Jasper Therapeutics Reports Positive Data from BEACON Study of Briquilimab in Chronic Spontaneous Urticaria
Jasper Therapeutics (JSPR) reported positive preliminary data from its BEACON Phase 1b/2a study of briquilimab in treating Chronic Spontaneous Urticaria (CSU). The study showed significant clinical responses across multiple dosing cohorts, with the 240mg single-dose group achieving a mean UAS7 change of -26.6 from baseline at 8 weeks.
Key highlights include 100% Complete Response (UAS7 = 0) in the 240mg single-dose cohort (N=3) at 8 weeks, with 66% maintaining Well Controlled disease at 12 weeks. Multiple dosing regimens ≥120mg demonstrated UAS7 changes exceeding -25 points. The drug showed rapid onset of action, with responses observed as early as 1-week post-first dose.
Briquilimab demonstrated a favorable safety profile with no dose-limiting toxicities. Based on these results, Jasper plans to commence a CSU registrational program with a Phase 2b study in the second half of 2025.
Jasper Therapeutics (JSPR) ha riportato dati preliminari positivi dal suo studio BEACON di fase 1b/2a sull'uso di briquilimab per il trattamento dell'Urticaria Spontanea Cronica (CSU). Lo studio ha mostrato risposte cliniche significative in vari gruppi di dosaggio, con il gruppo a dose singola da 240 mg che ha raggiunto una variazione media dell'UAS7 di -26,6 rispetto al valore iniziale a 8 settimane.
I punti salienti includono una risposta completa del 100% (UAS7 = 0) nel gruppo a dose singola da 240 mg (N=3) a 8 settimane, con il 66% dei pazienti che ha mantenuto una malattia ben controllata a 12 settimane. I regimi di dosaggio multiplo ≥120 mg hanno dimostrato variazioni dell'UAS7 superiori a -25 punti. Il farmaco ha mostrato un rapido inizio d'azione, con risposte osservate già 1 settimana dopo la prima dose.
Briquilimab ha dimostrato un profilo di sicurezza favorevole, senza tossicità limitanti per la dose. Sulla base di questi risultati, Jasper prevede di avviare un programma di registrazione per la CSU con uno studio di fase 2b nella seconda metà del 2025.
Jasper Therapeutics (JSPR) informó datos preliminares positivos de su estudio BEACON de fase 1b/2a sobre el uso de briquilimab en el tratamiento de la Urticaria Espontánea Crónica (CSU). El estudio mostró respuestas clínicas significativas en múltiples cohortes de dosificación, con el grupo de dosis única de 240 mg logrando un cambio medio en el UAS7 de -26.6 desde el inicio a las 8 semanas.
Los aspectos destacados incluyen una respuesta completa del 100% (UAS7 = 0) en el grupo de dosis única de 240 mg (N=3) a las 8 semanas, con un 66% de los pacientes manteniendo la enfermedad bien controlada a las 12 semanas. Los regímenes de dosificación múltiple ≥120 mg demostraron cambios en el UAS7 superiores a -25 puntos. El fármaco mostró un inicio de acción rápido, con respuestas observadas tan pronto como 1 semana después de la primera dosis.
Briquilimab demostró un perfil de seguridad favorable, sin toxicidades limitantes de dosis. Basándose en estos resultados, Jasper planea iniciar un programa de registro de CSU con un estudio de fase 2b en la segunda mitad de 2025.
Jasper Therapeutics (JSPR)는 만성 자발적 두드러기(CSU) 치료를 위한 briquilimab의 BEACON 1b/2a 임상 시험에서 긍정적인 예비 데이터를 보고했습니다. 이 연구는 여러 투약 집단에서 유의미한 임상 반응을 보였으며, 240mg 단일 투여군이 8주 후 기준 대비 평균 UAS7 변화가 -26.6을 기록했습니다.
