STOCK TITAN

Korro Reports Full Year 2024 Financial Results and Provides Business Updates

Rhea-AI Impact
(Moderate)
Rhea-AI Sentiment
(Neutral)
Tags

Korro Bio (NASDAQ: KRRO) has reported its full-year 2024 financial results and business updates. The company completed dosing of the first two single ascending dose cohorts in the Phase 1/2a REWRITE clinical study of KRRO-110 for AATD, with no serious adverse events observed. An interim readout is expected in H2 2025.

Financial highlights include: cash position of $163.1 million as of December 31, 2024, expected to fund operations into H2 2026; collaboration revenue of $2.3 million from Novo Nordisk partnership; R&D expenses increased to $63.6 million from $57.2 million in 2023; G&A expenses rose to $30.5 million from $27.3 million; net loss widened to $83.6 million from $81.2 million in 2023.

The company received Orphan Drug Designation for KRRO-110 and is executing its 3-2-1 strategy through 2027, aiming to establish three clinical-stage programs in two tissue types with a single RNA-editing platform. A second development candidate nomination is expected by end of 2025.

Korro Bio (NASDAQ: KRRO) ha riportato i risultati finanziari e aggiornamenti aziendali per l'intero anno 2024. L'azienda ha completato la somministrazione delle prime due coorti di dosi ascendenti singole nello studio clinico Fase 1/2a REWRITE di KRRO-110 per AATD, senza osservare eventi avversi gravi. Si prevede una lettura intermedia nel secondo semestre del 2025.

I punti salienti finanziari includono: una posizione di cassa di $163,1 milioni al 31 dicembre 2024, prevista per finanziare le operazioni fino al secondo semestre del 2026; ricavi da collaborazioni di $2,3 milioni dalla partnership con Novo Nordisk; le spese per R&S sono aumentate a $63,6 milioni rispetto ai $57,2 milioni del 2023; le spese generali e amministrative sono salite a $30,5 milioni rispetto ai $27,3 milioni; la perdita netta è aumentata a $83,6 milioni rispetto agli $81,2 milioni del 2023.

L'azienda ha ricevuto la Designazione di Farmaco Orfano per KRRO-110 e sta attuando la sua strategia 3-2-1 fino al 2027, mirando a stabilire tre programmi in fase clinica in due tipi di tessuto con una singola piattaforma di editing RNA. Si prevede una seconda nomina di candidato allo sviluppo entro la fine del 2025.

Korro Bio (NASDAQ: KRRO) ha informado sus resultados financieros y actualizaciones empresariales para el año completo 2024. La compañía completó la dosificación de las dos primeras cohortes de dosis ascendentes únicas en el estudio clínico de Fase 1/2a REWRITE de KRRO-110 para AATD, sin observar eventos adversos graves. Se espera un informe intermedio en la segunda mitad de 2025.

Los aspectos financieros destacados incluyen: una posición de efectivo de $163.1 millones al 31 de diciembre de 2024, que se espera financie las operaciones hasta la segunda mitad de 2026; ingresos por colaboración de $2.3 millones de la asociación con Novo Nordisk; los gastos en I+D aumentaron a $63.6 millones desde $57.2 millones en 2023; los gastos generales y administrativos aumentaron a $30.5 millones desde $27.3 millones; la pérdida neta se amplió a $83.6 millones desde $81.2 millones en 2023.

La compañía recibió la Designación de Medicamento Huérfano para KRRO-110 y está ejecutando su estrategia 3-2-1 hasta 2027, con el objetivo de establecer tres programas en etapa clínica en dos tipos de tejido con una única plataforma de edición de ARN. Se espera una segunda nominación de candidato de desarrollo para finales de 2025.

Korro Bio (NASDAQ: KRRO)는 2024년 전체 연도 재무 결과 및 비즈니스 업데이트를 보고했습니다. 이 회사는 AATD를 위한 KRRO-110의 1상/2a REWRITE 임상 연구에서 첫 두 개의 단일 상승 용량 코호트에 대한 투여를 완료했으며, 심각한 부작용은 관찰되지 않았습니다. 중간 결과는 2025년 하반기에 예상됩니다.

