Welcome to our dedicated page for Carisma Therapeutics news (Ticker: CARM), a resource for investors and traders seeking the latest updates and insights on Carisma Therapeutics stock.
Carisma Therapeutics, Inc. (Nasdaq: CARM) is a cutting-edge clinical-stage biopharmaceutical company headquartered in Philadelphia, PA. The company is dedicated to developing transformative immunotherapies for cancer and other serious diseases using its proprietary chimeric antigen receptor macrophage (CAR-M) and monocyte cell engineering platforms.
Carisma is pioneering the use of engineered macrophages and monocytes, which are types of white blood cells essential for immune response. By harnessing these cells, Carisma aims to create innovative treatments for diseases with unmet medical needs. The company's leading product candidates include CT-0508 and CT-0525, both targeting HER2-overexpressing tumors.
CT-0508 is a CAR-M therapy currently in a Phase 1 clinical trial, marking the first time engineered macrophages are being tested in humans. It targets patients with recurrent or metastatic HER2-overexpressing solid tumors who have not responded to standard treatments. CT-0525, on the other hand, is an autologous chimeric antigen receptor-monocyte (CAR-Monocyte) cellular therapy. Recently cleared by the FDA, it has shown promising preclinical results and is expected to begin Phase 1 trials shortly.
The company's collaboration with Moderna, Inc. to develop in vivo CAR-M therapeutics highlights Carisma's commitment to innovative partnerships. This joint effort aims to leverage Moderna's mRNA and lipid nanoparticle (LNP) technologies to create new cancer treatments.
Carisma has also made significant strides in non-oncology applications. Recently, preclinical data demonstrated the efficacy of engineered macrophages in treating liver fibrosis, indicating potential for broader applications of their technology.
Financially, Carisma is robust, with $94.1 million in cash, cash equivalents, and marketable securities as of September 30, 2023. This financial stability enables the company to sustain its planned operations into the first quarter of 2025.
For more information, please visit www.carismatx.com.
Carisma Therapeutics (NASDAQ: CARM) announced a strategic restructuring, including discontinuation of CT-0525 development and a 34% workforce reduction. The company will redirect focus to its in vivo macrophage engineering platform for fibrosis, oncology, and autoimmune disease therapies.
Key developments include: plans to nominate a liver fibrosis development candidate in Q1 2025; ongoing collaboration with Moderna on multiple oncology and autoimmune programs; and expected restructuring costs of approximately $2.7 million. Three senior executives, including the CFO, General Counsel, and SVP of Human Resources, will depart by December 31, 2024.
The decision to discontinue the anti-HER2 program was based on competitive landscape assessment and recent developments in anti-HER2 therapies affecting antigen loss/downregulation.
Carisma Therapeutics (Nasdaq: CARM), a clinical-stage biopharmaceutical company specializing in immunotherapies, announced its participation in the 7th Annual Evercore ISI HealthCONx Conference. Steven Kelly, President and CEO, will engage in a fireside chat on December 5th at 9:35 am ET. The event will be accessible via audio webcast on the company's Investor Relations webpage under the Investor Events section, with -time archive availability.
Carisma Therapeutics (NASDAQ: CARM) presented promising preclinical data on engineered macrophages for treating liver fibrosis at AASLD The Liver Meeting® 2024. The research shows that macrophages can be genetically engineered to target specific pathways in liver disease using factors like TIM4, relaxin, and IL10. A single dose of TIM4-expressing macrophages, alone or with relaxin, significantly reduced liver fibrosis in the CDAHFD MASH model. The engineered cells were well-tolerated and outperformed non-engineered cells. The company plans to nominate a development candidate for its liver fibrosis program in Q1 2025.
Carisma Therapeutics (NASDAQ: CARM) announced positive pre-clinical data for its anti-GPC3 in vivo CAR-M therapy for hepatocellular carcinoma (HCC), developed with Moderna. The therapy demonstrated ability to create CAR-M directly in vivo, reprogramming myeloid cells to target GPC3-expressing cancer cells. Pre-clinical results showed specificity for GPC3 tumor antigen with dose-dependent cytotoxicity against GPC3+ tumor cells. In both syngeneic and humanized tumor models, the therapy significantly reduced tumor burden and suppressed liver metastasis. The treatment was well-tolerated in mouse models, showing promise as an off-the-shelf treatment for GPC3+ solid tumors, including HCC.
