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Atossa Therapeutics Announces Third Quarter 2024 Financial Results and Provides Corporate Update

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Atossa Therapeutics (NASDAQ: ATOS) announced Q3 2024 financial results and corporate updates. Key highlights include positive topline results from KARISMA-Endoxifen Phase 2 study showing significant mammographic breast density reductions of 19.3% and 26.5% in 1mg and 2mg treatment arms. The I-SPY 2 trial met its primary endpoint with 95% of patients completing treatment, showing 69% reduction in Ki-67 and 30.4% reduction in tumor volume. The company ended Q3 with $74.8 million in cash and no debt. Operating expenses decreased to $6.4 million in Q3 2024 from $7.5 million in Q3 2023.

Atossa Therapeutics (NASDAQ: ATOS) ha annunciato i risultati finanziari del terzo trimestre 2024 e aggiornamenti aziendali. Tra i principali risultati spiccano i risultati positivi della fase 2 dello studio KARISMA-Endoxifene, che ha mostrato significative riduzioni della densità mammografica del 19,3% e del 26,5% nei gruppi di trattamento da 1 mg e 2 mg. Il trial I-SPY 2 ha raggiunto il suo obiettivo principale con il 95% dei pazienti che ha completato il trattamento, mostrando una riduzione del 69% nel Ki-67 e una riduzione del 30,4% nel volume tumorale. L'azienda ha chiuso il terzo trimestre con 74,8 milioni di dollari in cassa e senza debiti. Le spese operative sono diminuite a 6,4 milioni di dollari nel terzo trimestre 2024 rispetto ai 7,5 milioni di dollari del terzo trimestre 2023.

Atossa Therapeutics (NASDAQ: ATOS) anunció los resultados financieros del tercer trimestre de 2024 y actualizaciones corporativas. Los puntos destacados incluyen resultados positivos de la fase 2 del estudio KARISMA-Endoxifeno, que mostró reducciones significativas en la densidad mamográfica del 19.3% y del 26.5% en los grupos de tratamiento de 1 mg y 2 mg. El ensayo I-SPY 2 cumplió con su objetivo principal, con el 95% de los pacientes completando el tratamiento, mostrando una reducción del 69% en Ki-67 y una reducción del 30.4% en el volumen tumoral. La compañía terminó el tercer trimestre con 74.8 millones de dólares en efectivo y sin deudas. Los gastos operativos se redujeron a 6.4 millones de dólares en el tercer trimestre de 2024, desde 7.5 millones de dólares en el tercer trimestre de 2023.

Atossa Therapeutics (NASDAQ: ATOS)는 2024년 3분기 재무 결과 및 기업 업데이트를 발표했습니다. 주요 내용으로는 KARISMA-Endoxifen 2상 연구에서 1mg 및 2mg 치료군에서 각각 19.3% 및 26.5%의 유방 밀도 감소를 보여주는 긍정적인 최종 결과가 포함됩니다. I-SPY 2 시험은 환자의 95%가 치료를 완료하며 주요 목표를 달성했고, Ki-67은 69% 줄어들며 종양 부피는 30.4% 감소했습니다. 회사는 3분기를 7,480만 달러의 현금으로 마감하였고 부채는 없습니다. 운영 비용은 2024년 3분기 640만 달러로 감소했으며, 2023년 3분기 750만 달러에서 감소했습니다.

Atossa Therapeutics (NASDAQ: ATOS) a annoncé les résultats financiers du troisième trimestre 2024 ainsi que des mises à jour d'entreprise. Les points saillants comprennent des résultats positifs de l'étude de phase 2 KARISMA-Endoxifène, montrant des réductions significatives de la densité mammaire mammographique de 19,3 % et de 26,5 % dans les groupes de traitement de 1 mg et 2 mg. L'essai I-SPY 2 a atteint son objectif principal, avec 95 % des patients ayant terminé le traitement, montrant une réduction de 69 % dans le Ki-67 et une réduction de 30,4 % du volume tumoral. L'entreprise a terminé le troisième trimestre avec 74,8 millions de dollars en liquidités et sans dettes. Les dépenses d'exploitation ont diminué à 6,4 millions de dollars au troisième trimestre 2024, contre 7,5 millions de dollars au troisième trimestre 2023.