재무 하이라이트는 다음과 같습니다: 2024년 12월 31일 기준 현금 보유액은 $163.1 백만으로, 2026년 하반기까지 운영 자금을 지원할 것으로 예상됩니다; Novo Nordisk 파트너십으로부터의 협력 수익은 $2.3 백만; 연구 및 개발 비용은 2023년의 $57.2 백만에서 $63.6 백만으로 증가했습니다; 일반 관리 비용은 $27.3 백만에서 $30.5 백만으로 증가했습니다; 순손실은 2023년의 $81.2 백만에서 $83.6 백만으로 확대되었습니다.

회사는 KRRO-110에 대해 희귀약 지정(Orphan Drug Designation)을 받았으며, 2027년까지 3-2-1 전략을 실행하고 있으며, 단일 RNA 편집 플랫폼을 통해 두 가지 조직 유형에서 세 가지 임상 단계 프로그램을 설정하는 것을 목표로 하고 있습니다. 두 번째 개발 후보 지명은 2025년 말까지 예상됩니다.

Korro Bio (NASDAQ: KRRO) a annoncé ses résultats financiers pour l'année complète 2024 ainsi que des mises à jour sur ses activités. L'entreprise a terminé l'administration des deux premières cohortes de doses ascendantes uniques dans l'étude clinique de Phase 1/2a REWRITE de KRRO-110 pour AATD, sans observer d'événements indésirables graves. Un rapport intermédiaire est attendu au second semestre 2025.

Les points saillants financiers incluent : une position de trésorerie de $163,1 millions au 31 décembre 2024, prévue pour financer les opérations jusqu'au second semestre 2026 ; des revenus de collaboration de 2,3 millions de dollars provenant du partenariat avec Novo Nordisk ; les dépenses de R&D ont augmenté à 63,6 millions de dollars contre 57,2 millions de dollars en 2023 ; les dépenses générales et administratives ont augmenté à 30,5 millions de dollars contre 27,3 millions de dollars ; la perte nette s'est creusée à 83,6 millions de dollars contre 81,2 millions de dollars en 2023.

L'entreprise a reçu la désignation de médicament orphelin pour KRRO-110 et met en œuvre sa stratégie 3-2-1 jusqu'en 2027, visant à établir trois programmes en phase clinique dans deux types de tissus avec une seule plateforme d'édition d'ARN. Une deuxième nomination de candidat au développement est attendue d'ici la fin de 2025.

Korro Bio (NASDAQ: KRRO) hat seine Finanzzahlen und Unternehmensupdates für das gesamte Jahr 2024 veröffentlicht. Das Unternehmen hat die Dosierung der ersten beiden Einzelaufwärtsdosis-Kohorten in der klinischen Studie Phase 1/2a REWRITE von KRRO-110 für AATD abgeschlossen, ohne dass schwerwiegende unerwünschte Ereignisse festgestellt wurden. Ein Zwischenbericht wird für das zweite Halbjahr 2025 erwartet.

Zu den finanziellen Höhepunkten gehören: eine Liquiditätsposition von $163,1 Millionen zum 31. Dezember 2024, die voraussichtlich die Betriebstätigkeiten bis ins zweite Halbjahr 2026 finanzieren wird; Kooperationsumsätze von $2,3 Millionen aus der Partnerschaft mit Novo Nordisk; die F&E-Ausgaben stiegen auf $63,6 Millionen von $57,2 Millionen im Jahr 2023; die allgemeinen und Verwaltungskosten stiegen auf $30,5 Millionen von $27,3 Millionen; der Nettoverlust weitete sich auf $83,6 Millionen von $81,2 Millionen im Jahr 2023 aus.

Das Unternehmen erhielt die Orphan Drug Designation für KRRO-110 und setzt seine 3-2-1-Strategie bis 2027 um, mit dem Ziel, drei klinische Programme in zwei Gewebetypen mit einer einzigen RNA-Editing-Plattform zu etablieren. Eine zweite Nominierung eines Entwicklungskandidaten wird bis Ende 2025 erwartet.

