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Lixte Biotechnology Holdings, Inc. (Lixte) is a clinical-stage public pharmaceutical company focused on developing drugs for more effective cancer treatments. The company has identified molecular signaling pathways and designed compounds to target them safely in animal models. Lixte's drug portfolio includes inhibitors of protein phosphatases critical to cell division and DNA damage repair, as well as inhibitors of protein deacetylases that regulate gene expression and protein degradation. Their lead compound, LB-100, is in phase I trials and has the potential to be first-in-class.
LIXTE Biotechnology Holdings, Inc. (Nasdaq: LIXT) has expanded its clinical trial for ovarian clear cell cancer by adding the Robert H. Lurie Comprehensive Cancer Center of Northwestern University as a second site. The trial combines LIXTE's proprietary compound LB-100 with GSK's immunotherapy Dostarlimab.
Dr. Emily M. Hinchcliff will lead the trial at Lurie Cancer Center, where patient recruitment is underway and the first patient has already been dosed. This expansion follows the trial's initial launch in January 2024 at The University of Texas MD Anderson Cancer Center under lead investigator Dr. Amir Jazaeri.
The clinical trial aims to determine if adding LB-100 to Dostarlimab enhances immunotherapy effectiveness in treating ovarian clear cell carcinoma, which represents a disease with high unmet medical needs.
LIXTE Biotechnology (Nasdaq: LIXT) has completed its previously announced registered direct offering, raising $1.05 million through the sale of 434,784 common shares at $2.415 per share. The company also issued unregistered warrants in a concurrent private placement to purchase up to 434,784 shares at an exercise price of $2.29, valid for five years.
H.C. Wainwright & Co. served as the exclusive placement agent. The net proceeds, after deducting placement agent fees and offering expenses, will be used for working capital and general corporate purposes. The common shares were offered through a shelf registration statement, while the warrants were issued through a private placement under Section 4(a)(2) of the Securities Act.
LIXTE Biotechnology (Nasdaq: LIXT) has announced a $1.05 million registered direct offering priced at-the-market under Nasdaq rules. The company will sell 434,784 shares of common stock at $2.415 per share, along with unregistered warrants in a concurrent private placement. The warrants, exercisable for five years, will allow purchase of up to 434,784 additional shares at $2.29 per share.
The offering, expected to close around February 12, 2025, is being exclusively placed by H.C. Wainwright & Co. LIXTE plans to use the net proceeds for working capital and general corporate purposes. The common stock offering is made through a shelf registration statement, while the warrants are being issued through a private placement under Section 4(a)(2) of the Securities Act.
LIXTE Biotechnology Holdings (Nasdaq: LIXT) announced on February 10, 2025, that it has submitted a request to withdraw its Form S-1 Registration Statement (No. 333-282781) with the SEC. The Registration Statement, originally filed on October 23, 2024, was intended for a public offering, which the company has now decided not to pursue at this time.
The company confirmed that the Registration Statement had not been declared effective by the SEC, and no securities were sold in connection with the proposed offering. LIXTE, a clinical-stage pharmaceutical company, emphasized that this announcement does not constitute an offer to sell or solicitation to buy securities.
LIXTE Biotechnology Holdings (Nasdaq: LIXT) has received a Notice of Allowance from the USPTO for a patent application covering the combination of its LB-100 compound with various cancer immunotherapies. This patent strengthens LIXTE's intellectual property portfolio and highlights its commitment to innovative cancer research. The company is currently conducting clinical trials at the Netherlands Cancer Institute and MD Anderson Cancer Center, testing LB-100 in combination with immunotherapies for metastatic colon cancer and ovarian clear cell carcinoma. LIXTE recently signed an exclusive patent license agreement with NINDS and NCI, opening up opportunities for developing novel combination therapies in cancer treatment.
LIXTE Biotechnology Holdings (Nasdaq: LIXT) has announced the dosing of the first patient in a new clinical trial for treating unresponsive metastatic colorectal cancer. The trial is a collaboration with the Netherlands Cancer Institute (NKI) and is supported by Roche. LIXTE is providing its lead compound, LB-100, while Roche is supplying atezolizumab (Tecentriq®), a PDL1 inhibitor. The trial aims to make immunotherapy an effective treatment option for approximately 85% of colorectal cancer patients who have not responded to traditional protocols. This marks the second recent clinical trial combining LB-100 with immunotherapy funded by a major pharmaceutical company, following an earlier trial with GSK for clear cell ovarian cancer treatment.
LIXTE Biotechnology Holdings, Inc. (LIXT) has announced several significant developments:
1. A new collaboration with The Netherlands Cancer Institute, supported by Roche, for a clinical trial in metastatic colorectal cancer using LB-100 and atezolizumab.
2. Appointment of Dr. Jan Schellens as Chief Medical Officer, bringing extensive oncology and drug development experience.
3. Publication of preclinical data in EMBO Reports showing LB-100's potential to enhance immunotherapy benefits.
4. Ongoing clinical trials, including a GSK-funded study of LB-100 with dostarlimab-gxly in ovarian clear cell cancer and a soft tissue sarcomas trial with expected data in early 2025.
5. Upcoming presentations at two investor conferences in August and September 2024.
LIXTE Biotechnology Holdings (Nasdaq: LIXT) announced its participation in two upcoming investor conferences. The company will present at the Investor Summit Summer 2024 Virtual Conference on August 20, 2024, at 2 p.m. EDT, and the H.C. Wainwright 26th Annual Global Investment Conference from September 9-11, 2024.
CEO Bas van der Baan will provide an overview of LIXTE's clinical trials with LB-100, their proprietary compound designed to enhance chemotherapy and immunotherapy treatments for cancer. The company is currently conducting proof-of-concept clinical trials for colorectal, ovarian, and sarcoma cancers, including trials funded by GSK and Roche.
Investors can access the presentations through LIXTE's investor relations website and the H.C. Wainwright conference registration page.
LIXTE Biotechnology Holdings announced a collaboration with Roche and the Netherlands Cancer Institute (NKI) to conduct a new clinical trial targeting immune therapy unresponsive (MSI Low) metastatic colon cancer. The trial, listed as NCT06012734, will investigate the efficacy of LIXTE's lead compound, LB-100, in combination with Roche's PD-L1 inhibitor, atezolizumab (Tecentriq®). Approximately 85% of colon cancers are MSI Low and non-responsive to immunotherapy. The aim is to enhance immunotherapy efficacy for these patients. The collaboration highlights the scientific potential of LB-100, which has shown promise in pre-clinical data and previous trials. This study is the second recent collaboration with a major pharmaceutical company, following a GSK-supported trial for clear cell ovarian cancer.
LIXTE Biotechnology Holdings has announced a collaboration with Roche and the Netherlands Cancer Institute (NKI) for a new clinical trial targeting MSI Low metastatic colon cancer. The trial, registered as NCT06012734, will test LIXTE's lead compound LB-100 in combination with Roche's PD-L1 inhibitor, atezolizumab. NKI's Dr. Neeltje Steeghs will lead the trial, aiming to improve immunotherapy efficacy for the 85% of colon cancers unresponsive to current treatments. This collaboration follows another recent trial funded by GSK for clear cell ovarian cancer, highlighting the pharmaceutical industry's support for LB-100's potential. This trial could significantly impact colon cancer treatment by making immunotherapy viable for a larger patient group.
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