Welcome to our dedicated page for Corvus Pharmaceuticals news (Ticker: CRVS), a resource for investors and traders seeking the latest updates and insights on Corvus Pharmaceuticals stock.
Corvus Pharmaceuticals, Inc. (NASDAQ: CRVS) is a pioneering clinical-stage biopharmaceutical company focused on the development of novel immunotherapies to treat a broad spectrum of cancers and immune diseases. The company's core innovation is the selective inhibition of interleukin-2-inducible T cell kinase (ITK), which plays a crucial role in T cell and natural killer (NK) cell immune functions. Corvus' lead investigational product, soquelitinib (formerly CPI-818), has shown promise in optimizing T cell differentiation and enhancing immune responses against tumors, as well as in the management of autoimmune diseases.
Corvus is advancing soquelitinib through a Phase 3 registrational trial for relapsed peripheral T cell lymphoma (PTCL), an aggressive and typically treatment-resistant form of non-Hodgkin’s lymphoma. The company’s focus on ITK inhibition offers a new therapeutic approach, given the lack of FDA-approved treatments for relapsed PTCL. Soquelitinib has demonstrated the ability to prevent T cell exhaustion and promote the generation of cytotoxic killer T cells, critical in cancer therapy.
In addition, Corvus is investigating soquelitinib for other immune-mediated conditions, including atopic dermatitis. The company recently initiated a randomized, double-blind Phase 1 clinical trial to evaluate soquelitinib in patients with moderate to severe atopic dermatitis, aiming to provide an oral treatment alternative to current injectable biologics.
Other promising candidates in Corvus' pipeline include ciforadenant, an adenosine A2A receptor inhibitor that disables tumors' immune evasion mechanisms, and mupadolimab, a monoclonal antibody targeting CD73. These candidates are being studied for their efficacy in combination therapies for various cancers, including head and neck cancers and non-small cell lung cancer.
Financially, Corvus maintains a strong position, having raised significant capital through direct offerings to support its clinical trials and operational needs. With cash reserves projected to fund operations into late 2025, Corvus is well-positioned to achieve substantial milestones in its clinical programs. The company continues to foster critical partnerships, including collaborations with Angel Pharmaceuticals for the Chinese market.
Latest news highlights Corvus' progress in clinical trials and strategic financing moves, underscoring its commitment to bringing innovative immunotherapies to patients in need. For more information, visit the Corvus Pharmaceuticals website.
Corvus Pharmaceuticals (Nasdaq: CRVS) announced new preclinical data for its drug CPI-818 during the ongoing Phase 1/1b clinical trial aimed at treating refractory T cell lymphoma. The data, to be presented at the AACR Annual Meeting from April 14-19, 2023, showcases CPI-818's anti-tumor activity in murine models, including complete tumor elimination in combination with anti-PD1 and anti-CTLA4 therapies. The findings suggest a broad potential for CPI-818 in solid tumors and indicate favorable immune responses, highlighting its role in enhancing tumor immunotherapy.
Corvus Pharmaceuticals (NASDAQ: CRVS) announced new data at the 30th Annual Conference on Retroviruses and Opportunistic Infections, showing the potential of CPI-818, an ITK inhibitor, to reduce reliance on chronic HIV therapy. The study involved two models, revealing a statistically significant reduction in the reversal of viral latency (P<0.0001) when treated with CPI-818. This suggests that ITK inhibition may enable a 'block-and-lock' strategy to maintain viral suppression, potentially eliminating the need for lifelong antiretroviral therapy for people living with HIV. Further research will continue to develop novel HIV cure strategies.
Corvus Pharmaceuticals (CRVS) announced promising interim results from its Phase 1/1b trial of CPI-818, an ITK inhibitor targeting T cell lymphoma. The trial showed anti-tumor activity with 4 out of 11 evaluable patients achieving objective responses, including one complete response lasting 25 months. Corvus plans to initiate a Phase 2 trial in T cell lymphoma and a Phase 1 trial in atopic dermatitis in 2023. The data suggests CPI-818 effectively modulates T cell differentiation, indicating potential applications in autoimmune diseases as well.
