Alterity Therapeutics Announces Positive ATH434 Phase 2 Trial Results in Multiple System Atrophy Led By Robust Clinical Efficacy
Alterity Therapeutics announced positive topline results from their ATH434-201 Phase 2 clinical trial for treating early-stage multiple system atrophy (MSA). The trial demonstrated significant clinical benefits, with the 50mg dose showing a 48% slowing of clinical progression (p=0.03) and the 75mg dose showing a 29% slowing at Week 52 compared to placebo.
Key findings include:
- Reduced iron accumulation in MSA-affected brain regions
- Trends in preservation of brain volume
- Improved motor performance on the Parkinson's Plus rating scale
- Favorable safety profile with no serious adverse events related to ATH434
The study enrolled 77 adults across 23 sites in six countries, with participants randomly assigned to receive either 50mg, 75mg, or placebo. The 50mg dose demonstrated the most promising results, showing statistically significant improvement on the modified UMSARS Part I, a key clinical endpoint for FDA approval.
Alterity Therapeutics ha annunciato risultati iniziali positivi dal loro studio clinico di fase 2 ATH434-201 per il trattamento dell'atrofia multisistemica (MSA) in fase precoce. Lo studio ha dimostrato benefici clinici significativi, con la dose di 50 mg che ha mostrato un rallentamento del 48% nella progressione clinica (p=0.03) e la dose di 75 mg che ha mostrato un rallentamento del 29% alla settimana 52 rispetto al placebo.
I risultati chiave includono:
- Riduzione dell'accumulo di ferro nelle aree cerebrali colpite dalla MSA
- Tendenze nella preservazione del volume cerebrale
- Performance motoria migliorata sulla scala di valutazione Parkinson's Plus
- Profilo di sicurezza favorevole senza eventi avversi gravi correlati ad ATH434
Lo studio ha arruolato 77 adulti in 23 centri in sei paesi, con i partecipanti assegnati in modo casuale a ricevere 50 mg, 75 mg o placebo. La dose di 50 mg ha dimostrato i risultati più promettenti, mostrando un miglioramento statisticamente significativo nel modified UMSARS Parte I, un endpoint clinico chiave per l'approvazione dalla FDA.
Alterity Therapeutics anunció resultados preliminares positivos de su ensayo clínico de fase 2 ATH434-201 para el tratamiento de la atrofia multisistémica (MSA) en etapa temprana. El ensayo demostró beneficios clínicos significativos, con la dosis de 50 mg mostrando una desaceleración del 48% en la progresión clínica (p=0.03) y la dosis de 75 mg mostrando una desaceleración del 29% a la semana 52 en comparación con el placebo.
Los hallazgos clave incluyen:
- Reducción de la acumulación de hierro en las regiones cerebrales afectadas por la MSA
- Tendencias en la preservación del volumen cerebral
- Mejora del rendimiento motor en la escala de evaluación Parkinson's Plus
- Perfil de seguridad favorable sin eventos adversos graves relacionados con ATH434
El estudio inscribió a 77 adultos en 23 sitios en seis países, con participantes asignados aleatoriamente para recibir 50 mg, 75 mg o placebo. La dosis de 50 mg demostró los resultados más prometedores, mostrando una mejora estadísticamente significativa en el modified UMSARS Parte I, un endpoint clínico clave para la aprobación de la FDA.
Alterity Therapeutics는 조기 다계통 위축증(MSA) 치료를 위한 ATH434-201 2상 임상 시험의 긍정적인 최종 결과를 발표했습니다. 이 시험은 임상 진행을 50mg 용량에서 48% 느리게(p=0.03) 하고, 75mg 용량에서 위약에 비해 52주째 29% 느리게 하는 등 상당한 임상 혜택을 입증했습니다.
주요 발견은 다음과 같습니다:
- MSA에 영향을 받은 뇌 영역에서의 철 저장량 감소
- 뇌 용적 보존에 대한 경향
- 파킨슨병 플러스 평가 척도에서의 운동 수행 개선
- ATH434와 관련된 심각한 부작용이 없는 유리한 안전성 프로필
이 연구는 6개국 23개 사이트에서 77명의 성인을 등록하였으며, 참가자들은 무작위로 50mg, 75mg, 또는 위약을 받도록 배정되었습니다. 50mg 용량은 임상적 기점인 수정된 UMSARS Part I에서 통계적으로 유의미한 개선을 보여주며 가장 유망한 결과를 나타냈습니다.