주요 성과로는 8주차에 240mg 단일 투여군(N=3)에서 100% 완전 반응 (UAS7 = 0)이 있었으며, 12주차에는 66%가 잘 조절된 질병을 유지했습니다. 120mg 이상의 다중 투여 요법에서는 UAS7 변화가 -25점을 초과했습니다. 이 약물은 빠른 작용 발현을 보여주었으며, 첫 번째 투여 후 1주 만에 반응이 관찰되었습니다.
Briquilimab는 용량 제한 독성이 없는 호전적인 안전성 프로필을 나타냈습니다. 이러한 결과를 바탕으로 Jasper는 2025년 하반기에 CSU 등록 프로그램과 함께 2b 임상 시험을 시작할 계획입니다.
Jasper Therapeutics (JSPR) a rapporté des données préliminaires positives de son étude BEACON de phase 1b/2a sur le briquilimab dans le traitement de l'Urticaria Spontanée Chronique (CSU). L'étude a montré des réponses cliniques significatives dans plusieurs cohortes de dosage, le groupe à dose unique de 240mg ayant atteint une variation moyenne de l'UAS7 de -26,6 par rapport à la ligne de base à 8 semaines.
Les points forts comprennent une réponse complète de 100% (UAS7 = 0) dans la cohorte à dose unique de 240mg (N=3) à 8 semaines, avec 66% des patients maintenant la maladie bien contrôlée à 12 semaines. Plusieurs schémas posologiques ≥120mg ont montré des changements de l'UAS7 dépassant -25 points. Le médicament a montré un début d'action rapide, avec des réponses observées dès 1 semaine après la première dose.
Le briquilimab a démontré un profil de sécurité favorable sans toxicités limitantes de dose. Sur la base de ces résultats, Jasper prévoit de commencer un programme d'enregistrement pour la CSU avec une étude de phase 2b dans la seconde moitié de 2025.
Jasper Therapeutics (JSPR) berichtete über positive vorläufige Daten aus seiner BEACON-Studie der Phase 1b/2a zur Behandlung der chronischen spontanen Urtikaria (CSU) mit briquilimab. Die Studie ergab signifikante klinische Antworten in mehreren Dosierungsgruppen, wobei die Gruppe mit einer Einzeldosis von 240 mg nach 8 Wochen eine mittlere Änderung des UAS7 von -26,6 gegenüber dem Ausgangswert erreichte.
Zu den wichtigsten Ergebnissen gehört eine 100% vollständige Antwort (UAS7 = 0) in der 240mg Einzeldosisgruppe (N=3) nach 8 Wochen, wobei 66% der Erkrankten 12 Wochen nachbehandelt gut kontrolliert blieben. Mehrere Dosierungsschemata ≥120mg zeigten UAS7-Änderungen von über -25 Punkten. Das Medikament zeigte einen schnellen Wirkungseintritt, wobei Reaktionen bereits 1 Woche nach der ersten Dosis beobachtet wurden.
Briquilimab wies ein günstiges Sicherheitsprofil ohne dosislimitierende Toxizitäten auf. Basierend auf diesen Ergebnissen plant Jasper, ein Registrierungsprogramm für CSU mit einer Phase 2b-Studie in der zweiten Hälfte des Jahres 2025 zu starten.
- Strong efficacy with 100% Complete Response in 240mg single-dose cohort
- Significant UAS7 score reduction (-26.6 points) in 240mg single-dose cohort
- Rapid onset of action (within 1 week)
- Favorable safety profile with no dose-limiting toxicities
- Multiple dosing regimens ≥120mg showed strong efficacy (>-25 points UAS7 change)
- Single Grade 3 neutropenia event reported in one patient
- Some patients experienced decreases in neutrophil counts
Insights
The BEACON study data reveals exceptional clinical efficacy for briquilimab in treating Chronic Spontaneous Urticaria (CSU). The
Particularly noteworthy is the rapid onset of action, with clinical responses observed within one week post-treatment. The durability of response shows dose-dependency, with the
The trial design and execution demonstrate strong scientific rigor. Key strengths include the double-blind, placebo-controlled structure and strategic dose escalation approach. The baseline disease burden was well-balanced across cohorts (UAS7 ~26-29), indicating appropriate patient selection.
