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Athira Pharma, Inc. (NASDAQ: ATHA) is a late clinical-stage biopharmaceutical company based in the Seattle, Washington area, dedicated to developing small molecule therapeutics aimed at restoring neuronal health and slowing neurodegeneration. Athira's innovative pipeline includes several promising compounds, particularly targeting the neurotrophic hepatocyte growth factor (HGF) system, which plays a crucial role in nervous system maintenance and repair.
The company’s lead candidate, Fosgonimeton (ATH-1017), is a subcutaneously administered small molecule designed to positively modulate the HGF/MET system. It is currently being evaluated in the Phase 2/3 LIFT-AD clinical trial for the treatment of mild-to-moderate Alzheimer’s disease, with topline data expected in the second half of 2024. Fosgonimeton has shown potential in enhancing neuroprotective, neurotrophic, and anti-inflammatory pathways, which are critical in combating neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease.
In addition to Fosgonimeton, Athira’s pipeline includes ATH-1105 and ATH-1020, both designed to be orally available treatments enhancing the HGF/MET system. ATH-1105 is particularly promising in preclinical models of amyotrophic lateral sclerosis (ALS), demonstrating significant neuroprotective effects, enhanced survival, and improved motor and nerve functions. The company plans to initiate first-in-human studies for ATH-1105 in the first half of 2024.
Athira's research is bolstered by funding from notable organizations such as the Alzheimer’s Drug Discovery Foundation, Washington’s Life Sciences Discovery Fund, and Dolby Family Ventures. This support underscores the company’s strong financial position and its capacity to advance its therapeutic candidates through key development milestones.
Recent updates highlight the therapeutic potential of Athira’s small molecules. For instance, fosgonimeton has demonstrated promising results in preclinical models of Alzheimer’s and Parkinson’s diseases, showing neuroprotective effects and improvement in cognitive and motor functions. Additionally, ATH-1105's preclinical studies have shown consistent beneficial effects in ALS models, reinforcing Athira’s approach and commitment to developing novel therapies for neurodegenerative diseases.
Athira is also active in the scientific community, regularly presenting its findings at major conferences and publishing in peer-reviewed journals. The company’s efforts are focused on leveraging its patented technologies to develop cost-effective treatments that address the root causes of neurodegenerative diseases, setting it apart from competitors that primarily target disease symptoms.
For more information about Athira Pharma, Inc., visit www.athira.com and follow the company on Facebook, LinkedIn, X (formerly known as Twitter), and Instagram.
Athira Pharma (NASDAQ: ATHA) has appointed Barbara Kosacz to its Board of Directors. Kosacz, COO and General Counsel at Kronos Bio, brings over 25 years of experience in life sciences, having led significant transactions in the industry. CEO Leen Kawas emphasized her expertise will enhance the Board's capabilities as Athira progresses with its clinical trials. Kosacz expressed enthusiasm for Athira's novel drug development platform aimed at treating neurological diseases like Alzheimer's and Parkinson's. Athira continues to advance its lead candidate, ATH-1017.
Athira Pharma (NASDAQ: ATHA) will present a corporate overview at the H.C. Wainwright & Co. Global Life Sciences Conference. Leen Kawas, Ph.D., President and CEO, will lead the pre-recorded presentation available at 7:00 am ET on March 9, 2021. The presentation can be accessed on-demand through the Athira website, with an archived replay available for 90 days post-event. Athira focuses on developing small molecules to restore neuronal health, targeting Alzheimer’s and Parkinson’s dementia with its lead candidate, ATH-1017.
Athira Pharma, Inc. (Nasdaq: ATHA) announced that underwriters exercised their option to purchase an additional 600,000 shares at $22.50 each, generating total gross proceeds of $103.5 million from its public offering. The closing of this sale occurred on February 10, 2021. Goldman Sachs, Jefferies, and Stifel managed the offering, which became effective after a registration statement filed with the SEC on January 20, 2021. The offering is strictly subject to the terms outlined in the prospectus and does not constitute an offer to sell securities in jurisdictions where it would be unlawful.
Athira Pharma has announced a public offering of 4,000,000 shares of common stock at a price of $22.50 per share, aiming to raise gross proceeds of $90 million. The offering is expected to close on January 25, 2021, pending standard closing conditions. Athira has also granted underwriters a 30-day option to purchase an additional 600,000 shares. The offering is being managed by Goldman Sachs, Jefferies, and Stifel, with a registration statement that became effective on January 20, 2021. The proceeds will support the company’s efforts in developing therapies for neurodegeneration.
Athira Pharma has launched an underwritten public offering of 4,000,000 shares of its common stock, with an additional option for underwriters to purchase 600,000 more shares. The offering will be conducted by Goldman Sachs, Jefferies, and Stifel as joint book-running managers. The offering is subject to market conditions and the registration statement is pending effectiveness. This move aims to raise capital for ongoing development efforts in restoring neuronal health and combating neurodegeneration. Further details are accessible via the underwriters.
Athira Pharma, a late clinical-stage biopharmaceutical company listed on NASDAQ under the symbol ATHA, announced that its President and CEO, Leen Kawas, Ph.D., will present at the 39th Annual J.P. Morgan Conference on January 14, 2021, at 2:50 p.m. ET. The presentation will focus on the company's pipeline and innovations aimed at restoring neuronal health and combating neurodegeneration.
A live webcast will be available on the company's investor website, with an archived replay accessible for 90 days post-presentation.
Athira Pharma (NASDAQ: ATHA) announced the appointment of Kelly A. Romano to its Board of Directors. Romano, founder of BlueRipple Capital, brings over 30 years of experience in technology and operations, previously serving at United Technologies Corp. Her addition aims to support Athira's goal of advancing ATH-1017 for Alzheimer’s disease in clinical trials. Athira’s efforts focus on developing treatments that restore neuronal health, with promising clinical data for ATH-1017 noted. The company emphasizes ongoing commitment to patient care in neurodegenerative diseases.
Athira Pharma (NASDAQ: ATHA) has received a $15 million research grant from the National Institute on Aging to support the ACT-AD Phase 2 clinical trial for its lead candidate, ATH-1017, targeting mild-to-moderate Alzheimer's disease. This grant emphasizes the federal commitment to advancing innovative research in cognitive health. The ACT-AD trial will assess ATH-1017's impact on cognitive functions using quantitative EEG and other metrics. ATH-1017 aims to enhance brain health by targeting Hepatocyte Growth Factor and its receptor, MET.
Athira Pharma (NASDAQ: ATHA) has initiated patient dosing in the Phase 2 ACT-AD clinical trial, focusing on its drug ATH-1017 for mild-to-moderate Alzheimer’s disease. This randomized, placebo-controlled study will enroll around 75 participants across the US and Australia, evaluating cognitive improvements over 26 weeks. The trial aims to use EEG measures to assess brain function, building on previous data from the LIFT-AD trial. Athira aims to leverage this innovative approach to advance their treatment options for Alzheimer’s and potentially other dementias.
Athira Pharma (NASDAQ: ATHA) announced significant developments in their LIFT-AD clinical trial for ATH-1017, focusing on mild-to-moderate Alzheimer’s disease. The trial is actively enrolling patients, and dosing has commenced. As of September 30, 2020, the company reported a robust cash position of $259.9 million, a notable increase from $85.2 million in June 2020. R&D expenses rose to $5.8 million due to clinical trial preparations, while G&A expenses increased to $1.6 million. The net loss for Q3 2020 was $8.5 million, or $1.12 per share.
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