Atossa Therapeutics (NASDAQ: ATOS) hat die finanziellen Ergebnisse für das 3. Quartal 2024 und Unternehmensaktualisierungen bekannt gegeben. Zu den wichtigsten Punkten gehören positive Ergebnisse der Phase-2-Studie KARISMA-Endoxifen, die signifikante Reduktionen der mammografischen Brustdichte von 19,3 % und 26,5 % in den Behandlungsgruppen von 1 mg und 2 mg zeigt. Die I-SPY-2-Studie erreichte ihr primäres Ziel, wobei 95 % der Patienten die Behandlung abgeschlossen haben, mit einer Reduktion von 69 % im Ki-67 und einer Reduktion des Tumorvolumens um 30,4 %. Das Unternehmen schloss das 3. Quartal mit 74,8 Millionen Dollar an liquiden Mitteln und ohne Schulden ab. Die Betriebsausgaben sind im 3. Quartal 2024 auf 6,4 Millionen Dollar gesunken, verglichen mit 7,5 Millionen Dollar im 3. Quartal 2023.

Positive
  • Strong cash position of $74.8 million with no debt
  • Significant clinical efficacy in KARISMA-Endoxifen Phase 2 study with 19.3-26.5% MBD reduction
  • Positive I-SPY 2 trial results with 95% patient completion rate
  • Operating expenses decreased by $1.1 million year-over-year
  • New patent granted for (Z)-endoxifen compositions
Negative
  • Investment in equity securities written down by $1.7 million due to impairment
  • Interest income decreased by $0.3 million in Q3 compared to prior year

Insights

This earnings report reveals significant operational and financial developments. With $74.8 million in cash and no debt, Atossa maintains a strong financial position. Operating expenses decreased by $1.1 million and $1.9 million for Q3 and YTD respectively, demonstrating improved cost management. Notable is the 26% reduction in clinical trial expenses and 40% decrease in G&A compensation costs.

The positive clinical trial results for (Z)-endoxifen, including significant MBD reductions of up to 26.5% and meeting primary endpoints in the I-SPY 2 trial, strengthen the company's market position. The new patent grant and strategic partnerships enhance long-term value potential.

The clinical data presents compelling evidence for (Z)-endoxifen's efficacy. Key findings include:

  • Significant mammographic breast density reductions of 19.3% and 26.5% in low-dose groups
  • 95% treatment completion rate in the I-SPY 2 trial
  • 69% reduction in Ki-67 biomarker and 30.4% reduction in tumor volume
The combination trial with abemaciclib expands the potential therapeutic applications. The favorable safety profile and minimal side effects enhance the drug's commercial viability.

  • Announced positive topline results from KARISMA-Endoxifen Phase 2 study which demonstrated that low doses of (Z)-endoxifen significantly reduced mammographic breast density (MBD), addressing a key breast cancer risk factor
  • Released a preliminary analysis from I-SPY 2 Endocrine Optimization Pilot (EOP) Phase 2 trial of (Z)-endoxifen which met the primary endpoint with 95 percent (19/20 patients) receiving > 75 percent of planned treatment
  • Announced the dosing of the first patient in a clinical trial conducted in partnership with Quantum Leap Healthcare Collaborativeä evaluating Atossa’s proprietary (Z)-endoxifen in combination with abemaciclib (VERZENIO)
  • Received a new patent (U.S. Patent No. 12,071,391) covering certain compositions of (Z)-endoxifen in free base or salt forms with enteric material, as well as methods of administering these compositions
  • Ended third quarter 2024 with $74.8 million in cash and cash equivalents and no debt

SEATTLE, Nov. 12, 2024 (GLOBE NEWSWIRE) -- Atossa Therapeutics, Inc. (Nasdaq: ATOS) (“Atossa” or the “Company”) a clinical-stage biopharmaceutical company developing innovative medicines for breast cancer, today announced financial results for the fiscal quarter ended September 30, 2024, and provided an update on recent company developments.