The safety profile is particularly encouraging - no dose-limiting toxicities and manageable neutropenia that resolved during treatment. The planned expansion to include
Looking ahead to the Phase 2b registrational program, the
This data positions Jasper competitively in the $2+ billion CSU market. The efficacy profile, particularly the rapid onset and durability of response, could differentiate briquilimab from current standard-of-care treatments like omalizumab. The positive results in omalizumab-experienced patients suggest potential as a superior second-line therapy.
The Q8W and Q12W dosing schedules, if confirmed in larger trials, would offer favorable administration frequency compared to monthly dosing required by some competitors. With Phase 2b initiation planned for H2 2025, Jasper is executing well on its clinical development timeline. These results should strengthen investor confidence in briquilimab's commercial potential across multiple mast cell-driven diseases.
Rapid onset of deep and durable clinical responses observed across multiple dosing cohorts with a favorable safety profile
Mean change in UAS7 from baseline of -26.6 observed in the 240mg single dose cohort at 8 weeks, multiple dosing regimens ≥120mg demonstrated UAS7 change of more than -25 points
Serum tryptase reductions below the lower limit of quantification observed at multiple dose levels
Data supports commencement of CSU registrational program expected to commence second half of 2025
Company to host conference call and webinar today at 8:00 a.m. EST
REDWOOD CITY, Calif., Jan. 08, 2025 (GLOBE NEWSWIRE) -- Jasper Therapeutics, Inc. (Nasdaq: JSPR) (Jasper), a clinical stage biotechnology company focused on development of briquilimab, a novel antibody therapy targeting c-Kit (CD117) to address mast cell driven diseases such as chronic spontaneous urticaria (CSU), chronic inducible urticaria (CIndU) and asthma, today reported positive preliminary data from Jasper’s ongoing BEACON Phase 1b/2a study of subcutaneous briquilimab in adult participants with CSU. Substantial reductions in UAS7 were reported, with a mean change from baseline at 8 weeks of -26.6 in the 240mg single-dose cohort and multiple dosing regimens at or above 120mg demonstrating UAS7 changes of more than -25 points. Clinical responses were observed as early as 1-week post-first dose, and Complete Responses (UAS7 = 0) were achieved by patients at each therapeutic dose level (80mg, 120mg, 180mg and 240mg), most notably, all patients in the 240mg single-dose cohort (N=3) maintained Complete Responses through the 8-week time-point. Durability of response was generally dose dependent and reductions in serum tryptase to levels below the lower limit of quantification were observed at multiple dose levels. Briquilimab was well tolerated in the study with a favorable safety profile.
“I am excited to see the preliminary clinical data which demonstrated that treatment with briquilimab led to rapid and durable symptom control in patients with CSU, especially given the omalizumab-experienced population enrolled in the BEACON study,” said Thomas B. Casale, M.D., Professor of Medicine and Pediatrics, University of South Florida Morsani College of Medicine. “I am also very encouraged by the safety and tolerability profile observed thus far in both the BEACON and SPOTLIGHT studies. I believe these data support advancing briquilimab into a registrational program following the completion of BEACON, and I look forward to participating in additional studies of briquilimab in chronic urticaria.”
“We are very pleased to present the positive preliminary data from the BEACON study, which demonstrates the potential of briquilimab as a leading therapeutic for CSU patients,” said Edwin Tucker, Chief Medical Officer of Jasper. “The profound reduction in UAS7 from baseline in multiple cohorts, the dose dependent durability of response and the significant and prolonged drops in mean serum tryptase from baseline demonstrate the potential for deep and durable efficacy of briquilimab in CSU. Combined with the favorable safety profile enabled by our optimal biologic dosing approach, we believe briquilimab has demonstrated the potential to be a leading therapeutic option for patients with CSU. On behalf of the entire Jasper team, I’d like to thank the investigators and the patients who are participating in the study, along with their families and caregivers.”