Positive
  • Received FDA Orphan Drug Designation for KRRO-110
  • No serious adverse events observed in first two REWRITE trial cohorts
  • Secured $163.1M cash runway into H2 2026
  • Generated first collaboration revenue of $2.3M from Novo Nordisk partnership
Negative
  • Net loss increased to $83.6M from $81.2M in 2023
  • R&D expenses rose 11.2% to $63.6M
  • G&A expenses increased 11.7% to $30.5M
  • Cash position decreased from $166.1M to $163.1M year-over-year

Insights

Korro Bio's full-year 2024 report demonstrates continued execution on clinical and strategic objectives despite widening losses. The company has successfully initiated its Phase 1/2a REWRITE study for lead candidate KRRO-110 in Alpha-1 Antitrypsin Deficiency (AATD), completing the first two cohorts with no serious adverse events observed – a critical early safety signal for their RNA editing approach.

The $163.1 million cash position provides runway into H2 2026, giving Korro sufficient capital to reach key value-creating milestones, including the REWRITE interim readout expected in H2 2025. While R&D expenses increased 11.2% year-over-year to $63.6 million, this reflects appropriate investment in their clinical programs and pipeline expansion.

The Novo Nordisk collaboration delivers strategic validation for Korro's OPERA platform technology in high-prevalence indications, while generating $2.3 million in collaboration revenue. The receipt of Orphan Drug Designation for KRRO-110 provides potential regulatory advantages including tax credits and potential market exclusivity.

Korro's "3-2-1 strategy" (three clinical-stage programs in two tissue types with one platform by 2027) represents a focused approach to creating multiple shots on goal while leveraging platform synergies. The planned nomination of a second development candidate targeting rare metabolic disorders by year-end will further validate their platform's modularity.

While the $83.6 million net loss represents a 3% increase from 2023, this level of cash burn is typical for clinical-stage biotechs advancing first-in-class therapeutic modalities and appears sustainable given their current cash position.

Korro's financials reflect typical pre-revenue biotech economics with strategically managed cash burn. Their $163.1 million cash position, down just $3 million from year-end 2023, demonstrates remarkable cash preservation while advancing clinical programs. With a monthly burn rate of approximately $7 million, their projected runway into H2 2026 appears credible and provides cushion for potential clinical timeline extensions.

The $2.3 million collaboration revenue from Novo Nordisk represents an initial recognition from what could become a more significant revenue stream if milestones are achieved. While modest relative to operating expenses, this partnership model provides non-dilutive capital that validates their platform technology.

R&D investment increased 11.2% to $63.6 million, reflecting appropriate capital allocation toward value-creating activities as the company advances its clinical programs. The 11.7% increase in G&A expenses to $30.5 million appears justified given the infrastructure requirements for a public clinical-stage company.

The R&D to G&A expense ratio of approximately 2:1 indicates disciplined spending with sufficient resources allocated to pipeline advancement. While the $83.6 million net loss represents a slight increase from 2023, this 3% growth in losses is modest compared to the company's clinical progression.

With no debt mentioned and sufficient liquidity to reach multiple value-inflection points, Korro appears positioned to navigate the typical biotech "valley of death" between early clinical development and potential partnerships or commercial revenue. However, investors should anticipate potential dilutive financing in late 2026 if additional capital is required before reaching profitability.

Completed dosing of first two cohorts in Phase 1/2a REWRITE Clinical Study of KRRO-110 for Alpha-1 Antitrypsin Deficiency (AATD); Interim readout expected in the second half of 2025
  
U.S. Food and Drug Administration (FDA) Granted Orphan Drug Designation to KRRO-110 for the treatment of AATD
  
Executing 3-2-1 strategy through end of 2027 with the goal of establishing three clinical-stage development programs, targeting two tissue types with a single RNA-editing platform; Second development candidate expected to be announced in 2025
  
Strengthened leadership team with the formation of Clinical Advisory Board and key additions to board and management team
  
Ended 2024 with a strong balance sheet of $163.1 million in cash, cash equivalents and marketable securities. Cash runway into the second half of 2026 expected to fund KRRO-110 through completion of the Phase 1/2a REWRITE clinical study and progress additional product candidates
  

CAMBRIDGE, Mass., March 18, 2025 (GLOBE NEWSWIRE) -- Korro Bio, Inc. (Korro) (Nasdaq: KRRO), a clinical-stage biopharmaceutical company focused on developing a new class of genetic medicines based on editing RNA for both rare and highly prevalent diseases, today reported full-year 2024 financial results, and provided an update on recent progress and anticipated milestones.

