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Caribou Biosciences, Inc. (CRBU) is a clinical-stage biotechnology company pioneering advancements in genome engineering. Leveraging revolutionary CRISPR-Cas9 technology, Caribou specializes in developing innovative cellular engineering solutions. Their technology, which pairs Cas9 with guide RNA to facilitate precise DNA modifications, is being harnessed for sophisticated gene knock-outs and knock-ins. Caribou's tools provide transformative capabilities across various sectors, including biological research, therapeutic development, agricultural biotechnology, and industrial biotechnology.
At the forefront of biopharmaceutical innovation, Caribou is dedicated to applying its proprietary CRISPR hybrid RNA-DNA (chRDNA) platform to create next-generation genome-edited cell therapies. Their pipeline includes allogeneic CAR-T and CAR-NK cell therapies, aimed at treating patients with hematologic malignancies and solid tumors.
Recent milestones include the FDA's feedback on a Phase 3 trial for CB-010, an allogeneic anti-CD19 CAR-T cell therapy targeting large B cell lymphoma (LBCL). The ongoing ANTLER Phase 1 trial has shown promising results, with CB-010 receiving Regenerative Medicine Advanced Therapy (RMAT), Fast Track, and Orphan Drug designations. Caribou is also expanding CB-010's potential application to lupus nephritis and extrarenal lupus, with a GALLOP Phase 1 trial planned for late 2024.
Financially, Caribou reported a net loss of $41.2 million for Q1 2024, with $345.9 million in cash, cash equivalents, and marketable securities, expected to fund operations into Q1 2026. Their strategic partnerships, including a collaboration with Pfizer, have bolstered their financial standing.
Caribou continues to push the boundaries of genome editing with its chRDNA technology, significantly improving the precision of genome edits. Their commitment to transforming patient lives through cutting-edge science positions them as a leader in the biotech landscape.
Caribou Biosciences, Inc. (Nasdaq: CRBU) announced that its trial-in-progress abstract for the ANTLER Phase 1 clinical trial of CB-010, targeting relapsed or refractory B cell non-Hodgkin lymphoma, has been accepted for a poster presentation at the 64th ASH Annual Meeting from December 10-13, 2022, in New Orleans.
The presentation, by Dr. Susan O’Brien, will detail the trial design and objectives. CB-010 is an allogeneic CAR-T cell therapy employing CRISPR technology. The poster will be accessible on the ASH website and Caribou's website following the presentation.
Caribou Biosciences has reported a 15-month complete response in the first patient treated with CB-010 for relapsed or refractory aggressive B cell non-Hodgkin lymphoma. This case, presented at the Lymphoma, Leukemia, & Myeloma Congress, shows promising results following a single dose of CB-010. The patient, previously heavily treated, achieved and maintained a complete response since 28 days post-treatment. Caribou is advancing the ANTLER Phase 1 trial, now enrolling patients at a higher dose level, aiming to enhance the therapy's efficacy.
Caribou Biosciences, a clinical-stage CRISPR genome-editing biopharmaceutical company, announced its participation in several upcoming investor conferences. Significant events include:
- Citi 17th Annual BioPharma Conference on September 8, 2022, at 11:20 am ET
- H.C. Wainwright 24th Annual Global Investment Conference on September 13, 2022, at 10:00 am ET
- Morgan Stanley 20th Annual Global Healthcare Conference on September 13, 2022, at 4:40 pm ET
- Jefferies Cell and Genetic Medicines Summit on September 29-30, 2022
Caribou Biosciences (CRBU) reported significant progress in its clinical pipeline and a strong financial position with $366.1 million in cash as of June 30, 2022. The company achieved a 100% complete response rate in its CB-010 ANTLER Phase 1 trial for relapsed or refractory B cell non-Hodgkin lymphoma. Plans include enrolling more patients and submitting IND applications for CB-011 and CB-012 in late 2022 and 2023, respectively. Revenue from licensing and collaborations increased significantly, but R&D and G&A expenses also rose, leading to a net loss of $26.7 million for Q2 2022.
Caribou Biosciences (CRBU) reported promising results from its ANTLER Phase 1 trial for CB-010, an allogeneic CAR-T cell therapy. A 100% complete response (CR) rate was observed in six patients following a single dose, with 40% maintaining CR at six months. The first patient treated remained in CR for 12 months. The trial is now enrolling at a higher dosage, reflecting an initial positive safety profile and clinical activity. Additional data is expected by year-end 2022, suggesting potential advancements in CRISPR-edited therapies.
Caribou Biosciences, Inc. (Nasdaq: CRBU) will present additional clinical data from its ANTLER Phase 1 trial of CB-010, a CRISPR-edited CAR-T cell therapy for relapsed/refractory B cell non-Hodgkin lymphoma, during a webcast on June 10, 2022. The presentation will feature longer duration data from six patients treated at dose level 1. The live webcast begins at 8:00 am ET, and the poster will be showcased at the European Hematology Association 2022 Congress in Vienna. CB-010 represents a novel approach with a PD-1 knockout design aimed at enhancing antitumor activity.
Caribou Biosciences (Nasdaq: CRBU) presented studies at the 25th Annual Meeting of the American Society for Gene and Cell Therapy (ASGCT) on May 16, 2022, showcasing the enhanced specificity of its CRISPR hybrid RNA-DNA (chRDNA) guides for genome editing. Dr. Steve Kanner highlighted that these guides improve the efficacy and persistence of allogeneic cell therapies by minimizing off-target activities. The optimized chRDNA guides demonstrate superior precision in editing primary human T cells, reinforcing their potential in therapeutic applications.
Caribou Biosciences (Nasdaq: CRBU) reported significant initial results from its ANTLER Phase 1 trial for CB-010, showing a 100% overall response rate (ORR) and 80% complete response rate (CR) in patients with relapsed or refractory B-cell non-Hodgkin lymphoma. The trial treated 5 evaluable patients, all responding positively. CB-010 is notable as the first allogeneic CAR-T cell therapy with a PD-1 knockout, enhancing potential treatment efficacy. Data will be shared at the upcoming European Hematology Association Congress, with ongoing enrollment at a higher dose level planned.
Caribou Biosciences has appointed David L. Johnson to its board of directors, enhancing its leadership as its pipeline of genome-edited cell therapies advances. With 30 years of experience, Johnson previously led global commercial efforts at Global Blood Therapeutics and held significant roles at Gilead Sciences. His expertise in building commercial infrastructure is expected to aid Caribou's progress, particularly in allogeneic cell therapies.
Caribou Biosciences (CRBU) reported financial results for Q1 2022, highlighting a cash position of $390.8 million. The company continues to advance its clinical pipeline with initial data from the ANTLER Phase 1 trial of CB-010 expected at the EHA 2022 Hybrid Congress. Plans include submitting an IND application for CB-011 in H2 2022 and ongoing research in allogeneic CAR-T and CAR-NK cell therapies. Revenues increased to $2.7 million, while R&D and G&A expenses rose significantly, contributing to a net loss of $19.1 million.
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