Key developments from Q3 2024 include:

  • Positive Topline Data from KARISMA-Endoxifen Phase 2 Study: Atossa reported topline results from its KARISMA-Endoxifen Phase 2 study conducted at the Karolinska Institute in Sweden, evaluating (Z)-endoxifen in premenopausal women with mammographic breast density (MBD). The study demonstrated significant MBD reductions of 19.3 percent and 26.5 percent in the 1 mg and 2 mg treatment arms, respectively, compared to placebo, over a six-month period. The treatment was well tolerated, with minimal side effects and no significant safety concerns. Although vasomotor symptoms slightly increased in active treatment groups, they were not a major reason for discontinuation. The Company believes that these findings support the potential of (Z)-endoxifen as a preventative therapy for women with dense breast tissue, an independent risk factor for breast cancer.
  • Promising Preliminary Analysis from Phase 2 I-SPY 2 EOP Trial: Atossa released a preliminary analysis from its Phase 2 trial of (Z)-endoxifen in ER+/HER2- breast cancer, showing that (Z)-endoxifen met the primary endpoint with 95 percent (19/20) of patients completing >75 percent of planned treatment. The data showed a rapid reduction in key breast cancer biomarkers, including a 69 percent reduction in Ki-67 and a 30.4 percent reduction in functional tumor volume after three weeks. The treatment was well tolerated, with mild side effects and no dose reductions or treatment discontinuations.
  • Initiation of Combination Trial with Quantum Leap Healthcare Collaborative™: Atossa, in collaboration with Quantum Leap Healthcare Collaborative™, announced that the first patient was dosed in their clinical trial evaluating (Z)-endoxifen in combination with abemaciclib (VERZENIO®) as a neoadjuvant treatment for high-risk women with newly diagnosed ER+/HER2- breast cancer. Part of the ongoing I-SPY 2 Endocrine Optimization Pilot Protocol (EOP), the trial targets patients whose tumors are predicted to be sensitive to endocrine therapy but unlikely to benefit from chemotherapy. The study is expected enroll approximately 80 participants, with pre- and postmenopausal women receiving daily (Z)-endoxifen and abemaciclib for 24 weeks prior to surgery. The trial aims to assess the efficacy and safety of this combination, with results anticipated in 2026.
  • New U.S. Patent Granted for (Z)-Endoxifen Compositions: The United States Patent and Trademark Office (USPTO) granted Atossa a new patent covering certain compositions of (Z)-endoxifen in free base or salt forms with enteric material, as well as methods of administering these compositions. This fourth issued patent for (Z)-endoxifen broadens Atossa’s protection and validates its intellectual property strategy.
  • Appointment of New Vice President of Investor and Public Relations: Atossa appointed Michael Parks as Vice President of Investor and Public Relations. With nearly 30 years of experience in investor relations and corporate communications, Mr. Parks leads Atossa's corporate, executive, and digital communications, investor relations, and branding.
  • Appointment of Claudia Lopez, DVM, MSc, as Vice President, Clinical Product Development: Dr. Lopez brings over 20 years of clinical development experience, including leadership roles at Landos Biopharma, Arena Pharmaceuticals, and Takeda Pharmaceuticals. Her expertise in global clinical programs and regulatory strategy will support Atossa’s efforts to advance its clinical pipeline and develop next-generation cancer treatments.

“We are energized by the substantial progress Atossa has made this quarter, particularly the positive results from our KARISMA-Endoxifen Phase 2 study, which demonstrated that low doses of (Z)-endoxifen elicited significant reductions in mammographic breast density—an important risk factor for breast cancer,” said Steven Quay, M.D., Ph.D., Atossa’s President and Chief Executive Officer. “Combined with the promising preliminary data from the I-SPY 2 EOP trial of (Z)-endoxifen showing rapid reductions in Ki-67 and tumor volume, we believe these results further validate the substantial potential of our programs and demonstrate our commitment to developing innovative therapies that can meaningfully impact breast cancer treatment and prevention.”

Comparison of Three and Nine Months Ended September 30, 2024 and 2023

Operating Expenses. Total operating expenses were $6.4 million and $20.5 million for the three and nine months ended September 30, 2024 which was a decrease of $1.1 million and $1.9 million, from total operating expenses for the three and nine months ended September 30, 2023 of $7.5 million and $22.4 million, respectively. Factors contributing to the decrease in operating expenses in the three and nine months ended September 30, 2024 are explained below.

