Gilead Sciences Announces Fourth Quarter and Full Year 2022 Financial Results

Rhea-AI Summary

Gilead Sciences (Nasdaq: GILD) reported its fourth quarter and full year 2022 financial results, highlighting an overall revenue increase of 2% to $7.4 billion in Q4. Notable year-over-year sales growth included Oncology sales up 71%, and Biktarvy sales rising 20% to $10.4 billion for the year. However, Veklury sales fell 26% in Q4 and decreased 30% for the year, reflecting reduced COVID-19 hospitalizations. Diluted EPS for Q4 was $1.30, a significant increase from $0.30 in 2021. For 2023, Gilead anticipates total product sales between $26.0 billion and $26.5 billion, with a focus on continued growth in HIV and oncology products.

Positive

• Q4 2022 revenue increased 2% to $7.4 billion.
• Oncology sales increased 71% year-over-year.
• Biktarvy sales grew 20% to $10.4 billion for full year 2022.
• Diluted EPS increased to $1.30 from $0.30 in Q4 2021.
• Total product sales excluding Veklury increased 8% for full year 2022.

Negative

• Veklury sales decreased 26% in Q4 2022 and 30% for the full year.
• Diluted EPS decreased to $3.64 from $4.93 for full year 2022 due to an IPR&D impairment charge.

Product Sales Excluding Veklury Increased Year-Over-Year by 8% for Full Year 2022

Biktarvy Sales Increased Year-Over-Year by 20% for Full Year 2022

Oncology Sales Increased Year-Over-Year by 71% for Full Year 2022

FOSTER CITY, Calif.--(BUSINESS WIRE)-- Gilead Sciences, Inc. (Nasdaq: GILD) announced today its results of operations for the fourth quarter and full year 2022.

“2022 marked Gilead’s strongest full year growth in our base business since HCV sales peaked in 2015. This return to growth was driven by consistent and high quality commercial and clinical execution across our portfolio,” said Gilead’s Chairman and Chief Executive Officer Daniel O’Day. “In HIV, Biktarvy gained market share in the U.S. as it has every quarter since launch, while our long-acting HIV agent, lenacapavir, received its first regulatory approvals. The strong full year growth in oncology was driven by continued increase in demand for Trodelvy and our Cell Therapies. We look forward to building on this momentum in 2023 and further increasing our impact for people and communities worldwide.”

Fourth Quarter 2022 Financial Results

• Total fourth quarter 2022 revenue of $7.4 billion increased 2% compared to the same period in 2021, primarily due to increased sales in Oncology, HIV and hepatitis C virus (“HCV”), partially offset by lower Veklury® (remdesivir) sales.
• Diluted Earnings Per Share (“EPS”) increased to $1.30 for the fourth quarter 2022 compared to $0.30 for the same period in 2021. Non-GAAP diluted EPS increased to $1.67 for the fourth quarter 2022 compared to $0.69 for the same period in 2021. The increase was primarily driven by two charges in the fourth quarter of 2021 which did not recur in 2022: the $1.25 billion charge for a legal settlement and the $625 million charge for the Arcus Biosciences, Inc. (“Arcus”) collaboration opt-in. The fourth quarter 2022 was, however, impacted by expenses related to the acquisition of GS-1811 from Jounce Therapeutics, Inc. (“Jounce”), the collaboration with MacroGenics, Inc. (“MacroGenics”), and the termination of the Trodelvy collaboration agreement with Everest Medicines (“Everest”), as well as higher R&D expenses.
• As of December 31, 2022, Gilead had $7.6 billion of cash, cash equivalents and marketable debt securities compared to $7.8 billion as of December 31, 2021.
• During the fourth quarter 2022, Gilead generated $2.6 billion in operating cash flow.
• During the fourth quarter 2022, Gilead paid cash dividends of $916 million and utilized $791 million to repurchase common stock.

Product Sales Performance for the Fourth Quarter 2022

Total fourth quarter 2022 product sales increased 2% to $7.3 billion compared to the same period in 2021. Total product sales excluding Veklury increased 9% to $6.3 billion for the fourth quarter 2022 compared to the same period in 2021, primarily due to increased sales in HIV and Oncology as well as contributions from HCV products.

HIV product sales increased 5% to $4.8 billion for the fourth quarter 2022 compared to the same period in 2021, reflecting higher demand and favorable pricing dynamics, partially offset by channel inventory dynamics in the United States.

• Biktarvy® (bictegravir 50mg/emtricitabine (“FTC”) 200mg/tenofovir alafenamide (“TAF”) 25mg) sales increased 15% to $2.9 billion for the fourth quarter 2022 compared to the same period in 2021, primarily reflecting higher demand and favorable pricing dynamics, partially offset by lower channel inventory.
• Descovy® (FTC 200mg/TAF 25mg) sales increased 13% to $537 million for the fourth quarter 2022 compared to the same period in 2021, primarily driven by favorable pricing dynamics as well as higher demand, partially offset by lower channel inventory.

HCV product sales increased 12% to $439 million for the fourth quarter 2022 compared to the same period in 2021, primarily driven by increased patient starts and favorable pricing dynamics in the United States, partially offset by fewer starts in Europe.

Hepatitis B virus (“HBV”) and hepatitis delta virus (“HDV”) product sales decreased 4% to $255 million for the fourth quarter 2022 compared to the same period in 2021. Vemlidy® (TAF 25 mg) sales decreased 2% in the fourth quarter 2022 compared to the same period in 2021, driven primarily by lower demand and pricing dynamics outside of the United States. Hepcludex^® (bulevirtide) contributed $13 million in the fourth quarter 2022 as launch activities continued across Europe.

Cell Therapy product sales increased 75% to $419 million for the fourth quarter 2022 compared to the same period in 2021.

• Yescarta® (axicabtagene ciloleucel) sales increased to $337 million in the fourth quarter 2022, primarily driven by increased demand in relapsed or refractory (“R/R”) large B-cell lymphoma (“LBCL”) in the United States and Europe.
• Tecartus® (brexucabtagene autoleucel) sales increased to $82 million in the fourth quarter 2022, driven by increased demand in adult R/R B-cell precursor acute lymphoblastic leukemia (“ALL”) and mantle cell lymphoma (“MCL”) in the United States and Europe.

