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Karyopharm Therapeutics Inc. - KPTI STOCK NEWS

Welcome to our dedicated page for Karyopharm Therapeutics news (Ticker: KPTI), a resource for investors and traders seeking the latest updates and insights on Karyopharm Therapeutics stock.

Karyopharm Therapeutics Inc. (Nasdaq: KPTI) is a commercial-stage pharmaceutical company focused on pioneering novel cancer therapies. The company specializes in the discovery, development, and commercialization of drugs targeting nuclear export proteins for the treatment of cancer and other significant diseases. Its flagship product, XPOVIO® (selinexor), is a first-in-class, oral exportin 1 (XPO1) inhibitor and is approved in the U.S. for multiple oncology indications. These include combination therapies with Velcade® (bortezomib) and dexamethasone for multiple myeloma, as well as treatments for adult patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL).

Recent achievements highlight the company's commitment to advancing its late-stage clinical pipeline. Notably, Karyopharm has been at the forefront in evaluating selinexor's efficacy in combination therapies for multiple myeloma, endometrial cancer, and myelofibrosis. The company recently reported long-term follow-up data from a Phase 1/3 study on selinexor in combination with ruxolitinib in myelofibrosis patients, showing promising results in spleen volume and symptom reduction.

Financially, Karyopharm reported total revenue of $33.7 million for Q4 2023, with a full-year revenue of $146.0 million. Despite a competitive market, the company managed to maintain steady growth and focused resources on its high-potential pipeline. With a cash position of $192.4 million as of December 31, 2023, Karyopharm is well-positioned to continue its innovative research and development efforts.

Karyopharm's collaborations with global partners, including Antengene, Menarini, Neopharm, and FORUS, have extended the reach of XPOVIO to various international markets such as Europe, China, South Korea, and Israel. This international expansion underscores the global demand for innovative cancer therapies.

For more information, please visit www.karyopharm.com.

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Karyopharm Therapeutics (Nasdaq: KPTI), a leader in cancer therapies, announced that CEO Richard Paulson will present at the 40th Annual J.P. Morgan Healthcare Conference on January 11 at 3:45 p.m. ET. There will be a Q&A session at 4:05 p.m. ET. The presentation will be held virtually, and a live webcast, along with presentation slides, will be available on the company’s investor website for 30 days post-event. Karyopharm specializes in innovative treatments targeting nuclear export for cancer and other diseases.

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Karyopharm Therapeutics (Nasdaq: KPTI) announced the granting of stock options for 5,600 shares to two new employees, effective December 31, 2021. The options, priced at $6.43 per share, are part of an inducement package compliant with Nasdaq Listing Rule 5635(c)(4). Each option vests over four years, with a portion vesting upon the one-year employment anniversary. Immediate exercise is possible upon termination for good reason or without cause within a year of a change in control. Karyopharm focuses on developing innovative cancer therapies, notably XPOVIO®, for various malignancies.

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Karyopharm Therapeutics (KPTI) has entered an exclusive licensing agreement with Menarini Group to commercialize NEXPOVIO (selinexor) across Europe and other global territories. In exchange, Karyopharm will receive a $75 million upfront payment and be eligible for up to $202.5 million in future milestones, plus royalties on net sales. NEXPOVIO is conditionally authorized in the EU for treating multiple myeloma patients who have undergone at least four prior therapies. The partnership aims to enhance patient access to this innovative cancer therapy.

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Karyopharm Therapeutics (Nasdaq: KPTI) has signed an exclusive licensing agreement with Menarini Group for the commercialization of NEXPOVIO (selinexor) in Europe and other regions. Karyopharm will receive an upfront payment of $75 million and potential milestones of up to $202.5 million, plus royalties on sales. NEXPOVIO, already authorized in the EU for treating multiple myeloma, may expand to additional oncology indications. This partnership aims to enhance patient access to innovative cancer treatments across key global markets.

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Karyopharm Therapeutics (KPTI) announced that its partner, Antengene Corporation, received conditional approval from China's NMPA for XPOVIO (selinexor) in combination with dexamethasone for relapsed or refractory multiple myeloma patients. This approval follows positive results from the Phase 2 STORM trial and Antengene's Phase 2 MARCH trial in China. The Phase 3 BENCH trial will serve as a confirmatory trial. CEO Richard Paulson highlighted the significance of this approval in providing new treatment options for patients. Karyopharm remains focused on expanding XPOVIO's availability globally.

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Karyopharm Therapeutics (Nasdaq: KPTI) presented updated data from the Phase 2 ESSENTIAL study on selinexor for myelofibrosis patients at the ASH 2021 Annual Meeting. Results revealed that 40% of patients achieved a spleen volume reduction (SVR) of at least 35%, and 60% experienced an SVR of at least 25% after 24 weeks of treatment. The drug exhibited a favorable safety profile with manageable side effects. Additionally, the company has initiated a new Phase 2 study comparing selinexor to physician's choice in previously treated myelofibrosis patients.

