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Altamira Therapeutics Announces Publication of Preclinical Data Showing Successful Treatment of Abdominal Aortic Aneurysm with SOD2 mRNA Delivered by SemaPhore Nanoparticles

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Altamira Therapeutics (Nasdaq:CYTO) has announced the publication of a preclinical study demonstrating effective treatment of abdominal aortic aneurysm (AAA) using their SemaPhore™ nanoparticles to deliver SOD2 mRNA. The study, conducted by researchers from Washington University and the University of South Florida, showed significant reduction in aorta dilation (p<0.05), delayed rupture, and highly significant improvement in survival rates (p<0.01) compared to untreated controls in an AAA mouse model.

The treatment approach targets oxidative stress by boosting mitochondrial SOD2 expression, reducing levels of reactive oxygen species (ROS). This nanotherapeutic mRNA delivery method may have potential applications in managing small AAAs and preventing ruptures, which are often life-threatening.

Altamira Therapeutics (Nasdaq:CYTO) ha annunciato la pubblicazione di uno studio preclinico che dimostra un trattamento efficace per l'aneurisma aortico addominale (AAA) utilizzando le nanoparticelle SemaPhore™ per somministrare mRNA SOD2. Lo studio, condotto da ricercatori della Washington University e dell'University of South Florida, ha mostrato una significativa riduzione della dilatazione dell'aorta (p<0.05), una rottura ritardata e un miglioramento altamente significativo dei tassi di sopravvivenza (p<0.01) rispetto ai controlli non trattati in un modello murino di AAA. L'approccio terapeutico mira a combattere lo stress ossidativo aumentando l'espressione mitocondriale di SOD2 e riducendo i livelli delle specie reattive dell'ossigeno (ROS). Questo metodo di somministrazione di mRNA nanoterapia potrebbe avere applicazioni potenziali nella gestione di piccoli AAA e nella prevenzione delle rotture, che sono spesso pericolose per la vita.
Altamira Therapeutics (Nasdaq:CYTO) ha anunciado la publicación de un estudio preclínico que demuestra un tratamiento eficaz para el aneurisma aórtico abdominal (AAA) utilizando sus nanopartículas SemaPhore™ para entregar el mRNA SOD2. El estudio, realizado por investigadores de la Universidad de Washington y la Universidad del Sur de Florida, mostró una reducción significativa en la dilatación de la aorta (p<0.05), un retraso en la ruptura y una mejora altamente significativa en las tasas de supervivencia (p<0.01) en comparación con controles no tratados en un modelo de ratones con AAA. Este enfoque de tratamiento se centra en el estrés oxidativo aumentando la expresión mitocondrial de SOD2 y reduciendo los niveles de especies reactivas de oxígeno (ROS). Este método de entrega de mRNA nanoteraéutico podría tener aplicaciones potenciales en el manejo de pequeños AAA y en la prevención de rupturas, que a menudo son amenazantes para la vida.
알타미라 테라퓨틱스(Nasdaq:CYTO)는 SemaPhore™ 나노입자를 사용하여 SOD2 mRNA를 전달함으로써 복부 대동맥류(AAA)에 대한 효과적인 치료를 입증한 전임상 연구 발표를 알렸습니다. 이 연구는 워싱턴 대학교와 플로리다 남부 대학교의 연구원들에 의해 수행되었으며, AAA 쥐 모델을 사용하여 untreated controls와 비교했을 때 대동맥 확장(p<0.05)에 대한 유의미한 감소, 파열 지연 및 생존율(p<0.01)의 매우 유의미한 개선을 보여주었습니다. 치료 접근법은 미토콘드리아 SOD2 발현을 증가시켜 산화 스트레스를 표적으로 삼고 반응성 산소 종(ROS) 수치를 줄입니다. 이 나노 치료 mRNA 전달 방법은 소규모 AAA 관리 및 파열 예방에 잠재적인 응용 가능성을 가질 수 있습니다.
Altamira Therapeutics (Nasdaq:CYTO) a annoncé la publication d'une étude préclinique démontrant un traitement efficace de l'aneurysme aortique abdominal (AAA) utilisant leurs nanoparticules SemaPhore™ pour livrer l'ARNm SOD2. L'étude, menée par des chercheurs de l'Université de Washington et de l'Université du Sud de la Floride, a montré une réduction significative de la dilatation de l'aorte (p<0.05), un retard dans la rupture, et une amélioration hautement significative des taux de survie (p<0.01) par rapport à des contrôles non traités dans un modèle murin de AAA. L'approche thérapeutique cible le stress oxydatif en augmentant l'expression mitochondriale de SOD2, réduisant les niveaux des espèces réactives de l'oxygène (ROS). Cette méthode de livraison de l'ARNm en nanotéran pourrait avoir des applications potentielles pour la gestion des petits AAA et la prévention des ruptures, souvent menaçantes pour la vie.
Altamira Therapeutics (Nasdaq:CYTO) hat die Veröffentlichung einer präklinischen Studie bekannt gegeben, die eine effektive Behandlung des abdominalen Aortenaneurysmas (AAA) mithilfe ihrer SemaPhore™-Nanopartikel zur Lieferung von SOD2-mRNA demonstriert. Die Studie, die von Forschern der Washington University und der University of South Florida durchgeführt wurde, zeigte eine signifikante Verringerung der Aortendilatation (p<0.05), eine verzögerte Ruptur und eine hoch signifikante Verbesserung der Überlebensraten (p<0.01) im Vergleich zu unbehandelten Kontrollen in einem AAA-Mausmodell. Der Therapieansatz zielt darauf ab, oxidativen Stress zu bekämpfen, indem die mitochondriale SOD2-Expression erhöht und die Werte reaktiver Sauerstoffspezies (ROS) gesenkt werden. Diese nanotherapeutische mRNA-Liefermethode könnte potenzielle Anwendungen bei der Behandlung kleiner AAA und der Verhinderung von Rupturen, die oft lebensbedrohlich sind, haben.
Positive
  • Significant reduction in aorta dilation (p<0.05) in AAA mouse model
  • Highly significant improvement in survival rates (p<0.01) compared to untreated controls
  • Successful delivery of SOD2 mRNA to mitochondria in aorta wall using SemaPhore nanoparticles
  • Good safety profile with no sustained accumulation or SOD2 expression in major organs
  • No changes in hematologic parameters or liver/kidney function observed
  • SemaPhore nanoparticles demonstrated good stability over time
Negative
  • None.