Trodelvy® (sacituzumab govitecan-hziy) sales increased 65% to $195 million for the fourth quarter 2022 compared to the same period in 2021, reflecting continued adoption in metastatic triple-negative breast cancer (“TNBC”) in the United States and Europe.

Veklury sales decreased 26% to $1.0 billion for the fourth quarter 2022 compared to the same period in 2021, primarily driven by lower rates of COVID-19 related hospitalizations. Veklury sales generally reflect COVID-19 related rates and severity of infections and hospitalizations, as well as the availability, uptake and effectiveness of vaccinations and alternative treatments for COVID-19.

Fourth Quarter 2022 Product Gross Margin, Operating Expenses and Tax

• Product gross margin was 81.0% for the fourth quarter 2022 compared to 63.3% in the same period in 2021. Non-GAAP product gross margin was 86.8% for the fourth quarter 2022 compared to 70.5% in the same period in 2021. Higher product gross margin in 2022 is primarily driven by a charge related to a legal settlement in the fourth quarter 2021 that did not repeat.
• R&D expenses for the fourth quarter 2022 were $1.5 billion compared to $1.4 billion⁽¹⁾ in the same period in 2021. Non-GAAP R&D expenses for the fourth quarter 2022 were $1.5 billion compared to $1.3 billion⁽¹⁾ in the same period in 2021. Higher R&D expenses primarily reflect increased clinical activities, mainly in Oncology.
• Acquired in-process research and development (“IPR&D”) expenses for the fourth quarter 2022 were $158 million compared to $669 million⁽¹⁾ in the same period in 2021. Fourth quarter 2022 expenses primarily relate to the acquisition of GS-1811 from Jounce and the MacroGenics upfront payment. Fourth quarter 2021 expenses mostly relate to the charge for the Arcus collaboration opt-in.
• Selling, General and Administrative (“SG&A”) expenses for the fourth quarter 2022 were $2.0 billion compared to $1.7 billion in the same period in 2021. Non-GAAP SG&A expenses for the fourth quarter 2022 were $2.0 billion compared to $1.6 billion in the same period in 2021. SG&A expenses increased primarily due to the charge of $406 million associated with the termination of the Trodelvy collaboration agreement with Everest, which had provided Everest with broad commercialization and development rights to Trodelvy in certain Asia territories. Gilead terminated the existing agreement and reacquired the Trodelvy rights in these territories.
• The effective tax rate (“ETR”) and non-GAAP ETR for the fourth quarter 2022 were 19.6% and 16.8%, respectively, compared to 50.5% and 32.2%, respectively, for the same period in 2021. The lower ETR reflects discrete tax charges recorded in the fourth quarter of 2021 that did not repeat.

Full Year 2022 Financial Results

• Total full year 2022 revenue of $27.3 billion was flat compared to 2021, driven by increased sales in Oncology and HIV, offset by lower sales of Veklury.
• Diluted EPS decreased to $3.64 for the full year 2022 compared to $4.93 in 2021. The decrease in diluted EPS was driven by an IPR&D impairment charge in the first quarter 2022 related to assets acquired by Gilead from Immunomedics in 2020, as well as the termination of the Trodelvy collaboration agreement with Everest and higher R&D expenses. This was partially offset by charges in the fourth quarter of 2021 that did not repeat related to a legal settlement.
• Non-GAAP diluted EPS increased 1% to $7.26 for the full year 2022 compared to $7.18 in 2021. The increase in non-GAAP diluted EPS was primarily due to a legal settlement charge in the fourth quarter of 2021 that did not repeat. This was partially offset by an increase in SG&A expenses mostly associated with the termination of the Trodelvy collaboration agreement with Everest and higher R&D expenses.

Product Sales Performance for the Full Year 2022

Total full year 2022 product sales were $27.0 billion for the full year 2022 and remained flat compared to the same period in 2021, with growth in HIV, Cell Therapy and Trodelvy, offset by lower Veklury sales. Total product sales excluding Veklury increased 8% to $23.1 billion for the full year 2022 compared to 2021 primarily driven by increased sales in HIV, Cell Therapy and Trodelvy.

HIV product sales increased 5% to $17.2 billion for the full year 2022 compared to 2021, primarily reflecting higher demand and favorable pricing dynamics, partially offset by channel inventory dynamics and unfavorable foreign exchange rates.

• Biktarvy sales increased 20% to $10.4 billion for the full year 2022, primarily reflecting higher demand in addition to favorable pricing dynamics, partially offset by inventory dynamics.
• Descovy sales increased 10% to $1.9 billion for the full year 2022, primarily driven by favorable pricing dynamics and higher demand, partially offset by inventory dynamics.

HCV product sales decreased 4% to $1.8 billion for the full year 2022 compared to 2021, primarily due to unfavorable foreign exchange rates, as well as fewer patient starts and unfavorable pricing dynamics.

HBV and HDV product sales increased 2% to $988 million for the full year 2022 compared to 2021, driven primarily by higher demand for Vemlidy, mainly in the United States.

Cell Therapy product sales increased 68% to $1.5 billion for the full year 2022 compared to 2021, primarily due to higher demand for Yescarta in R/R LBCL, as well as Tecartus in R/R ALL and MCL.

Trodelvy sales increased 79% to $680 million for the full year 2022 compared to 2021, reflecting continued adoption in metastatic TNBC in the United States and Europe.

Veklury sales decreased 30% to $3.9 billion for the full year 2022 compared to 2021, primarily driven by lower rates of COVID-19 related hospitalizations.

