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Lixte Biotechnology Holdings, Inc. (Lixte) is a clinical-stage public pharmaceutical company focused on developing drugs for more effective cancer treatments. The company has identified molecular signaling pathways and designed compounds to target them safely in animal models. Lixte's drug portfolio includes inhibitors of protein phosphatases critical to cell division and DNA damage repair, as well as inhibitors of protein deacetylases that regulate gene expression and protein degradation. Their lead compound, LB-100, is in phase I trials and has the potential to be first-in-class.
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LIXTE Biotechnology Holdings, Inc. announces a groundbreaking discovery that its lead clinical compound, LB-100, can force cancer cells to become less cancerous, opening up a new treatment strategy. The pre-clinical data published in Cancer Discovery shows that LB-100, when combined with a WEE1 kinase inhibitor, is highly effective in killing colon cancer cells. The unique feature of LB-100 is its ability to hyper-activate cancer signals, leading to cancer cells becoming less malignant and unable to form tumors. This 'tumor suppressive drug resistance' concept could revolutionize cancer treatment.
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LIXTE Biotechnology Holdings, Inc. provides an update on three ongoing clinical trials for treating ovarian, lung, and sarcoma cancers. The company is developing a new cancer therapy using LB-100 to enhance chemotherapy and immunotherapy. Significant developments include dosing the first patient in a Phase 1b/2 trial with GSK's dostarlimab-gxly for ovarian clear cell carcinoma, an exclusive patent license agreement with NIH, and new pre-clinical data presented by Dr. René Bernards on LB-100's unique mechanism of action.
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LIXTE Biotechnology Holdings, Inc. presents new pre-clinical data on their lead compound LB-100 at a cancer research conference in Dublin. The data shows how LB-100 drives cancer cells to evolve into less aggressive behavior, positioning it as a promising cancer therapy. LIXTE also enters into a Patent License Agreement with NIH and initiates a clinical trial to assess LB-100's effectiveness in combination with immunotherapy for ovarian clear cell carcinoma.
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LIXTE Biotechnology Holdings, Inc. signs exclusive patent license agreement with NIH to develop innovative cancer immunotherapies. The collaboration aims to combine LIXTE's LB-100 with various cancer treatments to enhance anti-cancer activity. Clinical trials are underway to evaluate LB-100's potential in combination with checkpoint inhibitors and chemotherapy for cancer treatment.
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LIXTE Biotechnology Holdings, Inc. announced the dosing of the first patient in a Phase 1b/2 clinical trial to evaluate the potential of adding LB-100 to GSK's dostarlimab-gxly in treating ovarian clear cell carcinoma. The trial is conducted at The University of Texas MD Anderson Cancer Center, based on the observation that reducing PP2A pharmacologically with LB-100 may enhance the anti-tumor effect of the PD-1 blocking monoclonal antibody in patients with OCCC lacking the genetic reduction in PP2A.
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LIXTE Biotechnology Holdings, Inc. (Nasdaq: LIXT and LIXTW) provides an update on its progress, including advancements in the development of LB-100, a new cancer therapy, through collaborations with GSK, The University of Texas - MD Anderson Cancer Center, and other institutions. The company also announces the appointment of Bas van der Baan as President and CEO and Chairman of the Board of Directors, following the passing of the founder. Additionally, LIXTE closed a registered direct offering and private placement, raising approximately $3,500,000.
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LIXTE Biotechnology Holdings, Inc. announces the passing of its founder and Executive Chairman
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Bas van der Baan named President and CEO of LIXTE Biotechnology Holdings, Inc.
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LIXTE announces Phase 1b clinical trial for LB-100 and dostarlimab combination in ovarian clear cell carcinoma
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LIXTE Biotechnology Holdings, Inc. has closed its registered direct offering and concurrent private placement, raising approximately $3.5 million. The offering consisted of 583,334 shares of common stock at a purchase price of $6.00 per share. The common warrants issued in the private placement have an exercise price of $6.00 per share and expire in 5 years. A.G.P./Alliance Global Partners acted as the sole placement agent for the offering.
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FAQ
What is the current stock price of Lixte Biotechnology Holdings Warrants (LIXTW)?
The current stock price of Lixte Biotechnology Holdings Warrants (LIXTW) is $0.0248 as of November 4, 2024.
What is Lixte Biotechnology Holdings, Inc. focused on?
Lixte is focused on developing drugs for more effective cancer treatments.
What are some key points about Lixte's drug portfolio?
The drug portfolio includes inhibitors of protein phosphatases critical to cell division and DNA damage repair, as well as inhibitors of protein deacetylases.
What is the lead compound being developed by Lixte?
LB-100 is the lead compound, currently in phase I trials with potential to be first-in-class.
What is the unique approach taken by Lixte in cancer treatment?
Lixte has identified molecular signaling pathways and designed compounds to target them in animal models.
How can Lixte's inhibitors benefit cancer treatment?
The inhibitors have the potential to enhance the effectiveness of cytotoxic anti-cancer drugs and radiation therapy, making them useful in combination with existing standard chemotherapy regimens.
What is the contact information for Lixte Biotechnology Holdings, Inc.?
For more information, contact Lixte at info@lixte.com or call General Phone: (631) 830-7092 / Investor Phone: (888) 289-5533.
Where can investors find information about Lixte's stock?
Investors can reach out to PondelWilkinson Inc. by email at pwinvestor@pondel.com or by phone at Roger Pondel: (310) 279-5965 / Laurie Berman: (310) 279-5962.
What makes Lixte's approach to cancer treatment promising?
The company's inhibitors of protein phosphatases have shown therapeutic potential for a broad range of cancers, aiming to improve patients' lives.
What are some recent highlights from Lixte Biotechnology Holdings, Inc.?
Recent highlights include the filing of Quarterly Report on Form 10-Q and the development of LB-100, a promising compound in phase I trials.
How does Lixte Biotechnology Holdings, Inc. contribute to the field of cancer research?
Lixte's focus on targeting molecular signaling pathways and developing compounds for safer cancer treatments demonstrates their commitment to advancing the field of cancer research.
What potential does Lixte's lead compound have in cancer therapy?
LB-100 has the potential to be a groundbreaking first-in-class compound, enhancing the efficacy of existing cancer treatments and offering a new approach to personalized cancer medicine.
What is the company's stock symbol?
Lixte Biotechnology Holdings, Inc. Warrants are listed on the stock market under the symbol LIXTW.
Lixte Biotechnology Holdings, Inc. Warrants