Insights

The recent preclinical data from Altamira Therapeutics showcases a promising breakthrough in the treatment of abdominal aortic aneurysm (AAA) using SOD2 mRNA delivered via SemaPhore nanoparticles. The study indicates significant improvements in reducing aorta dilation, delaying rupture and enhancing survival rates in an established animal model.

From a medical standpoint, the use of SOD2 mRNA to tackle oxidative stress, a key factor in AAA progression, demonstrates a novel approach compared to traditional antioxidant treatments, which have yielded unsatisfactory results. This innovative strategy of boosting mitochondrial SOD2 expression directly addresses the excess of reactive oxygen species (ROS), potentially offering a more effective and targeted therapy for AAA. The preclinical results are promising, but the transition to human trials will be important to validate efficacy and safety in a clinical setting.

Moreover, the safety profile highlighted, with no major organ accumulation or adverse hematologic or liver/kidney function changes, suggests that this treatment could minimize systemic side effects, a significant consideration for new therapeutic interventions.

For investors, while this research is in the preclinical stage, the innovative approach and promising results could signal a strong future potential if subsequent clinical trials confirm these findings. It's worth following Altamira's progress to see how well these early results translate into human applications.

From a market perspective, Altamira Therapeutics’ breakthrough in delivering SOD2 mRNA using SemaPhore nanoparticles marks a substantial step forward in RNA-based therapies, particularly for conditions outside the liver, which is traditionally a challenging target for RNA delivery.

Financially, this innovation can place Altamira in a unique market position, potentially leading to partnerships, licensing opportunities and increased investor interest. AAA presents a significant market due to the high mortality and morbidity rates associated with its rupture and an effective non-surgical treatment could be a game-changer. Additionally, the broader applicability of this technology to other oxidative stress-related disorders could expand its market reach, enhancing long-term revenue potential.