“We executed on our key objectives in 2024 by initiating the Phase 1/2a REWRITE clinical study of KRRO-110 for AATD, announcing a collaboration with Novo Nordisk, and advancing multiple product candidates in our pipeline,” said Ram Aiyar, PhD, CEO and President of Korro.

“KRRO-110 has best-in-class potential based on our preclinical data, and we are excited to potentially demonstrate this in PiZZ patients in the second half of 2025 with the interim data readout of REWRITE. We also anticipate announcing our second development candidate by the end of 2025. Our strategy of taking three development candidates in two tissue types with a single RNA-editing platform in the clinic by the end of 2027 will expand the possibilities of RNA editing, underscoring our commitment to progressing both our wholly owned and partnered programs.”

Pipeline and Business Updates:

  • Completed dosing of the first two single ascending dose cohorts in healthy adult volunteers in Phase 1/2a REWRITE clinical study of KRRO-110. Korro has not observed any serious adverse events through completion of dosing of the first two cohorts as of today and continues to progress enrollment in Australia, and potential expansion into multiple jurisdictions, including the United States. An interim readout is expected in the second half of 2025 and study completion expected in 2026.
  • KRRO-110 Granted Orphan Drug Designation for the treatment of AATD. The FDA's Office of Orphan Products Development grants orphan designation status to drugs and biologics that are intended for the treatment of rare diseases affecting fewer than 200,000 people in the United States. Orphan Drug designation provides various development incentives, including tax credits for qualified clinical testing, prescription drug user fee exemptions, and the potential for market exclusivity following FDA approval.
  • Executing 3-2-1 strategy through end of 2027. Korro expects to establish three clinical-stage development programs, in two tissue types with a single modular RNA-editing platform.
  • Strengthened leadership with key appointments to board and management team. Korro formed a Clinical Advisory Board, consisting of esteemed lung and liver scientific experts, to guide the development strategy of KRRO-110. GaoZhong Zhu, Ph.D. also joined Korro as Senior Vice President of Chemistry, Manufacturing and Controls (CMC) & Technical Operations to further reinforce Korro’s commitment to advancing its innovative pipeline.
  • In February 2025, the American College of Chest Physicians (CHEST) Journal published, “Editing Approaches to Treat Alpha-1 Antitrypsin Deficiency.” The publication highlights the merits of RNA editing in AATD and its potential for treatment for both liver and lung disease, while highlighting KRRO-110 as an RNA editing oligonucleotide delivered via lipid nanoparticle.
  • Collaboration with Novo Nordisk continues to progress. Korro’s partnership with Novo Nordisk focuses on leveraging Korro’s OPERA platform for up to two disease targets, with the initial target intended to treat cardiometabolic diseases.

Upcoming Milestones:

  • Interim readout from Phase 1/2a REWRITE clinical study of KRRO-110 for AATD expected in the second half of 2025, and completion of the REWRITE clinical study expected in 2026.
  • Korro expects to nominate a development candidate for its rare metabolic disorder program targeting the liver (GalNAc) with subcutaneous delivery to create de novo protein variants by the end of 2025.
  • Progress partnership with Novo Nordisk in cardiometabolic diseases with high prevalence.

Full Year 2024 Financial Results:

Cash Position: Cash, cash equivalents and marketable securities were $163.1 million as of December 31, 2024, compared to $166.1 million as of December 31, 2023. Korro expects its cash, cash equivalents and marketable securities will fund operating expenses and capital expenditure requirements into the second half of 2026.

Collaboration Revenue: There was $2.3 million of collaboration revenue for the year ended December 31, 2024, as compared to no collaboration revenue for the year ended December 31, 2023. The increase was due to collaboration revenue earned in the fourth quarter of 2024 from the company’s partnership with Novo Nordisk.

Research and Development (R&D) Expenses: R&D expenses were $63.6 million for the year ended December 31, 2024, as compared to $57.2 million for the year ended December 31, 2023. The increase was driven primarily by increases in KRRO-110 external research and development expenses, personnel expenses and facilities expenses, offset by a decrease in other research and pre-development candidate expenses.

General and Administration (G&A) Expenses: G&A expenses were $30.5 million for the year ended December 31, 2024, as compared to $27.3 million for the year ended December 31, 2023. The increase was primarily due to increased information technology, insurance and other costs, as well as increased professional fees and facility costs attributable to build-out of the G&A function.

