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Athira Pharma, Inc. (NASDAQ: ATHA) is a late clinical-stage biopharmaceutical company based in the Seattle, Washington area, dedicated to developing small molecule therapeutics aimed at restoring neuronal health and slowing neurodegeneration. Athira's innovative pipeline includes several promising compounds, particularly targeting the neurotrophic hepatocyte growth factor (HGF) system, which plays a crucial role in nervous system maintenance and repair.
The company’s lead candidate, Fosgonimeton (ATH-1017), is a subcutaneously administered small molecule designed to positively modulate the HGF/MET system. It is currently being evaluated in the Phase 2/3 LIFT-AD clinical trial for the treatment of mild-to-moderate Alzheimer’s disease, with topline data expected in the second half of 2024. Fosgonimeton has shown potential in enhancing neuroprotective, neurotrophic, and anti-inflammatory pathways, which are critical in combating neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease.
In addition to Fosgonimeton, Athira’s pipeline includes ATH-1105 and ATH-1020, both designed to be orally available treatments enhancing the HGF/MET system. ATH-1105 is particularly promising in preclinical models of amyotrophic lateral sclerosis (ALS), demonstrating significant neuroprotective effects, enhanced survival, and improved motor and nerve functions. The company plans to initiate first-in-human studies for ATH-1105 in the first half of 2024.
Athira's research is bolstered by funding from notable organizations such as the Alzheimer’s Drug Discovery Foundation, Washington’s Life Sciences Discovery Fund, and Dolby Family Ventures. This support underscores the company’s strong financial position and its capacity to advance its therapeutic candidates through key development milestones.
Recent updates highlight the therapeutic potential of Athira’s small molecules. For instance, fosgonimeton has demonstrated promising results in preclinical models of Alzheimer’s and Parkinson’s diseases, showing neuroprotective effects and improvement in cognitive and motor functions. Additionally, ATH-1105's preclinical studies have shown consistent beneficial effects in ALS models, reinforcing Athira’s approach and commitment to developing novel therapies for neurodegenerative diseases.
Athira is also active in the scientific community, regularly presenting its findings at major conferences and publishing in peer-reviewed journals. The company’s efforts are focused on leveraging its patented technologies to develop cost-effective treatments that address the root causes of neurodegenerative diseases, setting it apart from competitors that primarily target disease symptoms.
For more information about Athira Pharma, Inc., visit www.athira.com and follow the company on Facebook, LinkedIn, X (formerly known as Twitter), and Instagram.
Athira Pharma (NASDAQ: ATHA) announced the dosing of the first subject in a Phase 1 clinical trial for ATH-1020, aimed at treating neuropsychiatric conditions. This trial marks a crucial milestone as it is Athira's second clinical candidate and its first oral small molecule. The study will enroll approximately 68 healthy volunteers and will focus on the safety and tolerability of ATH-1020, which has shown promise in preclinical data by mitigating depression-like behaviors and normalizing sensory processing deficits in schizophrenia. Initial results are anticipated to guide future developments.
Athira Pharma (NASDAQ: ATHA) issued a statement addressing concerns from Richard Kayne regarding its governance and clinical focus. The company emphasizes its commitment to advancing fosgonimeton for Alzheimer’s disease, with results from the Phase 2 ACT-AD study expected soon. Athira has added three independent directors and seeks collaboration with Kayne but has faced rejection. The board dismissed former CEO Dr. Leen Kawas due to integrity concerns following an investigative report. Investors are advised to review the preliminary proxy statement filed on March 25, 2022.
Ric Kayne, a significant shareholder of Athira Pharma (NASDAQ: ATHA), has nominated himself and George Bickerstaff for the Board of Directors, citing urgent leadership changes needed after the hasty resignation of Co-Founder Dr. Leen Kawas. Kayne emphasizes that current CEO Dr. Mark Litton lacks the operational and clinical trial experience necessary to lead pivotal trials for ATH-1017, resulting in a significant decline in shareholder value, over 25% since Litton took over. Kayne calls for a proper succession plan and oversight to maximize the potential of ATH-1017.