Carisma Therapeutics reported Q3 2024 financial results with cash and cash equivalents of $26.9 million, expected to fund operations into Q3 2025. Research and development expenses decreased to $11.3 million from $19.6 million year-over-year. The company anticipates initial results from the Phase 1 study of CT-0525 in Q1 2025 and plans to nominate a development candidate for its liver fibrosis program in the same quarter. New preclinical data for anti-GPC3 CAR-M therapy and liver fibrosis will be presented at upcoming scientific meetings. The company recently expanded its collaboration with Moderna to include autoimmune disease targets.
Carisma Therapeutics (Nasdaq: CARM) announced new pre-clinical data presentation on their anti-GPC3 in vivo CAR-M therapy for hepatocellular carcinoma (HCC) at SITC 2024. The therapy, developed with Moderna, uses lipid nanoparticles to deliver mRNA that reprograms endogenous myeloid cells, creating an off-the-shelf treatment approach for GPC3+ solid tumors.
The data, demonstrating robust anti-tumor activity, will be presented on November 8, 2024, at the SITC Annual Meeting in Houston, Texas. The presentation focuses on targeting Glypican-3, a tumor-associated antigen commonly expressed in HCC. Two posters will be presented, including one on the pre-clinical efficacy of anti-GPC3 CAR-M and another on a Phase 1 study of anti-HER2 CAR therapy.
Carisma Therapeutics (Nasdaq: CARM) has announced changes to its Board of Directors. Sohanya Cheng, MBA will join the board effective October 31, 2024, while Michael Torok will step down on the same date due to other professional commitments. Board Chair Sanford Zweifach highlighted Cheng's experience in oncology, leadership, strategic planning, and commercialization as valuable assets for advancing the company's portfolio. Cheng expressed enthusiasm about supporting Carisma's mission in developing innovative immunotherapies and strengthening its position in engineered macrophages.
Carisma Therapeutics Inc. (Nasdaq: CARM), a clinical-stage biopharmaceutical company, has announced its upcoming poster presentations at the Society for Immunotherapy of Cancer (SITC) 2024 in Houston, Texas, from November 6-10. The company will present two posters:
1. Pre-clinical efficacy of a novel anti-GPC3 in vivo CAR-M for hepatocellular carcinoma (Publication Number: 329)
2. A Phase 1, First-in-Human study of autologous monocytes engineered to express an anti-HER2 chimeric antigen receptor (CAR) in participants with HER2 overexpressing solid tumors (Publication Number: 659)
Both presentations are scheduled for Friday, November 8, 2024, at the Exhibit Halls A B George R. Brown Convention Center. The posters will be available on Carisma's website in the 'Publications' section following the start of the poster session.
Carisma Therapeutics Inc. (Nasdaq: CARM) has expanded its collaboration with Moderna, Inc. (Nasdaq: MRNA) to develop in vivo CAR-M therapies for autoimmune diseases. This expansion builds on their successful pre-clinical oncology data and includes the nomination of two autoimmune disease targets by Moderna. Carisma will receive research funding and is eligible for milestone and royalty payments.
The collaboration leverages Carisma's proprietary CAR-M technology and Moderna's mRNA/LNP platform. Carisma will handle discovery and optimization of development candidates, while Moderna will lead clinical development and commercialization. This partnership aims to revolutionize treatments for autoimmune conditions, expanding the potential of CAR-M technology beyond oncology.
Carisma Therapeutics (Nasdaq: CARM), a clinical-stage biopharmaceutical company, has announced its participation in four upcoming healthcare conferences. Steven Kelly, President and CEO, will represent the company at these events:
1. Baird 2024 Global Healthcare Conference on September 10 at 12:50 PM ET in New York, NY
2. H.C. Wainwright 26th Annual Global Investment Conference on September 11 at 1:30 PM ET in New York, NY
3. Chardan's 8th Annual Genetic Medicines Conference on September 30 at 4:00 PM ET in New York, NY
4. The Cell & Gene Meeting on the Mesa on October 7 at 9:30 AM MST in Phoenix, AZ
Live webcasts of these presentations will be available on Carisma's Investor Events webpage, with replays archived for a time after each event.
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