Full Year 2022 Product Gross Margin, Operating Expenses and Tax

• Product gross margin was 79.0% for the full year 2022 compared to 75.6% in 2021. Non-GAAP product gross margin was 86.6% for the full year 2022 compared to 83.2% in 2021. Higher product gross margin is primarily driven by a charge related to a legal settlement in the fourth quarter 2021 that did not repeat, slightly offset by other year-over-year changes.
• R&D expenses for the full year 2022 were $5.0 billion compared to $4.6 billion⁽¹⁾ in 2021. Non-GAAP R&D expenses for the full year 2022 were $5.0 billion compared to $4.5 billion⁽¹⁾ in 2021. Higher R&D expenses primarily reflect increased clinical activities, mainly in Oncology, as well as inflationary increases.
• Acquired IPR&D expenses for the full year 2022 were $944 million compared to $939 million⁽¹⁾ in the same period in 2021.
• SG&A expenses for the full year 2022 were $5.7 billion compared to $5.2 billion in 2021. Non-GAAP SG&A expenses for full year 2022 were $5.6 billion compared to $5.0 billion in 2021. SG&A expenses increased primarily due to the charge of $406 million associated with the termination of the Trodelvy collaboration with Everest, increased promotional and marketing investment, mostly in Trodelvy and Cell Therapy, as well as higher corporate activities and inflationary increases. GAAP SG&A expenses were slightly offset by a decrease in donations to the Gilead Foundation in 2022 as compared to prior year.
• The ETR and non-GAAP ETR for the full year 2022 were 21.5% and 19.3%, respectively, compared to 25.1% and 20.4%, respectively, in 2021. Lower ETR is primarily due to a beneficial change in jurisdictional mix of income and lower state taxes in 2022.

________________________________
(1)		Beginning in the second quarter of 2022, expenses related to development milestones and other collaboration payments made prior to regulatory approval of a developed product were reclassified from R&D expenses to Acquired IPR&D expenses in the Condensed Consolidated Statements of Income. We believe this presentation assists users of the financial statements to better understand the total costs incurred to acquire IPR&D projects. Prior periods have been recast for both GAAP and Non-GAAP reporting to reflect this classification, resulting in a reduction of previously reported R&D expenses of $669 million and $762 million for the fourth quarter and full year 2021, respectively, and $8 million for the three months ended March 31, 2022.

Guidance and Outlook

Gilead is providing full-year 2023 guidance below:

• Total product sales between $26.0 billion and $26.5 billion.
• Total product sales, excluding Veklury, between $24.0 billion and $24.5 billion.
• Total Veklury sales of approximately $2.0 billion are expected to be highly variable, depending on the frequency and severity of surges, and our guidance will continue to be updated on a quarterly basis as necessary.
• Earnings per share between $5.30 and $5.70.
• Non-GAAP earnings per share between $6.60 and $7.00.

A reconciliation between GAAP and non-GAAP financial information for the 2023 guidance is provided in the accompanying tables. Also see the Forward-Looking Statements described below. The financial guidance is subject to a number of risks and uncertainties, including uncertainty around the duration and magnitude of the COVID-19 pandemic.

Key Updates Since Our Last Quarterly Release

Virology

• Announced FDA approval of Sunlenca (lenacapavir), in combination with other antiretroviral(s), for the treatment of HIV-1 infection in heavily treatment-experienced adults with multi-drug resistant HIV-1 infection.
• Announced the European Commission (“EC”) authorized an extended indication and line extension for a low-dosage tablet form of Biktarvy (bictegravir 30mg/FTC 120mg/TAF 15mg) for the treatment of HIV in virologically suppressed children who are at least 2 years of age and weigh at least 14 kg.
• Announced FDA approval of Vemlidy for the treatment of chronic HBV infection in pediatric patients 12 years and older with compensated liver disease.

Oncology

• Announced that the European Medicines Agency has validated a Type II variation of the Marketing Authorization Application for Trodelvy for the treatment of adult patients with pre-treated HR+/HER2- metastatic breast cancer (“mBC”).
• Presented post-hoc analysis from the Phase 3 TROPiCS-02 study of Trodelvy in HR+/HER2- mBC at the 2022 San Antonio Breast Cancer Symposium. In the analysis Trodelvy demonstrated consistent efficacy across Trop-2 expression levels in patients with pre-treated HR+/HER2- mBC with improvement across progression-free survival (“PFS”), overall survival and objective response rate as compared to standard chemotherapy. The safety profile for Trodelvy was consistent with prior studies, with no new safety signals identified in this population.
• Announced the transfer of the Marketing Authorization for Yescarta in Japan from Daiichi Sankyo Co., Ltd. (“Daiichi Sankyo”) to Gilead K.K. in 2023.
• Received approval from the Ministry of Health, Labour and Welfare in Japan for Yescarta for the initial treatment of R/R LBCL.
• Entered into a strategic collaboration between Kite, a Gilead company, and Arcellx, Inc. (“Arcellx”) to co-develop and co-commercialize CART-ddBMCA, a late-stage clinical asset in development for the treatment of multiple myeloma.
• Entered into an agreement to acquire Tmunity Therapeutics Inc. (“Tmunity”), a clinical stage private biotech company, which will provide Kite with preclinical and clinical programs, including an “armored” CAR T technology platform that has the potential to be applied to a variety of CAR Ts to enhance anti-tumor activity, as well as rapid manufacturing processes. The transaction is expected to close in the first quarter of 2023.
• Presented long-term data and real-world analysis of Yescarta and Tecartus at the American Society of Hematology 2022 meeting. Results showed that in a real-world analysis, shorter vein-to-vein times were associated with improved outcomes for patients treated with Yescarta for R/R LBCL. Additionally, in a three-year follow-up analysis of ZUMA-5 in R/R indolent non-Hodgkin lymphoma showed continued response in 52% of patients and prolonged duration of PFS. Three follow-up analyses were presented on Tecartus, including a two-year follow-up of ZUMA-3 compared to SCHOLAR-3 in R/R B-cell acute lymphoblastic leukemia and updated three-year results from ZUMA-2 study in R/R mantle cell lymphoma.
• Presented positive data, alongside Arcus, from the fourth interim analysis of the Phase 2 ARC-7 study at the American Society of Clinical Oncology Monthly Plenary Session. The study is evaluating the combinations of domvanalimab plus zimberelimab (doublet) and domvanalimab plus zimberelimab and etrumadenant (triplet), versus zimberelimab monotherapy in patients with first-line, metastatic PD-L1-high NSCLC. In the study, both the doublet and triplet combinations demonstrated clinically meaningful improvements in median PFS compared to zimberelimab monotherapy, with a 45% reduction in risk of disease progression or death for the doublet and 35% for the triplet.
• Acquired the remaining rights to GS-1811, an anti-CCR8 antibody, developed by Jounce for the treatment of solid tumors.

Inflammation

• Announced a collaboration and licensing agreement with EVOQ Therapeutics, Inc. (“EVOQ”) to advance EVOQ’s proprietary NanoDisc technology for the treatment of rheumatoid arthritis and lupus.