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Karyopharm Therapeutics (Nasdaq: KPTI) announced the appointment of Peter K Honig, MD, MPH, to its Board of Directors effective December 3, 2021. Dr. Honig brings over 30 years of experience in drug development from leadership roles at Pfizer, Merck, and the FDA. He replaces Mikael Dolsten, who stepped down on December 2, 2021, due to competing demands. Dr. Honig expressed enthusiasm for contributing to Karyopharm's growth and advancing its cancer therapies. The company is focused on pioneering novel cancer treatments, including its lead drug, XPOVIO®.

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Karyopharm Therapeutics (KPTI) has commenced a Phase 2 study (XPORT-MF-035) to assess the efficacy of oral selinexor in myelofibrosis patients previously treated with JAK inhibitors. The trial aims to enroll up to 112 patients, evaluating the primary endpoint of spleen volume reduction. This study follows promising results from the ESSENTIAL trial, where 33% of patients experienced significant SVR after 24 weeks of treatment. The company emphasizes its commitment to addressing unmet medical needs in serious conditions like myelofibrosis.

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Karyopharm Therapeutics (Nasdaq: KPTI) announced the completion of patient recruitment for the Phase 3 SIENDO study, evaluating selinexor for front-line maintenance therapy in advanced or recurrent endometrial cancer. With over 250 patients enrolled, the study aims to show improved progression-free survival rates. There are currently no approved maintenance therapies for this cancer type. Karyopharm expects to report top-line data by year-end 2021 or early 2022, which could demonstrate selinexor's therapeutic potential and impact future treatment options.

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Karyopharm Therapeutics (Nasdaq: KPTI) announced on December 1, 2021, that its Compensation Committee granted stock options for 68,900 shares to 13 new employees, effective November 30, 2021. The options have an exercise price of $6.95 per share, equal to the closing price on the grant date. Each option vests over four years, with 25% vesting after one year, and can be exercised immediately upon termination under certain conditions. This move is part of Karyopharm's strategy to attract talent as it develops novel cancer therapies.

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FAQ

What is the current stock price of Karyopharm Therapeutics (KPTI)?

The current stock price of Karyopharm Therapeutics (KPTI) is $0.635 as of December 20, 2024.

What is the market cap of Karyopharm Therapeutics (KPTI)?

The market cap of Karyopharm Therapeutics (KPTI) is approximately 82.5M.

What is Karyopharm Therapeutics' main focus?

Karyopharm Therapeutics specializes in the discovery, development, and commercialization of drugs targeting nuclear export proteins for the treatment of cancer and other major diseases.

What is XPOVIO® (selinexor)?

XPOVIO® is a first-in-class, oral exportin 1 (XPO1) inhibitor approved for the treatment of multiple oncology indications, including multiple myeloma and diffuse large B-cell lymphoma (DLBCL).

What recent achievements has Karyopharm reported?

Karyopharm recently announced promising long-term follow-up data from a Phase 1/3 study on selinexor in combination with ruxolitinib for myelofibrosis. The company also reported strong financial performance with total revenue of $146.0 million for the year 2023.

Who are Karyopharm's global partners?

Karyopharm has partnered with Antengene, Menarini, Neopharm, and FORUS to market XPOVIO in international markets, including Europe, China, South Korea, and Israel.

What are Karyopharm's financial highlights?

For Q4 2023, Karyopharm reported total revenue of $33.7 million and a full-year revenue of $146.0 million. The company had a cash position of $192.4 million as of December 31, 2023.

What are the key indications for XPOVIO?

XPOVIO is approved for use in combination with Velcade and dexamethasone for multiple myeloma, in combination with dexamethasone for heavily pre-treated multiple myeloma, and as a monotherapy for relapsed or refractory diffuse large B-cell lymphoma (DLBCL).

What is the significance of Karyopharm's research on nuclear export proteins?

Karyopharm's research targets nuclear export dysregulation, a fundamental mechanism of oncogenesis, aiming to develop therapies that inhibit this process and treat various cancers effectively.

How does Karyopharm support clinical trials and research?

Karyopharm is engaged in several mid- and late-stage clinical trials across multiple high unmet need cancer indications, including endometrial cancer and myelofibrosis. The company also collaborates with global partners and research institutions to advance its pipeline.

What are the safety considerations for XPOVIO?

Common treatment-emergent adverse events for XPOVIO include nausea, vomiting, diarrhea, and neutropenia. Patients are advised not to breastfeed during treatment. Full prescribing information is available on www.XPOVIO.com.

How can I get more information about Karyopharm's products or clinical trials?

For more information, you can contact Karyopharm's Medical Information department at +1 (888) 209-9326 or via email at medicalinformation@karyopharm.com.

Karyopharm Therapeutics Inc.

Nasdaq:KPTI

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