Altamira Therapeutics Provides Business Update and First Half 2024 Financial Results
Altamira Therapeutics (Nasdaq:CYTO) reported its first half 2024 financial results, highlighting key developments in RNA delivery and business restructuring.
The company showcased progress in its RNA delivery platforms, OligoPhore and SemaPhore, with notable scientific publications demonstrating efficacy in cancer and inflammatory disease treatments. Altamira's R&D team moved to new facilities at Switzerland Innovation Park, enhancing their capabilities.
Financial results showed a net loss of $4.3 million, a 27% improvement from the previous year's $5.9 million. Operating loss from continuing operations was $3.9 million, up from $3.6 million in H1 2023, mainly due to increased R&D expenses. Cash used in operations decreased significantly to $3.2 million from $8.4 million in H1 2023.
Altamira expanded distribution territories for Bentrio®, its nasal spray, and continued strategic repositioning towards RNA delivery by divesting a 51% stake in Altamira Medica for $2.3 million. The company also raised $4.7 million through share issuances and a public offering.
Altamira Therapeutics (Nasdaq:CYTO) ha riportato i risultati finanziari del primo semestre 2024, mettendo in evidenza i principali sviluppi nella consegna di RNA e nella ristrutturazione aziendale.
La società ha mostrato progressi nelle sue piattaforme di consegna di RNA, OligoPhore e SemaPhore, con pubblicazioni scientifiche significative che dimostrano l’efficacia nei trattamenti per il cancro e le malattie infiammatorie. Il team di R&D di Altamira si è trasferito in nuove strutture presso il Switzerland Innovation Park, migliorando le proprie capacità.
I risultati finanziari hanno evidenziato una perdita netta di $4,3 milioni, con un miglioramento del 27% rispetto ai $5,9 milioni dell’anno precedente. La perdita operativa dalle operazioni continuative è stata di $3,9 milioni, in aumento rispetto ai $3,6 milioni del primo semestre 2023, principalmente a causa dell’aumento delle spese di R&D. Il denaro utilizzato nelle operazioni è diminuito significativamente a $3,2 milioni rispetto agli $8,4 milioni del primo semestre 2023.
Altamira ha ampliato i territori di distribuzione per Bentrio®, il suo spray nasale, e ha continuato il riposizionamento strategico verso la consegna di RNA disinvestendo una quota del 51% in Altamira Medica per $2,3 milioni. La società ha anche raccolto $4,7 milioni tramite emissioni di azioni e un’offerta pubblica.
Altamira Therapeutics (Nasdaq:CYTO) reportó sus resultados financieros del primer semestre de 2024, destacando los desarrollos clave en la entrega de RNA y la reestructuración empresarial.
La compañía mostró avances en sus plataformas de entrega de RNA, OligoPhore y SemaPhore, con publicaciones científicas notables que demuestran eficacia en el tratamiento del cáncer y enfermedades inflamatorias. El equipo de I+D de Altamira se trasladó a nuevas instalaciones en el Switzerland Innovation Park, mejorando así sus capacidades.
Los resultados financieros mostraron una pérdida neta de $4.3 millones, una mejora del 27% respecto a los $5.9 millones del año anterior. La pérdida operativa de las operaciones continuas fue de $3.9 millones, en comparación con los $3.6 millones en el primer semestre de 2023, principalmente debido al aumento de los gastos de I+D. El efectivo utilizado en operaciones disminuyó significativamente a $3.2 millones desde los $8.4 millones en el primer semestre de 2023.
Altamira amplió los territorios de distribución para Bentrio®, su spray nasal, y continuó con el reposicionamiento estratégico hacia la entrega de RNA al desinvertir una participación del 51% en Altamira Medica por $2.3 millones. La compañía también recaudó $4.7 millones a través de emisiones de acciones y una oferta pública.
Altamira Therapeutics (Nasdaq:CYTO)는 2024년 상반기 재무 결과를 발표하며 RNA 전달 및 사업 구조 조정의 주요 발전 사항을 강조했습니다.
회사는 OligoPhore 및 SemaPhore RNA 전달 플랫폼에서의 진전을 보여주었으며, 암 및 염증 질환 치료의 효능을 입증하는 주목할 만한 과학 출판물이 있었습니다. Altamira의 R&D 팀은 Switzerland Innovation Park의 새로운 시설로 이전하여 능력을 향상시켰습니다.
