Welcome to our dedicated page for Crispr Therapeut news (Ticker: CRSP), a resource for investors and traders seeking the latest updates and insights on Crispr Therapeut stock.
CRISPR Therapeutics (CRSP) is a clinical-stage biopharmaceutical leader pioneering CRISPR/Cas9 gene editing therapies for serious diseases. This page aggregates official announcements, clinical trial updates, and strategic developments directly from the company and verified sources.
Investors and researchers will find timely updates on therapeutic programs targeting hemoglobinopathies, oncology, and autoimmune disorders. Track regulatory milestones, partnership announcements with industry leaders, and financial performance reports. All content is curated to meet investor needs for decision-making clarity.
Key updates include progress in allogeneic CAR-T cell therapies, hemoglobinopathy treatment approvals, and manufacturing scale-up initiatives. Bookmark this page for structured access to CRISPR Therapeutics' latest scientific advancements and business developments.
CRISPR Therapeutics (Nasdaq: CRSP) announced a poster presentation on its investigational therapy CTX110® at the ASH 2022 Annual Meeting, scheduled for December 10-13, 2022. The poster will showcase preliminary results from the ongoing Phase 1 CARBON trial, which involves 32 patients with Large B-Cell Lymphoma (LBCL). Updates on the safety and efficacy of CTX110®, a gene-edited CAR-T therapy targeting CD19, will be highlighted. The study has received Regenerative Medicine Advanced Therapy designation from the FDA.
CRISPR Therapeutics (CRSP) reported its Q3 2022 financial results, highlighting a net loss of $174.5 million, an increase from $127.2 million in Q3 2021. Collaboration revenue fell to $0.1 million, down from $0.3 million the previous year. R&D expenses surged to $116.6 million, attributed to advancements in clinical programs. The company is advancing its gene-editing therapies, with multiple submissions expected for exa-cel, a therapy for sickle cell disease and beta thalassemia, with FDA review starting in November 2022.
CRISPR Therapeutics announced the resignation of its Chief Operating Officer, Lawrence Klein, effective year-end 2022, to pursue external opportunities. During his tenure, Klein significantly contributed to the company’s strategic direction and leadership. The company is currently searching for a successor while preparing for the regulatory filing of its lead program, exa-cel, with multiple other clinical programs also in progress. CEO Samarth Kulkarni expressed gratitude for Klein's contributions and highlighted the company's solid position for future success.
CRISPR Therapeutics (Nasdaq: CRSP) announced participation in the Society for Immunotherapy of Cancer's 37th Annual Meeting from November 8-12, 2022. Key presentations include:
- Oral Presentation: CTX130 allogeneic CRISPR-Cas9 CAR T cells in advanced clear cell renal cell carcinoma, scheduled for November 10 at 5:37 PM ET.
- Poster Presentation: CRISPR/Cas9 gene-edited anti-CD83 CAR-T cells in GvHD and AML models, on November 10 from 9:00 AM to 9:00 PM.
The company focuses on gene-based medicines for serious diseases using CRISPR/Cas9 technology.
CRISPR Therapeutics (Nasdaq: CRSP) announced participation in the BMO Biopharma Spotlight Series on October 6, 2022, at 9:00 a.m. ET. Members of its senior management team will share insights on gene editing and therapy. A live webcast will be accessible on the company's Investors page, and a replay will be available for 14 days post-event. CRISPR Therapeutics specializes in transformative gene-based medicines for serious diseases, utilizing its proprietary CRISPR/Cas9 technology across various therapeutic programs.
CRISPR Therapeutics (Nasdaq: CRSP) announced that the FDA granted Regenerative Medicine Advanced Therapy (RMAT) designation to its CTX130™ CAR T cell therapy for treating Mycosis Fungoides and Sézary Syndrome. This designation acknowledges the therapy's potential based on positive clinical data. RMAT designation can expedite development, providing intensive FDA guidance and opportunities for accelerated approval. CTX130, targeting CD70, is evaluated in ongoing trials for safety and efficacy in various malignancies, having also received Orphan Drug status.
Vertex Pharmaceuticals and CRISPR Therapeutics have announced a rolling review of exa-cel by the U.S. FDA for treating sickle cell disease (SCD) and transfusion-dependent beta thalassemia (TDT), with submission starting in November 2022 and completion expected by Q1 2023. Submissions to the EMA and MHRA are also on track for Q4 2022. Exa-cel received multiple designations, including Fast Track and Orphan Drug status. The therapy aims to edit patients' stem cells for improved disease outcomes.
CRISPR Therapeutics (Nasdaq: CRSP) announced its participation in two upcoming investor conferences in September 2022. The first event is the Citi 17th Annual BioPharma Conference on September 7 at 8:50 a.m. ET, followed by the Morgan Stanley 20th Annual Global Healthcare Conference on September 12 at 11:40 a.m. ET. Both presentations will be webcast live and archived for 14 days on the company's website. CRISPR Therapeutics focuses on gene-based medicines for serious diseases using its proprietary CRISPR/Cas9 gene editing technology.
CRISPR Therapeutics announced positive results from its Phase 1 COBALT™-LYM trial for CTX130, an allogeneic CAR-T cell therapy targeting CD70, focusing on treating peripheral T-cell lymphoma (PTCL) and cutaneous T-cell lymphoma (CTCL). At Dose Level 3 and above, the overall response rate was 70%, with a complete response rate of 30%. The safety profile was favorable, with no dose limiting toxicities reported. The trial involved 19 patients, demonstrating significant clinical benefits and responses across various disease compartments.
Vertex Pharmaceuticals and CRISPR Therapeutics unveiled promising new data on exa-cel for treating transfusion-dependent beta thalassemia and severe sickle cell disease. The study involved 75 patients, with up to 37.2 months of follow-up. Key findings include:
- 42 out of 44 patients with beta thalassemia were transfusion-free post-treatment.
- All 31 patients with sickle cell disease experienced cessation of vaso-occlusive crises.
The safety profile aligns with myeloablative conditioning and stem cell transplant protocols.
