Welcome to our dedicated page for I-MAB American Depositary Shares news (Ticker: IMAB), a resource for investors and traders seeking the latest updates and insights on I-MAB American Depositary Shares stock.
I-Mab American Depositary Shares (Nasdaq: IMAB) represent a leading clinical-stage biopharmaceutical company dedicated to the discovery, development, and commercialization of novel and highly differentiated biologics to treat diseases with unmet medical needs, focusing on cancers and autoimmune disorders. With operations in Rockville, Maryland, and San Diego, California, I-Mab is actively involved in groundbreaking research and innovative drug development.
The company’s pipeline includes several promising candidates:
- Felzartamab (TJ202): A CD38 antibody in Phase III trials for multiple myeloma and autoimmune diseases.
- Eftansomatropin (TJ101): A long-acting human growth hormone that has completed Phase II trials for pediatric growth hormone deficiency.
- Olamkicept (TJ301): An IL-6 blocker in Phase II trials for ulcerative colitis and autoimmune diseases.
- Enoblituzumab: A humanized B7-H3 antibody that has completed Phase I trials for head and neck cancer and other oncology diseases.
- Efineptakin (TJ107): A long-acting recombinant human IL-7 in Phase II trials for glioblastoma multiforme (GBM).
I-Mab's innovative pipeline is driven by its internal R&D strategies, Fast-to-Proof-of-Concept, and Fast-to-Market development, often in collaboration with global partners. Recently, I-Mab announced the divestiture of its Chinese assets and operations, aiming to focus on the U.S. and other international markets. This strategic move included the transfer of its Greater China rights for various assets, potentially generating up to US$80 million based on future milestone achievements.
Notably, the company has entered into a clinical trial collaboration with Bristol Myers Squibb to evaluate givastomig combined with nivolumab and chemotherapy as a first-line treatment for advanced Claudin 18.2-positive gastric and esophageal cancers. I-Mab’s robust development pipeline and strategic global partnerships exemplify its commitment to advancing novel therapies to address critical medical needs.
For the latest updates and detailed information, visit the official website at I-Mab Biopharma.
I-Mab (Nasdaq: IMAB) announced interim results from its clinical trial of lemzoparlimab, a CD47 antibody, in combination with rituximab for heavily treated patients with relapsed or refractory non-Hodgkin's lymphoma (NHL). The study reported safety and tolerability with no need for a priming dose, and an overall response rate of 71%, with 4 complete responses among 7 evaluable patients. The ongoing study aims to expand patient enrollment for further evaluation. I-Mab continues to accelerate the clinical development of lemzoparlimab both in the U.S. and China.
I-Mab (Nasdaq: IMAB) announced an investor call scheduled for December 14, 2021, at 8:00 a.m. EST to discuss recent clinical data on lemzoparlimab combined with rituximab for treating relapsed or refractory non-Hodgkin's lymphoma. The company is focused on developing lemzoparlimab, a novel CD47 antibody designed to minimize side effects typically associated with this class of drugs. Ongoing studies in the U.S. and China aim to explore its efficacy across various malignancies, which could pave the way for future registrational trials.
I-Mab (Nasdaq: IMAB) announced the dosing of the first patient in a U.S. Phase I study of Protollin, an investigational drug for Alzheimer's disease. Conducted by Brigham and Women's Hospital, this randomized, double-blind trial assesses the safety and immune effects of Protollin on early symptomatic Alzheimer’s patients. The drug is designed to stimulate the innate immune system to combat beta amyloid plaques. Following FDA's acceptance of its IND submission in July 2021, this marks a significant milestone in developing new Alzheimer’s therapies.
I-Mab (Nasdaq: IMAB) announced its Board of Directors approved a motion for a dual listing of the company's ordinary shares on The Main Board of The Stock Exchange of Hong Kong Limited. The move is subject to market conditions, further Board approvals, and necessary regulatory clearances. I-Mab aims to enhance its global presence and facilitate capital raising through this initiative. As a clinical-stage biopharmaceutical company, I-Mab focuses on developing novel biologics for immuno-oncology and autoimmune diseases, supported by a robust pipeline of drug candidates.
I-Mab (Nasdaq: IMAB) announced the dosing of the first two patients in the U.S. phase 2 clinical study of its CD73 antibody, uliledlimab (TJD5), combined with atezolizumab (Tecentriq®) for patients with advanced ovarian cancer and other solid tumors. The study aims to evaluate uliledlimab's therapeutic potential and biomarkers in immune-resistant cancer types. Previous phase 1 trials showed favorable safety and promising efficacy. I-Mab is concurrently advancing uliledlimab’s development in China, indicating a robust strategy for global clinical advancement.
I-Mab (Nasdaq: IMAB) has formed a strategic partnership with Jumpcan Pharmaceutical Group to commercialize eftansomatropin alfa in mainland China. The deal is valued at up to RMB 2.016 billion (approximately $315 million) and includes an upfront payment of RMB 224 million (around $35 million). This collaboration is aimed at enhancing I-Mab’s commercialization efforts, with Jumpcan managing product distribution, targeting over 23,000 hospitals. Eftansomatropin alfa is in Phase 3 trials for pediatric growth hormone deficiency and offers a promising alternative to daily injections.
I-Mab (Nasdaq: IMAB) and ABL Bio announced promising preclinical data on their bispecific antibodies TJ-CD4B/ABL111 and TJ-L14B/ABL503 at the SITC Annual Meeting. Both candidates are currently in Phase 1 clinical trials in the U.S. The data indicates enhanced anti-tumor activity and a favorable safety profile, potentially addressing dose-limiting toxicities associated with 4-1BB targeting drugs. The studies demonstrate significant immune responses and minimal systemic toxicity, positioning these candidates as innovative therapies for cancer treatment.
I-Mab (Nasdaq: IMAB) has announced a strategic collaboration with Roche Diagnostics to co-develop companion diagnostics (CDx) solutions aimed at enhancing the efficiency of biologics R&D. This partnership, unveiled at the Fourth China International Import Expo in Shanghai, will leverage Roche's technology to improve patient selection and drug efficacy. The collaboration is intended to fast-track I-Mab's innovative pipeline for potential cancer treatments, aligning with the company's goal to become a fully integrated global biopharmaceutical entity.
I-Mab (Nasdaq: IMAB) announced that initial clinical results of its differentiated CD47 monoclonal antibody, lemzoparlimab, will be presented at the ASH 2021 Annual Meeting from December 11-14, 2021. The trial is assessing lemzoparlimab's safety and efficacy in combination with rituximab for patients with relapsed or refractory non-Hodgkin's lymphoma (NHL). This ongoing multi-center trial includes sites in the U.S. and China. I-Mab plans to host an investor call on December 14, 2021, to discuss these results.
I-Mab (Nasdaq: IMAB), a biopharmaceutical company, announced its participation in several healthcare conferences in November 2021. Notable events include the Goldman Sachs Asia Pacific Healthcare Forum, Jefferies London Healthcare Conference, BioCentury-BayHelix China Healthcare Summit, Morgan Stanley Asia Pacific Summit, and Piper Sandler Healthcare Conference. Key management personnel, including Dr. Jingwu Zang and Dr. Joan Huaqiong Shen, will represent the company in various discussions. I-Mab's focus remains on advancing its innovative pipeline in immuno-oncology and autoimmune diseases.
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