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Century Therapeutics Announces Upcoming Poster Presentations at the 2024 American Society of Hematology (ASH) Annual Meeting

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Century Therapeutics (NASDAQ: IPSC) announced it will present preclinical data from its iPSC-derived cell therapy platform in five posters at the 2024 ASH Annual Meeting. The presentations will showcase advances in their iNK, γδ iT, and αβ iT cell therapy programs for oncology and autoimmune diseases. Key highlights include the development of iPSC-derived CD4+ and CD8+ CAR T cells with functionality comparable to primary αβ CAR-T cells, enhanced Allo-Evasion™ technology, and data demonstrating CAR iNK and γδ iT cells' potential in treating B-cell-mediated autoimmune diseases. The meeting will be held in San Diego from December 7-10, 2024.

Century Therapeutics (NASDAQ: IPSC) ha annunciato che presenterà dati preclinici della sua piattaforma di terapia cellulare derivata da iPSC in cinque poster durante il 2024 ASH Annual Meeting. Le presentazioni metteranno in mostra i progressi nei programmi di terapia cellulare iNK, γδ iT e αβ iT per l'oncologia e le malattie autoimmuni. Tra i punti salienti vi è lo sviluppo di cellule T CAR CD4+ e CD8+ derivate da iPSC con funzionalità comparabile a quella delle cellule T CAR αβ primarie, una tecnologia migliorata di Allo-Evasion™ e dati che dimostrano il potenziale delle cellule CAR iNK e γδ iT nel trattamento delle malattie autoimmuni mediate dalle cellule B. L'incontro si terrà a San Diego dal 7 al 10 dicembre 2024.

Century Therapeutics (NASDAQ: IPSC) anunció que presentará datos preclínicos de su plataforma de terapia celular derivada de iPSC en cinco posters en el 2024 ASH Annual Meeting. Las presentaciones mostrarán avances en sus programas de terapia celular iNK, γδ iT y αβ iT para oncología y enfermedades autoinmunes. Los puntos destacados incluyen el desarrollo de células CAR T CD4+ y CD8+ derivadas de iPSC con funcionalidad comparable a las células CAR T αβ primarias, tecnología mejorada de Allo-Evasion™ y datos que demuestran el potencial de las células CAR iNK y γδ iT para tratar enfermedades autoinmunes mediadas por células B. La reunión se llevará a cabo en San Diego del 7 al 10 de diciembre de 2024.

센추리 테라퓨틱스 (NASDAQ: IPSC)는 2024 ASH 연례회의에서 iPSC 유래 세포 치료 플랫폼의 전임상 데이터를 5개의 포스터로 발표할 것이라고 발표했습니다. 발표에서는 종양학 및 자가면역 질환을 위한 iNK, γδ iT 및 αβ iT 세포 치료 프로그램의 발전이 소개됩니다. 주요 하이라이트로는 1차 αβ CAR-T 세포와 비교할 수 있는 기능을 갖춘 iPSC 유래 CD4+ 및 CD8+ CAR T 세포의 개발, 향상된 Allo-Evasion™ 기술, 및 B세포 매개 자가면역 질환 치료에 있어 CAR iNK 및 γδ iT 세포의 잠재력을 입증하는 데이터가 포함됩니다. 회의는 2024년 12월 7일부터 10일까지 샌디에고에서 열릴 예정입니다.

Century Therapeutics (NASDAQ: IPSC) a annoncé qu'elle présentera des données précliniques de sa plateforme de thérapie cellulaire dérivée de l'iPSC dans cinq posters lors de la 2024 ASH Annual Meeting. Les présentations mettront en avant les avancées de ses programmes de thérapie cellulaire iNK, γδ iT et αβ iT pour l'oncologie et les maladies auto-immunes. Les points saillants incluent le développement de cellules CAR T CD4+ et CD8+ dérivées d'iPSC avec une fonctionnalité comparable à celle des cellules CAR-T αβ primaires, une technologie améliorée Allo-Evasion™ et des données démontrant le potentiel des cellules CAR iNK et γδ iT dans le traitement des maladies auto-immunes médiées par les cellules B. La réunion se tiendra à San Diego du 7 au 10 décembre 2024.

Century Therapeutics (NASDAQ: IPSC) gab bekannt, dass es auf dem 2024 ASH Annual Meeting fünf Poster mit präklinischen Daten seiner iPSC-abgeleiteten Zelltherapie-Plattform präsentieren wird. Die Präsentationen werden Fortschritte in ihren iNK-, γδ iT- und αβ iT-Zelltherapie-Programmen für Onkologie und Autoimmunerkrankungen vorstellen. Zu den wichtigsten Highlights gehören die Entwicklung von iPSC-abgeleiteten CD4+ und CD8+ CAR T-Zellen mit einer Funktionalität, die mit primären αβ CAR-T-Zellen vergleichbar ist, verbesserte Allo-Evasion™-Technologie und Daten, die das Potenzial von CAR iNK- und γδ iT-Zellen zur Behandlung von B-zellvermittelten Autoimmunerkrankungen aufzeigen. Die Veranstaltung findet vom 7. bis 10. Dezember 2024 in San Diego statt.

