Revolutionizing Healthcare: Lexaria Highlights Expanding Therapeutic Benefits of GLP-1 Drugs
Lexaria Bioscience provides a strategic update on the expanding therapeutic benefits of GLP-1 drugs, highlighting their growing applications beyond diabetes and weight loss. The market, dominated by semaglutide and tirzepatide, has seen remarkable growth from $300 million in 2018 to projected $30 billion in 2024. New therapeutic applications being investigated include heart disease, Alzheimer's, liver disease, sleep apnea, knee pain, and chronic kidney disease. Clinical trials have shown promising results, including a 14% reduction in cardiovascular events and significant improvements in liver conditions, cognitive function, and kidney disease progression.
Lexaria Bioscience fornisce un aggiornamento strategico sui benefici terapeutici in espansione dei farmaci GLP-1, evidenziando le loro crescenti applicazioni oltre il diabete e la perdita di peso. Il mercato, dominato da semaglutide e tirzepatide, ha visto una crescita notevole, passando da 300 milioni di dollari nel 2018 a una previsione di 30 miliardi di dollari nel 2024. Nuove applicazioni terapeutiche in fase di indagine includono malattie cardiache, Alzheimer, malattie epatiche, apnea del sonno, dolori al ginocchio e malattie renali croniche. Gli studi clinici hanno mostrato risultati promettenti, tra cui una riduzione del 14% degli eventi cardiovascolari e miglioramenti significativi nelle condizioni epatiche, nelle funzioni cognitive e nella progressione delle malattie renali.
Lexaria Bioscience proporciona una actualización estratégica sobre los beneficios terapéuticos en expansión de los medicamentos GLP-1, destacando sus crecientes aplicaciones más allá de la diabetes y la pérdida de peso. El mercado, dominado por semaglutida y tirzepatida, ha experimentado un crecimiento notable, pasando de 300 millones de dólares en 2018 a una proyección de 30 mil millones de dólares en 2024. Nuevas aplicaciones terapéuticas que se están investigando incluyen enfermedades cardíacas, Alzheimer, enfermedades del hígado, apnea del sueño, dolor de rodilla y enfermedad renal crónica. Los ensayos clínicos han mostrado resultados prometedores, incluyendo una reducción del 14% en los eventos cardiovasculares y mejoras significativas en las condiciones del hígado, la función cognitiva y la progresión de la enfermedad renal.
Lexaria Bioscience는 GLP-1 약물의 확장된 치료 이점에 대한 전략적 업데이트를 제공하며, 당뇨병 및 체중 감소를 넘어서는 애플리케이션의 증가를 강조합니다. 세마글루타이드와 티르제파타이드가 지배하는 시장은 2018년 3억 달러에서 2024년 300억 달러로의 괄목할 성장세를 보이고 있습니다. 현재 조사 중인 새로운 치료 응용 프로그램으로는 심장병, 알츠하이머, 간 질환, 수면 무호흡증, 무릎 통증 및 만성 신장 질환이 포함됩니다. 임상 시험에서 심혈관 사건의 14% 감소와 간 질환, 인지 기능 및 신장 질병 진행의 유의미한 개선과 같은 유망한 결과가 나타났습니다.
Lexaria Bioscience fournit une mise à jour stratégique sur les avantages thérapeutiques en expansion des médicaments GLP-1, soulignant leurs applications croissantes au-delà du diabète et de la perte de poids. Le marché, dominé par le sémaglutide et le tirzepatide, a connu une croissance remarquable, passant de 300 millions de dollars en 2018 à une prévision de 30 milliards de dollars en 2024. De nouvelles applications thérapeutiques en cours d'examen incluent les maladies cardiaques, la maladie d'Alzheimer, les maladies du foie, l'apnée du sommeil, les douleurs au genou et les maladies rénales chroniques. Les essais cliniques ont montré des résultats prometteurs, y compris une réduction de 14 % des événements cardiovasculaires et des améliorations significatives des conditions hépatiques, du fonctionnement cognitif et de la progression de la maladie rénale.
Lexaria Bioscience gibt ein strategisches Update zu den expanding therapeutischen Vorteilen von GLP-1-Medikamenten und hebt die wachsenden Anwendungen über Diabetes und Gewichtsverlust hinaus hervor. Der Markt, der von Semaglutid und Tirzepatid dominiert wird, hat ein bemerkenswertes Wachstum von 300 Millionen Dollar im Jahr 2018 auf prognostizierte 30 Milliarden Dollar im Jahr 2024 erlebt. Neue therapeutische Anwendungen, die untersucht werden, umfassen Herzkrankheiten, Alzheimer, Lebererkrankungen, Schlafapnoe, Knieschmerzen und chronische Nierenerkrankungen. Klinische Studien haben vielversprechende Ergebnisse gezeigt, darunter eine Verringerung der kardiovaskulären Ereignisse um 14 % und signifikante Verbesserungen bei Lebererkrankungen, kognitiven Funktionen und dem Fortschreiten von Nierenerkrankungen.