Alterity Therapeutics a annoncé des résultats préliminaires positifs de son essai clinique de phase 2 ATH434-201 pour le traitement de l'atrophie multisystémique (MSA) à un stade précoce. L'essai a démontré des avantages cliniques significatifs, la dose de 50 mg montrant un ralentissement de la progression clinique de 48 % (p=0.03) et la dose de 75 mg montrant un ralentissement de 29 % à la semaine 52 par rapport au placebo.
Les principales conclusions comprennent:
- Réduction de l'accumulation de fer dans les régions cérébrales touchées par la MSA
- Tendances dans la préservation du volume cérébral
- Amélioration des performances motrices sur l'échelle d'évaluation Parkinson's Plus
- Profil de sécurité favorable sans événements indésirables graves liés à ATH434
L'étude a enrollé 77 adultes dans 23 sites dans six pays, les participants étant assignés aléatoirement à recevoir 50 mg, 75 mg ou placebo. La dose de 50 mg a montré les résultats les plus prometteurs, montrant une amélioration statistiquement significative au niveau de l'UMSARS modifié Partie I, un critère clinique clé pour l'approbation par la FDA.
Alterity Therapeutics hat positive vorläufige Ergebnisse aus ihrer Phase-2-Studie ATH434-201 zur Behandlung der frühen multiplen Systematrophie (MSA) bekannt gegeben. Die Studie zeigte erhebliche klinische Vorteile, wobei die Dosis von 50 mg eine Verzögerung der klinischen Progression um 48 % (p=0.03) und die Dosis von 75 mg eine Verzögerung von 29 % in Woche 52 im Vergleich zum Placebo aufwies.
Wichtige Ergebnisse sind:
- Verminderte Eisenakkumulation in von MSA betroffenen Gehirnregionen
- Tendenzen zur Erhaltung des Gehirnvolumens
- Verbesserte motorische Leistung auf der Parkinson's Plus Bewertungsskala
- Günstiges Sicherheitsprofil ohne schwere unerwünschte Ereignisse im Zusammenhang mit ATH434
Die Studie schloss 77 Erwachsene an 23 Standorten in sechs Ländern ein, wobei die Teilnehmer zufällig einer Behandlung mit 50 mg, 75 mg oder Placebo zugewiesen wurden. Die Dosis von 50 mg zeigte die vielversprechendsten Ergebnisse mit einer statistisch signifikanten Verbesserung der modifizierten UMSARS Teil I, einem wichtigen klinischen Endpunkt für die Zulassung durch die FDA.
- 48% slowing of clinical progression at 50mg dose with statistical significance (p=0.03)
- Reduced iron accumulation in MSA-affected brain regions, significant at 26 weeks
- Favorable safety profile with no treatment-related serious adverse events
- Zero discontinuations in 50mg dose group due to adverse events
- Demonstrated target engagement through MRI biomarkers
- 75mg dose showed less efficacy (29% slowing) than 50mg dose
- Higher discontinuation rate in 75mg group (n=5) compared to 50mg group (n=0)
- Some endpoints only showed trends rather than statistical significance
Insights
The Phase 2 results for ATH434 represent a significant breakthrough in MSA treatment, marking the first time a therapeutic has demonstrated meaningful disease modification in this devastating neurological condition. The 48% slowing of progression at the 50mg dose achieves statistical significance (p=0.03), while the 75mg dose shows a robust early effect with 62% slowing at 26 weeks (p=0.05).
The biomarker data strongly supports the drug's mechanism of action. MRI evidence shows reduced iron accumulation in critical brain regions, particularly the substantia nigra, putamen and globus pallidus. This aligns with ATH434's proposed mechanism of redistributing labile iron, potentially disrupting the pathological cascade in MSA. The preservation of brain volume, assessed via the MSA atrophy index, provides additional evidence of neuroprotection.
Three key aspects make these results particularly compelling for future development:
- The primary efficacy measure (UMSARS Part I) is already aligned with FDA requirements for approval
- The clean safety profile, with no treatment-related serious adverse events
- Multiple supporting endpoints (Clinical Global Impression, Parkinson Plus scale) showing concordant benefits
The data suggests optimal dosing at 50mg, which demonstrated superior efficacy and safety compared to 75mg. This clear dose-response relationship strengthens the validity of the results and simplifies the path forward for Phase 3 planning.
These compelling Phase 2 results substantially de-risk ATH434's development program and position Alterity for potential accelerated regulatory pathways. The demonstration of disease-modifying effects in MSA - a rare disease with no approved treatments - creates significant value potential through:
- Orphan drug designation benefits including market exclusivity
- Premium pricing potential given the robust efficacy data
- Clear path to market with aligned regulatory endpoints
Beyond MSA, these results validate Alterity's iron-targeting approach for neurodegenerative diseases. The successful proof-of-concept in MSA has positive implications for the company's broader pipeline, including potential applications in Friedreich's ataxia, Parkinson's disease and Alzheimer's disease.
