Erasca Reports Third Quarter 2021 Financial Results and Business Updates
Erasca, Inc. (Nasdaq: ERAS) reported strong execution in its recent financial results for Q3 2021, highlighting the initiation of two clinical trials for ERAS-007 in lung and gastrointestinal cancers. The company maintained a robust cash position of $487 million, bolstered by a $345 million IPO. Notably, it was named one of Fierce Biotech's "Fierce 15" innovative companies. However, the firm reported a net loss of $46.1 million for the quarter, influenced by significant R&D and G&A expenses, including a $17.5 million donation to the Erasca Foundation.
- Initiated two clinical trials for ERAS-007, expanding pipeline.
- Strong cash position of $487 million to support future operations.
- Recognized as one of Fierce Biotech's "Fierce 15" promising companies.
- Net loss of $46.1 million in Q3 2021, higher than previous year.
- Increased R&D expenses at $20 million, impacting financial performance.
Strong execution leading to four ongoing clinical trials evaluating lead candidates ERAS-007 (ERKi) and ERAS-601 (SHP2i)
Named one of Fierce Biotech’s “Fierce 15” most promising biotechnology companies of 2021
Donated
Robust balance sheet with cash of
SAN DIEGO, Nov. 10, 2021 (GLOBE NEWSWIRE) -- Erasca, Inc. (Nasdaq: ERAS), a clinical-stage precision oncology company singularly focused on discovering, developing, and commercializing therapies for patients with RAS/MAPK pathway-driven cancers, today reported financial results for the fiscal quarter ended September 30, 2021, and provided business updates.
“Erasca continued our strong execution this quarter, delivering on key milestones, advancing new clinical trials, and generating exciting preclinical data,” said Jonathan E. Lim, M.D., Erasca’s chairman, CEO, and co-founder. “With the initiation in September of our HERKULES-2 and -3 trials in non-small cell lung cancer and gastrointestinal malignancies, respectively, we currently have four ongoing clinical trials with multiple clinical data readouts anticipated in 2022. We are excited about recent preclinical data that further support the planned IND filings for ERAS-801 (CNS-penetrant EGFR inhibitor for refractory glioblastoma multiforme) in the first quarter of 2022 and ERAS-3490 (CNS-penetrant KRAS G12C inhibitor) in the second half of 2022.”
Dr. Lim continued, “At the corporate level, we are honored to be named one of Fierce Biotech’s ‘Fierce 15’ most promising and innovative biotechnology companies of 2021. We remain focused on our mission to erase cancer and believe this mission goes beyond therapeutic development to include a broader social contribution. We were pleased to donate
Research and Development (R&D) Highlights
- Dosed First Patient in HERKULES-2 Trial: In September 2021, Erasca dosed the first patient in HERKULES-2, a Phase 1b/2 trial evaluating ERAS-007 (ERK1/2 inhibitor) in multiple combinations as part of Erasca’s lung cancer master protocol, with a focus on patients with advanced non-small cell lung cancer (NSCLC)
- Dosed First Patient in HERKULES-3 Trial: In September 2021, Erasca dosed the first patient in HERKULES-3, a Phase 1b/2 trial evaluating ERAS-007 (ERK1/2 inhibitor) in multiple combinations as part of Erasca’s gastrointestinal cancer master protocol, with an initial focus on patients with advanced colorectal cancer (CRC)
- Presented Preclinical Data for ERAS-801: In October 2021, Erasca announced the presentation of preclinical data for ERAS-801, a central nervous system (CNS)-penetrant epidermal growth factor receptor (EGFR) inhibitor for the treatment of refractory glioblastoma multiforme (GBM), at the American Association for Cancer Research (AACR) Special Virtual Conference on Brain Cancer
Corporate Highlights
- Completed
$345 Million Initial Public Offering: In July 2021, Erasca sold 21,562,500 shares of common stock, which included the exercise in full by the underwriters of their option to purchase 2,812,500 shares of common stock, at a public offering price of$16 per share. The gross proceeds from the offering were$345 million - Named a 2021 “Fierce 15” Winner: Named one of Fierce Biotech’s “Fierce 15” most promising biotechnology companies of 2021
- Entered into a Clinical Trial Collaboration and Supply Agreement with Pfizer: Pfizer will supply its BRAF inhibitor encorafenib (BRAFTOVI®) at no cost in connection with a clinical proof-of-concept study evaluating ERAS-007 in combination with encorafenib and the EGFR inhibitor cetuximab for the treatment of patients with BRAF V600E-mutant metastatic CRC as part of the ongoing Phase 1b/2 HERKULES-3 trial
- Contributed to the Erasca Foundation: Issued
$17.5 million of common shares to the Erasca Foundation to fund charitable activities related to Erasca’s mission
Key Upcoming Milestones
- ERAS-801: CNS-penetrant EGFR inhibitor
- IND filing expected in first quarter of 2022
- HERKULES-4: Phase 1b/2 clinical trial for ERAS-007/MAPKlamp in combination with various agents in patients with hematological malignancies
- Dosing of the first patient expected in first quarter of 2022
Third Quarter 2021 Financial Results
Cash Position: Cash, cash equivalents, and investments were
Research and Development (R&D) Expenses: R&D expenses were
General and Administrative (G&A) Expenses: G&A expenses were
Net Loss: For the quarter ended September 30, 2021, Erasca reported a net loss of
About Erasca
At Erasca, our name is our mission: To erase cancer. We are a clinical-stage precision oncology company singularly focused on discovering, developing, and commercializing therapies for patients with RAS/MAPK pathway-driven cancers. Our company was co-founded by leading pioneers in precision oncology and RAS targeting to create novel therapies and combination regimens designed to comprehensively shut down the RAS/MAPK pathway for the treatment of cancer. We have assembled what we believe to be the deepest RAS/MAPK pathway-focused pipeline in the industry. We believe our team’s capabilities and experience, further guided by our scientific advisory board which includes the world’s leading experts in the RAS/MAPK pathway, uniquely position us to achieve our bold mission of erasing cancer.