BEACON Study Design and Data Summary:
The BEACON study is a randomized, double-blind, and placebo-controlled Phase 1b/2a trial evaluating multiple ascending doses of subcutaneous briquilimab as a treatment for adult patients with moderate to severe CSU despite high dose antihistamines and treatment with, or who cannot tolerate, omalizumab. The primary endpoints are safety and tolerability of briquilimab and secondary endpoints are focused on clinical activity and PK/PD, including measurement of serum tryptase and mast cells in skin. Primary measurements used to assess clinical activity were the sum of the Hives Severity Score and the daily Itch Severity Score (ISS), as measured via the Urticaria Activity Score over 7 days (UAS7) on a 0 to 42-point scale.
The preliminary data, as of December 31, 2024, include the results from 49 participants (N=3 at 10mg, N=3 at 40mg, N=6 at 80mg, N=8 at 120mg, N=14 at 180mg, N=3 at 240mg, and N=12 placebo) who completed at least 12 weeks of follow-up following initial dosing with investigational product. Participants had high disease burden as assessed by UAS7 score with mean baseline score of 27.9 in the 120mg dose group, 25.9 in the 180mg dose group, 26.6 in the 240mg dose group, and 28.6 in the placebo group.
Substantial reductions in UAS7 score were reported with multiple dosing regimens at or above 120mg demonstrating mean change from baseline of greater than -25 points at 12 weeks, as well as a mean change from baseline at 8 weeks of -26.6 points in the 240mg single-dose cohort. Complete responses (UAS7 = 0) were achieved by patients treated at each therapeutic dose level (80mg, 120mg, 180mg and 240mg), and all patients in the 240mg single-dose cohort (N=3) maintained Complete Responses through the 8-week time-point. In general, clinical responses following first dose at the 120mg and 180mg dose levels showed durability out to 4-6 weeks, while clinical responses at the 240mg level showed durability out to 8-12 weeks. These data demonstrate that treatment with briquilimab leads to rapid onset of durable and dose-dependent symptom control in patients with CSU.
Single-Dose Clinical Activity Assessments Summary at Week 8
| 240 mg Single-Dose (N=3) | Placebo (N=12) | |||
| UAS7 Changes | ||||
| Baseline mean UAS7 (SD) | 26.6 (10.9) | 28.6 (9.4) | ||
| Mean change at Week 8 | -26.6 | -12.4 | ||
| Mean difference from placebo | -14.2 | - | ||
| Clinical Responses | ||||
| UAS7≤6 (Well Controlled) | ||||
| UAS7=0 (Complete Response) | ||||
Q8W Dose Clinical Activity Assessments Summary at Week 12
| 80mg Q8W (N=6) | 120 mg Q8W (N=4) | 180mg Q8W (N=7) | Placebo (N=12) | |||||
| UAS7 Changes | ||||||||
| Baseline mean UAS7 (SD) | 31.0 (7.9) | 27.0 (7.5) | 26.5 (8.0) | 28.6 (9.4) | ||||
| Mean change at Week 12 | -9.3 | -27.2 | -13.2 | -9.2 | ||||
| Mean difference from placebo | -0.1 | -18.0 | -4.0 | - | ||||
| Clinical Responses | ||||||||
| UAS7≤6 (Well Controlled) | ||||||||
| UAS7=0 (Complete Response) | ||||||||
Q12W Dose Clinical Activity Assessments Summary at Week 16
| 120 mg Q12W (N=4) | 180mg Q12W (N=7) | Placebo (N=12) | ||||
| UAS7 Changes | ||||||
| Baseline mean UAS7 (SD) | 28.8 (10.6) | 27.8 (7.8) | 28.6 (9.4) | |||
| Mean change at Week 16 | -29.8 | -21.7 | -10.1 | |||
| Mean difference from placebo | -19.7 | -11.6 | - | |||
| Clinical Responses | ||||||
| UAS7≤6 (Well Controlled) | ||||||
| UAS7=0 (Complete Response) | ||||||
Mean baseline serum tryptase for participants in the enrolled in the study was within the normal range in all cohorts. Substantial reductions in tryptase were observed as early as the week 1 assessment and were correlated with the onset of clinical responses. Tryptase levels below the lower limit of quantification were reported for
Briquilimab was well tolerated in the study, with no dose limiting toxicities observed. Safety observations potentially related to c-Kit blockade were infrequent and generally limited to low grade events, none of which resulted in discontinuations or dose delays and the majority of which resolved during repeat dosing. Predictable decreases in neutrophil counts were observed upon dosing, with counts generally recovering prior to subsequent dose and no association to fever or infection. A single Grade 3 neutropenia event was reported in a participant with prior history of idiopathic neutropenia and thrombocytopenia.