Positive
  • Development of first iPSC-derived CD4+ and CD8+ CAR T cells with comparable function to primary αβ CAR-T cells
  • Successful demonstration of universal protection from NK cells via novel CD300a TASR technology
  • Preclinical data shows potent activity in treating B-cell-mediated autoimmune diseases
Negative
  • None.

Insights

The preclinical data presentation at ASH reveals significant technological breakthroughs in Century Therapeutics' iPSC-derived cell therapy platform. The development of iPSC-derived CD4+ and CD8+ CAR T cells that match primary αβ CAR-T cell functionality represents a major technical achievement in the field. This could potentially solve manufacturing scalability issues that plague current CAR-T therapies.

The enhanced Allo-Evasion™ technology with CD300a TASR for NK cell protection and improved CAR endo-domains demonstrates meaningful advances in cell therapy engineering. These innovations could lead to better persistence and efficacy of allogeneic cell therapies. The expansion into both oncology and autoimmune diseases, particularly with CAR iNK and γδ iT cells showing promise in B-cell-mediated autoimmune conditions, significantly broadens the platform's commercial potential.

– Company to share preclinical data across diverse pipeline of iNK, γδ iT, and αβ iT cell therapy programs for oncology and autoimmune disease (AID) –

– Preclinical data on development of iPSC-derived CD4+ and CD8+ CAR T cells that demonstrate function comparable to primary αβ CAR-T cells, allowing for control of tumors in vivo without the need for exogenous or engineered cytokines

– Posters include demonstration of advances in gene editing and transgene design that enable greater control and improved functionality of iPSC derived immune cells –

PHILADELPHIA, Nov. 05, 2024 (GLOBE NEWSWIRE) -- Century Therapeutics (NASDAQ: IPSC), an innovative biotechnology company developing induced pluripotent stem cell (iPSC)-derived cell therapies in immuno-oncology and autoimmune disease, today announced that preclinical data from the Company’s iPSC-derived cell therapy platform will be presented in five posters at the 2024 ASH Annual Meeting to be held in San Diego, CA from December 7-10, 2024.

“We are pleased to spotlight continued achievement across our pre-clinical pipeline as we develop a diverse portfolio of iNK, γδ iT, and αβ iT-cell programs spanning oncology and autoimmune diseases,” said Chad Cowan, Ph.D., Chief Scientific Officer at Century Therapeutics. “Most notably, we will be showcasing what we believe to be the first iPSC-derived CD4+ and CD8+ CAR T cells that demonstrate function comparable to primary αβ CAR-T cells. The engineerability of iPSC-derived immune effector cells, which is a core benefit of the Company’s platform, will also be highlighted at ASH. This includes data relating to our enhanced Allo-Evasion™ via a novel CD300a TASR that demonstrated universal protection from NK cells, advanced CAR endo-domains that improve cytotoxicity and persistence, and differentiation-stage-specific promoters that allow for selective control of gene expression. Furthermore, we are encouraged by data demonstrating our CAR iNK and γδ iT cells’ potent preclinical ability to treat B-cell-mediated autoimmune diseases. We believe the breadth of these pre-clinical findings further underscores the compelling rationale behind our iPSC-derived cell therapies across multiple indications.”

Details of the posters being presented are as follows:

Successful Generation of iPSC-Derived CD4+ and CD8+ CAR T Cells with αβ-like T Cell Function, Including Antigen-Dependent Expansion and IL-2 Production
Publication Number4819
Session Title703. Cellular Immunotherapies Other than CAR-T Cells: Basic and Translational: Poster III
Session Date & TimeMonday, December 9, 2024, at 6:00 PM - 8:00 PM PT

Universal Cloaking of Allogeneic T Cell Therapies Against Natural Killer Cells Via CD300a Agonism
Publication Number: 4821
Session Title: 703. Cellular Immunotherapies other than CAR-T Cells: Basic and Translational: Poster III
Session Date & Time: Monday, December 9, 2024, at 6:00 PM - 8:00 PM PT

Optimizing Chimeric Antigen Receptor Endodomains for Effector Function and Cell Expansion in iPSC-Derived T-Cell Therapies 
Publication Number: 2063
Session Title: 703. Cellular Immunotherapies other than CAR-T Cells: Basic and Translational: Poster I
Session Date & Time: Saturday, December 7, 2024, at 5:30 PM - 7:30 PM PT

Leveraging Stage-Specific Promoters to Enhance Immune Cell Engineering in iPSC-Derived Cells for Cancer Immunotherapy
Publication Number: 4820
Session Title: 703. Cellular Immunotherapies other than CAR-T Cells: Basic and Translational: Poster III
Session Date & Time: Monday, December 9, 2024, at 6:00 PM - 8:00 PM PT

Natural Killer and γδ T Cells Derived from Engineered Induced Pluripotent Stem Cells Have Potent Preclinical Activity to Treat B Cell-Mediated Autoimmune Diseases
Publication Number: 3437
Session Title: 703. Cellular Immunotherapies other than CAR-T Cells: Basic and Translational: Poster II
Session Date & Time: Sunday, December 8, 2024, at 6:00 PM - 8:00 PM PT

Century's 2024 ASH posters will be available for download shortly after their scheduled presentation on the Scientific Resources page of the Company’s site.

