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BioCryst Pharmaceuticals Inc. (Nasdaq: BCRX) is a global biotechnology company dedicated to improving the lives of individuals living with rare and serious diseases. Founded in 1986, BioCryst specializes in designing, optimizing, and developing novel small-molecule drugs that block key enzymes involved in infectious and rare diseases. Headquartered in Research Triangle Park, North Carolina, with a discovery center in Birmingham, Alabama, the company harnesses its expertise in drug discovery, clinical development, regulatory affairs, and product commercialization.
BioCryst is known for its flagship product, ORLADEYO® (berotralstat), the first oral, once-daily plasma kallikrein inhibitor specifically designed to prevent attacks of hereditary angioedema (HAE) in adults and pediatric patients aged 12 years and older. The efficacy of ORLADEYO has been demonstrated through multiple clinical studies and real-world data, showing significant reductions in HAE attack rates across various patient profiles.
The company's robust pipeline includes several innovative programs such as BCX17725 for Netherton syndrome and avoralstat for diabetic macular edema (DME). BioCryst's research spans multiple scientific disciplines, including biology, computer modeling, and medicinal chemistry, targeting therapeutic areas like acute uncomplicated influenza, hereditary angioedema, filoviruses (Ebola and Marburg), and oncology.
In recent announcements, BioCryst reported strong financial performance with ORLADEYO net revenue experiencing substantial growth. The company also continues to expand globally, with recent approvals of ORLADEYO in major markets, including Brazil and Mexico. Partnerships with organizations such as Pint Pharma help BioCryst extend its reach and bring life-changing treatments to patients worldwide.
BioCryst remains committed to advancing its clinical programs, generating new compounds, and upholding a culture of engagement and accountability. The company's ongoing dedication to developing innovative therapeutics aims to address unmet medical needs and provide better health outcomes for patients suffering from rare and serious conditions.
For more information, please visit www.biocryst.com or follow them on LinkedIn.
BioCryst Pharmaceuticals (Nasdaq: BCRX) has announced its participation in two major upcoming investor conferences in March 2025. The company will present at the TD Cowen 45th Annual Health Care Conference in Boston on March 5 at 9:10 a.m. ET, and at the Barclays 27th Annual Global Healthcare Conference in Miami on March 11 at 10:00 a.m. ET.
Investors and interested parties can access live audio webcasts and replay recordings of both presentations through the Investors & Media section of BioCryst's website at biocryst.com.
BioCryst Pharmaceuticals (BCRX) has received a recommendation from Infarmed in Portugal for ORLADEYO® (berotralstat), marking its entry into the Portuguese market. The drug is approved for routine prevention of recurrent hereditary angioedema (HAE) attacks in patients aged 12 and older.
ORLADEYO is significant as the first oral, once-daily therapy for HAE attack reduction in Portugal. This follows the European Commission's marketing authorization granted in April 2021. The drug is now licensed in 44 countries globally, expanding BioCryst's international market presence.
BioCryst Pharmaceuticals (BCRX) has announced plans to present five abstracts featuring new clinical and real-world outcomes of ORLADEYO® (berotralstat) at the 2025 AAAAI/WAO joint congress in San Diego. The presentations will include a significant late-breaking abstract showcasing the first results from the APeX-P trial, which evaluates ORLADEYO in pediatric HAE patients aged 2 to <12 years.
The presentations, scheduled for March 2, 2025, will cover various aspects including: HAE attack rates in pediatric patients, real-world attack rates before and after berotralstat initiation in different patient groups, patient willingness to change long-term prophylaxis, and patient-reported impact of berotralstat as long-term prophylaxis. All abstracts are accessible through The Journal of Allergy and Clinical Immunology's online supplement.
BioCryst Pharmaceuticals (Nasdaq: BCRX) has announced it will release its fourth quarter 2024 financial results on Monday, February 24, 2025. The company will host a conference call and webcast at 8:30 a.m. ET on the same day, where management will discuss financial results and provide a corporate update. Interested parties can access the live call by dialing 1-844-481-2942 (domestic) or 1-412-317-1866 (international). A live webcast and replay will be available in the investors section of BioCryst's website.
BioCryst Pharmaceuticals (BCRX) has granted stock options and restricted stock units (RSUs) to eight newly-hired employees as employment inducements. The compensation committee approved options to purchase 22,575 shares and RSUs covering 27,550 shares of common stock, effective January 31, 2025.
The stock options were granted at an exercise price of $7.90 per share, matching the closing price on the grant date. Both options and RSUs will vest in four equal annual installments, starting from the one-year anniversary of the grant date, contingent on continued employment. The stock options have a 10-year term and are subject to BioCryst's Inducement Equity Incentive Plan terms.
BioCryst Pharmaceuticals reported preliminary ORLADEYO® net revenue of $437 million for 2024, marking a 34% year-over-year growth. The company expects ORLADEYO revenue between $515-$535 million and total revenue of $540-$560 million in 2025.
Key highlights include achieving operating profit in 2024 (excluding stock-based compensation) and projecting quarterly EPS profitability/positive cash flow in 2H 2025. The company plans a new drug application in 2025 for ORLADEYO granules for children under 12.
Q4 2024 ORLADEYO net revenue reached $123.5 million (+36% y-o-y), with total revenue of $130.8 million (+40% y-o-y). Over 1,200 U.S. physicians have prescribed ORLADEYO across 30+ countries. The company expects 2025 GAAP operating expenses between $485-495 million, including $60 million in stock-based compensation.
BioCryst Pharmaceuticals (Nasdaq: BCRX) has announced its upcoming presentation at the 43rd Annual J.P. Morgan Healthcare Conference in San Francisco. The presentation is scheduled for Tuesday, January 14, 2025, at 6:00 p.m. ET. Interested parties can access both the live audio webcast and a replay of the presentation through the Investors & Media section on BioCryst's official website (www.biocryst.com).
BioCryst Pharmaceuticals (Nasdaq: BCRX) has announced inducement grants for 10 newly-hired employees. The compensation committee approved stock options to purchase 52,750 shares and restricted stock units (RSUs) covering 36,975 shares of BioCryst common stock, granted on December 31, 2024.
The stock options have an exercise price of $7.52 per share, matching the closing price on the grant date. Both options and RSUs will vest in four equal annual installments, starting from the one-year anniversary of the grant date, contingent on continued employment. The stock options have a 10-year term and were granted under Nasdaq Listing Rule 5635(c)(4) as employment inducements.
BioCryst Pharmaceuticals (BCRX) has granted stock-based compensation to five newly-hired employees as employment inducements. The package includes stock options to purchase 17,400 shares and restricted stock units (RSUs) covering 12,150 shares of common stock. The options were granted at an exercise price of $7.50 per share, matching the closing price on November 29, 2024.
Both options and RSUs will vest over four equal annual installments, starting from the one-year anniversary of the grant date, contingent on continued employment. The stock options have a 10-year term and were granted under BioCryst's Inducement Equity Incentive Plan in accordance with Nasdaq Listing Rule 5635(c)(4).
BioCryst Pharmaceuticals (Nasdaq: BCRX) announced that Ireland's Health Services Executive (HSE) has recommended ORLADEYO (berotralstat) for routine prevention of hereditary angioedema (HAE) attacks in patients 12 years and older. This marks the introduction of the first oral, once-daily therapy for HAE attack reduction in Ireland. The recommendation follows the European Commission's marketing authorization granted in April 2021. ORLADEYO is currently licensed in 44 countries.