Exact Sciences Lab and OncoExTra Test Selected by National Cancer Institute for ComboMATCH Clinical Trials
- Participation in ComboMATCH trials reinforces commitment to personalized cancer care
- OncoExTra test provides comprehensive molecular picture of patient's cancer
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ComboMATCH trials will use Exact Sciences' new OncoExTra™ therapy selection test to analyze tumor samples for participants in this large precision medicine initiative
Participation in trials reinforces company's commitment to enable delivery of personalized cancer care
The ComboMATCH registration trial is the gateway to a set of clinical trials evaluating new anti-cancer treatment combinations directed by NGS testing in select groups of adults and children with locally advanced or advanced (metastatic) cancer.
"Most cancers do not have a single underlying cause or driver; so, no single targeted therapy is likely to work, especially in the long-term given the challenge of drug resistance," said James M. Ford, M.D., Stanford University School of Medicine, co-leader of ComboMATCH and leader of the coordination effort by the ECOG-ACRIN Cancer Research Group. "Mounting evidence demonstrates the important role of genomic profiling to guide therapeutic choices when treating cancer, and offers the potential for greater patient benefit, paving the way to new frontiers in cancer treatment."
"The ComboMATCH trials will use our OncoExTra test to provide the most informed picture of a patient's individual tumor biology. We are eager to work with trial investigators and are proud the NCI chose Exact Sciences for this important initiative," said Rick Baehner, M.D., chief medical officer of Precision Oncology at Exact Sciences. "Our company is dedicated to providing comprehensive tumor information for patients in clinical trials like ComboMATCH, and to enabling the delivery of personalized cancer care."
The OncoExTra test profiles the entire exome (DNA) and the transcriptome (RNA) across approximately 20,000 genes, uncovering variants possibly missed by only evaluating DNA. It also uses matched tumor-normal sequencing to limit potentially false positive results and allow physicians to make clinical decisions based on variants related only to the tumor. The American Society of Clinical Oncology (ASCO) has updated its guidelines to recommend RNA-based fusion testing for patients with no actionable information provided by a standard DNA, multigene panel test. OncoExTra also analyzes all National Comprehensive Cancer Network® (NCCN®) recommended genes for patients with solid tumors and provides expertly curated, intuitive reports.
For more information about the OncoExTra test, visit precisiononcology.exactsciences.com.
About ComboMATCH
A unique initiative to test new combinations of cancer drugs guided by tumor biology, ComboMATCH (Molecular Analysis for Combination Therapy Choice) is a coordinated set of precision medicine cancer clinical trials led by the ECOG-ACRIN Cancer Research Group and National Cancer Institute (NCI), part of the National Institutes of Health, through the NCI's National Clinical Trials Network (NCTN). ComboMATCH includes participation by the other NCTN groups in
About Exact Sciences' Precision Oncology portfolio
Exact Sciences' Precision Oncology portfolio delivers actionable genomic insights to inform prognosis and cancer treatment after a diagnosis. In breast cancer, the Oncotype DX Breast Recurrence Score® test is the only test shown to predict the likelihood of chemotherapy benefit as well as recurrence in invasive breast cancer. The Oncotype DX Breast Recurrence Score test is recognized as a standard of care and is included in all major breast cancer treatment guidelines. The OncoExTra™ test applies comprehensive tumor profiling, utilizing whole exome and whole transcriptome sequencing, to aid in therapy selection for patients with advanced, metastatic, refractory, relapsed, or recurrent cancer. With an extensive panel of approximately 20,000 genes, the OncoExTra test is one of the most comprehensive molecular tests available to patients today. Exact Sciences enables patients to take a more active role in their cancer care and makes it easy for providers to order tests, interpret results, and personalize medicine by applying real-world evidence and guideline recommendations. To learn more, visit precisiononcology.exactsciences.com.
About Exact Sciences Corp.
A leading provider of cancer screening and diagnostic tests, Exact Sciences gives patients and health care professionals the clarity needed to take life-changing action earlier. Building on the success of the Cologuard® and Oncotype® tests, Exact Sciences is investing in its pipeline to develop innovative solutions for use before, during, and after a cancer diagnosis. For more information, visit ExactSciences.com, follow Exact Sciences on Twitter @ExactSciences, or find Exact Sciences on LinkedIn and Facebook.
NOTE: Oncotype, Oncotype DX, Oncotype DX Breast Recurrence Score, Recurrence Score, and OncoExTra are trademarks or registered trademarks of Genomic Health, Inc. Exact Sciences and Cologuard are trademarks or registered trademarks of Exact Sciences Corporation. All other trademarks and service marks are the property of their respective owners.
Forward-Looking Statements
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