Corvus Pharmaceuticals announced an investor conference call regarding CPI-818, an ITK inhibitor, on December 12, 2022, from 4:30 PM ET. The call will provide updates on data presented at the 64th ASH Annual Meeting and progress in the company's development programs. Highlights include results from the Phase 1/1b clinical trial targeting T-cell lymphomas and autoimmune diseases.
The ASH presentation will feature data on Th1 skewing in normal T cells, presented by Dr. Ryan Wilcox. Access details for the call and a 90-day webcast replay are available on the Corvus website.
On November 12, 2022, James T. Rosenbaum, MD, Senior VP of Research at Corvus Pharmaceuticals (Nasdaq: CRVS), received the Distinguished Service Award from the American College of Rheumatology (ACR), recognizing his contributions to rheumatology. Dr. Rosenbaum, who joined Corvus in July 2022, leads the development of CPI-818, an ITK inhibitor targeting immune disorders. Under his guidance, new clinical studies for CPI-818 are being prepared, with results from a Phase 1/1b trial to be shared at the upcoming ASH Annual Meeting from December 10-13, 2022.
Corvus Pharmaceuticals (CRVS) reported its Q3 2022 financial results and provided a business update, highlighting key milestones in drug development. The company focuses on CPI-818 for T cell lymphoma, with ongoing clinical trials showing promising patient responses and upcoming data to be presented at the ASH annual meeting. Additionally, a Phase 1b/2 trial for ciforadenant in renal cell cancer has commenced, and a Phase 1/1b trial for mupadolimab is approved in China. As of September 30, 2022, Corvus had cash reserves of $49.6 million, down from $69.5 million in 2021, with expected operational funding until early 2024.
Corvus Pharmaceuticals (NASDAQ: CRVS) will present new data from its Phase 1/1b trial of CPI-818, an ITK inhibitor, at the 64th American Society of Hematology Annual Meeting from December 10-13, 2022. The presentation will take place on December 12, 2022, at 6:00 PM ET, detailing CPI-818's effects on T-cell lymphoma and its potential in treating autoimmune diseases. Following the presentation, the company will host a conference call at 4:30 PM ET on the same day to discuss the findings. For further details, visit www.corvuspharma.com.
Corvus Pharmaceuticals (CRVS) will host a conference call and webcast on November 3, 2022, at 4:30 pm ET to report its third-quarter 2022 financial results and provide a business update. Interested participants can join the call by dialing specific numbers, and a replay will be available on the company's website for 90 days. Corvus focuses on developing innovative therapies, with its lead candidate CPI-818 undergoing clinical trials for T-cell lymphomas. Other programs include CPI-444 and CPI-006, targeting critical pathways in cancer treatment.
Corvus Pharmaceuticals (Nasdaq: CRVS) announced the launch of a Phase 1b/2 clinical trial for ciforadenant, aimed at treating metastatic renal cell cancer (RCC). The trial, conducted with the Kidney Cancer Research Consortium, will enroll up to 60 patients, evaluating ciforadenant combined with ipilimumab and nivolumab. The primary endpoints focus on safety and anti-tumor activity, with preliminary results expected early in the trial. The company highlights previous positive data on ciforadenant's efficacy, providing a strong rationale for this investigation.
Corvus Pharmaceuticals announced the approval of an IND application to initiate a Phase 1/1b clinical trial for mupadolimab in China, in partnership with Angel Pharmaceuticals. Mupadolimab targets CD73 to activate immune responses in patients with relapsed refractory non-small cell lung cancer (NSCLC) and head and neck squamous cell cancers (HNSCC). The trial aims to evaluate the drug’s safety, pharmacokinetics, and efficacy, with plans for a subsequent randomized Phase 2 trial in combination with pembrolizumab and chemotherapy.
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