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Compass Therapeutics Inc - CMPX STOCK NEWS

Welcome to our dedicated page for Compass Therapeutics news (Ticker: CMPX), a resource for investors and traders seeking the latest updates and insights on Compass Therapeutics stock.

About Compass Therapeutics Inc.

Compass Therapeutics Inc. (Nasdaq: CMPX) is a clinical-stage oncology-focused biopharmaceutical company dedicated to developing innovative antibody-based therapeutics to treat a range of cancers and other human diseases. Headquartered in Boston, Massachusetts, Compass leverages cutting-edge science to address the intricate relationship between angiogenesis, the immune system, and tumor growth. The company’s mission is to deliver transformative therapies that target critical biological pathways, enabling more effective anti-tumor responses.

Core Focus and Proprietary Platforms

Compass Therapeutics is at the forefront of antibody discovery and development, with a focus on bispecific antibodies, monoclonal antibodies, and engineered protein constructs. The company’s proprietary platforms, including StitchMabs and common light chain technologies, empower researchers to empirically identify optimal drug combinations. This approach allows for rapid translation of preclinical insights into tailored therapeutics with monoclonal-like manufacturability, positioning Compass as a leader in the field of combinatorial immunotherapy.

Pipeline and Clinical Programs

Compass Therapeutics boasts a robust pipeline targeting multiple critical pathways involved in tumor progression and immune evasion:

  • Tovecimig (CTX-009): A bispecific antibody targeting DLL4 and VEGF-A, designed to inhibit angiogenesis and tumor vascularization. Currently in Phase 2/3 clinical trials for advanced biliary tract cancers (BTC) and being evaluated for additional indications like colorectal cancer (CRC).
  • CTX-471: A novel CD137 agonist antibody that activates immune effector cells within the tumor microenvironment. Early clinical results suggest potential efficacy in melanoma, small-cell lung cancer, and mesothelioma, with biomarker-driven Phase 2 trials planned.
  • CTX-8371: A next-generation bispecific checkpoint inhibitor targeting PD-1 and PD-L1, with a unique mechanism involving proteolytic cleavage of cell surface PD-1. This program is in Phase 1 trials for solid tumors.
  • CTX-10726: A newly announced PD-1 x VEGF-A bispecific antibody advancing through preclinical development, with an IND submission expected by year-end 2025.

These candidates reflect Compass’s commitment to addressing high unmet medical needs, particularly in patient populations resistant to existing therapies.

Scientific Excellence and Biomarker-Driven Strategy

Compass Therapeutics integrates biomarker-driven strategies into its clinical development programs. For example, the identification of NCAM (CD56) as a potential biomarker for CTX-471 highlights the company’s ability to leverage cutting-edge science to enhance patient selection and therapeutic efficacy. Similarly, the use of DLL4 as a biomarker in CRC studies underscores Compass’s precision medicine approach.

Collaborative and Industrialized Approach

The company’s “partnership-first” mentality enables it to collaborate with top-tier academic institutions and leverage best-in-class technologies. This decentralized validation model accelerates the transition from discovery to clinical development, ensuring that only the most promising therapeutic combinations advance to human trials.

Competitive Landscape and Market Position

Operating in the highly competitive field of oncology-focused biopharmaceuticals, Compass Therapeutics distinguishes itself through its emphasis on bispecific antibodies and its robust biomarker-driven approach. Competitors include established players like Genentech and Bristol Myers Squibb, but Compass’s focus on immune-oncology and angiogenesis modulation positions it uniquely within the market. The company’s ability to identify and exploit novel biological pathways gives it a competitive edge in addressing complex cancer mechanisms.

Challenges and Opportunities

While Compass Therapeutics faces challenges typical of clinical-stage biopharma companies—such as regulatory hurdles and the inherent risks of drug development—it is well-positioned to overcome these obstacles through its innovative platforms, strong clinical pipeline, and strategic collaborations. The growing emphasis on immuno-oncology and biomarker-driven therapies provides significant opportunities for the company to expand its impact and market presence.

