Cue Biopharma to Present at the 16th Annual PEGS Boston Essential Protein Engineering & Cell Therapy Summit
On August 24, 2020, Cue Biopharma (NASDAQ: CUE) announced a poster presentation of its Neo-STAT biologics at the 16th Annual PEGS Boston Summit. This next-generation platform targets tumor-specific T cells with enhanced antigen modularity, enabling incorporation of diverse T cell epitopes. The presentation, led by Dr. Ahmet S. Vakkasoglu, will occur from August 31 to September 4, 2020. The Neo-STAT platform aims to advance cancer immunotherapy while exploring applications for infectious diseases. Cue Biopharma is focused on transforming treatment strategies through its proprietary Immuno-STAT technology.
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CAMBRIDGE, Mass., Aug. 24, 2020 (GLOBE NEWSWIRE) -- Cue Biopharma, Inc. (NASDAQ: CUE), a clinical-stage biopharmaceutical company engineering a novel class of injectable biologics to selectively engage and modulate targeted T cells within the body, announced today a poster presentation featuring Neo-STAT™, the Company’s next generation Immuno-STAT™ (Selective Targeting and Alteration of T cells) scaffold, at the 16th Annual PEGS Boston Essential Protein Engineering & Cell Therapy Summit. Neo-STAT biologics are designed for targeted modulation of tumor-specific T cells with enhanced antigen modularity.
Presentation Details
Title: Neo-STAT™: A new biologics platform for selective targeting of tumor-specific T cells with enhanced antigen modularity
Presenter: Ahmet S. Vakkasoglu, Ph.D., senior scientist
Date: August 31-September 4, 2020
The poster highlights the engineering of the Neo-STAT platform, a scaffold with pocket-stabilized, peptide-free HLA molecules that enables enhanced antigen modularity through exogenous peptide loading. Compared to first generation scaffolds, the design of Neo-STAT improves the productivity and efficiency of scaffold production. Additionally, Neo-STAT biologics can incorporate diverse T cell epitopes, including peptides bearing post-translational modifications, peptide mixtures and peptides derived from tumor neo-antigens, thereby broadening the flexibility and therapeutic impact of the Immuno-STAT platform to target a wider spectrum of disease-associated epitopes.
“We are pleased to be presenting the Neo-STAT platform, which was developed to allow for the generation of therapeutic molecules incorporating diverse T cell epitopes,” said Anish Suri, Ph.D., president and chief scientific officer of Cue Biopharma. “The Neo-STAT platform enables us to access a wider range of therapeutically relevant epitopes, including near-term applications in cancer immunotherapy with shared as well as personalized tumor antigens. In addition to cancer immunotherapy, we are also assessing the potential applications of Neo-STAT in infectious diseases, particularly against novel pathogens where immediate T cell responses could provide protective immunity before other prophylactic vaccination approaches are developed.”
About Immuno-STAT
Immuno-STAT™ biologics are designed for targeted modulation of disease-associated T cells in the areas of immuno-oncology and autoimmune disease. Each of our biologic drugs is designed using our proprietary scaffold comprising: 1) a peptide-MHC complex (pMHC) to provide selectivity through interaction with the T cell receptor (TCR), and 2) a unique co-stimulatory signaling molecule to modulate the activity of the target T cells.
The simultaneous engagement of co-regulatory molecules and pMHC binding mimics the signals delivered by antigen presenting cells (APCs) to T cells during a natural immune response. This design enables Immuno-STAT biologics to engage with the T cell population of interest, resulting in highly targeted T cell modulation. Because our drugs are delivered directly in the patient’s body (in vivo), they are fundamentally different from other T cell therapeutic approaches that require the patients’ T cells to be extracted, modified outside the body (ex vivo), and reinfused.
About Cue Biopharma
Cue Biopharma, a clinical-stage biopharmaceutical company, is engineering a novel class of injectable biologics to selectively engage and modulate targeted T cells within the body to transform the treatment of cancer, infectious diseases and autoimmune diseases. The company’s proprietary platform, Immuno-STAT™ (Selective Targeting and Alteration of T cells) is designed to harness the body’s intrinsic immune system without the need for ex vivo manipulation.
Headquartered in Cambridge, Massachusetts, we are led by an experienced management team and independent Board of Directors with deep expertise in the design and clinical development of protein biologics, immunology and immuno-oncology.
For more information, visit www.cuebiopharma.com and follow us on Twitter https://twitter.com/CueBiopharma.
Forward-Looking Statements
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Investor Contact
George B. Zavoico, Ph.D.
VP, Investor Relations & Corporate Development
Cue Biopharma, Inc.
gzavoico@cuebio.com
Media Contact
Alison Chen
LifeSci Communications
achen@lifescicomms.com
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