Cautionary Note Regarding Forward-Looking Statements
Erasca cautions you that statements contained in this press release regarding matters that are not historical facts are forward-looking statements. The forward-looking statements are based on our current beliefs and expectations and include, but are not limited to: our expectations regarding the potential therapeutic benefits of our product candidates, including ERAS-007, ERAS-601, ERAS-801, and ERAS-3490; the expected timing of the first patient dosing for our HERKULES-4 clinical trial; the expected timing of the IND filings for each of ERAS-801 and ERAS-3490; the planned advancement of our development pipeline, including the anticipated timing of data readouts for our clinical trials and other upcoming development milestones; and the planned activities of the Erasca Foundation. Actual results may differ from those set forth in this press release due to the risks and uncertainties inherent in our business, including, without limitation: our approach to the discovery and development of product candidates based on our singular focus on shutting down the RAS/MAPK pathway, a novel and unproven approach; potential delays in the commencement, enrollment, and completion of clinical trials and preclinical studies; our dependence on third parties in connection with manufacturing, research, and preclinical and clinical testing; unexpected adverse side effects or inadequate efficacy of our product candidates that may limit their development, regulatory approval, and/or commercialization, or may result in recalls or product liability claims; unfavorable results from preclinical studies or clinical trials; results from preclinical studies or early clinical trials not necessarily being predictive of future results; the inability to realize any benefits from our current licenses and acquisitions and any future licenses, acquisitions, or collaborations, and our ability to fulfill our obligations under such arrangements; regulatory developments in the United States and foreign countries; our ability to obtain and maintain intellectual property protection for our product candidates and maintain our rights under intellectual property licenses; our ability to fund our operating plans with our current cash, cash equivalents, and investments; our ability to maintain undisrupted business operations due to the COVID-19 pandemic, including delaying or disrupting our clinical trials, manufacturing, and supply chain; and other risks described in our prior filings with the Securities and Exchange Commission (SEC), including under the heading “Risk Factors” in our most recent quarterly report on Form 10-Q and any subsequent filings with the SEC. You are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date hereof, and we undertake no obligation to update such statements to reflect events that occur or circumstances that exist after the date hereof. All forward-looking statements are qualified in their entirety by this cautionary statement, which is made under the safe harbor provisions of the Private Securities Litigation Reform Act of 1995.
Erasca, Inc.
Consolidated Balance Sheet Data
(In thousands)
(Unaudited)
| September 30, | December 31, | |||||||
| 2021 | 2020 | |||||||
| Balance Sheet Data: | ||||||||
| Cash, cash equivalents, and investments | $ | 486,645 | $ | 118,701 | ||||
| Working capital | 472,725 | 106,310 | ||||||
| Total assets | 521,948 | 124,825 | ||||||
| Accumulated deficit | (207,702 | ) | (115,402 | ) | ||||
| Total stockholders’ equity (deficit) | 482,991 | (113,984 | ) | |||||
Erasca, Inc.
Condensed Consolidated Statements of Operations and Comprehensive Loss
(In thousands, except share and per share amounts)
(Unaudited)
| Three months ended September 30, | Nine months ended September 30, | |||||||||||||||
| 2021 | 2020 | 2021 | 2020 | |||||||||||||
| Operating expenses: | ||||||||||||||||
| Research and development | $ | 19,951 | $ | 9,068 | $ | 49,794 | $ | 19,485 | ||||||||
| In-process research and development | 1,680 | 75 | 10,848 | 17,745 | ||||||||||||
| General and administrative | 6,916 | 2,020 | 15,696 | 5,052 | ||||||||||||
| Contribution of common stock to Erasca Foundation | 17,497 | — | 17,497 | — | ||||||||||||
| Total operating expenses | 46,044 | 11,163 | 93,835 | 42,282 | ||||||||||||
| Loss from operations | (46,044 | ) | (11,163 | ) | (93,835 | ) | (42,282 | ) | ||||||||
| Other income (expense) | ||||||||||||||||
| Interest income | 49 | 38 | 110 | 293 | ||||||||||||
| Other expense | (74 | ) | (38 | ) | (190 | ) | (79 | ) | ||||||||
| Change in fair value of preferred stock purchase right liability | — | 555 | 1,615 | 2,311 | ||||||||||||
| Total other income (expense), net | (25 | ) | 555 | 1,535 | 2,525 | |||||||||||
| Net loss | $ | (46,069 | ) | $ | (10,608 | ) | $ | (92,300 | ) | $ | (39,757 | ) | ||||
| Net loss per share, basic and diluted | $ | (0.46 | ) | $ | (0.50 | ) | $ | (1.90 | ) | $ | (1.91 | ) | ||||
| Weighted-average shares of common stock used in computing net loss per share, basic and diluted | 99,127,286 | 21,084,657 | 48,584,029 | 20,851,262 | ||||||||||||
| Other comprehensive income (loss): | ||||||||||||||||
| Unrealized gain (loss) on investments, net | 1 | 3 | (2 | ) | (11 | ) | ||||||||||
| Comprehensive loss | $ | (49,068 | ) | $ | (10,605 | ) | $ | (92,302 | ) | $ | (39,768 | ) | ||||
Contact:
Joyce Allaire
LifeSci Advisors, LLC
jallaire@lifesciadvisors.com
FAQ
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