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Cogent Biosciences, Inc. - COGT STOCK NEWS

Welcome to our dedicated page for Cogent Biosciences news (Ticker: COGT), a resource for investors and traders seeking the latest updates and insights on Cogent Biosciences stock.

Cogent Biosciences, Inc. (NASDAQ: COGT) is a pioneering biotechnology company focused on developing precision therapies for genetically defined diseases. Headquartered in Waltham, MA, and Boulder, CO, Cogent's mission is to design rational, targeted therapies that treat the underlying causes of disease, thereby improving the lives of patients. The company's lead program, bezuclastinib, is a selective tyrosine kinase inhibitor designed to potently inhibit the KIT D816V mutation and other mutations in KIT exon 17. This mutation is a key driver of Systemic Mastocytosis (SM) and Advanced Gastrointestinal Stromal Tumors (GIST), both serious diseases dependent on oncogenic KIT signaling.

Bezuclastinib is undergoing rigorous clinical trials, with the PEAK, SUMMIT, and APEX trials all targeted toward specific genetic mutations associated with these diseases. The company has made significant strides in 2024, including the initiation of a new Phase 2 clinical trial of bezuclastinib in later line GIST patients in collaboration with the Sarcoma Alliance for Research through Collaboration (SARC), The Life Raft Group, and Dana-Farber Cancer Institute.

In addition to bezuclastinib, the Cogent Research Team is developing a portfolio of novel targeted therapies focused on mutations in FGFR2, ErbB2, and PI3Kα. These programs aim to create therapies with potential best-in-class properties, targeting rare and genetically driven diseases.

The company recently secured $225 million in a private investment led by prominent investors, ensuring a robust financial position that supports its ambitious research and development goals. Cogent's financial stability is further reinforced by a strong cash runway projected to extend into 2027, allowing the company to complete its ongoing and planned clinical trials.

Latest News:

  • February 26, 2024: Cogent announces a successful $225 million funding round, enhancing its financial stability.
  • February 22, 2024: Positive Part 1b data from the ongoing SUMMIT trial evaluating bezuclastinib in NonAdvSM patients.
  • February 14, 2024: New Phase 2 clinical trial of bezuclastinib in later line GIST patients announced in collaboration with SARC.
  • January 9, 2024: Key milestones for 2024 highlighted at J.P. Morgan’s 42nd Annual Healthcare Conference.

For more detailed and updated information, visit Cogent Biosciences' official website and follow them on social media platforms like X (formerly known as Twitter) and LinkedIn.

Rhea-AI Summary
Cogent Biosciences, Inc. (Nasdaq: COGT) reported positive initial data from the ongoing Phase 2 SUMMIT trial evaluating bezuclastinib in patients with nonadvanced systemic mastocytosis (NonAdvSM) at the 65th American Society of Hematology (ASH 2023) Annual Meeting & Exposition. The trial demonstrated rapid and ongoing improvement in patient symptoms, with 57% median best improvement on MC-QoL and 78% of patients reporting ≥1 point improvement on PGIS by week 20. 100% of bezuclastinib treated patients achieved at least 50% improvement across all relevant biomarker measures, with a safety and tolerability profile supporting potential for chronic dosing. The company plans to advance into Part 2 of SUMMIT, a registration-directed, global, randomized placebo-controlled trial, and present additional data from SUMMIT in the first quarter of 2024.
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Cogent Biosciences, a biotechnology company (Nasdaq: COGT), presented updated preclinical data on its potent, selective, and brain-penetrant ErbB2 inhibitor program and initial preclinical data from its newly disclosed H1047R mutant-selective PI3Kα inhibitor discovery program at the 2023 San Antonio Breast Cancer Symposium.
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Cogent Biosciences, Inc. (Nasdaq: COGT) will review initial clinical data from SUMMIT Part 1a in patients with Nonadvanced Systemic Mastocytosis (NonAdvSM) and provide an additional clinical data update from APEX Part 1 in patients with Advanced Systemic Mastocytosis (AdvSM). The investor webcast will be held on Monday, December 11, 2023, at 8:00 a.m. ET. The SUMMIT data will be presented at the American Society of Hematology (ASH) Annual Meeting on December 9, 2023, and the APEX data will be presented in a poster session on December 11, 2023. The webcast will feature presentations by Cogent's President and CEO, Andrew Robbins, as well as leading medical professionals. The live webcast and replay will be accessible on Cogent's website at investors.cogentbio.com/events.
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Cogent Biosciences, Inc. (Nasdaq: COGT) announced two poster presentations at the 2023 San Antonio Breast Cancer Symposium, showcasing their precision therapies for genetically defined diseases. The posters will feature a brain penetrant, EGFR sparing, ErbB2 inhibitor and a wild-type-sparing, PI3Kα H1047R mutant-selective inhibitor.
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Cogent Biosciences, Inc. reported recent business highlights and financial results for Q3 2023. They completed enrollment for SUMMIT Part 1 and expect to begin SUMMIT Part 2 in 1H 2024. Updated PEAK lead-in data showed a 33% ORR and over 14 months median duration of treatment for 2nd-line GIST patients. The company ended Q3 with $312.8 million cash, providing runway into 2026.
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Cogent Biosciences, Inc. reported financial results for Q2 2023, ending with $350.9 million in cash. Positive data from Phase 3 PEAK trial on bezuclastinib and sunitinib combination in GIST patients. Selective FGFR2 inhibitor nominated as first clinical candidate. Preclinical data on ErbB2 inhibitor presented. Completed public offering with net proceeds of approximately $161.8 million. Upcoming milestones include presenting clinical data from SUMMIT and APEX trials in 2H 2023.
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FAQ