Conclusion

Compass Therapeutics Inc. exemplifies innovation and scientific rigor in the biopharmaceutical industry. With a robust pipeline, proprietary technologies, and a focus on addressing unmet medical needs, the company is poised to make significant contributions to the field of oncology. By targeting critical pathways involved in tumor growth and immune modulation, Compass is advancing the next generation of cancer therapeutics, offering hope to patients worldwide.

Rhea-AI Summary

Compass Therapeutics, Inc. (Nasdaq: CMPX) announced the appointment of two new directors, Ellen Chiniara and Mary Ann Gray, to its board. Chiniara, former Chief Legal Officer of Alexion Pharmaceuticals, and Gray, President of Gray Strategic Advisors, bring extensive experience in the life sciences and biopharmaceutical sectors. This strategic move aims to enhance Compass's leadership at a critical time for the company. The board believes their skills will support Compass in advancing its clinical pipeline and driving shareholder value.

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Compass Therapeutics (CMPX), a clinical-stage oncology company, recently presented promising preclinical data for its bispecific checkpoint inhibitor, CTX-8371, at the AACR Annual Meeting. This innovative therapy targets both PD-1 and PD-L1, showcasing a unique mechanism of action that leads to PD-1 loss on T cells. Key findings indicate significant tumor volume reduction and complete tumor eradication in mouse models. Clinical development of CTX-8371 is projected to start in early 2023, marking a significant step forward in cancer therapeutics.

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Compass Therapeutics Inc. (Nasdaq: CMPX) announced its presentation of preclinical data on CTX-8371, a bispecific checkpoint inhibitor targeting PD-1 and PD-L1, at the AACR Annual Meeting from April 8-13, 2022. The study, led by Diana Albu, Ph.D., will showcase the antibody's potential to enhance anti-tumor activity in solid tumors by converting PD-1-positive cells to PD-1-negative cells. As part of IND-enabling preclinical development, CTX-8371 shows promise over existing monoclonal antibodies, indicating its unique mechanism could mitigate immune suppression effectively.

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Compass Therapeutics reported a strong financial position with $144.5 million in cash as of 2021, bolstered by a $136 million public offering. The company is advancing its clinical pipeline, particularly the CTX-009 study for advanced biliary tract cancers, which met response criteria for progression to Phase 2. Additionally, CTX-471 showed encouraging results in patients with solid tumors. However, the company faced a net loss of $82.2 million for 2021, with R&D expenses rising significantly to $20.3 million, marking a 36% increase from 2020. The company expects to sustain operations into late 2024.

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Compass Therapeutics, Inc. (Nasdaq: CMPX) announced the FDA has cleared its IND application for CTX-009, enabling a global Phase 2 trial for Biliary Tract Cancers (BTC) in the U.S. and South Korea. CTX-009 is a bispecific antibody targeting DLL4 and VEGF-A, showing clinical benefit in heavily pre-treated patients. The ongoing Phase 2 study in South Korea has completed Stage 1, achieving a 29% overall response rate and a 100% clinical benefit rate. Expansion to U.S. sites is planned for Q2 2022, presenting potential growth opportunities for the company.

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Compass Therapeutics, Inc. (Nasdaq: CMPX) announced that CEO Thomas Schuetz will present at the 40th Annual J.P. Morgan Healthcare Conference on January 12, 2022, from 8:15 to 8:55 a.m. ET. The presentation will be virtual, with details to be updated on the company's investor webpage. Compass Therapeutics focuses on antibody-based therapeutics for cancer treatment, exploring the interplay between angiogenesis, the immune system, and tumor growth. Established in 2014 and based in Boston, Massachusetts, the company aims to advance its innovative pipeline through clinical development.

