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About Caribou Biosciences, Inc.
Caribou Biosciences, Inc. (Nasdaq: CRBU) is a clinical-stage biopharmaceutical company at the forefront of CRISPR genome-editing technology, dedicated to developing transformative, off-the-shelf cell therapies for patients with hematologic malignancies and autoimmune diseases. Leveraging its proprietary CRISPR hybrid RNA-DNA (chRDNA) technology platform, Caribou addresses challenges in genome editing, such as off-target effects, enabling precise and efficient modifications for therapeutic applications.
Proprietary Technology Platform
Caribou's chRDNA platform represents a next-generation advancement in CRISPR technology, offering significantly improved specificity and precision compared to traditional all-RNA guides. This innovation allows the company to perform complex genome edits, including multiplex gene insertions and immune cloaking strategies, which are critical for the development of durable and effective allogeneic cell therapies. By overcoming limitations associated with earlier CRISPR systems, Caribou's platform enables the creation of therapies that are armored to enhance antitumor activity and reduce immune rejection.
Clinical Pipeline
Caribou is advancing a robust pipeline of clinical-stage allogeneic CAR-T cell therapies designed to provide readily available treatment options:
- CB-010: The lead product candidate, CB-010, is an anti-CD19 CAR-T cell therapy with a PD-1 knockout, engineered to improve efficacy by reducing premature CAR-T cell exhaustion. It is being evaluated in the ANTLER Phase 1 trial for relapsed or refractory B cell non-Hodgkin lymphoma (r/r B-NHL) and in the GALLOP Phase 1 trial for lupus nephritis (LN) and extrarenal lupus (ERL).
- CB-011: This anti-BCMA CAR-T cell therapy targets relapsed or refractory multiple myeloma (r/r MM). CB-011 incorporates immune cloaking strategies, including a B2M knockout and B2M–HLA-E fusion protein insertion, to blunt immune-mediated rejection, enhancing its antitumor activity.
- CB-012: An anti-CLL-1 CAR-T cell therapy, CB-012 is being developed for relapsed or refractory acute myeloid leukemia (r/r AML). It features five genome edits, combining checkpoint disruption and immune cloaking to improve therapeutic outcomes.
Each of these therapies is designed to address significant unmet medical needs, offering innovative solutions for patients who may not respond to existing treatments.
Market Position and Competitive Landscape
Operating within the highly competitive biotechnology sector, Caribou differentiates itself through its proprietary chRDNA platform and focus on allogeneic CAR-T cell therapies. Unlike autologous CAR-T therapies, which require patient-specific manufacturing, Caribou's off-the-shelf therapies offer broader accessibility and faster availability. The company has secured multiple FDA designations, including Regenerative Medicine Advanced Therapy (RMAT), Fast Track, and Orphan Drug designations, underscoring the potential of its pipeline to address critical medical needs.
Caribou's competitors include other genome-editing companies such as CRISPR Therapeutics and Editas Medicine. However, its unique approach to precision editing and immune cloaking positions it as a key player in the development of next-generation cell therapies.
Conclusion
Caribou Biosciences is redefining the landscape of genome-editing therapeutics with its innovative chRDNA platform and commitment to developing transformative therapies. With a strong clinical pipeline and a focus on addressing unmet medical needs, the company is poised to make a significant impact on the treatment of hematologic malignancies and autoimmune diseases.
Caribou Biosciences (Nasdaq: CRBU) announced that CEO Rachel Haurwitz will present at two investor conferences in March 2022. The first event is the Oppenheimer 32nd Annual Healthcare Conference on March 16 at 10:00 am ET. The second is the H.C. Wainwright Gene Therapy and Gene Editing Conference on March 30, with a presentation webcast starting at 7:00 am ET. Webcasts will be available on Caribou's website for 30 days post-event. The company focuses on CRISPR genome editing technology to develop precise therapies for serious diseases.
On February 7, 2022, Caribou Biosciences (Nasdaq:CRBU) announced that its CEO, Rachel Haurwitz, Ph.D., will participate in a fireside chat at the SVB Leerink 11th Annual Global Healthcare Conference on February 17 at 2:20 pm ET. A live webcast will be available on Caribou's website, with an archived version accessible for 30 days post-event.
Caribou specializes in CRISPR genome editing, utilizing advanced technologies, including chRDNAs, for precise gene modifications aimed at developing innovative therapies for serious diseases.