- Revenue growth from $300M in 2018 to projected $30B in 2024 (10,000% increase)
- FDA approval for Wegovy in cardiovascular disease treatment
- Successful Phase III trial showing 14% reduction in cardiovascular events
- Potential expansion into $20B MASH liver disease market by 2032
- Positive clinical results in multiple new therapeutic areas
- None.
Insights
The GLP-1 market expansion represents a significant paradigm shift in pharmaceutical therapeutics, with unprecedented growth from
The most compelling data points include:
- A
14% reduction in cardiovascular events from Rybelsus - A remarkable
63% reduction in sleep apnea symptoms 24% reduction in kidney disease progression- Nearly
50% reduction in brain shrinkage for memory-related areas
These expanding applications, combined with the massive existing patient populations and strong safety profiles, suggest the
The strategic implications for Lexaria are substantial as they position their DehydraTECH delivery platform in this rapidly expanding market. Key market opportunities include:
- Only one oral GLP-1 option currently available (Rybelsus), indicating significant market potential for improved oral delivery systems
- Multiple major pharmaceutical companies (Novo Nordisk, Eli Lilly, Pfizer, Merck) actively expanding their GLP-1 portfolios
- Boehringer Ingelheim and others receiving FDA Fast Track designations, showing regulatory support for accelerated development
The pending brain absorption study results (WEIGHT-A24-1) could be particularly significant given the growing evidence of GLP-1's neurological benefits and Lexaria's demonstrated ability to enhance brain tissue drug delivery.
Semaglutide being investigated for applications in heart disease, Alzheimer's, liver disease, and more
GLP-1 drugs expected to generate multi-hundreds of billions of revenues in the years to come
KELOWNA, BC / ACCESSWIRE / November 26, 2024 / Lexaria Bioscience Corp. (NASDAQ:LEXX)(NASDAQ:LEXXW) (the "Company" or "Lexaria"), a global innovator in drug delivery platforms, provides the following strategic update.
Today's GLP-1 drug market consists primarily of semaglutide (Wegovy®, Ozempic®, and Rybelsus®), owned by Novo Nordisk®; and tirzepatide (Zepbound®, Mounjaro®), owned by Eli Lilly™. All five of those drug brands, with the exception of Rybelsus®, are administered by injection, whereas Rybelsus® is the only oral tablet currently approved by the FDA today. While these two drugs were originally approved by the FDA for diabetes management, weight-loss approvals soon followed and Wegovy® was also approved by the FDA in March 2024 to reduce the risk of cardiovascular death, heart attack and stroke.
Acceptance and use of these two drugs by the public has resulted in unprecedented demand, with estimates of 2024 revenue between them of ~
"The GLP-1 market may be the most significant development in pharmaceutical achievements of our lifetimes," said Richard Christopher, CEO of Lexaria. "Given the relatively early stage of investigation and development of these drugs, we simply do not know how big of an impact they will have, but it is safe to say that nearly every person in Europe or North America could experience improvement in their own health, or the health of a loved one, from GLP-1 drugs."
Some are asking whether this trend is a temporary one-off event and whether the recent revenue growth is sustainable; whereas there is a growing realization that - not only is this NOT a temporary event - future revenue growth is likely to be even stronger than that seen in recent years.
There are two main reasons for the growing consensus that revenue in the GLP-1 drug sector will soon be over
Cardiovascular Disease
Recently, Novo Nordisk® announced that Rybelsus® demonstrated a
Liver Disease
There are currently no FDA-approved treatments for metabolic dysfunction-associated steatohepatitis ("MASH") liver disease, or for non-alcoholic fatty liver disease. GLP-1RAs have been reported to reduce liver fat content and liver enzymes, reduce oxidative stress and improve hepatic de novo lipogenesis and the histopathology of MASH. The MASH treatment market is forecasted to possibly reach
In 2020, Merck® agreed to pay up to
Boehringer Ingelheim® has also been granted a Fast Track designation from the FDA for its molecule survodutide, yet another GLP-1 drug originally designed for application with obesity but now additionally being examined for certain liver diseases.
Sleep Apnea, Knee Pain
Following a Phase III study that showed an astonishing
Not to be outdone, Novo Nordisk® has also reported that those who are overweight place additional stress on the knee and its protective cartilage and that in a study of 407 people diagnosed with knee arthritis, knee pain was reduced more thoroughly when those patients were treated with semaglutide than when they received a placebo.
Alzheimer's and Dementia
While GLP-1 drugs are known for triggering gastro-intestinal effects that create a sense of fullness, thus facilitating the treatment of obesity and diabetes, many investors have not yet realized that GLP-1 and related drugs have actions at main types of human brain receptors. Commercially available GLP-1 drugs have already shown an ability to bind with those receptors, but if and only if they are capable of crossing the blood-brain-barrier sufficiently upon administration. Lexaria has repeatedly shown, in previous studies with other drugs, that its DehydraTECH technology can at times improve the delivery of drugs into brain tissue. Lexaria's recently completed animal study WEIGHT-A24-1, is investigating for the brain absorption of DehydraTECH-processed GLP-1 drugs in study animals with data pending and expected to be released in either December, or in January, 2025.