Short-term, investors should be cautious as the company still needs to conduct clinical trials, which can be lengthy and expensive. However, the positive preclinical data can drive near-term stock performance and funding opportunities through grants or partnerships.

Overall, while the immediate impact on revenue is limited, the long-term outlook appears positive if clinical trials support the preclinical findings, making it an interesting area for investors to monitor closely.

Hamilton, Bermuda, July 19, 2024 (GLOBE NEWSWIRE) --


  • Study shows significant reduction in aorta dilation, delayed rupture and lower mortality in established animal model of abdominal aortic aneurysm
  • Altamira’s SemaPhore™ nanoparticles delivering SOD2 mRNA successfully to mitochondria in aorta wall
  • Positive outcomes suggest potential use of treatment in management of small abdominal aortic aneurysm and prevention of ruptures    

Altamira Therapeutics Ltd. (“Altamira” or the “Company”) (Nasdaq:CYTO), a company dedicated to developing and commercializing RNA delivery technology for targets beyond the liver, today announced the preprint publication of a  study demonstrating effective treatment of abdominal aortic aneurysm (AAA) in an animal model.1 The study was conducted by a research group from Washington University, St. Louis MO, and the University of South Florida, Tampa FL. It showed that treatment with SOD2 mRNA delivered systemically with peptide-based nanoparticles (SemaPhore™ by Altamira) to AAA mice resulted in a significant reduction in aorta dilation (p<0.05), delayed rupture and a highly significant improvement in survival rates (p<0.01) compared to untreated controls.

AAA is a localized abnormal enlargement (bulge) of the abdominal aorta, i.e. the part of the main artery which runs through the belly. The rupture of an AAA may be life-threatening; more than 50% of patients die before they reach the emergency room, and those who survive have very high morbidity.2 The prevalence of AAAs increases with age and is 4-6 times more common in men than in women; it develops in approximately 1% of men between 55 and 64 years of age, and increases by 2 to 4% per decade thereafter.3 Surgery is the main treatment for large AAAs or those that are growing rapidly.

AAA is an inflammatory disease involving oxidative stress caused by excessive levels of reactive oxygen species (ROS). Although the use of antioxidants would appear a promising treatment strategy, clinical efficacy has turned out to be mostly unsatisfactory. By targeting SOD2 (superoxide dismutase 2), an enzyme known for its capacity to eliminate ROS, the researchers used a different approach. They delivered SOD2 mRNA through systemic injections of Altamira’s peptide-based SemaPhore nanoparticles in an established murine AAA model and were thus able to boost mitochondrial SOD2 expression, reduce levels of oxidative stress and in turn mitigate the expansion of small AAA and largely prevent rupture. The research group concluded: “This nanotherapeutic mRNA delivery approach may find translational application in the medical management of small AAA and the prevention of AAA rupture.”

“Using SOD2 mRNA to modulate oxidative stress appears a very promising approach in various challenging cardiovascular disorders such as abdominal aortic aneurysm or atherosclerosis and in other inflammatory or degenerative disease where ROS is a critical disease driver”, commented Samuel Wickline, M.D., Chief Scientific Adviser of Altamira and one of the co-authors of the study. “Importantly, the SemaPhore nanoparticles allowed for systemic delivery of the mRNA payload with efficient uptake and SOD2 expression in the aortic wall. Moreover, there was a good safety profile with no sustained accumulation or SOD2 expression in major organs, and no change in hematologic parameters or liver / kidney function. Last, but not least, the nanoparticles showed good stability over time.”