The clean safety profile and optimal efficacy at the lower dose (50mg) suggest favorable manufacturing economics and potential for good commercial margins. The results also position Alterity strongly for potential strategic partnerships or licensing deals, particularly given the scarcity of late-stage MSA assets in development.
– Clinically Meaningful Benefit Observed at Both ATH434 Doses Studied –
– Achieved Statistical Significance with Up to
– Key MRI Biomarker Shows Iron Stabilization in MSA Affected Brain Regions –
– ATH434 Demonstrated a Favorable Safety Profile –
– Webcast Held Yesterday with Access to the Recording Below –
MELBOURNE, Australia and SAN FRANCISCO, Jan. 30, 2025 (GLOBE NEWSWIRE) -- Alterity Therapeutics (ASX: ATH, NASDAQ: ATHE) (“Alterity” or “the Company”), a biotechnology company dedicated to developing disease modifying treatments for neurodegenerative diseases, today announced positive topline results from the ATH434-201 randomized, double-blind, placebo-controlled Phase 2 clinical trial in patients with early-stage multiple system atrophy (MSA).
The topline data showed that ATH434 produced clinically and statistically significant improvement on the modified UMSARS Part I, a functional rating scale that assesses disability on activities of daily living affected in MSA1. On this important clinical measure, ATH434 demonstrated
Biomarkers were used to evaluate potential drug effect and target engagement. Regarding iron content by MRI, the 50 mg dose reduced iron accumulation in MSA affected brain regions (substantia nigra, putamen, and globus pallidus) and the 75 mg dose reduced iron accumulation in the globus pallidus. The reduced accumulation of iron was significant for the 50 mg dose group at 26 weeks (putamen, P=0.025) and approached statistical significance at 52 weeks (globus pallidus, P=0.08). Trends in preservation of brain volume were observed in the 50 mg and 75 mg groups relative to placebo at both 26 and 52 weeks of treatment.
“We are thrilled that ATH434 has demonstrated significant slowing of clinical progression and an excellent safety profile in this rare, rapidly progressive disease,” said David Stamler, M.D., Chief Executive Officer of Alterity. “Currently, there are no approved treatments that slow the progression of MSA and these results show that ATH434’s targeted iron engagement may truly have a disease modifying effect. The fact that we achieved statistical significance on the UMSARS is extremely meaningful because it assesses the functional areas affected in MSA and is the endpoint needed to support drug approval by the U.S. Food and Drug Administration (FDA). Based on the strength of these Phase 2 data, we look forward to engaging with the FDA as quickly as possible to discuss the path forward for accelerating the development of ATH434 given the tremendous unmet need for treating MSA. We are very grateful for the invaluable contributions of the study participants and the clinical sites who contributed to the study.”
Daniel Claassen, M.D., M.S., Professor of Neurology at Vanderbilt University Medical Center and Coordinating Investigator for the ATH434-201 Phase 2 study, commented “The findings from the study are compelling because ATH434 appears to have meaningfully slowed MSA progression and stabilized motor function. To date, no treatment has altered the progression of this devastating disease. The slowing of clinical progression in this study, particularly at 50 mg, is impressive. I look forward to continue working with Alterity to bring this therapy to patients, and I know the MSA community welcomes this exciting advancement.”
Dr. Stamler concluded, “We now have evidence that targeting excess labile iron in neurodegenerative disease can be achieved. By redistributing this reactive form of iron that contributes to disease pathogenesis, not only can we target α‑synuclein aggregation, but we can also break the vicious cycle underlying disease progression. This has implications for developing disease modifying treatments for orphan diseases such as MSA and Friedreich’s ataxia as well as major neurodegenerative disorders such as Parkinson’s disease and Alzheimer’s disease.”
Webcast details
The webcast recording can be accessed on the Events and Presentation page of the Company’s website here.
ATH434-201 Topline Data Summary
The ATH434-201 Phase 2 clinical trial is a randomized, double-blind, placebo-controlled investigation of 12 months treatment with ATH434 in participants with early-stage MSA. The trial enrolled globally with 23 sites in six countries. The study evaluated the efficacy, safety and pharmacokinetics of ATH434 as well as the effect of ATH434 on neuroimaging and protein biomarkers. Wearable movement sensors were employed to evaluate motor activities in an outpatient setting. The study enrolled 77 adults who were randomly assigned to receive one of two dose levels of ATH434 (50mg or 75mg) or placebo. Treatment was administered orally twice-a-day (BID).
