Welcome to our dedicated page for I-Mab news (Ticker: IMAB), a resource for investors and traders seeking the latest updates and insights on I-Mab stock.
I-Mab American Depositary Shares (Nasdaq: IMAB) represent a leading clinical-stage biopharmaceutical company dedicated to the discovery, development, and commercialization of novel and highly differentiated biologics to treat diseases with unmet medical needs, focusing on cancers and autoimmune disorders. With operations in Rockville, Maryland, and San Diego, California, I-Mab is actively involved in groundbreaking research and innovative drug development.
The company’s pipeline includes several promising candidates:
- Felzartamab (TJ202): A CD38 antibody in Phase III trials for multiple myeloma and autoimmune diseases.
- Eftansomatropin (TJ101): A long-acting human growth hormone that has completed Phase II trials for pediatric growth hormone deficiency.
- Olamkicept (TJ301): An IL-6 blocker in Phase II trials for ulcerative colitis and autoimmune diseases.
- Enoblituzumab: A humanized B7-H3 antibody that has completed Phase I trials for head and neck cancer and other oncology diseases.
- Efineptakin (TJ107): A long-acting recombinant human IL-7 in Phase II trials for glioblastoma multiforme (GBM).
I-Mab's innovative pipeline is driven by its internal R&D strategies, Fast-to-Proof-of-Concept, and Fast-to-Market development, often in collaboration with global partners. Recently, I-Mab announced the divestiture of its Chinese assets and operations, aiming to focus on the U.S. and other international markets. This strategic move included the transfer of its Greater China rights for various assets, potentially generating up to US$80 million based on future milestone achievements.
Notably, the company has entered into a clinical trial collaboration with Bristol Myers Squibb to evaluate givastomig combined with nivolumab and chemotherapy as a first-line treatment for advanced Claudin 18.2-positive gastric and esophageal cancers. I-Mab’s robust development pipeline and strategic global partnerships exemplify its commitment to advancing novel therapies to address critical medical needs.
For the latest updates and detailed information, visit the official website at I-Mab Biopharma.
I-Mab (Nasdaq: IMAB) announced a 180-day voluntary lock-up of shares by key shareholders including CBC Group and Hony Capital, effective March 31, 2022. This decision reflects the shareholders' confidence in I-Mab's transformation into a fully integrated biopharma company. The lock-up involves 51,226,814 ordinary shares, representing 26.8% of total outstanding shares. Concurrently, I-Mab will register approximately 37.7 million ordinary shares to satisfy contractual registration rights, while the shareholders express no intention to sell during the lock-up period.
I-Mab (Nasdaq: IMAB) reported strong financial results for 2021, achieving numerous clinical milestones, including key data readouts for lemzoparlimab, uliledlimab, and felzartamab. The company established a $315M strategic partnership with Jumpcan for eftansomatropin alfa, advancing its pipeline with 10 clinical-stage assets, primarily in Phases 2 and 3. I-Mab expects 3-4 BLA filings between 2023-2025, supported by a robust cash position of $671M. With ongoing global expansions, the company is positioned for significant growth in the biopharmaceutical sector.
I-Mab, a clinical-stage biopharmaceutical company (Nasdaq: IMAB), will announce its full-year 2021 financial results on March 29, 2022, before the market opens. A conference call will follow at 8:00 a.m. EST to discuss the results and provide corporate updates. I-Mab focuses on developing novel biologics for immuno-oncology and autoimmune diseases, with over 20 clinical and preclinical drug candidates. The company aims to transition into a fully integrated global biopharmaceutical entity, enhancing its R&D and manufacturing capabilities.
I-Mab (Nasdaq: IMAB), a clinical-stage biopharmaceutical company, has provided updates regarding the Holding Foreign Companies Accountable Act (HFCAA). As of March 8, 2022, I-Mab is not listed as a 'Commission-Identified Issuer' by the SEC. To ensure compliance, the company plans to engage an accounting firm subject to PCAOB inspection for its fiscal year 2022 audit. I-Mab is also pursuing a dual listing on the Hong Kong Stock Exchange to enhance trading flexibility for shareholders, pending market conditions and regulatory approvals.
I-Mab (Nasdaq: IMAB) announced multiple poster presentations at the AACR 2022 Annual Meeting, showcasing findings on enoblituzumab and TJ-C64B. Enoblituzumab, a monoclonal antibody targeting B7-H3, is under Phase 2 trials in China for solid tumors, and data highlights its anti-tumor activity and potential for combination therapies. TJ-C64B, a bispecific antibody, shows promise for treating CLDN6-positive tumors while minimizing liver toxicity. These presentations reflect I-Mab's commitment to advancing its innovative pipeline in cancer therapeutics.
I-Mab (Nasdaq: IMAB) announced FDA's Orphan Drug Designation for TJ-CD4B, a bispecific antibody targeting Claudin 18.2 for gastric cancer, including gastroesophageal junction cancer. This designation highlights potential therapeutic benefits and aims to expedite clinical development. TJ-CD4B demonstrated a strong tumor-killing effect and was well-tolerated in ongoing Phase 1 trials. Gastric cancer is a significant health issue, with 26,000 new cases annually in the U.S. and high mortality rates in China. Orphan Drug designation offers I-Mab various developmental benefits, including market exclusivity upon approval.
I-Mab (Nasdaq: IMAB) has announced a strategic partnership with Hangzhou Qiantang New Area to establish local manufacturing for its innovative drugs in China. This collaboration aims to expedite the commercialization of its assets, particularly felzartamab, which has shown positive clinical trial results for multiple myeloma. The new manufacturing facility is compliant with international standards, laying the groundwork for future drug supply and commercialization. I-Mab is positioning itself to meet the growing demand for effective cancer treatments in the region.
I-Mab (Nasdaq: IMAB) has announced the first patient dosing in its Phase 2 trial of lemzoparlimab combined with toripalimab for advanced solid tumors in China. This basket trial may lead to further registrational studies. Lemzoparlimab, a novel CD47 antibody, shows strong anti-tumor activity with minimal red blood cell binding, addressing challenges faced by similar therapies. The company aims to leverage translational findings to target tumors with a higher success probability. Ongoing studies in the U.S. and China explore various cancer treatments using lemzoparlimab.
I-Mab (Nasdaq: IMAB) announced that its senior management team executed a share purchase plan, acquiring over 70,000 American depositary shares (ADSs) for an aggregate of over US$2.6 million at an average price of approximately US$38 per ADS. The team aims to invest a minimum of US$3 million and up to US$20 million cumulatively in open market purchases, reflecting their strong confidence in the Company’s innovative pipeline and long-term growth prospects. I-Mab focuses on developing novel biologics for immuno-oncology and autoimmune diseases.
I-Mab (Nasdaq: IMAB) has initiated a Phase 2 clinical trial in China for efineptakin alfa (TJ107), a long-acting recombinant human interleukin-7, in combination with pembrolizumab (Keytruda®) for advanced solid tumors. This study targets multiple tumor types, including triple-negative breast cancer and squamous cell carcinoma of the head and neck. Efineptakin alfa aims to enhance anti-tumor T cell responses and addresses an unmet need in patients who poorly respond to current PD-(L)1 therapies. The trial will validate its safety and efficacy as part of I-Mab's advancing pipeline.
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