Research & Development (R&D) Expenses. The following table provides a breakdown of major categories within R&D expenses for the three and nine months ended September 30, 2024 and 2023, together with the dollar change in those categories (dollars in thousands):

 For the Three Months Ended September 30, For the Nine Months Ended September 30,
 2024 2023 Increase (Decrease) % Increase (Decrease) 2024 2023 Increase (Decrease) % Increase (Decrease)
Research and Development Expense               
Clinical and non-clinical trials$2,490 $3,365 $(875)(26)% $7,875 $8,239 $(364)(4)%
Compensation 701  763  (62)(8)%  2,006  2,696  (690)(26)%
Professional fees and other 221  339  (118)(35)%  833  745  88 12%
Research and Development Expense Total$3,412 $4,467 $(1,055)(24)% $10,714 $11,680 $(966)(8%)
                      
  • Clinical and non-clinical trial expense decreased $0.9 million and $0.4 million for the three and nine months ended September 30, 2024, respectively, compared to the prior year periods due to a decrease in spending for the (Z)-endoxifen trials, including a decrease in drug development costs.
  • The decrease in R&D compensation expense of $0.1 million and $0.7 million for the three and nine months ended September 30, 2024, respectively, compared to the prior year periods was primarily due to a decrease in non-cash stock-based compensation expense of $0.1 million and $0.8 million for the three and nine months ended September 30, 2024, respectively. Non-cash stock-based compensation expense decreased compared to the prior year periods due to the weighted average fair value of stock options amortizing in the 2024 periods being lower.
  • The decrease in R&D professional fees and other expense of $0.1 million for the three months ended September 30, 2024 compared to the prior year period was primarily due to the timing of the study cohorts in clinical and non-clinical trials. The increase in R&D professional fees and other expense of $0.1 million for the nine months ended September 30, 2024 compared to the prior year period was primarily due to higher consulting fees in 2024 related to our (Z)-endoxifen program.

General and Administrative (G&A) Expenses. The following table provides a breakdown of major categories within G&A expenses for the three and nine months ended September 30, 2024 and 2023, together with the dollar change in those categories (dollars in thousands):

 For the Three Months Ended September 30, For the Nine Months Ended September 30,
 2024 2023 Increase (Decrease) % Increase (Decrease) 2024 2023 Increase (Decrease) % Increase (Decrease)
General and Administrative Expense               
Compensation$1,342 $1,534 $(192)(13)% $3,698 $6,153 $(2,455)(40)%
Professional fees and other 1,425  1,127  298 26%  5,374  3,502  1,872 53%
Insurance 206  340  (134)(39)%  684  1,023  (339)(33)%
General and Administrative Expense Total$2,973 $3,001 $(28)(1)% $9,756 $10,678 $(922)(9)%
                      
  • The decrease in G&A compensation expense of $0.2 million and $2.5 million for the three and nine months ended September 30, 2024, respectively, compared to the prior year periods was due to a decrease in both cash compensation and non-cash stock-based compensation expense. Non-cash stock-based compensation expense decreased by $0.1 million and $1.7 million for the three and nine months ended September 30, 2024, respectively, compared to the prior year periods due to the weighted average fair value of stock options amortizing in 2024 being lower. Cash compensation decreased by $0.1 million for the three months ended September 30, 2024 compared to the prior year period due to a different mix of employees. Cash compensation decreased by $0.7 million for the nine months ended September 30, 2024 compared to the prior year period primarily due to salary and bonus severance expense of $0.6 million for the nine months ended September 30, 2023 related to the departure of our former Chief Financial Officer.
  • G&A professional fees and other expense increased by $0.3 million and $1.9 million for the three and nine months ended September 30, 2024, respectively, compared to the prior year periods primarily due to the increase in legal fees of $0.2 million and $1.0 million for the three and nine months ended September 30, 2024, respectively, due to higher patent-related activity as well as other legal matters. Investor relations expenses increased by $0.5 million for the nine months ended September 30, 2024 compared to the prior year period due to an increase in investor outreach costs. Accounting fees increased by $0.2 million for the nine months ended September 30, 2024 compared to the prior year period due to a change in our accounting firm as well as the increased complexity of the business.
  • The decrease in G&A insurance expense of $0.1 million and $0.3 million for the three and nine months ended September 30, 2024, respectively, compared to the prior year periods was due to lower negotiated insurance premiums for the same or better coverage in 2024.

