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Karyopharm Therapeutics Inc. (Nasdaq: KPTI) is a commercial-stage pharmaceutical company focused on pioneering novel cancer therapies. The company specializes in the discovery, development, and commercialization of drugs targeting nuclear export proteins for the treatment of cancer and other significant diseases. Its flagship product, XPOVIO® (selinexor), is a first-in-class, oral exportin 1 (XPO1) inhibitor and is approved in the U.S. for multiple oncology indications. These include combination therapies with Velcade® (bortezomib) and dexamethasone for multiple myeloma, as well as treatments for adult patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL).
Recent achievements highlight the company's commitment to advancing its late-stage clinical pipeline. Notably, Karyopharm has been at the forefront in evaluating selinexor's efficacy in combination therapies for multiple myeloma, endometrial cancer, and myelofibrosis. The company recently reported long-term follow-up data from a Phase 1/3 study on selinexor in combination with ruxolitinib in myelofibrosis patients, showing promising results in spleen volume and symptom reduction.
Financially, Karyopharm reported total revenue of $33.7 million for Q4 2023, with a full-year revenue of $146.0 million. Despite a competitive market, the company managed to maintain steady growth and focused resources on its high-potential pipeline. With a cash position of $192.4 million as of December 31, 2023, Karyopharm is well-positioned to continue its innovative research and development efforts.
Karyopharm's collaborations with global partners, including Antengene, Menarini, Neopharm, and FORUS, have extended the reach of XPOVIO to various international markets such as Europe, China, South Korea, and Israel. This international expansion underscores the global demand for innovative cancer therapies.
For more information, please visit www.karyopharm.com.
Karyopharm Therapeutics (KPTI) announced the presentation of eight posters on XPOVIO (selinexor) and eltanexor at the EHA 2020 Virtual Annual Meeting from June 11-21, 2020. Key findings include a 9-month median overall survival in relapsed/refractory DLBCL patients treated with selinexor, demonstrating significant efficacy over historical controls. Additional analyses show durable responses across treatment histories. Eltanexor data highlights potential effectiveness against NPM1-mutated AML and predictive molecular markers for multiple myeloma responses. The FDA's decision on KPTI's supplemental application is expected later this month.
Karyopharm Therapeutics Inc. (Nasdaq: KPTI) announced the grant of stock options for 25,800 shares to seven new employees, effective May 29, 2020. This grant, in accordance with Nasdaq rules, serves as an employment inducement. Each option has an exercise price of $18.49 and will vest over four years. Notably, options can be exercised in full if employment ends without cause within a year following a change in control. Karyopharm focuses on innovative drugs targeting nuclear export for cancer treatments, with ongoing regulatory processes for its lead drug, XPOVIO.
Karyopharm Therapeutics (KPTI) announced significant results from the Phase 3 BOSTON study, which evaluated the once-weekly regimen of XPOVIO (selinexor), Velcade (bortezomib), and dexamethasone (SVd) in multiple myeloma patients. The study revealed a 47% increase in median progression-free survival (PFS) compared to the standard treatment. Additionally, SVd demonstrated superior overall response rates and lower rates of peripheral neuropathy. A supplemental New Drug Application has been submitted to the FDA for XPOVIO's approval as a new treatment option.
Karyopharm Therapeutics (Nasdaq: KPTI) has announced that CEO Michael Kauffman will participate in a fireside chat at the Jefferies Virtual Healthcare Conference on June 2, 2020, at 9:30 a.m. ET. A live webcast of the chat will be available on the company's investor website, with a replay accessible for 90 days. Karyopharm is focused on developing innovative pharmaceuticals targeting nuclear export for cancer treatment. Their lead drug, XPOVIO®, received FDA approval in July 2019 and is part of ongoing clinical trials.
Karyopharm Therapeutics (KPTI) announced a conference call on May 29, 2020, to discuss results from the pivotal Phase 3 BOSTON study, which evaluated XPOVIO (selinexor) combined with Velcade and low-dose dexamethasone in multiple myeloma patients. The study met its primary endpoint, showing a significant increase in progression-free survival compared to the standard treatment. The results will be presented at the ASCO 2020 Virtual Scientific Program. Karyopharm has submitted a supplemental New Drug Application for XPOVIO based on these promising findings.
Karyopharm Therapeutics (Nasdaq: KPTI) announced that CEO Michael Kauffman will participate in a fireside chat at the 2020 RBC Capital Markets Global Healthcare Virtual Conference on May 19, 2020, at 8:35 a.m. ET. A live webcast will be available on their website, with a replay accessible for 90 days post-event. Karyopharm focuses on developing novel drugs targeting nuclear export for cancer treatment. Their lead drug, XPOVIO (selinexor), received FDA accelerated approval in July 2019 for multiple myeloma and is under review in Europe and for additional indications.
Karyopharm Therapeutics reported a strong first quarter of 2020, with net product sales of $16.1 million and total revenues of $18.1 million. The pivotal Phase 3 BOSTON Study achieved its primary endpoint, showing a 47% increase in progression-free survival for patients on XPOVIO compared to standard therapy. Karyopharm plans to submit a supplemental New Drug Application to the FDA by the end of May for expanded use of XPOVIO in multiple myeloma. Additionally, the FDA accepted an sNDA for selinexor in DLBCL, granting priority review, with a PDUFA action date set for June 23, 2020.
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