About Altamira Therapeutics

Altamira Therapeutics (Nasdaq: CYTO) is developing and supplying peptide-based nanoparticle technologies for efficient RNA delivery to extrahepatic tissues (OligoPhore™ / SemaPhore™ platforms). The Company currently has two flagship siRNA programs using its proprietary delivery technology: AM-401 for KRAS driven cancer and AM-411 for rheumatoid arthritis, both in preclinical development beyond in vivo proof of concept. The versatile delivery platform is also suited for mRNA and other RNA modalities and made available to pharma or biotech companies through out-licensing. In addition, Altamira holds a 49% stake (with additional economic rights) in Altamira Medica AG, its commercial-stage legacy asset Bentrio®, an OTC nasal spray for allergic rhinitis. Further, the Company is in the process of partnering / divesting its inner ear legacy assets. Founded in 2003, Altamira is headquartered in Hamilton, Bermuda, with its main operations in Basel, Switzerland. For more information, visit: https://altamiratherapeutics.com/

Forward-Looking Statements

This press release may contain statements that constitute "forward-looking statements" within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. Forward-looking statements are statements other than historical facts and may include statements that address future operating, financial or business performance or Altamira’s strategies or expectations. In some cases, you can identify these statements by forward-looking words such as "may", "might", "will", "should", "expects", "plans", "anticipates", "believes", "estimates", "predicts", "projects", "potential", "outlook" or "continue", or the negative of these terms or other comparable terminology. Forward-looking statements are based on management's current expectations and beliefs and involve significant risks and uncertainties that could cause actual results, developments and business decisions to differ materially from those contemplated by these statements. These risks and uncertainties include, but are not limited to, the success of strategic transactions, including licensing or partnering, with respect to Altamira’s legacy assets, Altamira’s need for and ability to raise substantial additional funding to continue the development of its product candidates, the clinical utility of Altamira’s product candidates, the timing or likelihood of regulatory filings and approvals, Altamira’s intellectual property position and Altamira’s financial position, including the impact of any future acquisitions, dispositions, partnerships, license transactions or changes to Altamira’s capital structure, including future securities offerings. These risks and uncertainties also include, but are not limited to, those described under the caption "Risk Factors" in Altamira’s Annual Report on Form 20-F for the year ended December 31, 2023, and in Altamira’s other filings with the Securities Exchange Commission (“SEC”), which are available free of charge on the SEC’s website at: www.sec.gov. Should one or more of these risks or uncertainties materialize, or should underlying assumptions prove incorrect, actual results may vary materially from those indicated. All forward-looking statements and all subsequent written and oral forward-looking statements attributable to Altamira or to persons acting on behalf of Altamira are expressly qualified in their entirety by reference to these risks and uncertainties. You should not place undue reliance on forward-looking statements. Forward-looking statements speak only as of the date they are made, and Altamira does not undertake any obligation to update them in light of new information, future developments or otherwise, except as may be required under applicable law.


Investor Contact:
Hear@altamiratherapeutics.com

1 Yan et al. (2024), Systemic delivery of murine SOD2 mRNA to experimental abdominal aortic aneurysm mitigates expansion and rupture, bioRxiv: 2024.06.17.599454. 10.1101/2024.06.17.599454

2 Shaw et al. (2024), Abdominal aortic aneurysm, StatPearls. https://www.ncbi.nlm.nih.gov/books/NBK470237/

3 Aggarwal et al. (2011), Abdominal aortic aneurysm: A comprehensive review, Exp Clin Cardiol 16(1): 11–15.



FAQ

What is the purpose of Altamira Therapeutics' study on abdominal aortic aneurysm (AAA)?

The study aimed to demonstrate the effectiveness of treating abdominal aortic aneurysm using SOD2 mRNA delivered by Altamira's SemaPhore nanoparticles in an animal model.

What were the key results of Altamira Therapeutics' AAA study using CYTO's SemaPhore nanoparticles?

The study showed significant reduction in aorta dilation (p<0.05), delayed rupture, and highly significant improvement in survival rates (p<0.01) compared to untreated controls in an AAA mouse model.

How does Altamira Therapeutics' (CYTO) treatment approach for AAA work?

The treatment targets oxidative stress by delivering SOD2 mRNA using SemaPhore nanoparticles, boosting mitochondrial SOD2 expression and reducing levels of reactive oxygen species (ROS) in the aorta wall.

What potential applications does Altamira Therapeutics' (CYTO) AAA treatment have?

The nanotherapeutic mRNA delivery approach may have potential applications in managing small abdominal aortic aneurysms and preventing ruptures, which are often life-threatening.

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