Welcome to our dedicated page for C4 Therapeutics news (Ticker: CCCC), a resource for investors and traders seeking the latest updates and insights on C4 Therapeutics stock.
C4 Therapeutics, Inc. (NASDAQ: CCCC) is a clinical-stage biopharmaceutical company pioneering targeted protein degradation therapies for cancer and other challenging diseases. This news hub provides investors and industry professionals with timely updates on the company's scientific advancements, regulatory milestones, and strategic initiatives.
Access official press releases, clinical trial progress reports, and partnership announcements in one centralized location. Our curated collection includes updates on key pipeline assets like cemsidomide and CFT1946, collaboration developments with Biogen and Merck, and financial disclosures essential for informed decision-making.
Discover comprehensive coverage of C4 Therapeutics' innovative TORPEDO® platform advancements, protein degrader research breakthroughs, and participation in major medical conferences. All content is sourced directly from company filings and verified industry publications to ensure accuracy.
Bookmark this page to stay informed about CCCC's progress in developing novel therapies that address drug resistance and undruggable targets through targeted protein degradation science. Check regularly for new developments in this cutting-edge area of biopharmaceutical research.
C4 Therapeutics, Inc. (Nasdaq: CCCC) announced that the FDA granted orphan drug designation to its drug CFT7455 for treating multiple myeloma. This designation supports clinical development and provides potential market exclusivity in the U.S. Moreover, CFT7455 is designed to selectively target disease-causing proteins, with an ongoing Phase 1/2 trial aimed at evaluating its safety and anti-tumor activity, intending to enroll approximately 160 patients. C4 Therapeutics aims to improve outcomes for multiple myeloma patients who currently face limited treatment options.
C4 Therapeutics (Nasdaq: CCCC) announced the closing of an underwritten public offering of 4,887,500 shares at $37.00 per share, raising about $180.8 million in gross proceeds. This includes the full exercise of the underwriters' option for an additional 637,500 shares. The offering was managed by J.P. Morgan, Jefferies, Evercore ISI, BMO Capital Markets, and UBS Investment Bank. The funds will be directed towards advancing the company’s innovative small-molecule medicines aimed at degrading disease-causing proteins, a strategy that could potentially enhance cancer treatments.
C4 Therapeutics (Nasdaq: CCCC) presented promising pre-clinical data for its lead compound, CFT7455, at the ICML conference. This orally bioavailable MonoDAC™ demonstrated high binding affinity to cereblon and effective IKZF1/3 degradation in non-Hodgkin’s lymphoma (NHL) models. CFT7455 showed superior efficacy in xenograft models compared to approved therapies, including significant tumor regressions in various NHL subtypes. The Phase 1/2 trial, initiated in June 2021, aims to further assess CFT7455’s potential against multiple myeloma and NHLs, with top-line results expected in 2022.
C4 Therapeutics, Inc. (Nasdaq: CCCC) has announced the pricing of a public offering of 4.25 million shares of common stock at $37.00 each. The offering, expected to yield approximately $157 million in gross proceeds, is set to close around June 21, 2021, pending customary conditions. An option for underwriters to purchase an additional 637,500 shares is included. J.P. Morgan, Jefferies, and other banks are managing the offering. C4T focuses on targeted protein degradation therapies for cancer and other diseases.
C4 Therapeutics, Inc. (Nasdaq: CCCC) announced a proposed public offering of 4,250,000 shares of its common stock, with an option for underwriters to purchase an additional 637,500 shares. The net proceeds will support the company's research and clinical development activities. The offering is dependent on market conditions and has yet to be finalized. Lead managers include J.P. Morgan, Jefferies, Evercore ISI, BMO Capital Markets, and UBS Investment Bank. The registration statement has been filed with the SEC but is not yet effective.
C4 Therapeutics (Nasdaq: CCCC) has announced the successful dosing of the first patient in its clinical trial for CFT7455, an innovative MonoDAC™ treatment targeting IKZF1/3 for multiple myeloma and non-Hodgkin’s lymphomas. This significant milestone marks the company’s first program to advance to clinical trials. The Phase 1/2 trial will assess safety, tolerability, and anti-tumor activity in approximately 160 patients. Preliminary data from this trial is expected in 2022, reflecting C4T's commitment to improving cancer treatment outcomes.
C4 Therapeutics presented new pre-clinical data on CFT8919, a novel EGFR degrader, indicating significant tumor regression in models resistant to current EGFR inhibitors. The results suggest CFT8919 is effective against mutations like L858R, T790M, and C797S. Pre-clinical studies showed 85% degradation of mutant EGFR in tumors following treatment. The company plans to file an IND by mid-2022 and initiate a Phase 1 clinical trial by year-end 2022, aiming to address unmet needs in non-small cell lung cancer therapy.
C4 Therapeutics (Nasdaq: CCCC) announced the advancement of CFT8919, a selective BiDAC degrader targeting EGFR L858R, into IND-enabling studies. The company expects to file for an IND by mid-2022, aiming to initiate a Phase 1/2 trial by year-end 2022. Preclinical data highlighting CFT8919's potency and selective activity against NSCLC will be presented at the Keystone Symposium. The company continues to progress its other drug candidates and aims to have four in clinical trials by the end of 2022.
C4 Therapeutics (Nasdaq: CCCC) appointed Lauren White as chief financial officer effective June 21, 2021, succeeding Bill McKee, who will remain as a part-time consultant. White brings over 20 years of financial experience from Novartis, where she held senior roles including global head of business planning. C4T aims to advance its portfolio of targeted protein degraders and is preparing to initiate its first clinical trial. The leadership change is anticipated to strengthen financial strategies while enhancing the company's mission of transforming cancer treatment.
C4 Therapeutics, Inc. (CCCC) reported first-quarter 2021 revenue of $7.4 million, up from $6.8 million in Q1 2020, attributed to collaborations with Roche, Biogen, and Calico. R&D expenses rose to $20.5 million from $16.3 million, driven by increased preclinical costs and workforce expansion. General and Administrative expenses jumped to $7.4 million from $2.8 million. The net loss was $21.0 million with a per-share loss of $0.49. C4T remains on track for upcoming clinical trials and IND submissions, maintaining a strong cash position of $346.0 million.