Athira Pharma (NASDAQ: ATHA) reported its financial results for 2021 and provided a clinical update on its Alzheimer's disease programs. As of December 31, 2021, the company had $319.7 million in cash, up from $268.2 million the previous year. R&D expenses increased to $42.8 million, while G&A expenses rose to $21.2 million, reflecting expanded operations. Athira is set to report topline data from its Phase 2 ACT-AD study in Q2 2022 and aims to complete enrollment in the LIFT-AD Phase 3 study by Q3 2022. The company remains optimistic about its clinical pipeline and potential for shareholder value.
Athira Pharma has appointed Michael A. Panzara, M.D., MPH, a seasoned expert in CNS drug development, to its Board of Directors. With over 20 years in the biopharmaceutical industry, Panzara's experience includes pivotal roles at Wave Life Sciences, Sanofi Genzyme, and Biogen. Panzara's leadership in neurology drug development positions him to enhance Athira's clinical programs, especially for Alzheimer's and Parkinson's diseases. CEO Mark Litton highlighted Panzara's insights as critical in advancing therapies aimed at improving neurological health.
Athira Pharma (NASDAQ: ATHA) announced participation in two major investor conferences. The first is the Stifel 2022 Virtual CNS Days on March 28-29 at 2:30 PM ET, featuring a fireside chat with key executives including Dr. Mark Litton and Dr. Hans Moebius. The second event is the 21st Annual Needham Virtual Healthcare Conference from April 11-14, with a presentation scheduled for April 14 at 3:00 PM ET. Live webcasts will be available on the Athira website, with recordings accessible for 30 days after.
Athira Pharma (NASDAQ: ATHA) announced the presentation of baseline data from its fully enrolled Phase 2 ACT-AD clinical trial for its lead candidate, fosgonimeton (ATH-1017), targeting mild-to-moderate Alzheimer’s disease. The trial included 77 participants, averaging 71.4 years old, with 57 completing the study. Preliminary results are set for release in Q2 2022. These findings will inform the ongoing Phase 3 LIFT-AD study. Fosgonimeton aims to enhance neuronal health and cognitive function through its mechanism involving hepatocyte growth factor.
Athira Pharma, a late clinical-stage biopharmaceutical company, announced it will report its financial results for Q4 and full year 2021 on March 24, 2022. The conference call to discuss these results will start at 4:30 PM ET. Athira focuses on developing small molecules to enhance neuronal health and combat neurodegeneration, with its lead candidate, fosgonimeton (ATH-1017), targeting Alzheimer’s and Parkinson’s diseases. For more details, visit their website.
Athira Pharma (NASDAQ: ATHA) announced an update on its fully enrolled ACT-AD Phase 2 clinical trial for fosgonimeton (ATH-1017) in mild-to-moderate Alzheimer's disease. The trial has enrolled 77 subjects across the US and Australia, focusing on cognitive and functional measures. Presentation details include a session at the AD/PD 2022 congress in Barcelona on March 20, 2022. Fosgonimeton aims to restore neuronal health and slow neurodegeneration. The primary endpoint is Event-Related-Potential (ERP) P300 Latency.
Athira Pharma (NASDAQ: ATHA) announced promising preclinical data for its compounds, fosgonimeton and ATH-1020, targeting neurodegenerative and neuropsychiatric disorders. Fosgonimeton enhances the HGF/MET system, showing neurotrophic and procognitive effects in Alzheimer's and Parkinson's models. ATH-1020 demonstrated significant reductions in depression-like behaviors and normalized sensory deficits in schizophrenia models. Ongoing clinical trials, including Phase 2 and Phase 3 studies for Alzheimer’s, are underway, with expectations for future results to further validate these findings.
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