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Aprea Therapeutics, Inc. (APRE) is a clinical-stage biopharmaceutical leader developing precision oncology therapies through synthetic lethality approaches. This page provides investors and researchers with timely updates on the company’s progress in targeting DNA damage response pathways in solid tumors.
Access authoritative reporting on Aprea’s pipeline developments, including its ATRN-119 and APR-1051 programs. Our curated news collection covers clinical trial milestones, regulatory updates, and strategic collaborations, helping stakeholders track innovations in targeted cancer therapies.
Key content includes updates on phase 1/2 trial results, FDA communications, intellectual property expansions, and research partnerships. All content is verified through primary sources to ensure accuracy in this fast-evolving therapeutic area.
Bookmark this page for centralized access to Aprea’s latest scientific advancements and corporate announcements. Check regularly for developments in next-generation oncology treatments leveraging synthetic lethality mechanisms.
Aprea Therapeutics (Nasdaq: APRE) has engaged Philippe Pultar, MD as senior medical advisor to support the development of APR-1051, their potential best-in-class WEE1 inhibitor. Dr. Pultar brings extensive oncology experience, including the development of azenosertib, another WEE1 inhibitor. This aligns with Aprea's commitment to providing top resources for their WEE1 inhibitor program.
The Phase 1 ACESOT-1051 study is ongoing, evaluating APR-1051 in advanced solid tumors with specific gene alterations. Aprea plans to update on this study by year-end 2024. The WEE1 program is part of Aprea's DDR-targeted therapeutics portfolio, aiming to deliver precision medicine solutions.
Dr. Pultar expressed excitement about APR-1051's potential, citing its differentiated profile and compelling pre-clinical data. Aprea's CEO, Oren Gilad, Ph.D., highlighted Dr. Pultar's expertise as valuable for advancing their WEE1 program. Concurrently, Dr. Nadeem Mirza will step down as Chief Medical Officer, effective October 9, 2024.
Halda Therapeutics, a biotech company developing RIPTAC™ (Regulated Induced Proximity TArgeting Chimeras) therapeutics for cancer, has appointed Christian Schade as President, CEO, and Board member. Schade brings over 20 years of pharma and biotech industry experience, including leadership in clinical pipeline development and value-creating deals. Tim Shannon continues as Board Chairman.
Schade's appointment comes as Halda prepares to enter clinical trials, with the first RIPTAC therapeutic expected to begin trials in the first half of 2025. The company is focusing on developing therapies for prostate and breast cancer. Schade's previous roles include CEO of Aprea Therapeutics, Growth Partner at Flagship Pioneering, and executive positions at Novira, Omthera Pharmaceuticals, and Medarex.
Aprea Therapeutics (Nasdaq: APRE), a clinical-stage biopharmaceutical company focused on precision oncology through synthetic lethality, has announced its participation in the Lytham Partners Fall 2024 Investor Conference on October 1, 2024. The event will be held virtually, featuring:
1. A webcasted presentation by Oren Gilad, Ph.D., President and CEO, at 12:30pm ET.
2. One-on-one meetings with investors throughout the event.
The webcast can be accessed via the conference home page or a direct link, and will be available for replay after the event. Investors interested in arranging meetings with management can contact Lytham Partners or register through the provided link.
Aprea Therapeutics (Nasdaq: APRE), a clinical stage biopharmaceutical company focusing on precision oncology through synthetic lethality, has announced its participation in the H.C. Wainwright 26th Annual Global Investment Conference. The event is scheduled for September 9-11, 2024 in New York, NY.
Dr. Oren Gilad, President and CEO of Aprea, will deliver a corporate update during the conference. The presentation will be available on-demand starting at 7:00 A.M. (ET) on September 9, 2024, and will remain accessible for 90 days. Interested parties can access the webcast through the provided link.
Additionally, Aprea's management team will be available for one-on-one meetings with institutional investors during the conference. Attendees interested in scheduling a meeting are advised to contact their conference representative.
Aprea Therapeutics (Nasdaq: APRE), a clinical stage biopharmaceutical company focusing on precision oncology through synthetic lethality, has announced its participation in the H.C. Wainwright 26th Annual Global Investment Conference. The event is scheduled for September 9-11, 2024 in New York, NY.
Dr. Oren Gilad, President and CEO of Aprea, will deliver a corporate update during the conference. The presentation will be available on-demand starting at 7:00 A.M. (ET) on September 9, 2024, and will remain accessible for 90 days. Interested parties can access the webcast through a provided link.