재무 결과는 순손실이 430만 달러로, 작년 590만 달러에서 27% 개선되었음을 보여주었습니다. 지속적 운영에서의 운영 손실은 390만 달러로 2023년 H1의 360만 달러에서 증가했으며, 주로 R&D 비용 증가 때문입니다. 운영에서 사용된 현금은 2023년 H1의 840만 달러에서 320만 달러로 크게 감소했습니다.
Altamira는 자사 비강 스프레이인 Bentrio®의 배급 지역을 확대하고 RNA 전달을 위한 전략적 재편성 작업을 계속하며 Altamira Medica의 51% 지분을 230만 달러에 매각했습니다. 또한 470만 달러를 주식 발행 및 공모를 통해 모금했습니다.
Altamira Therapeutics (Nasdaq:CYTO) a publié ses résultats financiers pour le premier semestre 2024, mettant en avant des développements clés dans la livraison d'ARN et la restructuration de l'entreprise.
La société a montré des progrès dans ses plateformes de livraison d'ARN, OligoPhore et SemaPhore, avec des publications scientifiques notables démontrant l'efficacité des traitements pour le cancer et les maladies inflammatoires. L'équipe R&D d'Altamira a déménagé dans de nouvelles installations au Switzerland Innovation Park, améliorant ainsi ses capacités.
Les résultats financiers ont montré une perte nette de 4,3 millions de dollars, soit une amélioration de 27 % par rapport à la perte de 5,9 millions de dollars de l'année précédente. La perte d'exploitation des activités poursuivies s'est élevée à 3,9 millions de dollars, contre 3,6 millions de dollars au premier semestre 2023, principalement en raison de l'augmentation des dépenses R&D. Les liquidités utilisées dans les opérations ont considérablement diminué à 3,2 millions de dollars contre 8,4 millions de dollars au premier semestre 2023.
Altamira a élargi les territoires de distribution pour Bentrio®, son spray nasal, et a poursuivi son repositionnement stratégique vers la livraison d'ARN en cédant une participation de 51 % dans Altamira Medica pour 2,3 millions de dollars. L'entreprise a également levé 4,7 millions de dollars par le biais d'émissions d'actions et d'une offre publique.
Altamira Therapeutics (Nasdaq:CYTO) hat seine finanziellen Ergebnisse für das erste Halbjahr 2024 veröffentlicht und dabei wichtige Entwicklungen in der RNA-Zustellung und Unternehmensumstrukturierung hervorgehoben.
Das Unternehmen zeigte Fortschritte bei seinen RNA-Zustellplattformen OligoPhore und SemaPhore, mit bemerkenswerten wissenschaftlichen Veröffentlichungen, die die Wirksamkeit bei der Behandlung von Krebs und entzündlichen Erkrankungen demonstrieren. Das F&E-Team von Altamira hat neue Räumlichkeiten im Switzerland Innovation Park bezogen, um seine Fähigkeiten zu verbessern.
Die finanziellen Ergebnisse zeigten einen Nettoverlust von 4,3 Millionen US-Dollar, was einer Verbesserung von 27% gegenüber 5,9 Millionen US-Dollar im Vorjahr entspricht. Der operative Verlust aus fortgeführten Betrieben betrug 3,9 Millionen US-Dollar, verglichen mit 3,6 Millionen US-Dollar im ersten Halbjahr 2023, hauptsächlich aufgrund gestiegener F&E-Ausgaben. Der in den Betrieb verwendete Cashflow ging signifikant auf 3,2 Millionen US-Dollar zurück, von 8,4 Millionen US-Dollar im ersten Halbjahr 2023.
Altamira erweiterte die Vertriebsgebiete für Bentrio®, sein Nasenspray, und setzte die strategische Neupositionierung zur RNA-Zustellung fort, indem es eine 51% Beteiligung an Altamira Medica für 2,3 Millionen US-Dollar veräußerte. Das Unternehmen hat auch 4,7 Millionen US-Dollar durch Aktienemissionen und ein öffentliches Angebot gesammelt.
- Net loss decreased by 27% to $4.3 million in H1 2024.
- Cash used in operations decreased to $3.2 million from $8.4 million.
- Raised $4.7 million through share issuances and a public offering.
- Expanded distribution territories for Bentrio® nasal spray.