Corporate

• Recognized as one of the most sustainable pharmaceutical companies according to the Dow Jones Sustainability World Index, reflecting Gilead’s ongoing commitment to corporate responsibility.
• Announced the U.S. Supreme Court denied Juno Therapeutics, Inc.’s appeal in the Juno v. Kite case, effectively ending this patent dispute.

Certain amounts and percentages in this press release may not sum or recalculate due to rounding.

Conference Call

At 1:30 p.m. Pacific Time today, Gilead will host a conference call to discuss Gilead’s results. A live webcast will be available on http://investors.gilead.com and will be archived on www.gilead.com for one year.

Non-GAAP Financial Information

The information presented in this document has been prepared in accordance with U.S. generally accepted accounting principles (“GAAP”), unless otherwise noted as non-GAAP. Management believes non-GAAP information is useful for investors, when considered in conjunction with Gilead’s GAAP financial information, because management uses such information internally for its operating, budgeting and financial planning purposes. Non-GAAP information is not prepared under a comprehensive set of accounting rules and should only be used to supplement an understanding of Gilead’s operating results as reported under GAAP. Non-GAAP financial information generally excludes acquisition-related expenses including amortization of acquired intangible assets and inventory step-up charges, and other items that are considered unusual or not representative of underlying trends of Gilead’s business, fair value adjustments of equity securities and discrete and related tax charges or benefits associated with changes in tax related laws and guidelines. Although Gilead consistently excludes the amortization of acquired intangible assets from the non-GAAP financial information, management believes that it is important for investors to understand that such intangible assets were recorded as part of acquisitions and contribute to ongoing revenue generation. Non-GAAP measures may be defined and calculated differently by other companies in the same industry. Reconciliations of the non-GAAP financial measures to the most directly comparable GAAP financial measures are provided in the accompanying tables.

Beginning in the first quarter of 2022, consistent with recent industry communications from the U.S. Securities and Exchange Commission (“SEC”), Gilead no longer excludes the initial costs of acquired IPR&D projects from its non-GAAP financial measures. Prior period non-GAAP financial measures are revised to conform to the new presentation.

About Gilead Sciences

Gilead Sciences, Inc. is a biopharmaceutical company that has pursued and achieved breakthroughs in medicine for more than three decades, with the goal of creating a healthier world for all people. The company is committed to advancing innovative medicines to prevent and treat life-threatening diseases, including HIV, viral hepatitis and cancer. Gilead operates in more than 35 countries worldwide, with headquarters in Foster City, California.

Forward-Looking Statements

Statements included in this press release that are not historical in nature are forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Gilead cautions readers that forward-looking statements are subject to certain risks and uncertainties that could cause actual results to differ materially. These risks and uncertainties include those relating to: the impact of the COVID-19 pandemic on Gilead’s business, financial condition and results of operations; the development, manufacturing and distribution of Veklury as a treatment for COVID-19, including the uncertainty of the amount and timing of future Veklury sales and Gilead’s ability to effectively manage the global supply and distribution of Veklury; Gilead’s ability to achieve its anticipated full year 2023 financial results, including as a result of potential adverse revenue impacts from COVID-19 and potential revenues from Veklury; Gilead’s ability to make progress on any of its long-term ambitions or strategic priorities laid out in its corporate strategy; Gilead’s ability to accelerate or sustain revenues for its virology, oncology and other programs; Gilead’s ability to realize the potential benefits of acquisitions, collaborations or licensing arrangements, including those involving Arcellx, Daiichi Sankyo, EVOQ, Jounce and Tmunity; Gilead’s ability to identify suitable transactions as part of its business strategy and the risk that Gilead may not be able to complete any such transaction in a timely manner or at all, including the possibility that a governmental entity or regulatory body may delay or refuse to grant approval for the consummation of the transaction; patent protection and estimated loss of exclusivity for our products and product candidates; Gilead’s ability to initiate, progress or complete clinical trials within currently anticipated timeframes or at all, the possibility of unfavorable results from ongoing and additional clinical trials, including those involving Trodelvy, Tecartus, Yescarta, domvanalimab, etrumadenant and zimberelimab, and the risk that safety and efficacy data from clinical trials may not warrant further development of Gilead’s product candidates or the product candidates of Gilead’s strategic partners; Gilead’s ability to submit new drug applications for new product candidates or expanded indications in the currently anticipated timelines; Gilead’s ability to receive regulatory approvals in a timely manner or at all, including EC approval of Trodelvy for the treatment of adult patients with pre-treated HR+/HER2 mBC, and the risk that any such approvals, if granted, may be subject to significant limitations on use; Gilead’s ability to successfully commercialize its products; the risk of potential disruptions to the manufacturing and supply chain of Gilead’s products, including the risk that Kite may be unable to increase its manufacturing capacity, timely manufacture and deliver its products or produce an amount of supply sufficient to satisfy demand for such products; pricing and reimbursement pressures from government agencies and other third parties, including required rebates and other discounts; a larger than anticipated shift in payer mix to more highly discounted payer segments; market share and price erosion caused by the introduction of generic versions of Gilead products; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products, including Biktarvy, Sunlenca, Vemlidy and Yescarta; and other risks identified from time to time in Gilead’s reports filed with the SEC, including annual reports on Form 10-K, quarterly reports on Form 10-Q and current reports on Form 8-K. In addition, Gilead makes estimates and judgments that affect the reported amounts of assets, liabilities, revenues and expenses and related disclosures. Gilead bases its estimates on historical experience and on various other market specific and other relevant assumptions that it believes to be reasonable under the circumstances, the results of which form the basis for making judgments about the carrying values of assets and liabilities that are not readily apparent from other sources. There may be other factors of which Gilead is not currently aware that may affect matters discussed in the forward-looking statements and may also cause actual results to differ significantly from these estimates. Further, results for the quarter ended December 31, 2022 are not necessarily indicative of operating results for any future periods. Gilead directs readers to its press releases, annual reports on Form 10-K, quarterly reports on Form 10-Q and other subsequent disclosure documents filed with the SEC. Gilead claims the protection of the Safe Harbor contained in the Private Securities Litigation Reform Act of 1995 for forward-looking statements.