Additionally, Aprea's management team will be available for one-on-one meetings with institutional investors during the conference. Attendees interested in scheduling a meeting are advised to contact their conference representative.
Aprea Therapeutics (Nasdaq: APRE) reported Q2 2024 financial results and provided a business update. Key highlights include:
1. Enrollment began in the ACESOT-1051 Phase 1 trial for APR-1051, a WEE1 kinase inhibitor, with no myelosuppression observed in the first cohort.
2. Cash position of $28.7 million as of June 30, 2024, with runway extended into Q4 2025.
3. Q2 2024 operating loss of $3.8 million, compared to $3.7 million in Q2 2023.
4. Net loss of $3.5 million ($0.58 per basic share) for Q2 2024.
5. Ongoing progress in ABOYA-119 trial for ATRN-119, an ATR inhibitor.
6. Appointment of Nadeem Q. Mirza as Chief Medical Officer.
Aprea Therapeutics will host a virtual Key Opinion Leader (KOL) event on Monday, June 24, 2024, at 9:00 AM ET to discuss APR-1051, a highly selective, potentially best-in-class oral WEE1 inhibitor. The event will feature experts Joseph Vacca, PhD, and Eric J. Brown, PhD, who will delve into the drug's medicinal chemistry history, selective design, and preclinical findings.
APR-1051 targets WEE1, an enzyme important to the DNA damage response pathway, making it a validated oncology target. The drug is designed to minimize off-target toxicity and is currently being evaluated in the Phase 1 ACESOT-1051 trial for patients with significant unmet medical needs, including those with Cyclin E overexpression. The event will also include a live Q&A session.
Joseph Vacca, a seasoned medicinal chemist with significant contributions to several approved drugs, and Eric J. Brown, an expert on replication stress response, will lead the discussions. This event aims to provide a comprehensive overview of APR-1051 in the context of emerging WEE1 inhibitors while highlighting its potential benefits and ongoing research.
Aprea Therapeutics has announced the dosing of the first patient in the ACESOT-1051 Phase 1 trial for their oral WEE1 inhibitor, APR-1051. This study is evaluating APR-1051 as a monotherapy for patients with advanced solid tumors who have unmet medical needs. APR-1051, developed by Aprea, targets the WEE1 kinase, an enzyme involved in the DNA damage response pathway. The trial will assess safety, pharmacokinetics, pharmacodynamics, and preliminary efficacy over 28-day cycles. The first part involves dose escalation, while the second part focuses on dose optimization. The trial aims to confirm APR-1051's safety and determine the recommended Phase 2 dose. Updates are expected by year-end 2024 with preliminary efficacy data in 2025.
Aprea Therapeutics announced that the Safety Review Committee (SRC) has approved dosing patients with ATRN-119 at 800 mg once daily in the ongoing ABOYA-119 clinical trial. ATRN-119, the first macrocyclic ATR inhibitor in clinic trials, has demonstrated a favorable safety profile through five dosage levels (up to 550 mg) with no dose-limiting toxicities. This advancement allows for Cohort 6 enrollment and positions Aprea to complete dose escalation and potentially release initial efficacy data by the second half of 2024. Clinical data show increasing systemic drug exposure with higher doses, and preliminary benefits observed in the trial include stable disease in two patients. The Phase 1 dose escalation is expected to conclude by the fourth quarter of 2024, with a recommended Phase 2 dosage to be identified by early 2025. Further Phase 2a cohort studies will begin in early 2025, aiming to evaluate ATRN-119's efficacy in advanced solid tumors with specific DDR pathway mutations.
Aprea Therapeutics (NASDAQ: APRE) announced FDA clearance for their new oral WEE1 inhibitor, APR-1051, and plans to initiate Phase 1 clinical trials in June 2024. Their ATR inhibitor, ATRN-119, is progressing in the ABOYA-119 trial, with initial efficacy data expected in 2H 2024. The company presented four posters at the AACR Annual Meeting, including updates on these key programs. Aprea has $32.4 million in cash as of March 31, 2024, and recently raised up to $34 million through a private placement. First-quarter 2024 results showed an operating loss of $3.1 million, down from $4.6 million in the same period of 2023, and net loss narrowed to $2.8 million. R&D expenses increased to $1.6 million, while G&A expenses decreased to $1.9 million. They also appointed Nadeem Q. Mirza, M.D., as Chief Medical Officer, effective May 1, 2024.
