Clinical Trial Shows Charlotte's Web Hemp Extract's Positive Effects on Stress, Sleep and Well Being

Rhea-AI Summary

Charlotte's Web Holdings, Inc. (CWBHF) announced positive results from a clinical trial evaluating its hemp-derived CBD products. The study, part of Radicle Science's initiative, involved hundreds of participants over four weeks, revealing significant improvements in stress, sleep quality, and overall well-being. Notably, 64% of stressed participants and 60% of those with sleep issues reported meaningful enhancements after using the Original Formula. Participants saw a 74% average improvement in overall well-being, with rapid effects noted within a week. This research underscores the efficacy of Charlotte's Web's products in support.

Positive

• 64% of participants with stress symptoms showed improvements compared to 22% in the control group.
• 60% of participants struggling with sleep reported improvements, against 15% in the control group.
• 74% average improvement in well-being as per the WHO-5 Well Being Index.
• Notable effects observed within the first week, with onset within four hours.

Negative

• None.

Majority experienced a clinically meaningful improvement in stress and sleep quality, and a significant 74% average improvement in well-being

DENVER, Feb. 8, 2022 /PRNewswire/ - (TSX:CWEB) (OTCQX:CWBHF) Charlotte's Web Holdings, Inc. ("Charlotte's Web" or the "Company"), the market leader in cannabidiol (CBD) hemp extract wellness products, shares the positive results from a randomized, controlled, clinical trial study which evaluated the effectiveness of hemp-derived CBD extracts. Charlotte's Web participated in the Radicle ACES (Advancing CBD Education and Science) study, conducted by Radicle Science, an independent health tech company validating health and wellness products. As part of a larger study, hundreds of participants from across the US used Charlotte's Web Original Formula for four weeks and were assessed for key health outcomes across five domains including general well-being, quality of life, sleep quality, feelings of daily stress or discomfort. Researchers conducted the study using standardized scientific methods and validated indices for measuring each outcome and tracked their progress repeatedly throughout the study.

"As a hemp company driven by sound science, we were encouraged by the Radicle Science study," Charlotte's Web President of CW Labs' Tim Orr said. "Independent third-party research and reporting on the efficacy of hemp wellness products help build long term consumer trust and is an ongoing commitment of Charlotte's Web."

"We're applying modern science to prove or predict the effectiveness of CBD products used by tens of millions of Americans every day," said Jeff Chen, MD/MBA, Co-founder and CEO of Radicle Science. "Our objective is to deliver accurate, transparent, and actionable insights to help create trust and transparency for the CBD industry."

People in the study regularly taking Charlotte's Web Original Formula on average realized a distinct and palpable improvement in their quality of life and well-being. A majority of people also experienced clinically meaningful improvements across the other health domains studied including sleep quality and feelings of daily stress or discomfort as compared to the baseline, before they started taking Charlotte's Web. People on average showed significant improvements as compared to the control group who did not take any hemp extract.

This clinical trial helps confirm the benefits of Charlotte's Web full spectrum hemp extract.  64% of participants with symptoms of stress experienced clinically meaningful improvements in their stress after taking Charlotte's Web Original Formula, versus only 22% of the control group.  60% of participants struggling with sleep issues experienced clinically meaningful improvements in sleep quality, versus only 15% of the control group. And  participants who took Charlotte's Web experienced a significant 74% improvement in their well-being assessed using the World Health Organization (WHO)-5 Well Being Index. The study also showed that Charlotte's Web worked quickly with notable improvements on average occurring within the first week, and generally reported effect onset within four hours after using the product. The study is therefore helpful in addressing a common question around hemp CBD: "How long will it take to work?"

"Charlotte's Web and other responsible participants in the CBD industry continue prudent research investment to contribute data on the safety and efficacy of hemp. This increases the standard of trust and transparency for consumers, healthcare providers, and regulators," said Jacques Tortoroli, Chief Executive Officer of Charlotte's Web. "Our Original Formula remains as effective today as when it was first developed by the founding Stanley Brothers years ago and took the world by storm. Consistency from year to year and bottle to bottle is a core driver of the trust that Charlotte's Web has earned."

"The rigor, large scale and intentional heterogeneity of our studies deliver the first ever scalable path to validate the health effects of health and wellness products," said Pelin Thorogood, Co-founder and Executive Chair of Radicle Science. "We are proud to partner with industry leaders such as Charlotte's Web to inform evidence-based decision making for consumers, brands, healthcare providers and regulators alike, increasing trust and transparency for the CBD industry."

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About Radicle Science
Radicle Science is a transformative health tech B-corp offering the first ever scalable path to validate and predict the health effects of health and wellness products, transforming them into democratized precision solutions for ailments or enhancement of human function. Radicle Science leverages a proprietary data analytics platform and a virtual, direct-to-consumer (D2C) clinical trial model to deliver objective health outcome data across diverse populations and conditions, at a fraction of the cost and time of traditional methods. Our Radicle Vision is a future where affordable, accessible, consumer health products are trusted by patients, recommended by healthcare providers, reimbursed by insurance, and used as widely as pharmaceutical drugs. To learn more, please visit www.radiclescience.com and follow their LinkedIn page and Twitter page.