The reader is cautioned that forward-looking statements are not guarantees of future performance and is cautioned not to place undue reliance on these forward-looking statements. All forward-looking statements are based on information currently available to Gilead and Gilead assumes no obligation to update or supplement any such forward-looking statements other than as required by law. Any forward-looking statements speak only as of the date hereof or as of the dates indicated in the statements.

# # #

Gilead owns or has rights to various trademarks, copyrights and trade names used in its business, including the following: GILEAD®, GILEAD SCIENCES®, KITE®, AMBISOME®, ATRIPLA®, BIKTARVY®, CAYSTON®, COMPLERA®, DESCOVY®, DESCOVY FOR PREP®, EMTRIVA®, EPCLUSA®, EVIPLERA®, GENVOYA®, HARVONI®, HEPCLUDEX®, HEPSERA®, JYSELECA®, LETAIRIS®, ODEFSEY®, RANEXA®, SOVALDI®, STRIBILD®, SUNLENCA® , TECARTUS®, TRODELVY®, TRUVADA®, TRUVADA FOR PREP®, TYBOST®, VEKLURY®, VEMLIDY®, VIREAD®, VOSEVI®, YESCARTA® and ZYDELIG®. This report may also refer to trademarks, service marks and trade names of other companies.

For more information on Gilead Sciences, Inc., please visit www.gilead.com or call the Gilead Public Affairs Department at 1-800-GILEAD-5 (1-800-445-3235).

GILEAD SCIENCES, INC.
CONDENSED CONSOLIDATED STATEMENTS OF INCOME
(unaudited)
		Three Months Ended								Twelve Months Ended
		December 31,								December 31,
(in millions, except per share amounts)		2022				2021				2022				2021
Revenues:
Product sales		$	7,333			$	7,160			$	26,982			$	27,008
Royalty, contract and other revenues			56				84				299				297
Total revenues			7,389				7,244				27,281				27,305
Costs and expenses:
Cost of goods sold			1,396				2,627				5,657				6,601
Research and development expenses			1,548				1,358				4,977				4,601
Acquired in-process research and development expenses			158				669				944				939
In-process research and development impairment			—				—				2,700				—
Selling, general and administrative expenses			2,020				1,650				5,673				5,246
Total costs and expenses			5,122				6,304				19,951				17,387
Operating income			2,267				940				7,330				9,918
Interest expense			(227	)			(238	)			(935	)			(1,001	)
Other income (expense), net			(9	)			57				(581	)			(639	)
Income before income taxes			2,031				759				5,814				8,278
Income tax expense			(398	)			(383	)			(1,248	)			(2,077	)
Net income			1,633				376				4,566				6,201
Net loss attributable to noncontrolling interest			7				6				26				24
Net income attributable to Gilead		$	1,640			$	382			$	4,592			$	6,225
Basic earnings per share attributable to Gilead		$	1.31			$	0.30			$	3.66			$	4.96
Shares used in per share calculation - basic			1,252				1,256				1,255				1,256
Diluted earnings per share attributable to Gilead		$	1.30			$	0.30			$	3.64			$	4.93
Shares used in per share calculation - diluted			1,264				1,262				1,262				1,262
Cash dividends declared per share		$	0.73			$	0.71			$	2.92			$	2.84
Research and development expenses as a % of revenues			20.9	%			18.7	%			18.2	%			16.9	%
Selling, general and administrative expenses as a % of revenues			27.3	%			22.8	%			20.8	%			19.2	%

GILEAD SCIENCES, INC.
TOTAL REVENUE SUMMARY
(unaudited)
		Three Months Ended									Twelve Months Ended
		December 31,									December 31,
(in millions, except percentages)		2022			2021			Change			2022			2021			Change
Product sales:
HIV		$	4,772		$	4,538		5	%		$	17,194		$	16,315		5	%
HCV			439			393		12	%			1,810			1,881		(4	)%
HBV/HDV			255			265		(4	)%			988			969		2	%
Cell Therapy			419			239		75	%			1,459			871		68	%
Trodelvy			195			118		65	%			680			380		79	%
Other			252			250		1	%			946			1,027		(8	)%
Total product sales excluding Veklury			6,333			5,803		9	%			23,077			21,443		8	%
Veklury			1,000			1,357		(26	)%			3,905			5,565		(30	)%
Total product sales			7,333			7,160		2	%			26,982			27,008		—	%
Royalty, contract and other revenues			56			84		(33	)%			299			297		1	%
Total revenues		$	7,389		$	7,244		2	%		$	27,281		$	27,305		—	%

GILEAD SCIENCES, INC.
NON-GAAP FINANCIAL INFORMATION(1)
(unaudited)
		Three Months Ended											Twelve Months Ended
		December 31,											December 31,
(in millions, except percentages)		2022				2021				Change			2022				2021				Change
Non-GAAP:
Cost of goods sold		$	968			$	2,111			(54	)%		$	3,602			$	4,538			(21	)%
Research and development expenses		$	1,544			$	1,315			17	%		$	4,968			$	4,464			11	%
Acquired IPR&D expenses		$	158			$	669			(76	)%		$	944			$	939			1	%
Selling, general and administrative expenses		$	2,020			$	1,642			23	%		$	5,587			$	4,974			12	%
Other income (expense), net		$	52			$	—			NM			$	77			$	(29	)		NM
Diluted EPS		$	1.67			$	0.69			141	%		$	7.26			$	7.18			1	%
Product gross margin			86.8	%			70.5	%		1628 bps				86.6	%			83.2	%		345 bps
Research and development expenses as a % of revenues			20.9	%			18.2	%		274 bps				18.2	%			16.3	%		186 bps
Selling, general and administrative expenses as a % of revenues			27.3	%			22.7	%		468 bps				20.5	%			18.2	%		226 bps
Operating margin			36.5	%			20.8	%		1573 bps				44.6	%			45.4	%		-75 bps
Effective tax rate			16.8	%			32.2	%		-1540 bps				19.3	%			20.4	%		-110 bps

________________________________
NM - Not Meaningful
(1)		Refer to Non-GAAP Financial Information section above for further disclosures on non-GAAP financial measures. A reconciliation between GAAP and non-GAAP financial information is provided in the tables on pages 12 - 13. Beginning in the first quarter of 2022, consistent with recent industry communications from the U.S. Securities and Exchange Commission, the Company no longer excludes the initial costs of acquired IPR&D projects from its non-GAAP financial measures. Prior period non-GAAP financial measures are revised to conform to the new presentation.