ATH434 Efficacy Results (n=61)
The principal efficacy analyses were performed on the modified Intent-to-Treat (mITT) population, which includes enrolled participants who received study drug and had at least one MRI evaluation for brain iron at six months. There were approximately 20 patients per arm in the mITT. Both clinical doses demonstrated improvement relative to placebo over 52 weeks, with the 50 mg dose showing a greater treatment effect. Additional analyses are ongoing to understand the differences between the two groups.
Key Biomarker Endpoint:
On the primary endpoint of iron content by MRI, ATH434 demonstrated reduced or stabilized iron content in key brain regions affected by MSA.
- Demonstrated target engagement of ATH434
- The 50 mg dose reduced iron accumulation in the substantia nigra, putamen, and globus pallidus
- The reduced accumulation of iron was significant at 26 weeks (putamen, P=0.025) and approached statistical significance at 52 weeks (globus pallidus, P=0.08)
- The 75 mg dose reduced iron accumulation in the globus pallidus
Other biomarkers were used to evaluate potential drug effect and target engagement.
- Brain Volume: ATH434 demonstrated a trend in preserving brain volume as compared to placebo at both 50 mg and 75 mg dose levels, as assessed by the MSA atrophy index (MSA-AI)3
- NfL: The analysis of neurofilament light chain (NfL) levels in spinal fluid is ongoing
Key Clinical Endpoint: UMSARS Part I
The key secondary endpoint was defined as the change in the Unified MSA Rating Scale Part I (UMSARS I). UMSARS I is a functional rating scale that assesses disability and disease severity in MSA. It is the most meaningful endpoint in the trial, as it is the clinical endpoint of interest to support approval by regulatory authorities such as the FDA.
- Placebo treated patients declined by a mean of 4.5 points over 26 weeks and 8.2 points over 52 weeks
- The 50 mg dose declined by a mean of 4.3 points over 52 weeks, equivalent to a
48% slowing of clinical progression (p=0.03) - The 75 mg dose declined by a mean of 5.8 points over 52 weeks, equivalent to a
29% slowing of clinical progression (p=0.2) - The 75 mg dose declined by a mean of 1.8 points over 26 weeks equivalent to a
62% slowing of clinical progression (p=0.05) - Both dose groups clearly separated from placebo.
Additional Secondary Endpoints:
Observed trends of improved motor performance support the efficacy of ATH434 in the clinical setting:
- Clinical Global Impression of Severity4 (7-point scale, higher score worse)
- Mean change at 50 mg: -0.81 (p=0.009)
- Mean change at 75 mg: -0.18 (p=NS)
- Parkinson Plus total motor scale: Trends in both dose groups at 26 and 52 weeks with a clinical benefit apparent in multiple domains
- Increased activity on wearable sensors in both groups with increases in step count, bouts of walking, total walking time, and standing time
- Orthostatic Hypotension Symptom Assessment (patient rated) showed trends favoring benefit in both groups (p=0.13 at 50 mg)
ATH434 Safety Results (n=77)
The safety population includes all enrolled participants who received at least one dose of study drug. Overall, 26 participants received the 50 mg dose, 25 participants received the 75 mg dose, and 26 participants received placebo.
- ATH434 was well-tolerated with similar adverse event (AE) rates in ATH434 treatment groups and placebo
- Most AEs were mild to moderate in severity
- No serious adverse events (SAEs) related to ATH434 were reported
- Discontinuations for AEs were similar in the placebo (n=3) and 75 mg dose (n=5) groups and lowest at 50 mg (n=0). None of the AEs leading to discontinuation were related to treatment.
About ATH434
Alterity’s lead candidate, ATH434, is an oral agent designed to inhibit the aggregation of pathological proteins implicated in neurodegeneration. ATH434 has been shown preclinically to reduce α-synuclein pathology and preserve neuronal function by restoring normal iron balance in the brain. As an iron chaperone, it has excellent potential to treat Parkinson’s disease as well as various Parkinsonian disorders such as Multiple System Atrophy (MSA). ATH434 successfully completed Phase 1 studies demonstrating the agent is well tolerated and achieved brain levels comparable to efficacious levels in animal models of MSA. ATH434 recently announced positive results from the randomized, double-blind, placebo-controlled Phase 2 clinical trial in patients with early-stage MSA. A second Phase 2 open-label 2 Biomarker trial in patients with more advanced MSA is ongoing. ATH434 has been granted Orphan Drug Designation for the treatment of MSA by the U.S. FDA and the European Commission.