- Operating loss from continuing operations increased to $3.9 million from $3.6 million.
- Higher R&D expenditures increased by 32.6% to $2.0 million.
Insights
Altamira Therapeutics' first half 2024 results reflect its strategic pivot towards RNA delivery technology, showing both progress and challenges:
- Operating loss from continuing operations increased slightly to
$3.9 million , driven by higher R&D expenses (+32.6% to$2.0 million ) - Net loss narrowed by
27% to$4.3 million , benefiting from lower finance expenses and the absence of losses from discontinued operations - Cash position remains tight at just
$65,000 as of June 30, 2024 - The company raised
$4.7 million in Q3 2024 through share issuances and a public offering - Expected cash needs of
$5.8-7.0 million for 2024 indicate ongoing funding requirements
While Altamira is making progress in its RNA delivery programs and Bentrio nasal spray commercialization, its financial position remains precarious. The company will need to carefully manage expenses and secure additional funding to support its development pipeline and transition to the new business model.
Altamira's focus on RNA delivery technology is showing promising results:
- Recent publications demonstrate the effectiveness of their SemaPhore platform in delivering mRNA for cancer treatment and aortic aneurysm therapy
- Improved nanoparticle stability addresses a key challenge in RNA formulation handling and transport
- Two flagship programs, AM-401 for KRAS-driven cancers and AM-411 for rheumatoid arthritis, are progressing towards IND filings in 2026
- Collaborations with Heqet Therapeutics and Univercells Group explore applications in cardiac regeneration and mRNA vaccines
These developments highlight the potential of Altamira's RNA delivery platforms. However, the company is still in early stages, with significant R&D ahead before potential commercialization. The "picks and shovels" strategy of licensing the technology could provide nearer-term revenue opportunities, but success will depend on demonstrating clear advantages over competing delivery methods.
Hamilton, Bermuda, Sept. 24, 2024 (GLOBE NEWSWIRE) --
- Company to host conference call today at 8.30 a.m. ET
- Continued progress within core activities in RNA delivery, supported by move into new R&D facilities
- Publications by independent research groups provide fresh evidence of effective mRNA delivery to extrahepatic targets
- Major territory expansion with two distribution partners for Bentrio®
- Financial results presented for first time in US dollars rather than Swiss francs
Altamira Therapeutics Ltd. (“Altamira” or the “Company”) (Nasdaq:CYTO), a company dedicated to developing and commercializing RNA delivery technology for targets beyond the liver, today provided a business update and reported its first half 2024 financial results.
"We are excited to continue to gain momentum with our new core activities in RNA delivery," commented Thomas Meyer, Altamira Therapeutics' founder, Chairman, and CEO. "Fresh in vivo data, recently published in a top-ranking scientific journal, show dramatic reductions in sarcoma and breast cancer growth following treatment with Zbtb46 mRNA delivered with our SemaPhore nanoparticle technology. The antitumor effect was further augmented when combined with anti-PD1 treatment. These impressive outcomes add to the growing body of evidence supporting the great potential of RNA therapeutics and the ability of our platform to deliver RNA molecules effectively and safely into target cells outside the liver, especially in cancer and inflammatory diseases.”
Mr. Meyer added: “We are progressing with the development of both the OligoPhore and the SemaPhore platforms as well as with our AM-401 and AM-411 flagship programs in KRAS driven cancers and in rheumatoid arthritis, benefiting from our new access to laboratory space at the Switzerland Innovation Park in the Basel area. At the same time, we are evaluating our platforms for use in cardiac regeneration and for mRNA vaccines in joint projects with two partners and pursuing additional collaboration opportunities with other pharma and biotech companies. Further, we keep working towards completion of our strategic repositioning around RNA delivery through partnering of our legacy assets in inner ear therapeutics. Lastly, thanks to the recent public offering of shares, we have been able to strengthen our financial position for our transition to a much less capital-intensive business model based on contract development and licensing of our RNA delivery technology.”
RNA Delivery Technology
Research and development activities in Altamira’s core business of RNA delivery – built on its peptide based OligoPhore™ and SemaPhore™ nanoparticle platforms – continue to progress. The key focus is on nanoparticle formulation and process development around the platforms, the evaluation and development of nanoparticles for delivery of specific siRNA or mRNA payloads for collaboration partners, and the two flagship programs AM-401 or AM-411 for treatment of KRAS driven cancers and rheumatoid arthritis (RA), respectively. In August 2024, part of the Company’s expanding research and development team moved to the Switzerland Innovation Park in Allschwil near Basel. At the new location, the Company has access to modern and well-equipped lab facilities to support its growing activities.