About Charlotte's Web Original Formula™
In 2013, Colorado's seven Stanley Brothers famously developed a unique CBD hemp extract to help a little girl (Charlotte Figi) in need, and changed global perceptions around the wellness benefits of hemp.  Charlotte's Web Original Formula™ full spectrum CBD hemp extract – first used by Charlotte Figi, the namesake of the Company - has been credited with supporting numerous wellness goals, improving lives, and launching a global CBD industry. The 2018 Farm Bill federally legalized hemp. Charlotte's Web is the Worlds Most Trusted Hemp Extract™ and continues to lead the way for consumer access. Since its founding, Charlotte's Web's mission has been  "To unleash the healing powers of botanicals with compassion and science, benefiting the planet and all who live upon it."

About Charlotte's Web Holdings, Inc.
Charlotte's Web Holdings, Inc., a Certified B Corporation headquartered in Denver, is the market leader in innovative hemp extract wellness products under a family of brands which includes Charlotte's Web™, CBD Medic™, CBD Clinic™, and Harmony Hemp™. Charlotte's Web branded premium quality products start with proprietary hemp genetics that are 100-percent American farm grown and manufactured into hemp extracts containing naturally occurring phytocannabinoids including cannabidiol ("CBD"), CBC, CBG, terpenes, flavonoids, and other beneficial hemp compounds. The Company's CW Labs R&D division, advances hemp science at two centers of excellence in Louisville, Colorado, and the Hauptmann Woodward Research Institute at the University at Buffalo, part of the State University of New York (SUNY) network. Charlotte's Web product categories include full-spectrum hemp CBD oil tinctures (liquid products), CBD gummies (sleep, stress, exercise recovery), CBD capsules, CBD topical creams and lotions, as well as CBD pet products for dogs.  Through its vertically integrated business model, Charlotte's Web maintains stringent control over product quality and consistency. Charlotte's Web products are distributed to more than 14,000 retail, over 8,000 health care practitioners, and online through the Company's website at www.CharlottesWeb.com.

Charlotte's Web is a science-driven and a socially and environmentally conscious company. It is committed to using business as a force for good and a catalyst for innovation. Charlotte's Web donates a portion of its pre-tax earnings to numerous charitable organizations in support of the greater good.

Forward-Looking Information

Certain information in this news release constitutes forward-looking statements and forward-looking information (collectively, ‎‎"forward-looking information"). In some cases, but not necessarily in all cases, forward looking information can be identified by the ‎use of forward-looking terminology such as "plans", "targets", "expects" or "does not expect", "is expected", "an opportunity exists", ‎‎"is positioned", "estimates", "intends", "assumes", "anticipates" or "does not anticipate" or "believes", or variations of such words and ‎phrases or state that certain actions, events or results "may", "could", "would", "might", "will" or "will be taken", "occur" or "be ‎achieved". In addition, any statements that refer to expectations, projections or other characterizations of future events or ‎circumstances contain forward-looking information. ‎Specifically, this news release contains forward-looking information relating to the Company's expansion activities and growth strategy; the Company's expectations regarding future cash flow and its financial position; the results of cost saving efforts; the impact and results of the Company's reorganization; market share expectations; and impacts of regulatory changes.

Statements containing forward-looking information are not historical facts but instead represent management's current ‎expectations, estimates and projections regarding the future of our business, future plans, strategies, projections, anticipated events ‎and trends, the economy and other future conditions. Forward-looking information is necessarily based on a number of opinions, ‎assumptions and estimates that, while considered reasonable by the Company as of the date of this news release, are subject to ‎known and unknown risks, uncertainties, assumptions and other factors that may cause the actual results, level of activity, ‎performance or achievements to be materially different from those expressed or implied by such forward-looking information. Important factors that could cause actual results and financial condition to differ materially from those indicated in the forward-looking information include, among others, the factors discussed throughout the "Risk Factors" section of the Company's most recently filed annual information form available on www.SEDAR.com and in the Company's most recently filed Form 10, as amended, and other filings with the Securities and Exchange Commission available on www.SEC.com. Except as required by applicable securities laws, the Company undertakes no obligation to publicly update any forward-looking information, whether written or oral, that may be made from time to time, whether as a result of new information, future developments or otherwise.

Charlotte's Web Holdings, Inc. 

THE WORLD'S MOST TRUSTED HEMP EXTRACT™ 

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SOURCE Charlotte's Web Holdings, Inc.

FAQ

What were the results of the clinical trial conducted by Charlotte's Web (CWBHF)?

The trial showed 64% of stressed participants and 60% of those with sleep issues experienced clinically meaningful improvements. An average of 74% improvement in overall well-being was also recorded.

What is the significance of the clinical trial for Charlotte's Web (CWBHF)?

The trial validates the effectiveness of their CBD products, enhancing consumer trust and supporting the CBD industry's credibility.

How long did participants take Charlotte's Web products during the trial?

Participants used Charlotte's Web Original Formula for four weeks during the study.

What kind of improvements did participants report from using Charlotte's Web (CWBHF) products?

Participants reported improvements in stress levels, sleep quality, and overall well-being.

What is the importance of the Radicle Science study for CBD products?

This study helps establish the safety and efficacy standards for hemp-derived wellness products, enhancing transparency and trust in the CBD market.