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Lyell Immunopharma, Inc. (Nasdaq: LYEL) is a clinical-stage company pioneering T-cell reprogramming to create cell therapies for patients with solid tumors. By employing advanced genetic and epigenetic technologies, Lyell aims to overcome major challenges in current cell-based immunotherapies, including T-cell exhaustion and lack of durable stemness. Their innovative approach has led to a robust pipeline featuring product candidates like LYL797, LYL119, and LYL845.
Lyell's product portfolio is designed to address the unmet needs in cancer treatment. LYL797 targets ROR1-positive cancers such as triple-negative breast cancer and non-small cell lung cancer, incorporating genetic reprogramming to overexpress c-Jun and epigenetic reprogramming for enhanced durability. LYL119 is another ROR1-targeted CAR T-cell therapy that uses four reprogramming technologies for sustained function and cytotoxicity. LYL845, a tumor-infiltrating lymphocyte (TIL) product, is enhanced with Lyell's proprietary Epi-R™ protocol to improve potency and durability.
Recent achievements include the FDA granting Orphan Drug Designation for LYL845 in advanced melanoma. The company's innovative Epi-R P2 manufacturing process has shown potential to reduce TIL culture time significantly. Lyell is also advancing collaborations, such as with Outpace Bio, to develop localized IL-12 activity in tumors, enhancing the efficacy of T-cell therapies.
Lyell's business strategy has been bolstered by a strong financial position, with cash reserves extending operational capabilities into 2027. Despite macroeconomic challenges, Lyell continues to focus on generating clinical data and advancing its clinical programs, aiming to deliver transformative treatments for cancer patients.
For the latest updates on Lyell Immunopharma, including their financial performance and ongoing clinical trials, visit their official website.
Lyell Immunopharma (Nasdaq: LYEL) announces the presentation of a poster at the ESMO Congress 2022 on the Phase 1 trial design for LYL797, a CAR T-cell therapy aimed at treating solid tumors. This innovative therapy utilizes Lyell’s Gen-R™ and Epi-R™ technologies to enhance T-cell functionality against challenges like exhaustion. The trial targets patients with advanced solid tumors, including triple-negative breast cancer and non-small cell lung cancer. The poster session occurred on September 12, 2022, in Paris, providing insights into Lyell's commitment to curative cell therapies.
Lyell Immunopharma (Nasdaq: LYEL) announced that its senior management will participate in a fireside chat at the Morgan Stanley 20th Annual Global Healthcare Conference on September 12, 2022, at 1:05 p.m. ET. The event will focus on the company’s innovative approaches to T-cell reprogramming aimed at treating solid tumors.
A live webcast can be accessed via the investor relations section of Lyell's website, with a replay available for 90 days post-presentation.
Lyell Immunopharma reported significant financial updates for Q2 2022, with revenue climbing to $35.7 million, a notable increase from $2.6 million in Q2 2021. This surge is attributed to a mutual agreement with GSK for a hematological cancer research initiative. Despite a net loss of $36.3 million, an improvement from $62.6 million in the prior year, Lyell's cash position remains strong at $787 million, expected to fund operations through 2025. The company continues to advance its clinical pipeline, focusing on overcoming T-cell exhaustion in solid tumor therapies.
Lyell Immunopharma, Inc. (Nasdaq: LYEL), a clinical-stage T-cell reprogramming company, will participate in the Goldman Sachs 43rd Annual Global Healthcare Conference on June 14 at 10:40 AM PT. A live webcast of the event will be available on the company’s website, with a replay accessible for 90 days afterward. Lyell focuses on developing curative cell therapies for solid tumors and utilizes proprietary technologies to enhance T-cell functionality. For more information, visit www.lyell.com.
Lyell Immunopharma reported a first-quarter net loss of $68.1 million for Q1 2022, up from $55.0 million in Q1 2021. The company holds $838 million in cash and marketable securities, expected to cover operations through 2025. Lyell advanced two products into Phase 1 clinical development and plans to submit INDs for LYL845 and LYL331 later this year. R&D expenses decreased to $35.8 million, while G&A expenses rose sharply to $34.4 million, driven by stock-based compensation and litigation costs. Upcoming presentations at ASGCT and AACR are expected to highlight advancements in their cell therapy pipeline.
Lyell Immunopharma, Inc. (Nasdaq: LYEL), a leader in T-cell reprogramming, announced participation in the BofA Securities 2022 Healthcare Conference on May 11 at 5:20 pm PT. The management team will engage in a fireside chat that can be accessed via a live webcast on the company's investor relations page. A replay will be available for 90 days after the event. Lyell focuses on overcoming challenges in adoptive T-cell therapy, utilizing proprietary technologies Gen-R and Epi-R to enhance T-cell functionality for combating solid tumors.
Lyell Immunopharma (Nasdaq: LYEL) announced two abstracts accepted for poster presentations at the 25th Annual Meeting of the American Society of Gene & Cell Therapy, from May 16 to May 19, 2022. The presentations will showcase preclinical data on LYL797 and LYL132, both in Phase 1 trials, focusing on Gen-R and Epi-R technologies that enhance T-cell performance against solid tumors. LYL797 targets ROR1-positive cancers, while LYL132 targets NY-ESO-1 expressing tumors. The aim is to improve T-cell durability and anti-tumor effectiveness.
Lyell Immunopharma (Nasdaq: LYEL) reported its 2021 financial results, highlighting a net loss of $250.2 million. Cash, equivalents, and marketable securities totaled $898 million as of Dec 31, 2021, supporting their cell therapy pipeline. The company received FDA clearance for two INDs and is initiating clinical trials for therapies targeting solid tumors. Key R&D expenses decreased to $138.7 million from $182.2 million in 2020. The team was strengthened with new executive appointments. Positive long-term outlook with cash expected to sustain operations until at least 2025.
Lyell Immunopharma has announced that its investigational LYL797, a ROR1 CAR T-cell therapy, will be presented at the AACR 2022 Annual Meeting from April 8-13 in New Orleans. The therapy employs advanced T-cell reprogramming technologies aimed at treating solid tumors. Preclinical data will be highlighted, showcasing Gen-R and Epi-R technologies that enhance T-cell durability and functionality. The poster presentation is scheduled for April 12, featuring Spencer Park, PhD.
LYL797 has received FDA clearance for Phase 1 clinical trials.
Lyell Immunopharma, Inc. (Nasdaq: LYEL) has appointed Gary Lee, Ph.D., as its new Chief Scientific Officer. Dr. Lee brings over a decade of experience in translational cell and gene therapy, aiming to advance the company’s research pipeline. This strategic move reflects Lyell's commitment to developing a multi-modality cell therapy pipeline using its innovative T-cell reprogramming technologies. Concurrently, Nick Restifo will transition to a scientific advisor role, continuing to support the company's programs.
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