Evidence for the effectiveness and versatility of Altamira’s RNA delivery platforms keeps growing, as shown by two recent scientific publications:
- In a peer reviewed article in Nature Immunology, a research group from Washington University, St. Louis, MO, showed that systemic delivery of Zbtb46 mRNA with SemaPhore nanoparticles in mouse models of sarcoma and metastatic breast cancer resulted in sustained Zbtb46 expression, a restored immunostimulatory tumor microenvironment and a highly significant reduction in tumor growth (p<0.0001).1 When combined with an immune checkpoint inhibitor (anti-PD1) treatment, outcomes were even more pronounced. According to the authors, the “Zbtb46 nanoparticles induced dramatic anti-PD1 response in both anti-PD1-responsive [sarcoma] and anti-PD1-refractory [breast cancer] tumor models, generating long-term complete remission of tumor in many of the treated animals.” Extended monotherapy with Zbtb46 nanoparticles produced complete remission even in mice refractory to anti-PD1 treatment. Mice whose sarcoma was eliminated through treatment did not develop additional tumors following repeated challenge, indicating the development of a protective immunological memory.
- Another research group from Washington University presented in a preprint publication the results of a study showing that treatment with Sod2 mRNA delivered systemically with SemaPhore nanoparticles to mice with abdominal aortic aneurysm (AAA) resulted in a significant reduction in aorta dilation (p<0.05), delayed rupture and a significant improvement in survival rates (p<0.01).2 AAA is an inflammatory disease involving oxidative stress caused by excessive levels of reactive oxygen species, which results in an abnormal enlargement (bulge) of the abdominal aorta. AAA rupture may be life-threatening.
Meanwhile, Altamira’s own development work has resulted in significant enhancement of nanoparticle stability, which has been one of the key challenges in the handling and transport of RNA formulations. Thanks to its new flow process production method, the Company obtained formulations of OligoPhore nanoparticles which are stable in liquid form when stored at 4°C for a period of at least one month. These formulations were, in addition, able to withstand shaking stress without significant physicochemical changes. The ability of nanoformulations to maintain their attributes during shaking stress is essential for transportation and one of the key limitations of lipid nanoparticles, the most common type of RNA delivery vehicles.
For its proprietary development programs AM-401 and AM-411, Altamira filed in the first half of 2024 patent applications with the US Patent and Trademark Office. These aim to complement the existing intellectual property and extend the duration of protection. For AM-401, coverage of different KRAS mutations in cancer treatment with nanoparticles comprising the OligoPhore platform and a single siRNA sequence, polyKRASmut is sought. In vitro data confirmed the ability of polyKRASmut siRNA to knock down KRAS carrying the following mutations: G12C, G12V, G12D, G12R, G12A, and A146T, which account for the majority of KRAS mutations in pancreatic, colorectal and non-small cell lung cancer. For AM-411, coverage of nanoparticles comprising siRNA sequences targeting the p65 protein, a component of the NF-κB transcription factor, and OligoPhore is sought. Activation of p65 has been observed in multiple types of cancer as well as in many inflammatory diseases. For instance, p65 is a well-known key checkpoint in RA inflammation, and thought to regulate cell proliferation, cell death, and stimulate metastasis in cancer. The Company aims to advance both AM-401 and AM-411 to an Investigational New Drug (IND) filing with the Food and Drug Administration (FDA) in 2026 and to out-license them either following the IND or after a Phase 1 clinical trial at the latest.
Altamira is pursuing with the RNA delivery business a ‘picks and shovels’ strategy based on the licensing of its platform technology to partners in the biotech and pharma industry for use in their own RNA drug product development programs. The first such collaborations have been set up:
- With Heqet Therapeutics s.r.l., a spin-out from King’s College London, Altamira is working on nanoparticles based on the OligoPhore platform and comprising certain non-coding RNAs (ncRNAs) for the regeneration of damaged heart tissue following myocardial infarction in animal models.