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Compass Therapeutics, Inc. (Nasdaq: CMPX) announced that CEO Thomas J. Schuetz, MD, PhD, will present at the Piper Sandler 33rd Annual Healthcare Conference held virtually from November 29 to December 2, 2021. The presentation will be available on-demand from November 22 to December 2, 2021. Compass Therapeutics focuses on developing proprietary antibody-based therapeutics targeting cancer through modulating immune responses and angiogenesis. Founded in 2014 and based in Boston, Massachusetts, the company aims to advance its clinical pipeline.

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Compass Therapeutics reported progress in its clinical studies and financial results for Q3 2021. The company advanced CTX-009 to the second stage of a Phase 2a study, with a 29% overall response rate observed in 17 patients. CTX-471 demonstrated two partial responses in melanoma patients. The recent public offering raised $125 million, extending its cash runway into Q4 2024. R&D expenses decreased to $3.2 million, and general and administrative expenses dropped to $2.7 million. The net loss was $6 million, or $0.10 per share, an improvement from the previous year.

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Compass Therapeutics, Inc. announced a public offering of 35,715,000 shares at $3.50 each, expected to raise approximately $125 million. The offering will close on November 4, 2021, and includes an option for underwriters to purchase an additional 5,357,250 shares. This follows the company's listing on the Nasdaq Capital Market under the symbol CMPX, effective November 2, 2021. Proceeds will fund ongoing clinical trials and operations. SVB Leerink is the book-running manager for the offering.

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Compass Therapeutics, Inc. announces an underwritten public offering of shares of common stock, intending to secure its listing on the Nasdaq Capital Market under the symbol CMPX. The company expects to grant underwriters a 30-day option to purchase an additional 15% of the shares. Proceeds from the offering will fund clinical trials for ongoing operations and general corporate purposes. Offering details are based on a previously effective shelf registration statement. SVB Leerink is the book-running manager.

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FAQ

What is the current stock price of Compass Therapeutics (CMPX)?

The current stock price of Compass Therapeutics (CMPX) is $1.46 as of April 4, 2025.

What is the market cap of Compass Therapeutics (CMPX)?

The market cap of Compass Therapeutics (CMPX) is approximately 208.8M.

What does Compass Therapeutics Inc. specialize in?

Compass Therapeutics focuses on developing antibody-based therapeutics to target cancer and immune pathways, leveraging proprietary platforms like StitchMabs.

What are Compass Therapeutics’ key pipeline products?

Key products include Tovecimig (CTX-009), CTX-471, CTX-8371, and CTX-10726, targeting pathways like DLL4, VEGF-A, PD-1, PD-L1, and CD137.

How does Compass Therapeutics differentiate itself in the oncology market?

Compass stands out with its focus on bispecific antibodies, biomarker-driven strategies, and its proprietary platforms for rapid therapeutic development.

What is the significance of biomarkers in Compass’s clinical programs?

Biomarkers like NCAM and DLL4 guide patient selection and enhance therapeutic efficacy, ensuring precision in clinical development.

What challenges does Compass Therapeutics face?

Challenges include regulatory hurdles, clinical trial risks, and competition in the oncology-focused biopharma sector.

What is the company’s approach to collaboration?

Compass adopts a partnership-first mentality, working with top-tier academic institutions and leveraging best-in-class technologies.

What are the clinical applications of Tovecimig (CTX-009)?

Tovecimig is being developed for advanced biliary tract cancers and colorectal cancer, targeting DLL4 and VEGF-A pathways.

What is CTX-471, and how does it work?

CTX-471 is a CD137 agonist antibody that activates immune effector cells in the tumor microenvironment, showing promise in melanoma and other cancers.
Compass Therapeutics Inc

Nasdaq:CMPX

CMPX Rankings

CMPX Stock Data

208.81M
89.46M
18.08%
70.94%
2.67%
Biotechnology
Biological Products, (no Disgnostic Substances)
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United States
BOSTON