Patients enrolled in the study will continue to be dosed and assessed for safety/tolerability and clinical activity, and Jasper has commenced an open-label extension study in chronic urticarias that will roll over patients from the BEACON to a 180mg Q8W dose upon completion of their initial follow up period. Consistent with the Company’s clinical development plan, Jasper submitted for regulatory review of two additional BEACON cohorts, 240mg Q8W (N=8) and 180mg Q8W following a 240mg induction dose (N=8).
Jasper expects to begin a registrational program in CSU with a Phase 2b study expected to commence in the second half of 2025. Final selection of doses for the Phase 2b study will be further informed by additional data at 180mg Q8W from the open-label extension study, as well as by further data from BEACON cohorts evaluating a 360mg single dose, a 240mg Q8W dose and a 180mg Q8W dose following a 240mg loading dose. Data from these additional cohorts are expected to be presented by mid-2025.
“We are very happy to report preliminary data from the BEACON study,” said Ronald Martell, President and Chief Executive Officer of Jasper. “The favorable safety profile, rapid onset of durable responses, the pharmacokinetic profile, and the depth and durability of tryptase reductions observed, all support advancing a 240mg dosing regimen into the Phase 2b portion of a CSU registrational program that we plan to commence in the second half of 2025. With positive data in both SPOTLIGHT and BEACON studies and preliminary data on the ETESIAN study in asthma expected in the second half of 2025, we continue to rapidly advance our briquilimab franchise in mast cell driven diseases.”
Conference Call / Webinar
Jasper will host a conference call and webinar today at 8:00 a.m. EST, including remarks from Dr. Thomas B. Casale, M.D., the lead US investigator for the BEACON study. A live question and answer session with management will follow the formal presentations. A link to the webinar, including presentation slides, can be found here.
The presentation slides and a link to the live and archived webcast will also be available on the Events & News – Events page of Jasper's Investor Relations website.
About Briquilimab
Jasper is a clinical-stage biotechnology company focused on developing briquilimab as a therapeutic for chronic mast cell diseases. Briquilimab is a targeted aglycosylated monoclonal antibody that blocks stem cell factor from binding to the cell-surface receptor c-Kit, also known as CD117, thereby inhibiting signaling through the receptor. This inhibition disrupts the critical survival signal, leading to the depletion of the mast cells via apoptosis which removes the underlying source of the inflammatory response in mast cell driven diseases such as chronic urticaria and asthma. Jasper is currently conducting clinical studies of briquilimab as a treatment in patients with CSU, CIndU or asthma. Briquilimab has a demonstrated efficacy and safety profile in patients and healthy volunteers, with positive clinical outcomes in CSU and CIndU. For more information, please visit us at www.jaspertx.com.