- With Belgium-based Univercells Group Altamira is evaluating the use of the SemaPhore platform for the delivery of mRNA vaccines. Thanks to lower mRNA loss during cell entrance, the nanoparticles may allow for using lower doses and thus result in potentially more effective and efficient vaccines.
Upon positive outcomes from these evaluations, Altamira and its partners intend to discuss and negotiate licensing agreements. Through its business development activities, the Company is pursuing additional collaboration opportunities with other pharma and biotech companies.
Bentrio® Nasal Spray
The Company’s associate Altamira Medica AG (“Medica”) made further progress on implementing its growth strategy with Bentrio®, a drug free, preservative free nasal spray for the treatment of allergic rhinitis. With two of its international distributors, it recently agreed on the expansion of their exclusive distribution territories:
- With Nuance Pharma (“Nuance”) to extend the territory across South East and East Asia. Under the amended agreement, Nuance’s territory will expand from China, Hong Kong, Macau and South Korea to also include Singapore, Malaysia, Thailand, the Philippines, Indonesia, Vietnam and Taiwan, with a combined population of greater than 630 million people. Nuance has been marketing Bentrio since late 2022 in Hong Kong and recently submitted the request for marketing approval for Mainland China.
- With Pharma Nordic to extend the territory from Norway to also include Sweden and Denmark, which together have a population of 16.5 million. Pharma Nordic launched Bentrio successfully in Norway in 2024 and intends to introduce the product to Sweden and Denmark in 2025.
In addition, discussions and negotiations for distribution in the US, Europe and other key markets are ongoing.
The efficacy and safety of Bentrio has been demonstrated in a total of four clinical trials. Results from the largest among them (the “NASAR” study), which enrolled 100 patients suffering from seasonal allergic rhinitis in Australia, were recently published in a peer reviewed article in one of the leading scientific journals in allergology.3 In NASAR, participants self-administered either Bentrio or saline nasal spray for two weeks 3 times per day. The study showed a statistically significant reduction in the mean daily reflective Total Nasal Symptom Score (rTNSS) for Bentrio compared to saline (p = 0.013), as well as a statistically highly significant improvement in health-related quality of life (Rhinoconjunctivitis Quality of Life Questionnaire, p < 0.001) and superior global ratings of efficacy by patients and investigators alike (p < 0.001). In addition, Bentrio showed good safety and tolerability, similar to saline controls, and fewer Bentrio treated patients used relief medication and more of them enjoyed symptom-free days compared to saline treatment.
In the context of its strategic pivot towards RNA delivery, Altamira divested in November 2023 a
Inner Ear Therapeutics
Altamira continues to work towards the partnering of its inner ear therapeutics assets, in particular AM-125, a patented nasal spray for the treatment of acute vestibular syndrome (AVS), which may be developed also for various other disorders of the central nervous system. AM-125 is a reformulation of betahistine, a histamine analog, which – in the traditional oral formulation – is the standard of care treatment for vertigo in many countries around the world. A phase 2 clinical trial in Europe demonstrated that a four-week treatment course with AM-125 in AVS patients was well tolerated and helped to accelerate vestibular compensation, enabling patients to regain balance and recover faster. In the U.S., where oral betahistine exceptionally has not been marketed for decades, Altamira received in summer 2023 IND clearance from the FDA for a phase 2 clinical trial in benign paroxysmal positional vertigo (BPPV), the most frequent type of AVS. BPPV accounts for 17 to
Continued simplification of group structure
Following the partial divestiture of the Bentrio activities in late 2023, Altamira has continued its efforts to simplify its corporate structure and align it with the strategic repositioning around its RNA delivery platform. The Company transferred its Irish subsidiary Auris Medical Ltd. to Altamira Medica AG and merged two of its subsidiaries in Basel (Switzerland), Auris Medical AG and Altamira Therapeutics AG. The merged entity is called Altamira Therapeutics AG and continues to serve as the core operating subsidiary of the Company. Following this restructuring, the Altamira Group comprises the parent company Altamira Therapeutics Ltd. (Hamilton, Bermuda), and its subsidiaries Altamira Therapeutics AG (Basel, Switzerland), Altamira Therapeutics Inc. (Newark DE, USA), Otolanum AG (Basel, Switzerland) as well as the associated company Altamira Medica AG (Basel, Switzerland).
