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Lixte Biotechnology Holdings, Inc. (symbol: LIXT) is a clinical-stage biopharmaceutical company focused on developing innovative treatments for cancer. The company has made significant strides in identifying molecular signaling pathways that are altered in various disease states. By designing compounds that can safely target these pathways in animal models, Lixte aims to enhance the effectiveness of existing cancer treatments.
The company's drug portfolio includes inhibitors of protein phosphatases and protein deacetylases. These inhibitors are crucial for cell division, DNA damage repair, and the regulation of gene expression and protein degradation. The phosphatase inhibitors, in particular, have shown potential in increasing the efficacy of cytotoxic anti-cancer drugs and radiation therapy. This makes them potentially useful for the treatment of a wide range of cancers when used in combination with standard chemotherapy regimens and emerging targeted therapies.
Lixte's lead compound, LB-100, is currently in Phase I trials and has the potential to be a first-in-class treatment. LB-100 has shown promising clinical anti-cancer activity with minimal toxicity. This compound is being developed as a protein phosphatase 2A inhibitor and has potential applications in combination with cytotoxic agents, x-rays, immune checkpoint blockers, and other cancer therapies.
In addition to its primary focus on protein phosphatase inhibitors, Lixte is exploring the therapeutic potential of protein deacetylase inhibitors. These inhibitors are involved in regulating gene expression and protein degradation pathways, offering another avenue for cancer treatment development.
Lixte Biotechnology Holdings, Inc. continues to make significant advancements in cancer research, aiming to provide more effective treatment options for patients worldwide. The company's ongoing projects, strategic partnerships, and innovative drug portfolio position it as a key player in the biopharmaceutical industry.
LIXTE Biotechnology Holdings announced promising results from preclinical studies using its lead clinical compound LB-100, in combination with a WEE1 kinase inhibitor, showing remarkable effectiveness in killing cancer cells, particularly in tough cases like colorectal, pancreatic, and bile duct carcinomas.
Notably, when cancer cells developed resistance to this therapy, they lost their cancerous properties in animal models. This indicates a novel concept termed “tumor suppressive drug resistance”, suggesting that the resistance can lead to decreased oncogenic capacity. The findings present a potential breakthrough in cancer treatment, emphasizing the unique mechanism of LB-100.
LIXTE Biotechnology Holdings (Nasdaq:LIXT) will present at the Planet MicroCap Showcase: VIRTUAL 2022 investor conference on December 7, 2022, at 3:30 p.m. EST. John S. Kovach, M.D., founder and CEO, will lead the presentation and host a Q&A session.
The conference showcases LIXTE's lead compound, LB-100, a novel protein phosphatase inhibitor with potential in cancer therapy. Interested attendees can access the presentation via this webcast link.
LIXTE Biotechnology Holdings (Nasdaq: LIXT) has gained authorization from the Spanish Agency for Medicines (AEMPS) for a Phase 1b/randomized Phase 2 study of LB-100, its lead compound, combined with doxorubicin for treating advanced soft tissue sarcomas (ASTS). This study aims to determine the efficacy and safety of the combination versus doxorubicin alone, which has been the standard treatment for over 40 years. With up to 170 patients expected, results may enhance treatment outcomes in this niche area, potentially changing existing protocols.
LIXTE Biotechnology Holdings, Inc. has appointed Bas van der Baan as an independent director to its Board of Directors. With over 20 years of experience in biotechnology, particularly in oncology, Mr. van der Baan is expected to enhance LIXTE's strategic direction, particularly in the commercialization of its first-in-class cancer drug, LB-100. This compound targets protein phosphatase 2A and aims to improve patient outcomes in chemotherapy and immunotherapy. LIXTE's novel approach is unique in the market and backed by a strong patent portfolio.
LIXTE Biotechnology Holdings has appointed Professor René Bernards as an independent director on its Board. Bernards, a renowned figure in cancer drug development, will leverage his expertise to guide the company as it advances its lead compound, LB-100, a first-in-class protein phosphatase 2A (PP2A) inhibitor. This appointment follows Bernards' presentation of promising data on LB-100’s effectiveness alongside other anti-cancer treatments. LIXTE focuses on innovative cancer therapies, positioning itself strategically in the competitive pharmaceutical landscape.
LIXTE Biotechnology Holdings, Inc. (Nasdaq: LIXT) has successfully closed a registered direct offering, raising $5.8 million through the issuance of 2,900,000 shares at $2.00 per share. The funds will be allocated for working capital and the clinical development of its lead compound, LB-100. The offering was facilitated by WestPark Capital, Inc. and WallachBeth Capital, LLC. The shares were offered pursuant to a previously filed 'shelf' registration statement with the SEC.
On April 14, 2022, WallachBeth Capital completed a registered direct offering for LIXTE Biotechnology Holdings, Inc. (Nasdaq: LIXT), selling 2,900,000 shares at $2.00 each, totaling $5.8 million in gross proceeds. The offering was facilitated by WallachBeth Capital and WestPark Capital. LIXTE is focused on cancer drug development and is advancing its lead compound, LB-100, which targets the PP2A protein. Initial clinical trials for LB-100 are underway, indicating its potential to enhance cancer therapy outcomes.
WestPark Capital announces the completion of a Registered Direct Offering for Lixte Biotechnology Holdings (Nasdaq: LIXT), raising $5.8 million through the issuance of 2,900,000 shares of common stock at $2.00 per share. The offering was made under a previously filed shelf registration statement with the SEC. This capital will support Lixte's ongoing development of innovative cancer therapies, including its lead compound, LB-100.
LIXTE Biotechnology Holdings has entered into definitive agreements for a registered direct offering of 2,900,000 shares at $2.00 per share, expecting gross proceeds of approximately $5.8 million. The offering's closing is anticipated around April 14, 2022, pending customary conditions. This move is supported by a shelf registration statement filed with the SEC. LIXTE is focused on developing innovative cancer therapies, highlighting its lead compound LB-100, which has shown promising results in early trials.
LIXTE Biotechnology Holdings, Inc. (Nasdaq: LIXT) announced a registered direct offering of 2,900,000 shares of common stock at $2.00 per share, expected to close on or about April 14, 2022. The offering will generate approximately $5.8 million in gross proceeds, which will be used for working capital and the further development of its lead clinical compound, LB-100. Co-placement agents for this offering are WestPark Capital, Inc. and WallachBeth Capital, LLC. This offering is conducted under a previously filed shelf registration statement with the SEC.
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