 

Interest Income. Interest income of $1.0 million for the three months ended September 30, 2024 represented a decrease of $0.3 million compared to the prior year period, and was primarily due to a decrease in funds invested in the money market account. Interest income of $3.2 million for the nine months ended September 30, 2024 represented an increase of $0.1 million compared to the prior year period, and was primarily due to a change in the mix of our money market accounts which yielded a higher rate of return in 2024.

Impairment Charge on Investment in Equity Securities. For the nine months ended September 30, 2024, we wrote down our Investment in equity securities by $1.7 million and for the nine months ended September 30, 2023, we wrote down our Investment in equity securities by $3.0 million due to impairment of our investment.

About (Z)-Endoxifen
(Z)-endoxifen is one of the most potent Selective Estrogen Receptor Modulator (SERM) for estrogen receptor inhibition and may cause estrogen receptor degradation. It has also been shown to have efficacy in the setting of patients with tumor resistance to other hormonal treatments. In addition to its potent anti-estrogen effects, (Z)-endoxifen has been shown to target PKCβ1, a known oncogenic protein, at clinically attainable blood concentrations. Finally, (Z)-endoxifen appears to deliver similar or even greater bone agonistic effects while resulting in little or no endometrial proliferative effects compared with standard treatments, like tamoxifen.

Atossa is developing a proprietary oral formulation of (Z)-endoxifen that is encapsulated to bypass the stomach, as acidic conditions in the stomach convert a significant proportion of (Z)-endoxifen to the inactive (E)-endoxifen. Atossa’s (Z)-endoxifen has been shown to be well tolerated in Phase 1 studies and in a small Phase 2 study of women with breast cancer. (Z)-endoxifen is currently being studied in five Phase 2 trials: one in healthy women with measurable breast density, one in women diagnosed with ductal carcinoma in situ, and three other studies including the EVANGELINE study and two I-SPY studies in women with ER+/HER2- breast cancer. Atossa’s (Z)-endoxifen is protected by four issued U.S. patents and numerous pending patent applications.

About Atossa Therapeutics
Atossa Therapeutics, Inc. is a clinical-stage biopharmaceutical company developing innovative medicines in areas of significant unmet medical need in oncology with a focus on using (Z)-endoxifen to prevent and treat breast cancer. For more information, please visit www.atossatherapeutics.com.

Contact
Michael Parks, VP Investor and Public Relations
484-356-7105
michael.parks@atossainc.com

FORWARD LOOKING STATEMENTS
This press release contains certain information that may constitute forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. We may identify these forward-looking statements by the use of words such as “expect,” “potential,” “continue,” “may,” “will,” “should,” “could,” “would,” “seek,” “intend,” “plan,” “estimate,” “anticipate,” “believe,” “design,” “predict,” “future,” or other comparable words. All statements made in this press release that are not statements of historical fact, including statements regarding data related to the (Z)-endoxifen program, the potential of (Z)-endoxifen as a breast cancer prevention and treatment agent, the expected timing of data and related publications, and the potential milestones and growth opportunities for the Company, are forward-looking statements. Forward-looking statements in this press release are subject to risks and uncertainties that may cause actual results, outcomes, or the timing of actual results or outcomes, to differ materially from those projected or anticipated, including risks and uncertainties associated with: macroeconomic conditions and increasing geopolitical instability; the expected timing of releasing data; any variation between interim or preliminary and final clinical results or analysis; actions and inactions by the FDA and foreign regulatory bodies; the outcome or timing of regulatory approvals needed by Atossa, including those needed to continue our planned (Z)-endoxifen trials; our ability to satisfy regulatory requirements; our ability to remain compliant with the continued listing requirements of the Nasdaq Stock Market; our ability to successfully develop and commercialize new therapeutics; the success, costs and timing of our development activities, including our ability to successfully initiate or complete our clinical trials, including our (Z)-endoxifen trials; our anticipated rate of patient enrollment; our ability to contract with third-parties and their ability to perform adequately; our estimates on the size and characteristics of our potential markets; our ability to successfully defend litigation and other similar complaints and to establish and maintain intellectual property rights covering our products; whether we can successfully complete our clinical trial of oral (Z)-endoxifen in women with mammographic breast density and our trials of (Z)-endoxifen in women with breast cancer, and whether the studies will meet their objectives; our expectations as to future financial performance, expense levels and capital sources, including our ability to raise capital; our ability to attract and retain key personnel; our anticipated working capital needs and expectations around the sufficiency of our cash reserves; and other risks and uncertainties detailed from time to time in Atossa’s filings with the Securities and Exchange Commission, including without limitation its Annual Reports on Form 10-K and Quarterly Reports on 10-Q. Forward-looking statements are presented as of the date of this press release. Except as required by law, we do not intend to update any forward-looking statements, whether as a result of new information, future events or circumstances or otherwise.