First Half 2024 Financial Results and Outlook
Following the partial divestiture of the Bentrio business, related activities have been reclassified and are reported as discontinued operations. Continuing operations thus comprise the RNA delivery development programs as well as those related to AM-125. The financial results are reported for the first time in US dollars, which the Company adopted as its new presentation currency, replacing the Swiss franc.
- Total operating loss from continuing operations was
$3.9 million in the first half of 2024, compared against$3.6 million in the first half of 2023. The increase was primarily related to higher expenditures on research and development (+32.6% to$2.0 million ), which was partially compensated by lower general and administrative expenses (-11.7% to$2.0 million ). - Net loss from continuing operations reached
$4.3 million in the first half of 2024, which was4.0% lower than in the corresponding reporting period in 2023. Finance expense decreased markedly ($0.2 million vs.$0.9 million ); on the other hand, the Company recorded a pro rata loss of its associate company Altamira Medica of$0.2 million (first half of 2023: none)5. - The Company’s net loss for the first half of 2024 amounted to
$4.3 million , which was27.0% lower than in the first half of 2023 ($5.9 million ). During the first six months of 2023 the Company had recorded an after-tax loss of$1.4 million from discontinued operations (first half of 2024: none)5. - Cash used in operations decreased from
$8.4 million in the first half of 2023 to$3.2 million in the first half of 2024. Financing activities provided$8.4 million in the first six months of 2023 vs.$2.5 million in the first six months of 2024. Cash and cash equivalents on June 30, 2024 totaled$65 thousand compared with$55 thousand at June 30, 2023. - Shareholders’ equity amounted to
$6.3 million as of June 30, 2024 compared with$7.7 million at year-end 2023. There was no financial debt outstanding at either timepoint.
Altamira expects total cash needs in 2024 to be in the range of
First Half 2024 and Business Update Conference Call & Webcast Details
Altamira’s Senior Management will hold an investor call today, Tuesday, September 24, 2024, at 8:30 a.m. EDT its business update and first half 2024 results. Founder, Chairman, and CEO Thomas Meyer and COO Covadonga Pañeda will deliver prepared remarks followed by a Q&A session where they will address questions from investors and analysts.
- Event: Altamira Therapeutics First Half 2024 Financial Results and Business Update Call
- Date: Tuesday, September 24, 2024
- Time: 8:30 am EDT
- Webcast URL: https://edge.media-server.com/mmc/p/4wp8659n
Registration for Call
- https://register.vevent.com/register/BI039aac00f0eb4f228e9662f9b90a1ea4
- Click on the call link and complete the online registration form.
- Upon registering you will receive the dial-in info and a unique PIN to join the call as well as an email confirmation with the details.
- Select a method for joining the call:
- Dial-In: A dial in number and unique PIN are displayed to connect directly from your phone.
- Call Me: Enter your phone number and click “Call Me” for an immediate callback from the system. The call will come from a US number.
Conference Call Replay
A replay of the call will be available after the live event and accessible through the webcast link:
https://edge.media-server.com/mmc/p/4wp8659n
Consolidated Statement of Profit or Loss and Other Comprehensive Income/(Loss)
For the six months ended June 30, 2024 and 2023 (in US$)
| Six months ended June 30 | |||
| 2024 | 20231) 2) | ||
| Other operating income | 34,298 | 77,474 | |
| Research and development | (1,963,664) | (1,480,708) | |
| General and administrative | (1,987,972) | (2,252,587) | |
| Operating loss | (3,917,338) | (3,655,821) | |
| Finance expense | (186,000) | (937,585) | |
| Finance income | 513 | 69,540 | |
| Share of loss of an associate | (237,007) | - | |
| Net loss from continuing operations | (4,339,832) | (4,523,866) | |
| Discontinued operations: | |||
| Loss after tax from discontinued operations | - | (1,420,862) | |
| Net loss attributable to owners of the Company | (4,339,832) | (5,944,728) | |
| Other comprehensive income/(loss): | |||
| Items that will never be reclassified to profit or loss | |||
| Remeasurements of defined benefit liability, net of taxes of | 198,277 | (31,634) | |
| Items that are or may be reclassified to profit or loss | |||
| Foreign currency translation differences, net of taxes of | 14,662 | (80,121) | |
| Share of other comprehensive income of an associate | (43,712) | - | |
| Other comprehensive income/(loss), net of taxes of | 169,227 | (111,755) | |
| Total comprehensive loss attributable to owners of the Company | (4,170,605) | (6,056,483) | |
| Basic and diluted loss per share3) | (2.11) | (28.31) | |
| Basic and diluted loss per share from continuing operations3) | (2.11) | (21.55) | |
1) Amounts have been re-presented from those previously published to reflect the change in the Company’s presentation currency from Swiss francs to US dollars
2) Revised for the reclassification of certain activities as discontinued operations.
