First-in-Disease Use of Kyverna Therapeutics' KYV-101 in Patients With Progressive Multiple Sclerosis Published in Med

Rhea-AI Summary

Kyverna Therapeutics, Inc. announces successful treatment of two multiple sclerosis patients with KYV-101, a fully human anti-CD19 CAR T-cell product candidate, in Germany. The treatment showed an acceptable safety profile, opening doors for larger clinical studies.

Insights

Medical Research Analyst

The administration of KYV-101 to patients with progressive multiple sclerosis (MS) represents a noteworthy development in the field of autoimmune disease treatments. The observed safety profile, notably the absence of early neurotoxicity, is a positive indicator for the potential scalability of this treatment. However, it is important to consider that these results are preliminary and derived from a very small sample size. A larger cohort will be necessary to validate these findings and fully understand the efficacy and safety of KYV-101.

From a research perspective, the mechanism of action of anti-CD19 CAR T-cell therapy, which involves genetically modifying a patient's T-cells to target specific proteins on the surface of B-cells, is a significant shift from traditional MS therapies that often focus on immunosuppression. The success of this approach could lead to a paradigm shift in MS treatment, potentially improving the quality of life for patients who do not respond to existing therapies.

Healthcare Industry Analyst

Kyverna Therapeutics' progress with KYV-101 could have meaningful implications for the company's valuation and the broader market for autoimmune disease treatments. The current treatment landscape for MS is competitive, with several established players. If KYV-101 advances through clinical trials and demonstrates superior safety and efficacy, it could capture a significant market share. However, the path to market for novel therapies is fraught with regulatory hurdles and commercialization challenges.

Investors should monitor subsequent trial results closely, as they will provide more substantial data to assess the commercial prospects of KYV-101. Furthermore, as Kyverna is a clinical-stage company, its financial health is heavily reliant on the progression of its pipeline. The successful development of KYV-101 could attract partnership opportunities, licensing deals, or even make Kyverna a target for acquisition by larger pharmaceutical companies seeking to expand their portfolios in the immunotherapy space.

Biotech Financial Analyst

While the initial results for KYV-101 are promising, the financial implications for Kyverna Therapeutics hinge on the outcomes of larger, controlled clinical trials. The biotech sector is known for its volatility, especially for companies like Kyverna that are in the clinical-stage with no products currently on the market. The investment required to bring a drug from discovery to market is substantial and Kyverna will likely need to secure additional funding, which could come at the cost of share dilution or strategic partnerships.

For stakeholders, the key metrics to watch in the upcoming months will include trial enrollment rates, speed of regulatory submissions and any early indicators of efficacy from expanded studies. The market's response to these developments will be telling, as positive data could lead to stock price appreciation, while any setbacks could have the opposite effect. Caution is advisable until more data is available, but the potential for KYV-101 to address an unmet need in MS therapy could represent a significant upside.

Two patients were treated with KYV-101, a fully human anti-CD19 CAR T-cell product candidate, in Germany as part of a named patient program after failure to respond to conventional therapies

The treatment resulted in an acceptable safety profile, with no observed clinical signs of early neurotoxicity, warranting larger clinical studies in subjects with multiple sclerosis

EMERYVILLE, Calif., March 29, 2024 /PRNewswire/ -- Kyverna Therapeutics, Inc. (Kyverna), a patient-centered, clinical-stage biopharmaceutical company focused on developing cell therapies for patients suffering from autoimmune diseases, announces today the publication in Med¹, of a report describing the first use of KYV-101, a fully human anti-CD19 chimeric antigen receptor (CAR) T-cell product candidate, in two patients suffering from progressive multiple sclerosis (MS) as part of a named patient program for critically ill patients after both patients failed to respond to conventional therapies.

"We are very pleased about offering this potentially paradigm-shifting treatment opportunity to patients that have exhausted other medical recourses," said Christoph Heesen, M.D., professor for clinical and rehabilitative MS research at the University Medical Center Hamburg-Eppendorf in Hamburg, Germany, and senior co-author. "Emerging findings indicating that this approach may affect disease biology in the central nervous system are promising, as preventing disease progression remains one of the most difficult challenges in MS therapy."

"Exploring the safety profile of CAR T administration in this population and hopefully establishing that it compares favorably to hematopoietic stem cell transplant may bring the cell therapy approach to a larger number of patients in need," said Nicolaus Kröger, M.D., professor of Medicine and medical director, Department of Stem Cell Transplantation at the University Medical Center Hamburg-Eppendorf in Hamburg, Germany, and senior co-author. "If safe administration can be replicated in other patients and efficacy be formally established in clinical trials, this may bring a relevant therapeutic option to patients with MS."

"We are committed to transforming the standard of treatment for patients living with multiple sclerosis," said Peter Maag, Ph.D., chief executive officer of Kyverna. "The pioneering work done with KYV-101 by medical teams in Hamburg and in our trials in the U.S. helps build the data backbone needed to further advance our knowledge and hopefully accelerate development of CAR T-cell therapies in autoimmune diseases."

