Welcome to our dedicated page for Karyopharm Therapeutics news (Ticker: KPTI), a resource for investors and traders seeking the latest updates and insights on Karyopharm Therapeutics stock.
Karyopharm Therapeutics Inc. (Nasdaq: KPTI) is a commercial-stage pharmaceutical company focused on pioneering novel cancer therapies. The company specializes in the discovery, development, and commercialization of drugs targeting nuclear export proteins for the treatment of cancer and other significant diseases. Its flagship product, XPOVIO® (selinexor), is a first-in-class, oral exportin 1 (XPO1) inhibitor and is approved in the U.S. for multiple oncology indications. These include combination therapies with Velcade® (bortezomib) and dexamethasone for multiple myeloma, as well as treatments for adult patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL).
Recent achievements highlight the company's commitment to advancing its late-stage clinical pipeline. Notably, Karyopharm has been at the forefront in evaluating selinexor's efficacy in combination therapies for multiple myeloma, endometrial cancer, and myelofibrosis. The company recently reported long-term follow-up data from a Phase 1/3 study on selinexor in combination with ruxolitinib in myelofibrosis patients, showing promising results in spleen volume and symptom reduction.
Financially, Karyopharm reported total revenue of $33.7 million for Q4 2023, with a full-year revenue of $146.0 million. Despite a competitive market, the company managed to maintain steady growth and focused resources on its high-potential pipeline. With a cash position of $192.4 million as of December 31, 2023, Karyopharm is well-positioned to continue its innovative research and development efforts.
Karyopharm's collaborations with global partners, including Antengene, Menarini, Neopharm, and FORUS, have extended the reach of XPOVIO to various international markets such as Europe, China, South Korea, and Israel. This international expansion underscores the global demand for innovative cancer therapies.
For more information, please visit www.karyopharm.com.
DiaMedica Therapeutics Inc. (Nasdaq: DMAC) announced the appointment of Tanya Lewis to its board of directors, effective March 1, 2023. With over 25 years in drug development, Ms. Lewis has a proven track record, having held leadership roles at Replimune Group and Karyopharm Therapeutics. Her experience includes overseeing the approval of several new drugs, including XPOVIO®. The board welcomed her expertise at a pivotal time for DiaMedica as they work to address the clinical hold on their ReMEDy2 AIS trial. Ms. Lewis aims to support the company’s mission of providing treatment options for stroke patients.
Karyopharm Therapeutics Inc. (Nasdaq: KPTI) announced the granting of 111,250 restricted stock units (RSUs) to eight new employees as part of its 2022 Inducement Stock Incentive Plan on February 28, 2023. The RSUs will vest over three years with one-third vesting on each anniversary of employment. If a change in control event occurs, the RSUs can be exercised if employment is terminated for good reason or without cause. Karyopharm specializes in innovative cancer therapies, notably its lead XPO1 inhibitor, XPOVIO®, which is approved in various regions for multiple oncology indications.
Karyopharm Therapeutics (Nasdaq: KPTI) and Menarini Group announced that the UK's Medicines and Healthcare Products Regulatory Agency has granted full Marketing Authorization for NEXPOVIO® (selinexor) in combination with bortezomib and dexamethasone for treating adult patients with multiple myeloma who have had at least one prior therapy. This authorization converts the previous conditional approval to full status, based on results from the Phase 3 BOSTON study that showed significant improvements in disease progression. The Menarini Group will handle commercialization in the UK.
Karyopharm Therapeutics reported total revenue of $157.1 million for 2022, with U.S. XPOVIO® net product revenue of $120.4 million, meeting company guidance. The fourth quarter saw a 4% increase in net product revenue year-over-year. For 2023, the company anticipates total revenue between $160 million and $175 million, including U.S. XPOVIO projections of $125 million to $140 million. Cash reserves are expected to sustain operations until late 2025. The company also revealed advancements in its clinical pipeline, including key studies in myelofibrosis and myelodysplastic neoplasms, with interim data expected in the first half of 2023.
Karyopharm Therapeutics Inc. (Nasdaq: KPTI) announced participation in the virtual SVB Securities Global Biopharma Conference on February 16, 2023, at 11:20 a.m. ET. The senior management team will engage in a fireside chat, with a live webcast available for replay on the company's website for 90 days post-event. Karyopharm specializes in novel cancer therapies and is known for its lead compound, XPOVIO® (selinexor), which addresses nuclear export dysregulation in oncogenesis. The company also has a diverse pipeline targeting high unmet cancer needs in multiple myeloma, endometrial cancer, and more. For further details, visit www.karyopharm.com.
Karyopharm Therapeutics Inc. (NASDAQ: KPTI) announced it will release its fourth quarter and full year 2022 financial results on February 15, 2023, during a conference call at 8:00 a.m. ET. The call will cover financial results and company updates. Karyopharm is known for developing novel cancer therapies, including its lead compound, XPOVIO® (selinexor), which is approved in the U.S. for multiple oncology indications. The company is focused on addressing high unmet needs in cancer treatment.
Karyopharm Therapeutics (NASDAQ: KPTI) announced on February 1, 2023, the grant of 113,250 restricted stock units (RSUs) to ten newly hired employees as part of its 2022 Inducement Stock Incentive Plan. The RSUs will vest over three years, with one-third vesting each year, contingent upon the employees' continued service. These grants align with Nasdaq Listing Rule 5635(c)(4), offering incentives to attract talent. Karyopharm develops innovative cancer therapies, including XPOVIO® (selinexor), an oral exportin 1 inhibitor approved for multiple oncology indications in the U.S. and other regions.
Karyopharm Therapeutics announced preliminary unaudited revenue estimates for Q4 and full-year 2022. Total revenue is expected to be approximately $157.7 million, including U.S. XPOVIO net product revenue of $120.4 million, marking a 22% increase from 2021. The company initiated a pivotal Phase 3 study for selinexor in advanced endometrial cancer and plans further studies in myelofibrosis. Additionally, Karyopharm has extended its cash runway to late 2025, emphasizing strong revenue growth and promising clinical pipeline prospects for 2023.
Karyopharm Therapeutics Inc. (Nasdaq: KPTI), a leader in cancer therapies, announced its participation in the 41st Annual J.P. Morgan Healthcare Conference. The presentation will occur on January 11, 2023, at 10:30 a.m. PT, followed by a Q&A session at 10:50 a.m. PT. A live webcast will be available on the Company's website and can be replayed for 30 days post-event. Karyopharm is known for its SINE compound technology and its lead product, XPOVIO®, which is approved for various oncology indications. For more details, visit www.karyopharm.com.
Karyopharm Therapeutics (Nasdaq: KPTI) reported promising results from the Phase 1 study of selinexor combined with ruxolitinib for treating treatment-naïve myelofibrosis. At week 24, 92% of efficacy-evaluable patients achieved ≥35% spleen volume reduction (SVR35), while 67% showed ≥50% symptom reduction (TSS50). Additionally, 57% of transfusion-independent patients stabilized their hemoglobin levels. The company aims to advance this combination therapy into randomized trials, highlighting its potential to improve current treatment standards.
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