3) Weighted average number of shares outstanding: first half 2024: 2,060,714; first half 2023: 209,955.
Consolidated Statement of Financial Position
As of June 30, 2024 and December 31, 2023 (in US$)
| June 30, | June 30, | ||
| 2024 | 2023 1) | ||
| ASSETS | |||
| Non-current assets | |||
| Property and equipment | 1 | 1 | |
| Right-of-use assets | 417,619 | 95,198 | |
| Intangible assets | 4,627,072 | 4,627,072 | |
| Other non-current financial assets | 88,999 | 95,070 | |
| Investment in an associate | 2,411,469 | 2,872,623 | |
| Total non-current assets | 7,545,160 | 7,689,964 | |
| Current assets | |||
| Other receivables | 121,310 | 88,916 | |
| Prepayments | 75,213 | 337,293 | |
| Derivative financial instruments | 262,035 | 293,630 | |
| Cash and cash equivalents | 65,455 | 733,701 | |
| Total current assets | 524,013 | 1,453,540 | |
| Total assets | 8,069,173 | 9,143,504 | |
| EQUITY AND LIABILITIES | |||
| Equity | |||
| Share capital | 5,341 | 2,956 | |
| Share premium | - | 23,889,332 | |
| Other reserves | 5,054,761 | 5,129,585 | |
| Retained earnings/(Accumulated deficit) | 1,258,213 | (21,346,630) | |
| Total shareholders’ equity/(deficit) attributable to owners of the Company | 6,318,315 | 7,675,243 | |
| Non-current liabilities | |||
| Non-current lease liabilities | 304,053 | - | |
| Employee benefit liability | 218,940 | 411,917 | |
| Total non-current liabilities | 522,993 | 411,917 | |
| Current liabilities | |||
| Current lease liabilities | 123,384 | 118,430 | |
| Trade and other payables | 526,571 | 523,367 | |
| Accrued expenses | 577,910 | 414,547 | |
| Total current liabilities | 1,227,865 | 1,056,344 | |
| Total liabilities | 1,750,858 | 1,468,261 | |
| Total equity and liabilities | 8,069,173 | 9,143,504 |
1) Amounts have been re-presented from those previously published to reflect the change in the Company’s presentation currency from Swiss francs to US dollars
About Altamira Therapeutics
Altamira Therapeutics (Nasdaq: CYTO) is developing and supplying peptide-based nanoparticle technologies for efficient RNA delivery to extrahepatic tissues (OligoPhore™ / SemaPhore™ platforms). The Company currently has two flagship siRNA programs using its proprietary delivery technology: AM-401 for KRAS driven cancer and AM-411 for rheumatoid arthritis, both in preclinical development beyond in vivo proof of concept. The versatile delivery platform is also suited for mRNA and other RNA modalities and made available to pharma or biotech companies through out-licensing. In addition, Altamira holds a
Forward-Looking Statements
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1 Kabir AU et al. (2024), ZBTB46 coordinates angiogenesis and immunity to control tumor outcome, Nat Immunol https://www.nature.com/articles/s41590-024-01936-4.
2 Yan et al. (2024), Systemic delivery of murine SOD2 mRNA to experimental abdominal aortic aneurysm mitigates expansion and rupture, bioRxiv: 2024.06.17.599454. https://www.biorxiv.org/content/10.1101/2024.06.17.599454v1.
3 Becker S et al. (2024), AM-301, a barrier-forming nasal spray, versus saline spray in seasonal allergic rhinitis: A randomized clinical trial, Allergy 79(7):1858-67. https://onlinelibrary.wiley.com/doi/10.1111/all.16116
4 Özgirgin et al. (2024), Residual dizziness after BPPV management: exploring pathophysiology and treatment beyond canalith repositioning maneuvers, Front Neurol 15:1382196. https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2024.1382196/full
5 Altamira Medica was deconsolidated and classified as associate upon its partial divestiture in November 2023.
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