Clene Presents Preliminary Data for CNM-Au8® as a Potential Treatment for Rett Syndrome
Clene presented preliminary data on June 19, 2024, at the International Rett Syndrome Foundation Annual Meeting, showcasing CNM-Au8® as a potential treatment for Rett Syndrome. This rare pediatric neurological disease, primarily affecting females, results in severe developmental impairments. CNM-Au8 demonstrated significant neuroprotective effects and mitochondrial function improvements in in vitro models. Clene aims to extend CNM-Au8’s applications beyond ALS and MS, leveraging its catalytic ability to enhance neuronal survival and remyelination. The study, in collaboration with Dr. Kathrin Meyer and researchers, highlights CNM-Au8's promise in treating multiple nervous system disorders.
- CNM-Au8 demonstrated significant neuroprotective effects (p<0.01) in an in vitro model of Rett Syndrome.
- CNM-Au8 showed significant improvements in neuron survival (p<0.0001) and neurite lengths (p<0.05).
- Statistically significant mitochondrial respiration improvements observed in patient-derived astrocytes with CNM-Au8 treatment.
- Potential for CNM-Au8 to treat multiple nervous system disorders beyond ALS and MS.
- Preliminary data only, with no clinical trials or FDA approval for Rett Syndrome treatment yet.
- Partial mitochondrial respiration improvements observed in one Rett line, indicating varied responses.
The preliminary data on CNM-Au8 for Rett Syndrome showcases promising neuroprotective effects and improvements in mitochondrial function. These findings suggest potential benefits for patients suffering from this severe neurodevelopmental disorder, which currently has limited treatment options. The emphasis on mitochondrial health is particularly noteworthy, given its central role in cellular energy metabolism and neuronal survival.
In vitro models that demonstrate increased neuronal health and survival provide an encouraging foundation for future clinical trials. However, it's essential to recognize that in vitro results don't always translate to clinical efficacy. The differentiation between full and partial mitochondrial rescue across different Rett patient-derived astrocytes also indicates potential variability in patient response, warranting further investigation.
Overall, these results position Clene's CNM-Au8 as a potential multifaceted therapeutic option not only for Rett Syndrome but also for other neurological conditions marked by mitochondrial dysfunction. If future studies confirm these preliminary results, CNM-Au8 could become a significant addition to the treatment landscape for neurodevelopmental disorders.
From a market perspective, Clene's exploration into Rett Syndrome with CNM-Au8 represents a strategic extension of its existing focus on neurological diseases like ALS and MS. Rett Syndrome, although rare, represents a high unmet medical need. The fact that CNM-Au8 addresses mitochondrial dysfunction—a common thread in several neurological disorders—could broaden the drug's applicability and market potential.
Investors should note the potential for diversification of Clene's therapeutic portfolio. A successful expansion into Rett Syndrome could not only provide new revenue streams but also enhance the company's valuation by showcasing the versatility of its nanotherapeutic platform. However, it's important to exercise caution since these findings are still preliminary and based on in vitro data.
In the short term, continued positive updates and advancements into clinical trials could drive stock price appreciation. In the long term, the commercial viability of CNM-Au8 for Rett Syndrome and other neurological conditions will depend heavily on successful clinical outcomes and regulatory approvals.
- CNM-Au8 demonstrated neuroprotective effects in an in vitro model of Rett Syndrome, a rare pediatric neurodevelopmental disease
- CNM-Au8 also demonstrated rescue of mitochondrial deficits in induced astrocytes derived from Rett patients
- Invited oral presentation and poster presented on June 19, 2024, at the International Rett Syndrome Foundation 2024 Annual Meeting in Westminster, Colorado
SALT LAKE CITY, June 21, 2024 (GLOBE NEWSWIRE) -- Clene Inc. (Nasdaq: CLNN) (along with its subsidiaries, “Clene”) and its wholly-owned subsidiary Clene Nanomedicine Inc., a clinical-stage biopharmaceutical company focused on improving mitochondrial health and protecting neuronal function to treat neurological diseases, including amyotrophic lateral sclerosis (ALS) and multiple sclerosis (MS), today announced it presented new, preliminary data demonstrating the potential of CNM-Au8 as a treatment for Rett Syndrome. Karen Ho, Ph.D., Clene’s vice president of translational medicine, unveiled the data in oral and poster presentations on June 19th at the International Rett Syndrome Foundation 2024 Annual Meeting in Westminster, Colorado. The presentation was titled, “CNM-Au8, a Candidate First-in-Class Nanotherapeutic for Treatment of Rett Syndrome.”