About Multiple System Atrophy
Multiple System Atrophy (MSA) is a rare, neurodegenerative disease characterized by failure of the autonomic nervous system and impaired movement. The symptoms reflect the progressive loss of function and death of different types of nerve cells in the brain and spinal cord. It is a rapidly progressive disease and causes profound disability. MSA is a Parkinsonian disorder characterized by a variable combination of slowed movement and/or rigidity, autonomic instability that affects involuntary functions such as blood pressure maintenance and bladder control, and impaired balance and/or coordination that predisposes to falls. A pathological hallmark of MSA is the accumulation of the protein α-synuclein within glia, the support cells of the central nervous system, and neuron loss in multiple brain regions. MSA affects at least 15,000 individuals in the U.S., and while some of the symptoms of MSA can be treated with medications, currently there are no drugs that are able to slow disease progression and there is no cure.5
About Alterity Therapeutics Limited
Alterity Therapeutics is a clinical stage biotechnology company dedicated to creating an alternate future for people living with neurodegenerative diseases. The Company’s lead asset, ATH434, has the potential to treat various Parkinsonian disorders and is currently being evaluated in two Phase 2 clinical trials in Multiple System Atrophy. Alterity also has a broad drug discovery platform generating patentable chemical compounds to treat the underlying pathology of neurological diseases. The Company is based in Melbourne, Australia, and San Francisco, California, USA. For further information please visit the Company’s web site at www.alteritytherapeutics.com.
Definitions and References
Unified MSA Rating Scale, Part I (historical review). Domains assessed include speech, swallowing, handwriting, cutting food/handling utensils, dressing, hygiene, walking, falling, orthostatic symptoms, urinary function, sexual function and bowel function.
^ All p-values are uncorrected
2 Natural History and Neuroprotection in Parkinson Plus Syndromes Parkinson’s Plus Rating Scale, (NNIPPS-PPS)
3 MSA Atrophy Index: This index measures the degree of atrophy relative to a normal population, with more negative values indicating greater atrophy
4 Clinical Global Impression of Severity: a clinician assessment of the total picture of the subject including the impact of the illness on function and level of distress
5 Multiple System Atrophy | National Institute of Neurological Disorders and Stroke (nih.gov)
Authorisation & Additional information
This announcement was authorized by David Stamler, CEO of Alterity Therapeutics Limited.
Investor and Media Contacts:
Australia
Ana Luiza Harrop
we-aualteritytherapeutics@we-worldwide.com
+61 452 510 255
U.S.
Remy Bernarda
remy.bernarda@iradvisory.com
+1 (415) 203-6386
Forward Looking Statements
This press release contains "forward-looking statements" within the meaning of section 27A of the Securities Act of 1933 and section 21E of the Securities Exchange Act of 1934. The Company has tried to identify such forward-looking statements by use of such words as "expects," "intends," "hopes," "anticipates," "believes," "could," "may," "evidences" and "estimates," and other similar expressions, but these words are not the exclusive means of identifying such statements.
Important factors that could cause actual results to differ materially from those indicated by such forward-looking statements are described in the sections titled “Risk Factors” in the Company’s filings with the SEC, including its most recent Annual Report on Form 20-F as well as reports on Form 6-K, including, but not limited to the following: statements relating to the Company's drug development program, including, but not limited to the initiation, progress and outcomes of clinical trials of the Company's drug development program, including, but not limited to, ATH434, and any other statements that are not historical facts. Such statements involve risks and uncertainties, including, but not limited to, those risks and uncertainties relating to the difficulties or delays in financing, development, testing, regulatory approval, production and marketing of the Company’s drug components, including, but not limited to, ATH434, the ability of the Company to procure additional future sources of financing, unexpected adverse side effects or inadequate therapeutic efficacy of the Company's drug compounds, including, but not limited to, ATH434, that could slow or prevent products coming to market, the uncertainty of obtaining patent protection for the Company's intellectual property or trade secrets, the uncertainty of successfully enforcing the Company’s patent rights and the uncertainty of the Company freedom to operate.
Any forward-looking statement made by us in this press release is based only on information currently available to us and speaks only as of the date on which it is made. We undertake no obligation to publicly update any forward-looking statement, whether written or oral, that may be made from time to time, whether as a result of new information, future developments or otherwise.
FAQ
What were the main results of ATHE's Phase 2 trial for ATH434 in MSA treatment?
How many patients were enrolled in ATHE's ATH434-201 Phase 2 trial?
What safety profile did ATH434 demonstrate in ATHE's Phase 2 trial?
Which dose of ATHE's ATH434 showed better results in the Phase 2 trial?
What were the key biomarker results for ATHE's ATH434 in MSA treatment?