Net Loss: Korro’s net loss was $83.6 million for the year ended December 31, 2024, as compared to $81.2 million for the year ended December 31, 2023.

About REWRITE

REWRITE is a two-part single and multiple dose-escalating study that will evaluate the safety and tolerability of KRRO-110, in up to 64 participants, including healthy adults and clinically stable AATD patients with the PiZZ genotype. Secondary and exploratory endpoints include pharmacokinetic and pharmacodynamic parameters that will guide optimal dose selection for later stage studies. Interim data from Part 1 (single ascending doses in healthy volunteers and individuals with AATD) is expected in the second half of 2025, and completion of the study is anticipated in 2026. For additional information about the REWRITE study, visit ClinicalTrials.gov (NCT06677307).

About Alpha-1 Antitrypsin Deficiency (AATD) and KRRO-110

AATD is a genetic disorder most commonly caused by a single missense mutation (G-to-A) in the SERPINA1 gene. Affected adults experience pulmonary emphysema and/or hepatic cirrhosis, as well as end organ manifestations. KRRO-110 is the first RNA editing oligonucleotide product candidate from Korro’s proprietary RNA editing platform, Oligonucleotide Promoted Editing of RNA (OPERA™). KRRO-110, a potential best-in-class compound based on preclinical data, is designed to co-opt an endogenous enzyme, Adenosine Deaminase Acting on RNA (ADAR), to edit the “A” variant on SERPINA1 RNA, repair an amino acid codon, and restore secretion of normal AAT protein. This repair of the endogenous protein has the potential to clear protein aggregates from within liver cells to create a potentially clinically differentiated benefit for liver function and to preserve lung function by providing an adequate amount of normal AAT protein.

About Korro

Korro is a clinical-stage biopharmaceutical company focused on developing a new class of genetic medicines based on editing RNA for both rare and highly prevalent diseases. Korro is generating a portfolio of differentiated programs that are designed to harness the body’s natural RNA editing process, enabling a precise yet transient single base edit. By editing RNA instead of DNA, Korro is expanding the reach of genetic medicines by delivering additional precision and tunability, which has the potential for increased specificity and improved long-term tolerability. Using an oligonucleotide-based approach, Korro expects to bring its medicines to patients by leveraging its proprietary platform with precedented delivery modalities, manufacturing know-how, and established regulatory pathways of approved oligonucleotide drugs. Korro is based in Cambridge, Massachusetts. For more information, visit korrobio.com.

Korro intends to use its Investor Relations website, LinkedIn, and X (Twitter) as means of disclosing material nonpublic information and for complying with its disclosure obligations under Regulation FD. Accordingly, investors should monitor Korro’s Investor Relations website and follow @KorroBio on LinkedIn, and X (Twitter), in addition to following Korro’s press releases, SEC filings, public conference calls, presentations, and webcasts.

Forward-Looking Statements

Certain statements in this press release may constitute “forward-looking statements” within the meaning of the Private Securities Litigation Reform Act of 1995, as amended. Forward-looking statements include, but are not limited to, express or implied statements regarding expectations, hopes, beliefs, intentions or strategies of Korro regarding the future including, without limitation, express or implied statements regarding: the timing of data readouts and completion of the Phase 1/2a REWRITE clinical trial; enrollment and expansion of the Phase 1/2a REWRITE clinical trial; execution of the 3-2-1 strategy; timing of nomination and target of a second development candidate; Korro’s cash runway and uses thereof; KRRO-110’s best-in-class potential; realizing the incentives offered from the orphan drug designation of KRRO-110; and Korro’s collaboration with Novo Nordisk; among others. In addition, any statements that refer to projections, forecasts, or other characterizations of future events or circumstances, including any underlying assumptions, are forward-looking statements. The words “anticipate,” “believe,” “continue,” “could,” “estimate,” “expect,” “intend,” “may,” “might,” “plan,” “possible,” “potential,” “predict,” “project,” “should,” “strive,” “would,” “aim,” “target,” “commit,” and similar expressions may identify forward-looking statements, but the absence of these words does not mean that statement is not forward looking. Forward-looking statements are based on current expectations and assumptions that, while considered reasonable are inherently uncertain. New risks and uncertainties may emerge from time to time, and it is not possible to predict all risks and uncertainties. Factors that may cause actual results to differ materially from current expectations include, but are not limited to, various factors beyond management’s control including risks of conducting a clinical study; risks associated with regulatory oversight of clinical studies, enrollment risks and risks of expanding to other jurisdictions along with other risks inherent in biopharmaceutical development; risks associated with pre-clinical studies and clinical studies; and other risks associated with obtaining regulatory approvals and protecting intellectual property; as well as risks associated with general economic conditions (including recent geopolitical uncertainty and potential supply chain disruptions due to changes in economic policy); and other risks and uncertainties indicated from time to time in Korro’s filings with the SEC, including Part I Item 1A. “Risk Factors” in Korro’s Annual Report on Form 10-K filed with the Securities and Exchange Commission, or SEC, on the date hereof, as such may be amended or supplemented by its other filings with the SEC. Nothing in this press release should be regarded as a representation by any person that the forward-looking statements set forth herein will be achieved or that any of the contemplated results of such forward-looking statements will be achieved. You should not place undue reliance on forward-looking statements in this press release, which speak only as of the date they are made and are qualified in their entirety by reference to the cautionary statements herein. Except as required by law, Korro does not undertake or accept any duty to release publicly any updates or revisions to any forward-looking statements to reflect any change in its expectations or in the events, conditions or circumstances on which any such statement is based. This press release does not purport to summarize all of the conditions, risks and other attributes of an investment in Korro.