About Century Therapeutics

Century Therapeutics (NASDAQ: IPSC) is harnessing the power of adult stem cells to develop curative cell therapy products for cancer and autoimmune diseases that we believe will allow us to overcome the limitations of first-generation cell therapies. Our genetically engineered, iPSC-derived cell product candidates are designed to specifically target hematologic and solid tumor cancers, with a broadening application to autoimmune diseases. We are leveraging our expertise in cellular reprogramming, genetic engineering, and manufacturing to develop therapies with the potential to overcome many of the challenges inherent to cell therapy and provide a significant advantage over existing cell therapy technologies. We believe our commitment to developing off-the-shelf cell therapies will expand patient access and provide an unparalleled opportunity to advance the course of cancer and autoimmune disease care. For more information on Century Therapeutics please visit www.centurytx.com.

Century Therapeutics Forward-Looking Statement

This press release contains forward-looking statements within the meaning of, and made pursuant to the safe harbor provisions of, The Private Securities Litigation Reform Act of 1995. All statements contained in this press release, other than statements of historical facts or statements that relate to present facts or current conditions, including but not limited to, statements regarding our clinical development plans and timelines, are forward-looking statements. These statements involve known and unknown risks, uncertainties and other important factors that may cause our actual results, performance, or achievements to be materially different from any future results, performance or achievements expressed or implied by the forward-looking statements. In some cases, you can identify forward-looking statements by terms such as “may,” “might,” “will,” “should,” “expect,” “plan,” “aim,” “seek,” “anticipate,” “could,” “intend,” “target,” “project,” “contemplate,” “believe,” “estimate,” “predict,” “forecast,” “potential” or “continue” or the negative of these terms or other similar expressions. The forward-looking statements in this press release are only predictions. We have based these forward-looking statements largely on our current expectations and projections about future events and financial trends that we believe may affect our business, financial condition, and results of operations. These forward-looking statements speak only as of the date of this press release and are subject to a number of risks, uncertainties and assumptions, some of which cannot be predicted or quantified and some of which are beyond our control, including, among others: our ability to successfully advance our current and future product candidates through development activities, preclinical studies, and clinical trials; our dependence on the success of our lead product candidate, CNTY-101; and our ability to progress CNTY-101 through our CALiPSO and ELiPSE Phase 1 clinical trials; our ability to meet development milestones on anticipated timelines; uncertainties inherent in the results of preliminary data, pre-clinical studies and earlier-stage clinical trials, which may not be predictive of final results or the results of later-stage clinical trials; our ability to obtain FDA clearance of our future IND submissions and commence and complete clinical trials on expected timelines, or at all; our reliance on the maintenance of certain key collaborative relationships for the manufacturing and development of our product candidates; the timing, scope and likelihood of regulatory filings and approvals, including final regulatory approval of our product candidates; the impact of geopolitical issues, banking instability and inflation on our business and operations, supply chain and labor force; the performance of third parties in connection with the development of our product candidates, including third parties conducting our clinical trials as well as third-party suppliers and manufacturers; our ability to successfully commercialize our product candidates and develop sales and marketing capabilities, if our product candidates are approved; our ability to recruit and maintain key members of management and our ability to maintain and successfully enforce adequate intellectual property protection. These and other risks and uncertainties are described more fully in the “Risk Factors” section of our most recent filings with the Securities and Exchange Commission and available at www.sec.gov. You should not rely on these forward-looking statements as predictions of future events. The events and circumstances reflected in our forward-looking statements may not be achieved or occur, and actual results could differ materially from those projected in the forward-looking statements. Moreover, we operate in a dynamic industry and economy. New risk factors and uncertainties may emerge from time to time, and it is not possible for management to predict all risk factors and uncertainties that we may face. Except as required by applicable law, we do not plan to publicly update or revise any forward-looking statements contained herein, whether as a result of any new information, future events, changed circumstances or otherwise.

For More Information:

Investor Relations & Media Contacts

Century Therapeutics
Katja Buhrer
SVP, Head of Corporate Affairs and Strategy
katja.buhrer@centurytx.com
917-969-3438

Argot Partners
Julie Seidel/Noor Pahlavi
century@argotpartners.com
212-600-1902


FAQ

What will Century Therapeutics (IPSC) present at the 2024 ASH Annual Meeting?

Century Therapeutics will present preclinical data from their iPSC-derived cell therapy platform across five posters, showcasing advances in iNK, γδ iT, and αβ iT cell therapy programs for oncology and autoimmune diseases.

What is the key breakthrough in Century Therapeutics' (IPSC) CAR T cell development?

The company developed the first iPSC-derived CD4+ and CD8+ CAR T cells that demonstrate function comparable to primary αβ CAR-T cells, capable of controlling tumors without requiring exogenous or engineered cytokines.

When and where will Century Therapeutics (IPSC) present at the 2024 ASH Annual Meeting?

The presentations will take place at the ASH Annual Meeting in San Diego, CA from December 7-10, 2024.

Century Therapeutics, Inc.

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