Compugen To Present Clinical Data from anti-TIGIT COM902 Monotherapy and Triple Combination Dose Escalation Studies at SITC 2021

Rhea-AI Summary

Compugen Ltd. (NASDAQ: CGEN) announced the presentation of new clinical and preclinical data at the 36th Annual Meeting of the Society for Immunotherapy of Cancer, scheduled for November 10-14, 2021. Key presentations include the evaluation of COM902, an anti-TIGIT antibody, in patients with advanced solid tumors, and the results of COM701 in combination with other therapies. Both studies emphasize safety, tolerability, and pharmacokinetics. Compugen continues to advance its lead product candidates in cancer immunotherapy, as they navigate through Phase 1 studies.

Positive

• Presentation of new clinical data at a prestigious conference enhances visibility.
• COM701 and COM902 are both undergoing key Phase 1 studies.
• Potentially strong partnerships with Bayer and AstraZeneca for drug development.

Negative

• None.

HOLON, Israel, Oct. 1, 2021 /PRNewswire/ -- Compugen Ltd. (NASDAQ: CGEN), a clinical-stage cancer immunotherapy company and a leader in predictive target discovery, today announced that new clinical and preclinical data will be presented at the 36^th Annual Meeting of the Society for Immunotherapy of Cancer, which will be held on November 10-14, 2021.

Poster Presentation Details:

Title: COM902 (anti-TIGIT antibody) monotherapy – preliminary evaluation of safety, tolerability, pharmacokinetics, and receptor occupancy in patients with advanced solid tumors (NCT04354246).
Abstract Number: 477
Lead Author: Dumbrava, E, E 
Date: Friday, November 12, 2021

Title: COM701 in combination with BMS-986207 (anti-TIGIT antibody) and nivolumab - preliminary results of safety, tolerability, and pharmacokinetics in patients with advanced solid tumors (NCT04570839). 
Abstract Number: 478
Lead Author: Dumbrava, E, E
Date: Saturday, November 13, 2021

Title: Novel DNAM-1 axis member, PVRIG, is potentially a dominant checkpoint involved in stem-like memory T cells – dendritic cell interaction.
Abstract Number: 252 
Lead Author: Alteber, Z
Date: Saturday, November 13, 2021

About Compugen  

Compugen is a clinical-stage discovery and development company utilizing its broadly applicable, predictive computational discovery platforms to identify novel drug targets and develop therapeutics in the field of cancer immunotherapy. Compugen's lead product candidate, COM701, a first-in-class anti-PVRIG antibody, for the treatment of solid tumors, is undergoing Phase 1 studies as a single agent and in dual, and triple combinations.  COM902, Compugen's second fully owned clinical antibody targeting TIGIT, for the treatment of solid and hematological tumors, is undergoing Phase 1 studies as a single agent and in dual combination. Partnered programs include bapotulimab, a first-in-class therapeutic antibody in Phase 1 development targeting ILDR2 licensed to Bayer under a research and discovery collaboration and license agreement, and AZD2936, a TIGIT/PD-1 bispecific entering Phase 1 development derived from COM902 through a license agreement with AstraZeneca for the development of bispecific and multi-specific antibodies. Compugen's therapeutic pipeline also includes early-stage immuno-oncology programs focused largely on myeloid targets. Compugen is headquartered in Israel, with offices in South San Francisco, CA. Compugen's shares are listed on Nasdaq and the Tel Aviv Stock Exchange under the ticker symbol CGEN. For additional information, please visit Compugen's corporate website at www.cgen.com. 

Company contact:

Yvonne Naughton, PhD  
Head of Investor Relations and Corporate Communications
Email: ir@cgen.com  
Tel: +1 (628) 241-0071  

Investor Relations contact:

John Mullaly
LifeSci Advisors, LLC
Email: jmullaly@lifesciadvisors.com  
Tel: +1 (617) 429-3548

 

View original content:https://www.prnewswire.com/news-releases/compugen-to-present-clinical-data-from-anti-tigit-com902-monotherapy-and-triple-combination-dose-escalation-studies-at-sitc-2021-301389580.html

SOURCE Compugen Ltd.

FAQ

What is the purpose of the COM902 study presented by CGEN?

The COM902 study evaluates the safety, tolerability, pharmacokinetics, and receptor occupancy in patients with advanced solid tumors.

When will CGEN present its clinical data?

Compugen will present its clinical data at the Society for Immunotherapy of Cancer from November 10-14, 2021.

What are the primary focuses of the clinical studies presented by CGEN?

The studies focus on the safety, tolerability, and pharmacokinetics of COM902 and COM701 in patients with advanced solid tumors.

What is the significance of the data presented by CGEN for investors?

The presentation of clinical data at a major conference may indicate progress in Compugen's pipeline and could impact investor sentiment positively.

What are the lead product candidates of CGEN?

CGEN's lead product candidates include COM701, a first-in-class anti-PVRIG antibody, and COM902, targeting TIGIT.