Rett Syndrome is a severe, rare pediatric neurologic disorder caused by mutations in the X chromosome-linked gene, methyl-CpG binding protein 2 (MECP2). The disorder primarily affects females, with an incidence of ~1:10,000 live female births. Children with mutations in MECP2 develop normally until about 6 months of age, after which they exhibit a regression in acquired skills and begin to display a wide range of neurological and developmental impairments that include hand-wringing with loss of purposeful hand movement, abnormal gait, respiratory dysregulation, autism spectrum features, motor dysfunction, loss of verbal communication skills, seizures, and Parkinson-like features. Microcephaly and white matter (myelin) loss are pathological features of the Rett brain. There is currently only one approved drug for the treatment of Rett Syndrome, trofinetide, which was approved by the U.S. Food and Drug Administration in 2023.
CNM-Au8 is an orally administered, catalytic nanotherapeutic that targets energy metabolism via mitochondria in nervous system cells, including neurons and oligodendrocytes, to enhance neuronal survival and function as well as to support remyelination. To date, Clene has focused on the development of CNM-Au8 for the treatment of ALS and MS.
The novel mechanism of CNM-Au8, with its catalytic ability to bolster mitochondrial function to aid in the survival and function of neurons, as well as the remyelinating properties of CNM-Au8, led Clene to also consider Rett Syndrome as a possible indication for treatment by CNM-Au8.
The project was conducted in collaboration with Dr. Kathrin Meyer, formerly of Nationwide Children’s Hospital in Columbus, Ohio, now Chief Scientific Officer of Alcyone Therapeutics, and her former postdoctoral researchers, Drs. Meysam Ganjibakhsh and Andrea Sierra Delgado. Dr. Delgado was former Chief Research Associate in the Meyer lab and is now Research Assistant Professor at the University of Missouri. The study’s main preliminary findings are:
- Statistically significant improvement in neuronal health (p<0.01), neuron survival (p<0.0001), and neurite lengths (p<0.05) in an in vitro model of Rett Syndrome, and;
- Improvements in the mitochondrial respiration deficits associated with Rett patient-derived astrocytes with CNM-Au8 treatment in vitro, with full rescue (p<0.0001) of both basal and ATP-linked respiration observed in one Rett line, and partial rescue observed in a second Rett line (ns change in basal respiration; p<0.001 improvement in ATP-linked respiration) at one concentration of CNM-Au8 treatment for 24 hours. All statistical analyses were done using one-way ANOVA, and all conditions were performed with a minimum of three replicates.
“Rett Syndrome has a disease mechanism that shares some common features with both ALS and MS,” said Dr. Ho. “Dysfunctional energy metabolism, glutamate excitotoxicity, demyelination, and mitochondrial dysfunction are all hallmarks of challenges faced by the nervous system in all three of these diseases. These preliminary data suggest that CNM-Au8 may treat Rett syndrome by potential rescue of mitochondrial dysfunction, thereby promoting neuronal health, survival, and synaptic structure. If CNM-Au8 proves to be a successful treatment for Rett syndrome, this will add further affirmation to Clene’s central thesis: that CNM-Au8—with its versatile and unique catalytic mechanism—holds promise as a potential treatment for multiple diseases of the nervous system, beyond its current targets of ALS and MS. It’s a truly rewarding time to participate in the development of CNM-Au8, which has strong potential to make a difference to the millions of people living with difficult-to-treat neurologic diseases.”
Support for the study from the Baby Eleanor Foundation, and the donation of Rett and healthy control cells from anonymous individuals, were gratefully acknowledged by the study team.
About Clene
Clene Inc., (Nasdaq: CLNN) (along with its subsidiaries, “Clene”) and its wholly owned subsidiary Clene Nanomedicine Inc., is a late clinical-stage biopharmaceutical company focused on improving mitochondrial health and protecting neuronal function to treat neurodegenerative diseases, including amyotrophic lateral sclerosis, Parkinson’s disease, and multiple sclerosis. CNM-Au8® is an investigational first-in-class therapy that improves central nervous system cells’ survival and function via a mechanism that targets mitochondrial function and the NAD pathway while reducing oxidative stress. CNM-Au8® is a federally registered trademark of Clene Nanomedicine, Inc. The company is based in Salt Lake City, Utah, with R&D and manufacturing operations in Maryland. For more information, please visit www.clene.com or follow us on X (formerly Twitter) and LinkedIn.
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