Immutep Reaches Enrolment Target for INSIGHT-003 Trial in 1st Line NSCLC

Rhea-AI Summary

Immutep Limited has announced the successful enrollment of 20 patients in the INSIGHT-003 trial, evaluating its lead product candidate, eftilagimod alpha (efti), in combination with standard anti-PD-1 therapy and chemotherapy for first-line non-small cell lung cancer (1L NSCLC). Initial results showed a promising 72.7% response rate and 90.9% disease control rate. The trial aims to assess the safety and efficacy of this triple therapy approach. Further data will be released throughout 2023 to guide the next steps in 1L NSCLC treatment.

Positive

• Enrollment of 20 patients in INSIGHT-003 trial completed.
• Initial response rate of 72.7% and disease control rate of 90.9% reported.
• Efti shows potential to be combined safely with existing therapies.

Negative

• None.

Media Release

• 20 patients with 1st line non-small cell lung cancer (1L NSCLC) now enrolled in the first triple combination therapy study of efti with standard-of-care combination of anti-PD-1 therapy and chemotherapy
• Promising initial efficacy results showing a 72.7% response rate and 90.9% disease control rate reported at SITC 2022
• Additional data is expected throughout calendar year 2023 and will further inform our next steps in 1L NSCLC
  
  

SYDNEY, AUSTRALIA, Feb. 06, 2023 (GLOBE NEWSWIRE) -- Immutep Limited (ASX: IMM; NASDAQ: IMMP) ("Immutep” or “the Company”), a clinical-stage biotechnology company developing novel LAG-3 immunotherapies for cancer and autoimmune diseases, today announces the investigator-initiated INSIGHT-003 trial has reached its enrolment target of 20 patients with 1L NSCLC. INSIGHT-003 is the first trial evaluating Immutep’s lead product candidate, eftilagimod alpha (“efti” or “IMP321”) as part of a triple combination therapy with standard-of-care anti-PD-1 therapy and chemotherapy.

Immutep’s CSO & CMO Dr Frederic Triebel said, “The promising initial efficacy and favourable safety results reported in November 2022 from this first triple combination approach instils more confidence in the flexibility of our novel immunotherapy, efti, to be combined with various therapeutics and safely drive superior patient outcomes. We are pleased to have reached our enrolment target and look forward to reporting as the results mature further. Additional data from INSIGHT-003 will help further inform our next steps in 1^st line NSCLC.”

In a poster presented at the Society for Immunotherapy of Cancer (SITC) Annual Meeting 2022, initial results in 1L NSCLC patients show the triple combination therapy is well-tolerated and provides promising early signals of therapeutic activity with an Objective Response Rate (ORR) of 72.7% (8/11) and a Disease Control Rate (DCR) of 90.9% (10/11). Nine patients had a PD-L1 Tumour Proportion Score (TPS) of <50% and this group reported an encouraging ORR of 66.7% and DCR of 88.9%. Patients with a PD-L1 of <50% represent approximately two-thirds of the 1L NSCLC patient population and are less responsive to anti-PD-1 therapy compared to patients with a PD-L1 TPS of ≥50%.

Additional data from INSIGHT-003 is expected to be presented throughout calendar year 2023. For more information on the study, please see the poster titled ‘Feasibility of eftilagimod alpha (soluble LAG-3 protein) combined with standard-of-care-therapy in advanced non-small-cell lung cancer (NSCLC). Initial results from INSIGHT 003’ in the Posters & Publications section of Immutep’s website.

About INSIGHT-003
INSIGHT-003 is an investigator-initiated study conducted by the Institute of Clinical Cancer Research IKF at Krankenhaus Nordwest in Frankfurt. It is being run as the third arm (Stratum C) of the ongoing Phase I INSIGHT trial with Prof. Dr. Salah-Eddin Al-Batran as lead investigator. The study is evaluating a triple combination therapy in front line non-small cell lung cancer patients consisting of efti administered subcutaneously in conjunction with an existing approved standard-of-care combination of anti-PD-1 therapy (pembrolizumab) and chemotherapy (carboplatin and pemetrexed) delivered intravenously. The trial will assess the safety, tolerability, and initial efficacy of the combination.

About Immutep
Immutep is a clinical stage biotechnology company developing novel LAG-3 immunotherapy for cancer and autoimmune disease. We are pioneers in the understanding and advancement of therapeutics related to Lymphocyte Activation Gene-3 (LAG-3), and our diversified product portfolio harnesses its unique ability to stimulate or suppress the immune response. Immutep is dedicated to leveraging its expertise to bring innovative treatment options to market for patients in need and to maximise value for shareholders. For more information, please visit www.immutep.com.

Australian Investors/Media:
Catherine Strong, Citadel-MAGNUS
+61 (0)406 759 268; cstrong@citadelmagnus.com

U.S. Investors/Media:
Chris Basta, VP, Investor Relations and Corporate Communications
+1 (631) 318 4000; chris.basta@immutep.com

FAQ

What is the significance of the INSIGHT-003 trial for IMMP?

The INSIGHT-003 trial evaluates efti in combination with anti-PD-1 therapy and chemotherapy, aiming to establish its effectiveness in treating 1L NSCLC.

What were the initial results of the INSIGHT-003 trial reported by IMMP?

Initial results indicate a 72.7% response rate and a 90.9% disease control rate for the triple therapy.

When can we expect more data from the INSIGHT-003 trial?

Additional data from the INSIGHT-003 trial is expected throughout 2023.

How many patients are enrolled in the INSIGHT-003 trial of IMMP?

The trial has successfully enrolled 20 patients.

What is the target patient group for the INSIGHT-003 trial?

The trial focuses on patients with first-line non-small cell lung cancer.