What is the current stock price of Cogent Biosciences (COGT)?

The current stock price of Cogent Biosciences (COGT) is $7.84 as of December 20, 2024.

What is the market cap of Cogent Biosciences (COGT)?

The market cap of Cogent Biosciences (COGT) is approximately 879.3M.

What does Cogent Biosciences, Inc. specialize in?

Cogent Biosciences specializes in developing precision therapies for genetically defined diseases, focusing on targeted treatments that address the underlying causes of these conditions.

What is the main clinical program of Cogent Biosciences?

The main clinical program of Cogent Biosciences is bezuclastinib, a selective tyrosine kinase inhibitor designed to inhibit KIT D816V and other mutations in KIT exon 17, crucial for treating Systemic Mastocytosis (SM) and Advanced Gastrointestinal Stromal Tumors (GIST).

Where is Cogent Biosciences headquartered?

Cogent Biosciences is headquartered in Waltham, Massachusetts, and Boulder, Colorado.

What recent achievements has Cogent Biosciences accomplished?

Recent achievements include securing $225 million in funding, announcing positive Part 1b data from the SUMMIT trial, and initiating a new Phase 2 clinical trial for bezuclastinib in collaboration with SARC.

What are the financial prospects of Cogent Biosciences?

Cogent Biosciences is financially stable, with a strong cash runway extending into 2027, supported by recent funding and strategic financial management.

What other programs is Cogent developing besides bezuclastinib?

Besides bezuclastinib, Cogent is developing novel targeted therapies focused on mutations in FGFR2, ErbB2, and PI3Kα, aiming to create best-in-class treatments for genetically driven diseases.

How can I stay updated with Cogent Biosciences' latest news?

You can stay updated by visiting Cogent Biosciences' official website and following their social media pages on X (formerly known as Twitter) and LinkedIn for the latest news and updates.

What are Cogent Biosciences' key clinical trials?

Key clinical trials include the PEAK, SUMMIT, and APEX trials, all focused on evaluating the efficacy of bezuclastinib in treating diseases driven by KIT mutations.

Who are Cogent Biosciences' key collaborators?

Key collaborators include the Sarcoma Alliance for Research through Collaboration (SARC), The Life Raft Group, and Dana-Farber Cancer Institute.

How does bezuclastinib work?

Bezuclastinib is designed to potently inhibit the KIT D816V mutation and other mutations in KIT exon 17, which are responsible for driving diseases like Systemic Mastocytosis and Advanced Gastrointestinal Stromal Tumors.

Cogent Biosciences, Inc.

Nasdaq:COGT

COGT Rankings

COGT Stock Data

879.28M
109.39M
0.12%
111.16%
6.99%
Biotechnology
Pharmaceutical Preparations
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United States of America
WALTHAM