KalVista Pharmaceuticals to Present New Sebetralstat Data at the American Academy of Allergy, Asthma & Immunology 2025 Annual Meeting

Rhea-AI Summary

KalVista Pharmaceuticals (Nasdaq: KALV) has announced the acceptance of six abstracts for presentation at the AAAAI/WAO 2025 Joint Congress in San Diego from February 28–March 3, 2025. The presentations focus on sebetralstat and hereditary angioedema (HAE) treatment research.

Three poster presentations on February 28 will address barriers to HAE treatment in Italian patients, burden of injectable treatments in adolescents, and delays in on-demand treatment across healthcare systems. Two late-breaking posters on March 1 will present findings on HAE with normal C1INH diagnoses and sebetralstat's effectiveness for laryngeal HAE attacks from the KONFIDENT-S study.

An oral presentation on March 1 will discuss sebetralstat's use for on-demand HAE attack treatment in adolescents, analyzing pooled data from KONFIDENT and KONFIDENT-S studies. All presentation materials will be available on KalVista's website under Publications.

CAMBRIDGE, Mass. & SALISBURY, England--(BUSINESS WIRE)-- KalVista Pharmaceuticals, Inc. (Nasdaq: KALV) today announced that six abstracts have been accepted for presentation at the American Academy of Allergy, Asthma & Immunology (AAAAI) / World Allergy Organization (WAO) 2025 Joint Congress taking place in San Diego, CA from February 28–March 3, 2025.

The following poster presentations will take place on Friday, February 28, 2025, from 2:45–3:45 pm PT in the Convention Center, Ground Level, Hall A:

• Barriers to Timely On-demand Treatment of Hereditary Angioedema Attacks in Italian Patients (#180): Mauro Cancian, Paola Triggianese, Pietro Accardo, Francesco Arcoleo, Donatella Bignardi, Caterina Colangelo, Francesco Giardino, Antonio Gidaro, Marica Giliberti, Maria Domenica Guarino, Paola Lucia Minciullo, Stefania Nicola, Francesca Perego, Riccardo Senter, Giuseppe Spadaro, Massimo Triggiani, Sherry Danese, Julie Ulloa, Vibha Desai, Paul Audhya, Andrea Zanichelli.
• Burden of Injectable On-Demand Treatment for Hereditary Angioedema Attacks in Adolescents (#185): Mauro Cancian, Paula Busse, Tariq El-Shanawany, Maeve O’Connor, Sinisa Savic, Paola Triggianese, Patrick Yong, Andrea Zanichelli, Sherry Danese, Julie Ulloa, Vibha Desai, Paul Audhya, Sandra Christiansen.
• Delays in the On-demand Treatment of Hereditary Angioedema Attacks and Associated Barriers Reported in Different Healthcare Systems (#187): Patrick Yong, Paula Busse, Timothy Craig, Tariq El-Shanawany, Padmalal Gurugama, Rashmi Jain, Maeve O’Connor, Cristine Radojicic, Sinisa Savic, James Wedner, Sherry Danese, Julie Ulloa, Vibha Desai, Paul Audhya, Sandra Christiansen.

The following late-breaking poster presentations will take place on Saturday, March 1, 2025, from 9:45–10:45 am PT in the Convention Center, Ground Level, Hall A:

• Study to Adjudicate Hereditary Angioedema with Normal C1INH Diagnoses in the PIONEER-HAE Database (#L14): Maeve O’Connor, Dana Withrow, Scott Milligan, Vibha Desai, Paul Audhya, Marc Riedl.
• Effectiveness of Sebetralstat for the On-demand Treatment of Laryngeal Hereditary Angioedema Attacks: Interim Analysis from KONFIDENT-S (#L15): Jonathan Bernstein, Emel Aygoren-Pursun, Vesna Grivcheva-Panovska, Inmaculada Martinez-Saguer, Danny Cohn, William Lumry, Marc Riedl, Andrea Zanichelli, James Hao, Michael Smith, Christopher Yea, Utpaul Audhya, Henriette Farkas.

The following oral presentation will take place on Saturday, March 1, 2025, from 2:25–2:35 pm PT in the Convention Center, Room 6C, Upper Level:

• On-demand Treatment Of Hereditary Angioedema Attacks With Sebetralstat In Adolescents: Pooled Analysis From KONFIDENT And KONFIDENT-S (#552): Danny Cohn, Aharon Kessell, Tamar Kinaciyan, Rand Arnaout, Jonathan Peter, H. James Wedner, Emel Aygoren-Pursun, Jonathan Bernstein, Henriette Farkas, William Lumry, Marcus Maurer, Marc Riedl, Andrea Zanichelli, James Hao, Matthew Iverson, Michael Smith, Christopher Yea, Utpaul Audhya, Fotios Psarros.