Forward-Looking Statements
Certain statements included in this press release that are not historical facts are forward-looking statements for purposes of the safe harbor provisions under the United States Private Securities Litigation Reform Act of 1995. Forward-looking statements are sometimes accompanied by words such as “believe,” “may,” “will,” “estimate,” “continue,” “anticipate,” “intend,” “expect,” “should,” “would,” “plan,” “predict,” “potential,” “seem,” “seek,” “future,” “outlook” and similar expressions that predict or indicate future events or trends or that are not statements of historical matters. These forward-looking statements include, but are not limited to, statements regarding briquilimab’s potential, including with respect to its potential in mast cell driven diseases such as CSU, CIndU, and asthma and as a leading therapeutic for CSU patients; the potential for deep and durable efficacy of briquilimab in CSU; briquilimab’s safety profile; the advancement of briquilimab into a registrational program; additional studies of briquilimab in chronic urticaria; patient enrollment in an open-label extension study in chronic urticarias that will roll over patients from the BEACON to a 180mg Q8W dose; regulatory review of two additional BEACON cohorts, 240mg Q8W (N=8) and 180mg Q8W following a 240mg induction dose (N=8); Jasper’s expectations regarding a registrational program in CSU, including the expected timing of the Phase 2b study and dose selection; Jasper’s expected timing for presenting data from additional BEACON cohorts; and Jasper’s expectations regarding rapidly advancing its briquilimab franchise in mast cell driven diseases. These statements are based on various assumptions, whether or not identified in this press release, and on the current expectations of Jasper and are not predictions of actual performance. These forward-looking statements are provided for illustrative purposes only and are not intended to serve as, and must not be relied on by an investor as, a guarantee, an assurance, a prediction or a definitive statement of fact or probability. Many actual events and circumstances are beyond the control of Jasper. These forward-looking statements are subject to a number of risks and uncertainties, including general economic, political and business conditions; the risk that the potential product candidates that Jasper develops may not progress through clinical development or receive required regulatory approvals within expected timelines or at all; the risk that clinical trials may not confirm any safety, potency or other product characteristics described or assumed in this press release; the risk that prior test, study and trial results, including preliminary results for the BEACON study reported in this press release, may not be replicated in continuing or future studies and trials; the risk that Jasper will be unable to successfully market or gain market acceptance of its product candidates; the risk that prior study results may not be replicated; the risk that Jasper’s product candidates may not be beneficial to patients or successfully commercialized; patients’ willingness to try new therapies and the willingness of physicians to prescribe these therapies; the effects of competition on Jasper’s business; the risk that third parties on which Jasper depends for laboratory, clinical development, manufacturing and other critical services will fail to perform satisfactorily; the risk that Jasper’s business, operations, clinical development plans and timelines, and supply chain could be adversely affected by the effects of health epidemics; the risk that Jasper will be unable to obtain and maintain sufficient intellectual property protection for its investigational products or will infringe the intellectual property protection of others; and other risks and uncertainties indicated from time to time in Jasper’s filings with the SEC, including its Annual Report on Form 10-K for the year ended December 31, 2023 and subsequent Quarterly Reports on Form 10-Q. If any of these risks materialize or Jasper’s assumptions prove incorrect, actual results could differ materially from the results implied by these forward-looking statements. While Jasper may elect to update these forward-looking statements at some point in the future, Jasper specifically disclaims any obligation to do so. These forward-looking statements should not be relied upon as representing Jasper’s assessments of any date subsequent to the date of this press release. Accordingly, undue reliance should not be placed upon the forward-looking statements.
Contacts:
Alex Gray (investors)
Jasper Therapeutics
650-549-1454
agray@jaspertherapeutics.com
Joyce Allaire (investors)
LifeSci Advisors
617-435-6602
jallaire@lifesciadvisors.com
Lauren Walker (media)
Real Chemistry
646-564-2156
lbarbiero@realchemistry.com
FAQ
What were the main results of JSPR's BEACON study for briquilimab in January 2025?
When will JSPR begin its Phase 2b registrational program for briquilimab in CSU?
What dosing levels were tested in JSPR's BEACON study?
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What safety concerns were identified in JSPR's BEACON study?