Dulaglutide, owned by Eli Lilly™, is a GLP-1 drug that has shown a particular affinity to enter the brain, and, in a large human study of 8,828 participants, it has shown a significant benefit to cognition.
As well, liraglutide, owned by Novo Nordisk®, has also evidenced an ability to slow cognitive decline in a Phase 2b clinical trial, and reduce shrinkage of those areas of the brain that control memory, learning, and language by nearly
Chronic Kidney Disease
Eli Lilly™ is conducting active research including a Phase II study expected to complete in early 2026, examining tirzepatide as a possible treatment for chronic kidney disease ("CKD"). If successful it is reasonable to expect Eli Lilly™ to progress to Phase III development and ultimately apply to the FDA for approval of the use of tirzepatide to treat this often life-threatening condition if successful.
Further, in a large analysis of over 165,000 patients, type-2 diabetic patients with acute kidney disease receiving GLP-1 drugs evidenced lower mortality rates and lower incidences of both major cardiovascular events and major adverse kidney events, than those patients not receiving GLP-1 drugs.
As well, Novo Nordisk® has earlier announced a successful outcome of a human trial of 3,533 people with CKD and type 2 diabetes using injected semaglutide. The study "demonstrated a statistically significant and superior reduction in kidney disease progression as well as cardiovascular and kidney death of
Conclusion
The applications of GLP-1 and related drugs are still being identified. Given the widespread and rapid adoption of these drugs by tens of millions of people, data is being generated in real time at a scale never encountered before. The benefits of weight loss and diabetic control are obvious though not even close to being fully realized at this time, while the benefits in other areas of human health are still being discovered. Lexaria intends to continue research and development of its DehydraTECH drug delivery platform technology with as many GLP-1 and related drug molecules as it possibly can, in an attempt to identify broad areas of prospective commercial applicability for it to continue to participate in arguably the most exciting field of drug development in modern times.
About Lexaria Bioscience Corp.
Lexaria Bioscience Corp.'s patented drug delivery technology, DehydraTECH™, improves the way active pharmaceutical ingredients (APIs) enter the bloodstream by promoting more effective oral delivery. Since 2016, DehydraTECH has repeatedly demonstrated the ability to increase bio-absorption with cannabinoids, antiviral drugs, GLP-1 and more. DehydraTECH has also evidenced an ability to deliver some drugs more effectively across the blood brain barrier. Lexaria operates a licensed in-house research laboratory and holds a robust intellectual property portfolio with 46 patents granted and many patents pending worldwide. For more information, please visit www.lexariabioscience.com.
CAUTION REGARDING FORWARD-LOOKING STATEMENTS
This press release includes forward-looking statements. Statements as such term is defined under applicable securities laws. These statements may be identified by words such as "anticipate," "if," "believe," "plan," "estimate," "expect," "intend," "may," "could," "should," "will," and other similar expressions. Such forward-looking statements in this press release include, but are not limited to, statements by the Company relating to the Company's ability to carry out research initiatives, receive regulatory approvals or grants or experience positive effects or results from any research or study. Such forward-looking statements are estimates reflecting the Company's best judgment based upon current information and involve a number of risks and uncertainties, and there can be no assurance that the Company will actually achieve the plans, intentions, or expectations disclosed in these forward-looking statements. As such, you should not place undue reliance on these forward-looking statements. Factors which could cause actual results to differ materially from those estimated by the Company include, but are not limited to, government regulation and regulatory approvals, managing and maintaining growth, the effect of adverse publicity, litigation, competition, scientific discovery, the patent application and approval process, potential adverse effects arising from the testing or use of products utilizing the DehydraTECH technology, the Company's ability to maintain existing collaborations and realize the benefits thereof, delays or cancellations of planned R&D that could occur related to pandemics or for other reasons, and other factors which may be identified from time to time in the Company's public announcements and periodic filings with the US Securities and Exchange Commission on EDGAR. The Company provides links to third-party websites only as a courtesy to readers and disclaims any responsibility for the thoroughness, accuracy or timeliness of information at third-party websites. There is no assurance that any of Lexaria's postulated uses, benefits, or advantages for the patented and patent-pending technology will in fact be realized in any manner or in any part. No statement herein has been evaluated by the Food and Drug Administration (FDA). Lexaria-associated products are not intended to diagnose, treat, cure or prevent any disease. Any forward-looking statements contained in this release speak only as of the date hereof, and the Company expressly disclaims any obligation to update any forward-looking statements or links to third-party websites contained herein, whether as a result of any new information, future events, changed circumstances or otherwise, except as otherwise required by law.
INVESTOR CONTACT:
George Jurcic - Head of Investor Relations
ir@lexariabioscience.com
Phone: 250-765-6424, ext 202
SOURCE: Lexaria Bioscience Corp.
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FAQ
What is the projected revenue growth for GLP-1 drugs according to Lexaria (LEXX)?
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What were the cardiovascular trial results for Rybelsus mentioned in Lexaria's (LEXX) update?
When will Lexaria (LEXX) release results from its WEIGHT-A24-1 study?
