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Cogent Biosciences, Inc. (NASDAQ: COGT) is a pioneering biotechnology company focused on developing precision therapies for genetically defined diseases. Headquartered in Waltham, MA, and Boulder, CO, Cogent's mission is to design rational, targeted therapies that treat the underlying causes of disease, thereby improving the lives of patients. The company's lead program, bezuclastinib, is a selective tyrosine kinase inhibitor designed to potently inhibit the KIT D816V mutation and other mutations in KIT exon 17. This mutation is a key driver of Systemic Mastocytosis (SM) and Advanced Gastrointestinal Stromal Tumors (GIST), both serious diseases dependent on oncogenic KIT signaling.
Bezuclastinib is undergoing rigorous clinical trials, with the PEAK, SUMMIT, and APEX trials all targeted toward specific genetic mutations associated with these diseases. The company has made significant strides in 2024, including the initiation of a new Phase 2 clinical trial of bezuclastinib in later line GIST patients in collaboration with the Sarcoma Alliance for Research through Collaboration (SARC), The Life Raft Group, and Dana-Farber Cancer Institute.
In addition to bezuclastinib, the Cogent Research Team is developing a portfolio of novel targeted therapies focused on mutations in FGFR2, ErbB2, and PI3Kα. These programs aim to create therapies with potential best-in-class properties, targeting rare and genetically driven diseases.
The company recently secured $225 million in a private investment led by prominent investors, ensuring a robust financial position that supports its ambitious research and development goals. Cogent's financial stability is further reinforced by a strong cash runway projected to extend into 2027, allowing the company to complete its ongoing and planned clinical trials.
Latest News:
- February 26, 2024: Cogent announces a successful $225 million funding round, enhancing its financial stability.
- February 22, 2024: Positive Part 1b data from the ongoing SUMMIT trial evaluating bezuclastinib in NonAdvSM patients.
- February 14, 2024: New Phase 2 clinical trial of bezuclastinib in later line GIST patients announced in collaboration with SARC.
- January 9, 2024: Key milestones for 2024 highlighted at J.P. Morgan’s 42nd Annual Healthcare Conference.
For more detailed and updated information, visit Cogent Biosciences' official website and follow them on social media platforms like X (formerly known as Twitter) and LinkedIn.
Cogent Biosciences, Inc. (Nasdaq: COGT) announced its financial results for Q1 2021, reporting R&D expenses of $8.2 million, down from $9.5 million in Q1 2020, attributed to a reduction in legacy trial activities. General and administrative expenses rose to $4.6 million from $3.7 million. The net loss widened to $11.7 million, compared to $6.1 million in the same period last year. The company has $230.7 million in cash, projected to support operations into 2024. Cogent also updated on its clinical trials and leadership additions, continuing its focus on precision therapies.
Cogent Biosciences (Nasdaq: COGT) appointed Evan Kearns as Chief Legal Officer on May 3, 2021. Kearns brings nearly 15 years of biopharmaceutical experience, previously serving at Agenus Inc. and Goodwin Procter LLP. He will oversee legal operations as the company prepares to initiate multiple clinical studies of CGT9486 this year, targeting genetically-driven diseases. Cogent is on track to commence three late-stage clinical trials in 2021, supported by a robust cash position, enabling the expansion of its research pipeline.
Cogent Biosciences (Nasdaq: COGT) announced the formation of the Cogent Research Team, spearheaded by new Chief Scientific Officer John Robinson, PhD. The team will focus on developing small molecule therapies for rare, genetically driven diseases. Robinson brings over 15 years of experience, having previously led teams at Pfizer and Array BioPharma. The company is set to initiate three late-stage clinical trials for its lead program, CGT9486, in 2021, supported by strong cash reserves into 2024.
Cogent Biosciences (Nasdaq: COGT) reported its financial results for Q4 2020, showing a net loss of $11.3 million, down from a net income of $2.3 million in Q4 2019. R&D expenses were $6.1 million for the quarter, while G&A expenses totaled $5.3 million. Despite these losses, Cogent had cash and equivalents of $242.2 million, sufficient to support operations through 2024. The company plans to initiate clinical trials for CGT9486 in systemic mastocytosis and GIST in 2021, supported by an upsized public offering that raised approximately $115 million.
Cogent Biosciences, Inc. (Nasdaq: COGT) announced the appointment of Todd E. Shegog to its Board of Directors, effective February 22, 2021. Shegog brings over 25 years of experience in finance and operations within the biotech sector, previously serving as CFO at Forma Therapeutics, Synlogic, and Millennium Pharmaceuticals. CEO Andrew Robbins expressed confidence in Shegog's ability to enhance the company’s financial strategies as it advances its lead program, CGT9486, into new clinical trials targeting systemic mastocytosis and GIST this year.
Cogent Biosciences will present at the 10th Annual SVB Leerlink Global Healthcare Conference on February 25, 2021, from 3:00-3:30 PM ET. CEO Andrew Robbins will lead the presentation. The event can be accessed via the investor relations section of their website, where a live webcast and archived recording will be available. Cogent specializes in developing precision therapies for genetically defined diseases, with its lead program, CGT9486, targeting the KIT D816V mutation related to systemic mastocytosis and gastrointestinal stromal tumors.
Cogent Biosciences (Nasdaq: COGT) announced that CEO Andrew Robbins will present a corporate overview at the LifeSci Partners Precision Oncology Day on February 17, 2021. The event will be held virtually, and a recording of the presentation will be accessible on Cogent's investor relations website after the event. The company focuses on developing precision therapies for genetically defined diseases, with its leading clinical program, CGT9486, addressing the KIT D816V mutation linked to systemic mastocytosis. For updates, follow Cogent on Twitter and LinkedIn.
Cogent Biosciences, Inc. (NASDAQ: COGT) has successfully closed an upsized public offering of 11,794,872 shares at $9.75 per share, raising approximately $108.1 million after costs. This includes the full exercise of the underwriters' option for an additional 1,538,461 shares. The proceeds are earmarked for the ongoing development and regulatory preparation of PLX9486, aimed at treating systemic mastocytosis and gastrointestinal stromal tumors (GIST). The offering was facilitated by Jefferies and Piper Sandler as joint book-running managers.
Cogent Biosciences, Inc. (Nasdaq: COGT) has announced the pricing of an underwritten public offering of 10,256,411 shares at $9.75 per share, up from an initial $60 million to approximately $100 million. The offering includes a 30-day option for underwriters to buy up to 1,538,461 additional shares. Proceeds will support development and regulatory activities for PLX9486 and other candidates, as well as general corporate purposes. The offering is expected to close around December 4, 2020.
Cogent Biosciences, a biotechnology company specializing in precision therapies for genetically defined diseases, has initiated a public offering of $60 million in common stock. Additionally, underwriters have a 30-day option to purchase up to $9 million more. The proceeds will support development and regulatory activities for PLX9486 and other candidates, along with general corporate expenses. Jefferies and Piper Sandler are leading the offering. The registration statement is effective, but these securities are not qualified under state laws.
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