ATOSSA THERAPEUTICS, INC.
CONDENSED CONSOLIDATED BALANCE SHEETS
(amounts in thousands, except share and per share data)
(Unaudited)
      
 September 30, 2024  December 31, 2023 
Assets     
Current assets     
Cash and cash equivalents$74,766  $88,460 
Restricted cash 110   110 
Prepaid materials 1,285   1,487 
Prepaid expenses and other current assets 950   2,162 
Total current assets 77,111   92,219 
Investment in equity securities    1,710 
Other assets 2,366   2,323 
Total assets$79,477  $96,252 
Liabilities and stockholders' equity     
Current liabilities     
Accounts payable$1,561  $806 
Accrued expenses 1,694   973 
Payroll liabilities 1,061   1,654 
Other current liabilities 1,480   1,803 
Total current liabilities 5,796   5,236 
Total liabilities 5,796   5,236 
Commitments and contingencies     
Stockholders' equity     
Convertible preferred stock - $0.001 par value; 10,000,000 shares authorized;
582 shares issued and outstanding as of September 30, 2024 and December 31, 2023
     
Common stock - $0.18 par value; 350,000,000 and 175,000,000 shares authorized
as of September 30, 2024 and December 31, 2023, respectively; 125,801,254
and 125,304,064 shares issued and outstanding as of September 30, 2024 and
December 31, 2023, respectively
 22,882   22,792 
Additional paid-in capital 257,719   255,987 
Treasury stock, at cost; 1,320,046 shares of common stock at September 30, 2024 and
December 31, 2023
 (1,475)  (1,475)
Accumulated deficit (205,445)  (186,288)
Total stockholders' equity 73,681   91,016 
Total liabilities and stockholders' equity$79,477  $96,252 


ATOSSA THERAPEUTICS, INC.
CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS
(amounts in thousands, except share and per share data)
(Unaudited)
       
 For the Three Months Ended
September 30,
   For the Nine Months Ended
September 30,
 
 2024  2023   2024  2023 
Operating expenses            
Research and development$3,412  $4,467   $10,714  $11,680 
General and administrative 2,973   3,001    9,756   10,678 
Total operating expenses 6,385   7,468    20,470   22,358 
Operating loss (6,385)  (7,468)   (20,470)  (22,358)
Impairment charge on investment in equity securities (1,710)      (1,710)  (2,990)
Interest income 1,001   1,274    3,213   3,107 
Other expense, net (136)  (35)   (190)  (99)
Loss before income taxes (7,230)  (6,229)   (19,157)  (22,340)
Income tax benefit            
Net loss (7,230)  (6,229)   (19,157)  (22,340)
Net loss per share of common stock - basic and diluted$(0.06) $(0.05)  $(0.15) $(0.18)
Weighted average shares outstanding used to compute net loss per share - basic and diluted 125,772,664   125,793,112    125,608,794   126,343,629 

FAQ

What were the key results of Atossa's (ATOS) KARISMA-Endoxifen Phase 2 study in Q3 2024?

The study showed significant mammographic breast density reductions of 19.3% and 26.5% in the 1mg and 2mg treatment arms respectively, compared to placebo over six months.

How much cash does Atossa Therapeutics (ATOS) have as of Q3 2024?

Atossa ended Q3 2024 with $74.8 million in cash and cash equivalents, with no debt.

What were the operating expenses for Atossa (ATOS) in Q3 2024?

Total operating expenses were $6.4 million in Q3 2024, a decrease of $1.1 million from $7.5 million in Q3 2023.

Atossa Therapeutics, Inc.

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Biotechnology
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