Biocryst Pharmaceuticals Inc - BCRX STOCK NEWS

BioCryst Pharmaceuticals (Nasdaq: BCRX) announced inducement grants for five newly-hired employees. The compensation package includes stock options to purchase 18,200 shares at $8.01 per share and restricted stock units (RSUs) covering 12,750 shares. Both options and RSUs will vest over four equal annual installments starting one year from the October 31, 2024 grant date. The stock options have a 10-year term, and all grants were made under Nasdaq Listing Rule 5635(c)(4) as employment inducements.

BioCryst Pharmaceuticals reported strong Q3 2024 financial results, with ORLADEYO net revenue reaching $116.3 million, a 35.7% year-over-year increase. The company achieved a GAAP operating profit of $7.7 million and adjusted its full-year 2024 ORLADEYO revenue guidance to $430-435 million. Total product revenue guidance for 2024 is set at $443-448 million. The company reported progress with BCX17725 for Netherton syndrome entering clinical trials and expects to be approaching quarterly positive EPS by second half of 2025.

BioCryst Pharmaceuticals presented new real-world evidence for ORLADEYO® (berotralstat), showing high adherence and persistence rates comparable to other HAE long-term prophylactic therapies. The study revealed that 86% of ORLADEYO patients filled at least two prescriptions, with 77% adherence and 71% persistence rates at 12 months.

Additional data demonstrated significant HAE attack rate reductions after ORLADEYO initiation, regardless of C1-inhibitor status. Patient survey results indicated a preference for oral therapy, with 54% choosing oral daily treatment over injectable options when efficacy is equal.

BioCryst Pharmaceuticals, Inc. (Nasdaq: BCRX) has announced that it will report its third quarter 2024 financial results on Monday, November 4, 2024. The company's management team will host a conference call and webcast at 8:30 a.m. ET on the same day to discuss the financial results and provide a corporate update.

Interested parties can access the live call by dialing 1-844-481-2942 for domestic callers and 1-412-317-1866 for international callers. Additionally, a live webcast and replay of the call will be available in the investors section of the company's website at www.biocryst.com.

BioCryst Pharmaceuticals (Nasdaq: BCRX) announced new real-world evidence on ORLADEYO® (berotralstat), showing significant reductions in healthcare resource utilization (HRU) for patients with hereditary angioedema (HAE) in the United States. The study, to be presented at the AMCP Nexus 2024 meeting, revealed:

• 34% reduction in all-cause hospitalizations
• 52% reduction in angioedema-related hospitalizations
• 51% reduction in HAE attack-related visits
• 39% reduction in use of on-demand therapies

The retrospective pre-post study analyzed U.S. claims data from 260 patients who initiated ORLADEYO between December 2020 and December 2022. Dr. Sandra Christiansen, from the University of California, San Diego, highlighted the study's importance in demonstrating ORLADEYO's clinical and financial value as a prophylactic therapy for HAE.

BioCryst Pharmaceuticals (Nasdaq: BCRX) will present four abstracts on ORLADEYO® (berotralstat) at the American College of Allergy, Asthma & Immunology (ACAAI) Annual Scientific Meeting in Boston from October 24-28, 2024. ORLADEYO is an oral, once-daily treatment for hereditary angioedema (HAE) prophylaxis in patients 12 years and older.

The presentations will focus on:

• Adherence and persistence among HAE patients treated with berotralstat and other therapies
• Sustained real-world attack reductions in HAE patients with and without C1-inhibitor deficiency
• Long-term prophylactic treatment preferences of HAE patients

The posters will be displayed in the exhibit hall at specific times and will also be accessible online to registered attendees starting October 24 at 8:00 a.m. ET on ACAAI's website.

BioCryst Pharmaceuticals (Nasdaq: BCRX) has announced the granting of stock options and restricted stock units (RSUs) to 21 newly-hired employees as inducement awards. The compensation committee of BioCryst's board of directors approved these grants on September 30, 2024, in accordance with Nasdaq Listing Rule 5635(c)(4).

The inducement package includes:

• Stock options to purchase 71,175 shares of BioCryst common stock
• RSUs covering 50,025 shares of BioCryst common stock

The stock options have an exercise price of $7.60 per share, equal to the closing price of BioCryst common stock on the grant date. Both options and RSUs will vest in four equal annual installments, beginning on the one-year anniversary of the grant date, subject to continued employment. The stock options have a 10-year term.

BioCryst Pharmaceuticals (Nasdaq: BCRX) has initiated enrollment in a Phase 1 trial for BCX17725, a potent and selective kallikrein 5 (KLK5) inhibitor designed to treat Netherton syndrome. This protein therapeutic aims to address the underlying cause of the disease, potentially offering a best-in-class targeted treatment. The trial will evaluate safety, tolerability, pharmacokinetics, and immunogenicity in healthy adults and Netherton syndrome patients.

Key points:

• First participant enrolled in the Phase 1 trial
• Initial data expected by the end of 2025
• BCX17725 is BioCryst's first protein therapeutic to reach clinical stage
• Netherton syndrome is a rare genetic disorder affecting skin, hair, and immune system
• Currently, no approved treatments exist for Netherton syndrome

BioCryst Pharmaceuticals has been awarded a contract worth up to $69 million by the U.S. Department of Health and Human Services for the procurement of up to 95,625 doses of RAPIVAB® (peramivir injection) over a five-year period. The contract is structured with a 12-month base ordering period and four optional 12-month periods. The first ordering period, worth $13.9 million for 19,125 doses, has been executed and will be fulfilled by September 29, 2025.

RAPIVAB will be supplied to the Strategic National Stockpile for use in potential public health emergencies related to influenza. This contract follows a previous $34.7 million contract awarded in 2018 for 50,000 doses, which was completed in 2022. RAPIVAB has been part of the U.S. government's influenza preparedness efforts since the 2009 H1N1 pandemic.