Links to all presentations can be found on the KalVista website under Publications.

About Sebetralstat

Sebetralstat is an investigational, novel oral plasma kallikrein inhibitor for the treatment of hereditary angioedema (HAE). We have filed multiple regulatory applications seeking approval of sebetralstat as the first oral, on-demand treatment for HAE in individuals aged 12 and older, with ongoing studies exploring its use in children aged 2 to 11. If approved, sebetralstat has the potential to become the foundational therapy for HAE management worldwide.

About Hereditary Angioedema

Hereditary angioedema (HAE) is a rare genetic disease resulting in deficiency or dysfunction in the C1 esterase inhibitor (C1INH) protein and subsequent uncontrolled activation of the kallikrein-kinin system. People living with HAE experience painful and debilitating attacks of tissue swelling in various locations of the body that can be life-threatening depending on the area affected. All currently approved on-demand treatment options require either intravenous or subcutaneous administration.

About KalVista Pharmaceuticals, Inc.

KalVista Pharmaceuticals, Inc., is a global biopharmaceutical company dedicated to developing and delivering life-changing oral therapies for individuals affected by rare diseases with significant unmet needs. Our lead investigational product is sebetralstat, a novel, oral, on-demand treatment for hereditary angioedema (HAE). Sebetralstat is under regulatory review by the U.S. FDA, with a PDUFA goal date of June 17, 2025. In addition, we have completed Marketing Authorization Applications for sebetralstat to the European Medicines Agency and multiple other global regulatory authorities.

For more information about KalVista, please visit www.kalvista.com or follow us on social media at @KalVista and LinkedIn.

Forward-Looking Statements

This press release contains "forward-looking" statements within the meaning of the safe harbor provisions of the U.S. Private Securities Litigation Reform Act of 1995. Forward-looking statements can be identified by words such as: "anticipate," "intend," "plan," "goal," "seek," "believe," "project," "estimate," "expect," "strategy," "future," "likely," "may," "should," "will" and similar references to future periods. These statements are subject to numerous risks and uncertainties that could cause actual results to differ materially from what we expect. Examples of forward-looking statements include, among others, timing or outcomes of communications with the FDA, our expectations about safety and efficacy of our product candidates and timing of clinical trials and its results, our ability to commence clinical studies or complete ongoing clinical studies, including our KONFIDENT-S and KONFIDENT-KID trials, and to obtain regulatory approvals for sebetralstat and other candidates in development, the success of any efforts to commercialize sebetralstat, the ability of sebetralstat and other candidates in development to treat HAE or other diseases, and the future progress and potential success of our oral Factor XIIa program. Further information on potential risk factors that could affect our business and financial results are detailed in our filings with the Securities and Exchange Commission, including in our annual report on Form 10-K for the year ended April 30, 2024, our quarterly reports on Form 10-Q, and our other reports that we may make from time to time with the Securities and Exchange Commission. We undertake no obligation to publicly update any forward-looking statement, whether written or oral, that may be made from time to time, whether as a result of new information, future developments or otherwise.

View source version on businesswire.com: https://www.businesswire.com/news/home/20250221753614/en/

Ryan Baker

Head, Investor Relations

(617) 771-5001

ryan.baker@kalvista.com

Molly Cameron

Director, Corporate Communications

(857) 356-0164

molly.cameron@kalvista.com

Source: KalVista Pharmaceuticals, Inc.

FAQ

What new sebetralstat data will KALV present at AAAAI 2025?

KALV will present data on sebetralstat's effectiveness for laryngeal HAE attacks from KONFIDENT-S and pooled analysis from KONFIDENT studies for adolescent HAE treatment at the AAAAI 2025 conference.

When and where will KALV present their HAE treatment research at AAAAI 2025?

KALV will present at the AAAAI/WAO 2025 Joint Congress in San Diego from February 28–March 3, 2025, with specific presentations scheduled for February 28 and March 1.

How many abstracts has KALV been approved to present at AAAAI 2025?

KALV has had six abstracts accepted for presentation at the AAAAI 2025 conference, including three poster presentations, two late-breaking posters, and one oral presentation.

What are the key topics of KALV's AAAAI 2025 presentations?

The presentations focus on barriers to HAE treatment, injectable treatment burden in adolescents, treatment delays across healthcare systems, HAE with normal C1INH diagnoses, and sebetralstat's effectiveness in treating HAE attacks.