GILEAD SCIENCES, INC.
RECONCILIATION OF GAAP TO NON-GAAP FINANCIAL INFORMATION
(unaudited)
		Three Months Ended								Twelve Months Ended
		December 31,								December 31,
(in millions, except percentages and per share amounts)		2022				2021				2022				2021
Cost of goods sold reconciliation:
GAAP cost of goods sold		$	1,396			$	2,627			$	5,657			$	6,601
Acquisition-related – amortization of acquired intangibles and inventory step-up charges			(428	)			(516	)			(2,013	)			(2,063	)
Other(1)			—				—				(42	)			—
Non-GAAP cost of goods sold		$	968			$	2,111			$	3,602			$	4,538
Product gross margin reconciliation:
GAAP product gross margin			81.0	%			63.3	%			79.0	%			75.6	%
Acquisition-related – amortization of acquired intangibles and inventory step-up charges			5.8	%			7.2	%			7.5	%			7.6	%
Other(1)			—	%			—	%			0.2	%			—	%
Non-GAAP product gross margin			86.8	%			70.5	%			86.6	%			83.2	%
Research and development expenses reconciliation:
GAAP research and development expenses		$	1,548			$	1,358			$	4,977			$	4,601
Acquisition-related – amortization of inventory step-up charges			—		.		(42	)			—				(109	)
Acquisition-related – other costs(2)			(1	)	.		—				13				(14	)
Other(1)			(4	)	.		(1	)			(22	)			(14	)
Non-GAAP research and development expenses		$	1,544			$	1,315			$	4,968			$	4,464
IPR&D impairment reconciliation:
GAAP IPR&D impairment		$	—			$	—			$	2,700			$	—
IPR&D impairment			—		.		—				(2,700	)			—
Non-GAAP IPR&D impairment		$	—			$	—			$	—			$	—
Selling, general and administrative expenses reconciliation:
GAAP selling, general and administrative expenses		$	2,020			$	1,650			$	5,673			$	5,246
Acquisition-related – other costs(2)			(1	)	.		(3	)			(3	)			(45	)
Other(1)			1		.		(5	)			(83	)			(227	)
Non-GAAP selling, general and administrative expenses		$	2,020			$	1,642			$	5,587			$	4,974
Operating income reconciliation:
GAAP operating income		$	2,267			$	940			$	7,330			$	9,918
Acquisition-related – amortization of acquired intangibles and inventory step-up charges			428		.		558				2,013				2,172
Acquisition-related – other costs(2)			2		.		3				(10	)			59
IPR&D impairment			—		.		—				2,700				—
Other(1)			2		.		6				147				241
Non-GAAP operating income		$	2,699			$	1,507			$	12,180			$	12,390
Operating margin reconciliation:
GAAP operating margin			30.7	%			13.0	%			26.9	%			36.3	%
Acquisition-related – amortization of acquired intangibles and inventory step-up charges			5.8	%			7.7	%			7.4	%			8.0	%
Acquisition-related – other costs(2)			—	%			0.1	%			—	%			0.2	%
IPR&D impairment			—	%			—	%			9.9	%			—	%
Other(1)			—	%			—	%			0.5	%			0.9	%
Non-GAAP operating margin			36.5	%			20.8	%			44.6	%			45.4	%
Other income (expense), net reconciliation:
GAAP other income (expense), net		$	(9	)		$	57			$	(581	)		$	(639	)
Loss (gain) from equity securities, net			61				(57	)			657				610
Non-GAAP other income (expense), net		$	52			$	—			$	77			$	(29	)

GILEAD SCIENCES, INC.
RECONCILIATION OF GAAP TO NON-GAAP FINANCIAL INFORMATION - (Continued)
(unaudited)
		Three Months Ended								Twelve Months Ended
		December 31,								December 31,
(in millions, except percentages and per share amounts)		2022				2021				2022				2021
Effective tax rate reconciliation:
GAAP effective tax rate			19.6	%			50.5	%			21.5	%			25.1	%
Income tax effect of above non-GAAP adjustments and discrete and related tax adjustments(3)			(2.8	)%			(18.3	)%			(2.1	)%			(4.7	)%
Non-GAAP effective tax rate			16.8	%			32.2	%			19.3	%			20.4	%
Net income attributable to Gilead reconciliation:
GAAP net income attributable to Gilead		$	1,640			$	382			$	4,592			$	6,225
Acquisition-related – amortization of acquired intangibles and inventory step-up charges			346				449				1,610				1,750
Acquisition-related – other costs(2)			1				—				(12	)			46
IPR&D impairment			—		.		—				2,057				—
Other(1)			2		.		3				106				146
Loss (gain) from equity securities, net			60				(56	)			630				631
Discrete and related tax charges(3)			57				88				175				267
Non-GAAP net income attributable to Gilead		$	2,106			$	866			$	9,158			$	9,065
Diluted EPS reconciliation:
GAAP diluted EPS		$	1.30			$	0.30			$	3.64			$	4.93
Acquisition-related – amortization of acquired intangibles and inventory step-up charges			0.27				0.36				1.28				1.39
Acquisition-related – other costs(2)			—				—				(0.01	)			0.04
IPR&D impairment			—				—				1.63				—
Other(1)			—				—				0.08				0.11
Loss (gain) from equity securities, net			0.05				(0.04	)			0.50				0.50
Discrete and related tax charges(3)			0.05				0.07				0.14				0.21
Non-GAAP diluted EPS		$	1.67			$	0.69			$	7.26			$	7.18
Non-GAAP adjustment summary:
Cost of goods sold adjustments		$	428			$	516			$	2,055			$	2,063
Research and development expenses adjustments			4				43				9				137
IPR&D impairment adjustments			—				—				2,700				—
Selling, general and administrative expenses adjustments			—				8				86				272
Total non-GAAP adjustments before other income (expense), net, and income taxes			432				567				4,850				2,472
Other income (expense), net, adjustments			61				(57	)			657				610
Total non-GAAP adjustments before income taxes			493				510				5,507				3,082
Income tax effect of non-GAAP adjustments above			(84	)			(114	)			(1,116	)			(509	)
Discrete and related tax charges(3)			57				88				175				267
Total non-GAAP adjustments after tax		$	466			$	484			$	4,566			$	2,840

______________________________
(1)		Adjustments to Cost of goods sold and Research and development expenses primarily include various restructuring expenses during the first quarter of 2022 and the second quarter of 2021. Adjustments to Selling, general and administrative expenses primarily include donations to the Gilead Foundation, a California nonprofit organization, during the second quarters of 2022 and 2021.
(2)		Adjustments include employee-related expenses, contingent consideration fair value adjustments and other expenses associated with Gilead’s acquisitions of MiroBio, Ltd., Immunomedics, Inc. and MYR GmbH.
(3)		Represents discrete and related deferred tax charges or benefits primarily associated with acquired intangible assets and transfers of intangible assets from a foreign subsidiary to Ireland and the United States.

