Bruker Launches timsTOF HT with Greater Dynamic Range for Further Enhancing Unbiased, High-Confidence 4D Proteomics™
Bruker Corporation has unveiled the timsTOF HT system at the 70th ASMS meeting, enhancing its 4D Multiomics platform with a fourth-generation TIMS XR cell and a 14-bit digitizer. This innovation boosts dynamic range and peptide coverage, enabling the identification of over 100,000 unique peptides with high quantification accuracy. The system supports high-throughput proteomics, achieving sample processing rates of up to 200 samples per day. Additionally, the PaSER mode allows real-time data streaming for intelligent acquisition, further advancing metabolomics and biomarker discovery.
- Launch of timsTOF HT system for enhanced 4D Multiomics capabilities.
- Ability to identify over 100,000 unique peptides with high quantification accuracy.
- Support for high-throughput proteomics, processing up to 200 samples per day.
- Integration of PaSER for real-time data streaming and intelligent acquisition.
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4th-generation TIMS XR cell with even greater dynamic range can identify more than 100k unique peptides with 60 min gradients at one microgram protein loads, with high-confidence at
1% FDR and without antigen cross-reactivity -
Increased dynamic range plus new 14-bit digitizer offer excellent quantitation with <
5% protein CVs for many proteins in three-proteome mixture - Co-distribution for CellenONE pico-dispenser for single cell proteomics (SCP)
- New PaSER™ real-time data streaming and intelligent acquisition control
- timsTOF Pro 2 system revolutionizes 4D Metabolomics together with pioneering partners in small molecule biomarker discovery
timsTOF HT instrument (Photo: Business Wire)
These advances are achieved without compromising the ultra-high sensitivity and extreme robustness for high-throughput proteomics, e.g., at 50 samples per day (SPD) or up to 200 SPD, or the high scientific confidence of better than
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At ASMS, Bruker also announced that its timsTOF SCP system with extreme sensitivity is now also available via a co-distribution agreement with Scienion, together with the CellenONE F1.4 single-cell pico-dispenser and the new ProteoChip™, as a single vendor solution for unbiased, label-free single cell proteomics (SCP).
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At ASMS, Bruker demonstrated PaSER’s real-time data streams and feedback loops for intelligent acquisition processes: developed in collaboration with the
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Transforming high-throughput and high-confidence discovery 4D Metabolomics
The high sensitivity timsTOF Pro 2 system assists pioneering small molecule biomarker discovery partners in revolutionizing metabolomics at unprecedented scale. New workflows for the discovery of biomarkers to accelerate drug discovery and novel natural products exploit the robustness, speed and confidence of the timsTOF platform in 4D metabolomics.
Dr. Viswa Colluru, CEO and Founder of Enveda Biosciences, uses timsTOF Pro 2 systems to discover new compounds in nature’s chemistry at an extraordinary pace. He said: “The trapped ion-mobility collision cross-section (CCS) data provided by Bruker’s timsTOF provides unprecedented 4D resolution of the many isomers in the natural world, enabling us to find novel therapeutic compounds in complex mixtures. The timsTOF Pro 2 combines cutting-edge virtually lossless ion-mobility technology with fast high-resolution TOF detection. This combination helps us profile the natural world at scale and industrialize applications in drug discovery. Bruker’s commitment to innovation and customers makes them a great partner. We are excited to continue to redefine the boundaries of metabolomics with them.”
OligoQuestTM enhanced RNA and Oligonucleotide characterization software
Bruker’s OligoQuest software offers enhanced RNA and oligonucleotide characterization for antisense research, RNA therapeutics, confirmation of guide RNA sequences for CRISPR, and other gene editing techniques. By exploiting the high isotopic fidelity and mass accuracy of Bruker’s maXis II and timsTOF platforms, OligoQuest enables identity confirmation by intact mass and MS2 analysis. Customers are using OligoQuest for confirmation of modified RNA sequences and base exchanges in isomeric oligonucleotides. OligoQuest fills the gap in RNA and oligonucleotide data analysis with tested algorithms, and also allowing customers to use their own oligonucleotide “alphabet” for standard or customized modifications.
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About
Bruker is enabling scientists to make breakthrough discoveries and develop new applications that improve the quality of human life. Bruker’s high performance scientific instruments and high value analytical and diagnostic solutions enable scientists to explore life and materials at molecular, cellular and microscopic levels. In close cooperation with our customers, Bruker is enabling innovation, improved productivity and customer success in life science molecular and cell biology research, in applied and pharma applications, in microscopy and nanoanalysis, as well as in industrial applications. Bruker offers differentiated, high-value life science and diagnostics systems and solutions in preclinical imaging, clinical phenomics research, proteomics and multiomics, spatial and single-cell biology, functional structural and condensate biology, as well as in clinical microbiology and molecular diagnostics. Please visit www.bruker.com.
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