Cytokinetics Announces Two Presentations at the AHA Scientific Sessions 2021

Rhea-AI Summary

Cytokinetics (CYTK) announced two presentations at the American Heart Association Scientific Sessions 2021 from Nov 13-15. One presentation will discuss the effects of omecamtiv mecarbil on stroke in heart failure patients with reduced ejection fraction, while another will showcase a novel small molecule troponin activator's impact on cardiac function. Cytokinetics is also progressing towards a U.S. NDA submission for omecamtiv mecarbil following positive results from the GALACTIC-HF trial and is advancing its clinical trials for other cardiac treatments.

Positive

• Cytokinetics is preparing for a U.S. NDA submission for omecamtiv mecarbil after positive GALACTIC-HF trial results.
• Positive results reported from the REDWOOD-HCM trial for aficamten, a cardiac myosin inhibitor.

Negative

• None.

SOUTH SAN FRANCISCO, Calif., Nov. 08, 2021 (GLOBE NEWSWIRE) -- Cytokinetics, Incorporated (Nasdaq: CYTK) today announced two presentations at the American Heart Association (AHA) Scientific Sessions 2021, taking place online from November 13, 2021 – November 15, 2021, including the presentation of additional results from GALACTIC-HF (Global Approach to Lowering Adverse Cardiac Outcomes Through Improving Contractility in Heart Failure) assessing the effect of omecamtiv mecarbil on stroke in patients with heart failure with reduced ejection fraction (HFrEF), and the presentation of preclinical data relating to a cardiac troponin activator that is a closely related analog to CK-3828136 (CK-136).

Session Title: Rapid Fire Secondary Trial Analyses in Heart Failure
Presentation Title: The Effect of Omecamtiv Mecarbil on Stroke in Patients With Heart Failure and Reduced Ejection Fraction in GALACTIC-HF
Presenter: John Teerlink, M.D., Professor of Medicine, University of California San Francisco, Director of Heart Failure, San Francisco Veterans Affairs Medical Center and Executive Committee Chair, GALACTIC-HF
Date: November 13, 2021
Session Time: 11:00 AM – 12:00 PM ET
Presentation Time: 11:30 AM – 11:38 AM ET

The following presentation will be available on demand for registered attendees beginning on November 13, 2021 at 8:00 AM ET.

Session Title: Insights About Pharmacologic Therapy and Medical Management
Presentation Title: A Novel Small Molecule Troponin Activator Increases Cardiac Contractile Function Without Negative Impact on Energetics or Diastolic Function
Presenter: Ivan Luptak, M.D., Ph.D., Assistant Professor of Medicine, Boston University School of Medicine

About Cytokinetics

Cytokinetics is a late-stage biopharmaceutical company focused on discovering, developing and commercializing first-in-class muscle activators and next-in-class muscle inhibitors as potential treatments for debilitating diseases in which muscle performance is compromised. As a leader in muscle biology and the mechanics of muscle performance, the company is developing small molecule drug candidates specifically engineered to impact muscle function and contractility. Cytokinetics is preparing a U.S. NDA submission of omecamtiv mecarbil, its novel cardiac muscle activator, following positive results from GALACTIC-HF, a large, international Phase 3 clinical trial in patients with heart failure. Cytokinetics is conducting METEORIC-HF, a second Phase 3 clinical trial of omecamtiv mecarbil. Cytokinetics is also developing aficamten, a next-generation cardiac myosin inhibitor, for the potential treatment of hypertrophic cardiomyopathies (HCM). The company has announced positive results from Cohorts 1 and 2 in REDWOOD-HCM, a Phase 2 clinical trial of aficamten in patients with obstructive HCM. Cytokinetics expects to start SEQUOIA-HCM, the Phase 3 clinical trial of aficamten in patients with obstructive HCM in Q4 2021. Cytokinetics is also developing reldesemtiv, a fast skeletal muscle troponin activator, currently the subject of COURAGE-ALS, a Phase 3 clinical trial in patients with ALS. Cytokinetics continues its over 20-year history of pioneering innovation in muscle biology and related pharmacology focused to diseases of muscle dysfunction and conditions of muscle weakness.

For additional information about Cytokinetics, visit www.cytokinetics.com and follow us on Twitter, LinkedIn, Facebook and YouTube.

Forward-Looking Statements

This press release contains forward-looking statements for purposes of the Private Securities Litigation Reform Act of 1995 (the "Act"). Cytokinetics disclaims any intent or obligation to update these forward-looking statements and claims the protection of the Act's Safe Harbor for forward-looking statements. Examples of such statements include, but are not limited to, statements relating to the REDWOOD-HCM, GALACTIC-HF, or any of our other clinical trials, statements relating to the potential benefits of omecamtiv mecarbil, aficamten, or any of our other drug candidates. Cytokinetics' research and development activities; the design, timing, results, significance and utility of preclinical and clinical results; and the properties and potential benefits of Cytokinetics' other drug candidates. Such statements are based on management's current expectations, but actual results may differ materially due to various risks and uncertainties, including, but not limited to, potential difficulties or delays in the development, testing, regulatory approvals for trial commencement, progression or product sale or manufacturing, or production of Cytokinetics' drug candidates that could slow or prevent clinical development or product approval; Cytokinetics' drug candidates may have adverse side effects or inadequate therapeutic efficacy; the FDA or foreign regulatory agencies may delay or limit Cytokinetics' ability to conduct clinical trials; Cytokinetics may be unable to obtain or maintain patent or trade secret protection for its intellectual property; standards of care may change, rendering Cytokinetics' drug candidates obsolete; and competitive products or alternative therapies may be developed by others for the treatment of indications Cytokinetics' drug candidates and potential drug candidates may target. For further information regarding these and other risks related to Cytokinetics' business, investors should consult Cytokinetics' filings with the Securities and Exchange Commission.

Contact:
Cytokinetics
Joanna Siegall
Senior Manager, Corporate Communications, Investor Relations
(425) 314-1721

FAQ

What is Cytokinetics presenting at the AHA Scientific Sessions 2021?

Cytokinetics is presenting results related to omecamtiv mecarbil's effect on stroke in heart failure patients and data on a novel small molecule troponin activator.

When are Cytokinetics' presentations scheduled during the AHA Scientific Sessions?

Cytokinetics' presentations are scheduled from November 13-15, 2021.

What are the implications of the GALACTIC-HF trial for Cytokinetics?

The GALACTIC-HF trial's positive results support Cytokinetics' NDA submission for omecamtiv mecarbil.

What is the focus of Cytokinetics' research and development?

Cytokinetics focuses on developing muscle activators and inhibitors for treating diseases related to compromised muscle performance.