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Caribou Biosciences, Inc. (CRBU) is a clinical-stage biotechnology company pioneering advancements in genome engineering. Leveraging revolutionary CRISPR-Cas9 technology, Caribou specializes in developing innovative cellular engineering solutions. Their technology, which pairs Cas9 with guide RNA to facilitate precise DNA modifications, is being harnessed for sophisticated gene knock-outs and knock-ins. Caribou's tools provide transformative capabilities across various sectors, including biological research, therapeutic development, agricultural biotechnology, and industrial biotechnology.
At the forefront of biopharmaceutical innovation, Caribou is dedicated to applying its proprietary CRISPR hybrid RNA-DNA (chRDNA) platform to create next-generation genome-edited cell therapies. Their pipeline includes allogeneic CAR-T and CAR-NK cell therapies, aimed at treating patients with hematologic malignancies and solid tumors.
Recent milestones include the FDA's feedback on a Phase 3 trial for CB-010, an allogeneic anti-CD19 CAR-T cell therapy targeting large B cell lymphoma (LBCL). The ongoing ANTLER Phase 1 trial has shown promising results, with CB-010 receiving Regenerative Medicine Advanced Therapy (RMAT), Fast Track, and Orphan Drug designations. Caribou is also expanding CB-010's potential application to lupus nephritis and extrarenal lupus, with a GALLOP Phase 1 trial planned for late 2024.
Financially, Caribou reported a net loss of $41.2 million for Q1 2024, with $345.9 million in cash, cash equivalents, and marketable securities, expected to fund operations into Q1 2026. Their strategic partnerships, including a collaboration with Pfizer, have bolstered their financial standing.
Caribou continues to push the boundaries of genome editing with its chRDNA technology, significantly improving the precision of genome edits. Their commitment to transforming patient lives through cutting-edge science positions them as a leader in the biotech landscape.
Caribou Biosciences (Nasdaq: CRBU) announced the appointment of Dara Richardson-Heron to its board and Ruhi Khan as chief business officer. Dr. Richardson-Heron brings over 25 years of healthcare experience, while Ms. Khan contributes 20 years of business development expertise. Both appointments are aimed at advancing Caribou’s allogeneic cell therapies, including the Phase 1 candidate CB-010. The company leverages its chRDNA genome-editing technology to develop CAR-T and CAR-NK therapies targeting hematologic malignancies and solid tumors.
Caribou Biosciences, a leading CRISPR genome-editing biopharmaceutical company, announced that its CEO, Rachel Haurwitz, will present at two upcoming investor conferences. The presentations are scheduled for the Jefferies Gene Therapy/Editing Summit on October 27 and the Barclays Gene Editing & Gene Therapy Summit on November 15. Live webcasts will be available on Caribou's website, with archived versions accessible for 30 days post-event. Caribou is focused on developing next-generation therapies using its proprietary chRDNA technology to enhance genome editing precision.
Caribou Biosciences (Nasdaq: CRBU) has appointed Ran Zheng to its board of directors, effective immediately. Zheng brings over 25 years of experience in the biotechnology industry, particularly in biologics drug development and gene therapy manufacturing. Her addition aims to enhance the company's capabilities as it advances its chRDNA-edited allogeneic CAR-T and CAR-NK cell therapies targeting hematologic malignancies and solid tumors. Zheng's prior roles include leadership positions at Landmark Bio and Orchard Therapeutics, contributing to significant advancements in gene therapy products.
Caribou Biosciences (CRBU), a CRISPR genome-editing biopharmaceutical company, announced that CEO Rachel Haurwitz will participate in a fireside chat on October 4, 2021, at the Chardan Virtual 5th Annual Genetic Medicines Conference. Haurwitz will also be part of a panel discussion titled "Gene Editing: Next-Generation Technologies Worth Watching" on October 5, 2021. The live webcast will be available on Caribou's website, with an archived version accessible for 30 days post-event.
Caribou aims to advance genome-edited therapies using its proprietary chRDNA technology.
Caribou Biosciences (Nasdaq:CRBU) has published data in Molecular Cell outlining its proprietary CRISPR hybrid RNA-DNA (chRDNA) technology, demonstrating enhanced genome editing specificity.
The study reveals that chRDNA guides outperform all-RNA guides in reducing off-target edits while achieving efficient genomic modifications, crucial for the development of CAR-T therapies targeting hematologic malignancies.
Initial clinical data from ongoing trials of their multiplex-edited candidate CB-010 is anticipated in 2022, signaling significant potential for therapeutic advancements.
Caribou Biosciences, Inc. (Nasdaq: CRBU) completed an upsized IPO, raising $349.6 million, alongside reporting Q2 2021 financial results. The company dosed its first patient in the ANTLER Phase 1 trial for CB-010 targeting relapsed B cell non-Hodgkin lymphoma. However, Caribou faced a substantial decrease in licensing revenue, down to $1.5 million from $8.5 million year-over-year. R&D expenses rose to $12.3 million, while G&A expenses increased to $5.1 million, contributing to a net loss of $14.3 million, a notable rise from the previous year's $1.9 million loss.
Caribou Biosciences, Inc. (Nasdaq: CRBU) announced that CEO Rachel Haurwitz, Ph.D., will join a panel at Citi’s 16th Annual BioPharma Virtual Conference on September 9, 2021, at 10:40 am ET. The panel, titled “Autologous, Allogeneic CAR-T, CAR-NK & More - Exploring the State of Play in Cell Therapy,” will focus on advances in cell therapies. A live and archived webcast will be available for 30 days on the company’s website. Caribou is committed to developing next-generation, genome-edited cell therapies using its proprietary technology.
Caribou Biosciences (Nasdaq: CRBU) has appointed Nancy Whiting, Pharm.D., to its board of directors. With over 17 years in biotechnology, Whiting has extensive experience in drug development, especially in oncology, which aligns with Caribou’s focus on advancing its cell therapy pipeline. Her previous role was as executive vice president at Seagen Inc., where she led late-stage clinical development. The company aims to leverage her expertise as it develops CRISPR-edited therapies for cancer treatment.
Caribou Biosciences, Inc. (Nasdaq: CRBU) has successfully closed its initial public offering of 19,000,000 shares at $16.00 each, raising approximately $304 million in gross proceeds. The offering includes a 30-day option for underwriters to purchase an additional 2,850,000 shares. Shares began trading on the Nasdaq on July 23, 2021. BofA Securities, Citigroup, and SVB Leerink acted as joint book-running managers. The registration statements were effective on July 22, 2021, allowing the offering to proceed under SEC regulations.
Caribou Biosciences priced its upsized initial public offering (IPO) of 19,000,000 shares at $16.00 each, aiming for gross proceeds of $304 million. The shares will trade on Nasdaq under the symbol CRBU, beginning July 23, 2021, with the offering expected to close around July 27, 2021. Underwriters have a 30-day option to purchase an additional 2,850,000 shares. BofA Securities, Citigroup, and SVB Leerink are serving as joint book-running managers for the offering.
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