Korro Bio Contact Information 

Investor & Media Contact

Tim Palmer
IR@korrobio.com

 
Korro Bio, Inc.
Consolidated Statements of Operations and Comprehensive Loss
(in thousands, except share and per share amounts)
 
  Years Ended December 31, 
  2024  2023 
Revenue:      
Collaboration revenue $2,271  $ 
Operating expenses:      
Research and development  63,636   57,250 
General and administrative  30,545   27,284 
Total operating expenses  94,181   84,534 
Loss from operations  (91,910)  (84,534)
Other income:      
Other income, net  8,470   3,389 
Total other income, net  8,470   3,389 
Loss before provision for income taxes  (83,440)  (81,145)
Provision for income taxes  (141)  27 
Net loss $(83,581) $(81,172)
Other comprehensive income      
Unrealized gain on available-for-sale investments  184    
Foreign currency translation adjustments, net  84    
Comprehensive loss $(83,313) $(81,172)
Net loss per share, basic and diluted $(9.37) $(53.08)
Weighted-average shares used in computing net loss per share, basic and diluted  8,920,561   1,529,321 
 


 
Korro Bio, Inc.
Selected Condensed Consolidated Balance Sheet Data
(in thousands)
 
  December 31, 
  2024  2023 
Cash, cash equivalents and investments $163,054  $166,150 
Working capital (1)  116,572   153,245 
Total assets  226,240   221,663 
Total liabilities  65,825   51,752 
Total stockholders' equity  160,415   169,911 
       
(1)   Working capital is defined as current assets less current liabilities.      
       

This press release was published by a CLEAR® Verified individual.


FAQ

What are the key financial metrics from Korro Bio's (KRRO) 2024 annual results?

Korro reported $163.1M in cash, $2.3M in collaboration revenue, $63.6M in R&D expenses, $30.5M in G&A expenses, and a net loss of $83.6M for 2024.

When will KRRO-110's Phase 1/2a REWRITE clinical trial interim results be available?

The interim readout from the REWRITE clinical study is expected in the second half of 2025, with study completion in 2026.

How long will Korro Bio's (KRRO) current cash position last?

The company's $163.1M cash position is expected to fund operations into the second half of 2026.

What is the status of Korro Bio's (KRRO) collaboration with Novo Nordisk?

The collaboration is progressing, focusing on up to two disease targets using Korro's OPERA platform, with initial focus on cardiometabolic diseases.

What major milestones does KRRO expect to achieve by the end of 2025?

KRRO expects to deliver REWRITE trial interim results and nominate a development candidate for its rare metabolic disorder program by end of 2025.
Korro Bio, Inc.

NASDAQ:KRRO

KRRO Rankings

KRRO Latest News

KRRO Stock Data

150.60M
8.75M
6.42%
101.67%
8.9%
Biotechnology
Pharmaceutical Preparations
Link
United States
CAMBRIDGE