GILEAD SCIENCES, INC.
RECONCILIATION OF GAAP TO NON-GAAP 2023 FULL YEAR GUIDANCE(1)
(unaudited)
(in millions, except percentages and per share amounts)		Provided February 2, 2023
Projected product gross margin GAAP to non-GAAP reconciliation:
GAAP projected product gross margin		79.0%
Acquisition-related expenses		~ 7%
Non-GAAP projected product gross margin		86.0%
Projected operating income GAAP to non-GAAP reconciliation:
GAAP projected operating income		$9,200 - $9,800
Acquisition-related expenses		~ 1,800
Non-GAAP projected operating income		$11,000 - $11,600
Projected effective tax rate GAAP to non-GAAP reconciliation:
GAAP projected effective tax rate		~ 22%
Discrete and related tax adjustments, and income tax effect of adjustments above		(~ 2%)
Non-GAAP projected effective tax rate		~ 20%
Projected diluted EPS GAAP to non-GAAP reconciliation:
GAAP projected diluted EPS		$5.30 - $5.70
Acquisition-related expenses and tax adjustments		~ 1.30
Non-GAAP projected diluted EPS		$6.60 - $7.00

________________________________
(1)		The non-GAAP 2023 full-year guidance includes non-GAAP adjustments to actual current period results as well as adjustments for the known future impact associated with events that have already occurred, such as future amortization of our intangible assets and the future impact of discrete and related deferred tax charges or benefits primarily associated with acquired intangible assets and transfers of intangible assets from a foreign subsidiary to Ireland and the United States. Our full-year guidance excludes the potential impact of any (i) acquisitions or business development transactions that have not been executed, (ii) future fair value adjustments of equity securities and (iii) discrete tax charges or benefits associated with changes in tax related laws and guidelines that have not been enacted, as Gilead is unable to project such amounts.

GILEAD SCIENCES, INC.
CONDENSED CONSOLIDATED BALANCE SHEETS
(unaudited)
		December 31,
(in millions)		2022				2021
Assets
Cash, cash equivalents and marketable securities		$	7,630			$	7,829
Accounts receivable, net			4,777				4,493
Inventories			2,820				2,734
Property, plant and equipment, net			5,475				5,121
Intangible assets, net			28,894				33,455
Goodwill			8,314				8,332
Other assets			5,261				5,988
Total assets		$	63,171			$	67,952
Liabilities and Stockholders’ Equity
Current liabilities		$	11,237			$	11,610
Long-term liabilities			30,725				35,278
Stockholders’ equity(1)			21,209				21,064
Total liabilities and stockholders’ equity		$	63,171			$	67,952

________________________________
(1)		As of December 31, 2022 and 2021, there were 1,247 and 1,254 shares of common stock issued and outstanding, respectively.

GILEAD SCIENCES, INC.
SELECTED CASH FLOW INFORMATION
(unaudited)
		Three Months Ended								Twelve Months Ended
		December 31,								December 31,
(in millions)		2022				2021				2022				2021
Net cash provided by operating activities		$	2,566			$	3,205			$	9,072			$	11,384
Net cash used in investing activities			(374	)			(278	)			(2,466	)			(3,131	)
Net cash used in financing activities			(1,554	)			(1,942	)			(6,469	)			(8,877	)
Effect of exchange rate changes on cash and cash equivalents			75				(9	)			(63	)			(35	)
Net change in cash and cash equivalents			713				976				74				(659	)
Cash and cash equivalents at beginning of period			4,699				4,362				5,338				5,997
Cash and cash equivalents at end of period		$	5,412			$	5,338			$	5,412			$	5,338

		Three Months Ended								Twelve Months Ended
		December 31,								December 31,
(in millions)		2022				2021				2022				2021
Net cash provided by operating activities		$	2,566			$	3,205			$	9,072			$	11,384
Capital expenditures			(181	)			(156	)			(728	)			(579	)
Free cash flow		$	2,386			$	3,049			$	8,344			$	10,805

GILEAD SCIENCES, INC.
PRODUCT SALES SUMMARY
(unaudited)
		Three Months Ended								Twelve Months Ended
		December 31,								December 31,
(in millions)		2022				2021				2022				2021
HIV
Biktarvy – U.S.		$	2,423			$	2,123			$	8,510			$	7,049
Biktarvy – Europe			295				262				1,103				969
Biktarvy – Other International			200				145				777				606
			2,918				2,530				10,390				8,624
Complera / Eviplera – U.S.			17				29				74				102
Complera / Eviplera – Europe			37				38				113				142
Complera / Eviplera – Other International			3				2				13				14
			58				69				200				258
Descovy – U.S.			479				403				1,631				1,397
Descovy – Europe			26				36				118				164
Descovy – Other International			31				34				123				139
			537				473				1,872				1,700
Genvoya – U.S.			543				634				1,983				2,267
Genvoya – Europe			64				85				284				391
Genvoya – Other International			33				37				136				221
			640				756				2,404				2,879
Odefsey – U.S.			295				303				1,058				1,076
Odefsey – Europe			85				104				364				440
Odefsey – Other International			11				13				47				52
			392				420				1,469				1,568
Stribild – U.S.			20				38				88				132
Stribild – Europe			7				10				29				43
Stribild – Other International			3				2				10				14
			29				50				127				189
Truvada – U.S.			37				46				113				314
Truvada – Europe			3				4				15				22
Truvada – Other International			5				11				18				35
			45				61				147				371
Revenue share – Symtuza(1) – U.S.			97				94				348				355
Revenue share – Symtuza(1) – Europe			42				40				168				165
Revenue share – Symtuza(1) – Other International			3				3				14				11
			142				137				530				531
Other HIV(2) – U.S.			4				26				15				136
Other HIV(2) – Europe			5				11				24				30
Other HIV(2) – Other International			3				5				17				29
			12				42				57				195
Total HIV – U.S.			3,914				3,696				13,820				12,828
Total HIV – Europe			566				590				2,219				2,366
Total HIV – Other International			293				252				1,155				1,121
			4,772				4,538				17,194				16,315