Caribou Biosciences has appointed Dr. Syed Rizvi as chief medical officer, a role aimed at steering its oncology cell therapy pipeline. Dr. Rizvi brings over 20 years of drug development experience, having previously led clinical strategy for CAR-T therapies like ABECMA and BREYANZI. The company plans to disclose initial data from its ANTLER Phase 1 clinical trial for product candidate CB-010 in 2022, file an IND application for CB-011, and select targets for its CAR-NK cell therapy, CB-020. Dr. Rizvi's leadership is anticipated to enhance Caribou’s development efforts.
Caribou Biosciences, Inc. (Nasdaq: CRBU) announced that Rachel Haurwitz, Ph.D., President and CEO, will present a corporate update at the 40th Annual J.P. Morgan Healthcare Conference on January 13, 2022, at 9:45 am ET. The presentation will be available via live webcast on Caribou's website, with an archived version accessible for 30 days post-event. Caribou is advancing its CRISPR genome-editing technology, focusing on developing next-generation CAR-T and CAR-NK cell therapies to treat severe diseases.
Caribou Biosciences (Nasdaq: CRBU) announced that CEO Rachel Haurwitz will attend investor conferences from November 30 to December 2, 2021. The events include the Piper Sandler 33rd Annual Virtual Healthcare Conference and the Evercore ISI 4th Annual HealthCONx Conference. A fireside chat at the latter is scheduled for December 2, from 4:20 to 4:40 PM ET. Webcasts will be available on Caribou's website for 30 days post-event. Caribou is focused on innovative CRISPR genome editing technologies, particularly using chRDNA for developing advanced therapies.
Caribou Biosciences reported promising advancements in its Q3 2021 financial results, with cash and equivalents of $435.3 million, bolstered by a successful IPO that raised $321.0 million. The company is progressing with its lead candidate, CB-010, in the ANTLER Phase 1 trial for non-Hodgkin lymphoma, aiming to share initial data in 2022. Caribou's proprietary chRDNA technology provides enhanced specificity for genome edits, crucial for developing CAR-T therapies. The firm also welcomed new board members and a chief business officer, enhancing its leadership team.
Caribou Biosciences (Nasdaq: CRBU) announced the appointment of Dara Richardson-Heron to its board and Ruhi Khan as chief business officer. Dr. Richardson-Heron brings over 25 years of healthcare experience, while Ms. Khan contributes 20 years of business development expertise. Both appointments are aimed at advancing Caribou’s allogeneic cell therapies, including the Phase 1 candidate CB-010. The company leverages its chRDNA genome-editing technology to develop CAR-T and CAR-NK therapies targeting hematologic malignancies and solid tumors.
Caribou Biosciences, a leading CRISPR genome-editing biopharmaceutical company, announced that its CEO, Rachel Haurwitz, will present at two upcoming investor conferences. The presentations are scheduled for the Jefferies Gene Therapy/Editing Summit on October 27 and the Barclays Gene Editing & Gene Therapy Summit on November 15. Live webcasts will be available on Caribou's website, with archived versions accessible for 30 days post-event. Caribou is focused on developing next-generation therapies using its proprietary chRDNA technology to enhance genome editing precision.
Caribou Biosciences (Nasdaq: CRBU) has appointed Ran Zheng to its board of directors, effective immediately. Zheng brings over 25 years of experience in the biotechnology industry, particularly in biologics drug development and gene therapy manufacturing. Her addition aims to enhance the company's capabilities as it advances its chRDNA-edited allogeneic CAR-T and CAR-NK cell therapies targeting hematologic malignancies and solid tumors. Zheng's prior roles include leadership positions at Landmark Bio and Orchard Therapeutics, contributing to significant advancements in gene therapy products.
Caribou Biosciences (CRBU), a CRISPR genome-editing biopharmaceutical company, announced that CEO Rachel Haurwitz will participate in a fireside chat on October 4, 2021, at the Chardan Virtual 5th Annual Genetic Medicines Conference. Haurwitz will also be part of a panel discussion titled "Gene Editing: Next-Generation Technologies Worth Watching" on October 5, 2021. The live webcast will be available on Caribou's website, with an archived version accessible for 30 days post-event.
Caribou aims to advance genome-edited therapies using its proprietary chRDNA technology.
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