, the "Parties") were supplied by Marvel, respectively, for inclusion herein and each parties' directors and officers have relied on each other for any information concerning such Party.
This news release may contain forward-looking statements and other statements that are not historical facts. Forward-looking statements are often identified by terms such as "will", "may", "should", "anticipate", "expects" and similar expressions. All statements other than statements of historical fact, included in this release, including, without limitation, statements regarding the future plans and objectives of the Company are forward-looking statements that involve risks and uncertainties. There can be no assurance that such statements will prove to be accurate and actual results and future events could differ materially from those anticipated in such statements. Important factors that could cause actual results to differ materially from the expectations of the Company and include other risks detailed from time to time in the filings made by the Company under securities regulations.
To view the source version of this press release, please visit https://www.newsfilecorp.com/release/226201
FAQ
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