GILEAD SCIENCES, INC.
PRODUCT SALES SUMMARY - (Continued)
(unaudited)
		Three Months Ended								Twelve Months Ended
		December 31,								December 31,
(in millions)		2022				2021				2022				2021
Veklury
Veklury – U.S.			395				877				1,575				3,640
Veklury – Europe			142				334				702				1,095
Veklury – Other International			462				146				1,628				830
			1,000				1,357				3,905				5,565
HCV
Ledipasvir / Sofosbuvir(3) – U.S.			19				21				46				84
Ledipasvir / Sofosbuvir(3) – Europe			4				7				17				31
Ledipasvir / Sofosbuvir(3) – Other International			8				21				51				97
			31				49				115				212
Sofosbuvir / Velpatasvir(4) – U.S.			214				166				844				815
Sofosbuvir / Velpatasvir(4) – Europe			67				82				355				316
Sofosbuvir / Velpatasvir(4) – Other International			87				59				331				331
			369				307				1,530				1,462
Other HCV(5) – U.S.			27				22				115				119
Other HCV(5) – Europe			9				10				40				74
Other HCV(5) – Other International			3				5				10				14
			39				37				166				207
Total HCV – U.S.			260				209				1,005				1,018
Total HCV – Europe			80				99				413				421
Total HCV – Other International			98				85				392				442
			439				393				1,810				1,881
HBV/HDV
Vemlidy – U.S.			123				118				429				384
Vemlidy – Europe			8				9				35				34
Vemlidy – Other International			89				98				379				396
			220				225				842				814
Viread – U.S.			2				3				6				11
Viread – Europe			6				6				23				28
Viread – Other International			14				17				62				72
			22				26				91				111
Other HBV/HDV(6) – U.S.			(1	)			1				—				2
Other HBV/HDV(6) – Europe			14				13				55				42
			13				14				55				44
Total HBV/HDV – U.S.			124				122				435				397
Total HBV/HDV – Europe			28				28				112				104
Total HBV/HDV – Other International			103				115				441				468
			255				265				988				969
Cell therapy
Tecartus – U.S.			61				42				221				136
Tecartus – Europe			19				15				75				40
Tecartus – Other International			1				—				3				—
			82				57				299				176
Yescarta – U.S.			219				106				747				406
Yescarta – Europe			103				65				355				253
Yescarta – Other International			15				11				57				36
			337				182				1,160				695
Total cell therapy – U.S.			281				148				968				542
Total cell therapy – Europe			122				80				430				293
Total cell therapy – Other International			17				11				60				36
			419				239				1,459				871

GILEAD SCIENCES, INC.
PRODUCT SALES SUMMARY - (Continued)
(unaudited)
		Three Months Ended								Twelve Months Ended
		December 31,								December 31,
(in millions)		2022				2021				2022				2021
Trodelvy
Trodelvy – U.S.			146				109				525				370
Trodelvy – Europe			44				9				143				10
Trodelvy – Other International			4				—				12				—
			195				118				680				380
Other
AmBisome – U.S.			9				7				57				39
AmBisome – Europe			66				72				258				274
AmBisome – Other International			42				41				182				227
			117				120				497				540
Letairis – U.S.			60				49				196				206
Other(7) – U.S.			44				27				135				136
Other(7) – Europe			13				47				65				115
Other(7) – Other International			18				7				53				30
			75				81				253				281
Total other – U.S.			113				83				388				381
Total other – Europe			79				119				323				389
Total other – Other International			61				48				235				257
			252				250				946				1,027
Total product sales – U.S.			5,234				5,244				18,716				19,176
Total product sales – Europe			1,061				1,259				4,342				4,678
Total product sales – Other International			1,037				657				3,924				3,154
		$	7,333			$	7,160			$	26,982			$	27,008

_______________________________
(1)		Represents Gilead’s revenue from cobicistat (“C”), FTC and TAF in Symtuza (darunavir/C/FTC/TAF), a fixed dose combination product commercialized by Janssen Sciences Ireland Unlimited Company.
(2)		Includes Atripla, Emtriva, Sunlenca and Tybost.
(3)		Amounts consist of sales of Harvoni and the authorized generic version of Harvoni sold by Gilead’s separate subsidiary, Asegua Therapeutics LLC.
(4)		Amounts consist of sales of Epclusa and the authorized generic version of Epclusa sold by Gilead’s separate subsidiary, Asegua Therapeutics LLC.
(5)		Includes Vosevi and Sovaldi.
(6)		Includes Hepcludex and Hepsera.
(7)		Includes Cayston, Jyseleca, Ranexa and Zydelig.

 

View source version on businesswire.com: https://www.businesswire.com/news/home/20230202005366/en/

Investors:

Jacquie Ross, CFA

investor_relations@gilead.com



Media:

Ashleigh Koss

public_affairs@gilead.com

Source: Gilead Sciences, Inc.

FAQ

What were Gilead's total revenues for 2022?

Gilead's total revenues for 2022 were $27.3 billion, flat compared to 2021.

What is Gilead's guidance for 2023 product sales?

Gilead's guidance for 2023 total product sales is between $26.0 billion and $26.5 billion.

How much did Biktarvy sales increase in Q4 2022?

Biktarvy sales increased 15% to $2.9 billion in Q4 2022 compared to the same period in 2021.

What were the diluted EPS figures for Gilead in Q4 2022?

Gilead's diluted EPS for Q4 2022 was $1.30.

What drove the decline in Veklury sales for Gilead?

Veklury sales fell primarily due to lower rates of COVID-19 related hospitalizations.