CAR T-cell therapy involves modifying a patient's T cells to recognize and remove B cells in the patient's body. CD19 CAR T-cell therapy specifically targets CD19, a protein expressed on the surface of B cells, which are involved in various types of autoimmune diseases.

About Multiple sclerosis (MS)
Multiple sclerosis is a chronic neurodegenerative autoimmune disease affecting over 2.8 million individuals worldwide². It affects more frequently women, people of Northern European descent, and is also associated with certain environmental and genetic factors. Patients with MS can experience a range of symptoms including blurred vision, slurred speech, tremors, numbness, extreme fatigue, problems with memory and concentration, and, in severe cases, the inability to walk or stand.
Current disease-modifying treatments for MS aim to reduce the frequency of disease relapses and delay progression of disability, but the disease remains a chronic condition that will progressively worsen for most patients.

About KYV-101
KYV-101 is an autologous, fully human CD19 CAR T-cell product candidate for use in B cell-driven autoimmune diseases. The CAR in KYV-101 was designed by the National Institutes of Health (NIH) to improve tolerability and tested in a 20-patient Phase 1 trial in oncology. Results were published by the NIH in Nature Medicine³.

KYV-101 is currently being evaluated in sponsored, open-label, Phase 1/2 trials of KYV-101 in patients with lupus nephritis, an autoimmune disease in which more than half of patients do not achieve a complete response to current therapies and are at risk of developing kidney failure. Additionally, FDA's IND clearance has been obtained for Phase 2 trials of KYV-101 for multiple sclerosis and myasthenia gravis, and a Phase 1/2 trial for systemic sclerosis. 

We believe that the differentiated properties of KYV-101 are critical for the potential success of CAR T cells as autoimmune disease therapies.

KYV-101 is also being evaluated in investigator-initiated trials for multiple indications in multiple geographies.

About Kyverna Therapeutics
Kyverna Therapeutics (NASDAQ: KYTX) is a patient-centered, clinical-stage biopharmaceutical company focused on developing cell therapies for patients suffering from autoimmune diseases.

Our lead CAR T-cell therapy candidate, KYV-101 is advancing through clinical development with sponsored clinical trials across two broad areas of autoimmune disease: rheumatology and neurology, including Phase 2 trials for multiple sclerosis and myasthenia gravis, a Phase 1/2 trial for systemic sclerosis, and two ongoing multi-center, open-label Phase 1/2 trials in the United States and Germany for patients with lupus nephritis.

Kyverna's pipeline includes next-generation chimeric antigen receptor (CAR) T-cell therapies in both autologous and allogeneic formats with properties intended to be well suited for use in B cell-driven autoimmune diseases.

Forward-Looking Statements
Statements in this press release about future expectations, plans and prospects, as well as any other statements regarding matters that are not historical facts, may constitute "forward-looking statements." The words, without limitation, "anticipate," "believe," "continue," "could," "estimate," "expect," "intend," "may," "plan," "potential," "predict," "project," "should," "target," "will," "would" and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these or similar identifying words. Actual results may differ materially from those indicated by such forward-looking statements as a result of various important factors, including: uncertainties related to market conditions, and other factors discussed in the "Risk Factors" section of the final prospectus. Any forward-looking statements contained in this press release are based on the current expectations of Kyverna's management team and speak only as of the date hereof, and Kyverna specifically disclaims any obligation to update any forward-looking statement, whether as a result of new information, future events or otherwise.

For more information, please visit https://kyvernatx.com.

Kyverna Media Contact:
Consort Partners for Kyverna
kyvernatx@consortpartners.com

<sup>1. Fischbach et al., Med (2024), https://doi.org/10.1016/j.medj.2024.03.002
2. Walton C, et al., Mult Scler. 2020; 26:1816-1821.
3. Brudno et al., Nature Medicine 2020; 26:270-280.</sup>

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SOURCE Kyverna Therapeutics

FAQ

What is KYV-101 and who developed it?

KYV-101 is a fully human anti-CD19 CAR T-cell product candidate developed by Kyverna Therapeutics, Inc.

How many patients were treated with KYV-101 in Germany?

Two patients were treated with KYV-101 in Germany as part of a named patient program.

What disease were the patients suffering from?

The patients were suffering from progressive multiple sclerosis (MS).

What was the outcome of the treatment with KYV-101?

The treatment resulted in an acceptable safety profile with no observed early neurotoxicity, indicating the need for larger clinical studies.

Where is Kyverna Therapeutics, Inc. based?

Kyverna Therapeutics, Inc. is based in Emeryville, California.

What publication featured the report on KYV-101 treatment?

The report on KYV-101 treatment was published in Med1.

What type of therapies does Kyverna Therapeutics focus on developing?

Kyverna Therapeutics focuses on developing cell therapies for patients suffering from autoimmune diseases.

What stage is Kyverna Therapeutics in?

Kyverna Therapeutics is a clinical-stage biopharmaceutical company.

What was the purpose of the named patient program?

The named patient program was for critically ill patients who failed to respond to conventional therapies.