Welcome to our dedicated page for Aprea Therapeutics news (Ticker: APRE), a resource for investors and traders seeking the latest updates and insights on Aprea Therapeutics stock.
Aprea Therapeutics, Inc. (APRE) is a clinical-stage biopharmaceutical leader developing precision oncology therapies through synthetic lethality approaches. This page provides investors and researchers with timely updates on the company’s progress in targeting DNA damage response pathways in solid tumors.
Access authoritative reporting on Aprea’s pipeline developments, including its ATRN-119 and APR-1051 programs. Our curated news collection covers clinical trial milestones, regulatory updates, and strategic collaborations, helping stakeholders track innovations in targeted cancer therapies.
Key content includes updates on phase 1/2 trial results, FDA communications, intellectual property expansions, and research partnerships. All content is verified through primary sources to ensure accuracy in this fast-evolving therapeutic area.
Bookmark this page for centralized access to Aprea’s latest scientific advancements and corporate announcements. Check regularly for developments in next-generation oncology treatments leveraging synthetic lethality mechanisms.
Aprea Therapeutics (Nasdaq: APRE) announced the results of its Phase 3 clinical trial evaluating eprenetapopt with azacitidine (AZA) for TP53 mutant myelodysplastic syndromes (MDS). The trial did not achieve its primary endpoint of complete remission (CR) rate, with 33.3% CR in the eprenetapopt plus AZA arm compared to 22.4% in the AZA alone arm (P = 0.13). Despite this, secondary endpoints showed some favor toward the experimental arm. The combination was well-tolerated, and further analyses will be conducted as patient data matures.
Aprea Therapeutics (Nasdaq: APRE) announced that the FDA granted Fast Track designation for eprenetapopt, aimed at treating patients with TP53 mutant acute myeloid leukemia (AML). This designation helps expedite the development and review process for drugs addressing serious conditions. Aprea previously obtained Breakthrough Therapy and Orphan Drug designations for eprenetapopt for myelodysplastic syndromes (MDS). The company is actively enrolling patients in clinical trials for eprenetapopt combined with azacitidine and venetoclax, with promising initial data expected in 2021.
Aprea Therapeutics (Nasdaq: APRE), a biopharmaceutical company focused on cancer therapeutics, will have its CEO Christian S. Schade and CMO Eyal Attar participate in a fireside chat at the virtual Piper Sandler Healthcare Conference from December 1-3, 2020. The pre-recorded chat will be available for limited viewing starting November 23, 2020, on the company's investors website. Aprea is known for developing drugs that reactivate the mutant tumor suppressor protein, p53, with its lead product candidate, eprenetapopt (APR-246), targeting hematologic malignancies.
Aprea Therapeutics (Nasdaq: APRE) reported its Q3 2020 financial results and business updates, focusing on its lead product candidate, eprenetapopt. The company has completed enrollment in pivotal Phase 3 trials for TP53 mutant MDS with azacitidine and is enhancing its clinical pipeline in AML and solid tumors. As of September 30, 2020, Aprea had $101.1 million in cash, down from $130.1 million at 2019 year-end, and anticipates a cash burn of $35-40 million for 2020. The net loss for Q3 2020 was $12.3 million, or $0.58 per share, compared to $6.2 million in Q3 2019.
Aprea Therapeutics (Nasdaq: APRE) hosted a virtual R&D Day Webinar on October 30, 2020, featuring discussions by experts in hematology regarding clinical therapies for TP53 mutant MDS/AML patients. The agenda included a review of Aprea's Phase 3 clinical program and commercial strategies. Aprea's lead candidate, eprenetapopt, targets mutant tumor suppressor protein p53 and has received multiple FDA designations for MDS. The company is developing APR-548 as a next-generation agent with a planned Phase 1 trial. For more information, visit Aprea's website.
Aprea Therapeutics, Inc. (Nasdaq: APRE) has launched p53reactivation.com to enhance disease awareness regarding p53 mutations in cancer. This initiative aims to educate healthcare professionals on how these mutations are linked to poor treatment outcomes. With approximately half of all cancers featuring p53 mutations, the site seeks to promote understanding of diagnostic tests and potential targeted therapies, marking a significant step in addressing this unmet medical need.
Aprea Therapeutics (NASDAQ: APRE) announced FDA acceptance of its IND application for APR-548, targeting TP53 mutant myelodysplastic syndromes (MDS). This milestone is crucial for the next-generation small molecule aimed at reactivating mutant p53. CEO Christian S. Schade expressed optimism about initiating a Phase 1 clinical trial for APR-548, reinforcing Aprea's commitment to advancing therapeutic options for p53 mutated cancers. The company is also progressing with its lead product, eprenetapopt, which has received multiple FDA designations for MDS and other malignancies.
Aprea Therapeutics (NASDAQ: APRE) announced the addition of Michael A. Kelly to its Board of Directors, where he will be part of the audit and governance committees. With over 20 years in life sciences, Kelly has held senior roles at Amgen and founded Sentry Hill Partners. His expertise is expected to enhance Aprea's mutant p53 reactivator oncology programs aimed at commercialization. The company focuses on developing innovative cancer therapies, including APR-246, which has received several FDA designations for hematologic malignancies.
Aprea Therapeutics (NASDAQ: APRE) announced the appointment of Michael A. Kelly to its Board of Directors, who brings over 20 years of life sciences leadership. Kelly's experience includes senior roles at Amgen and his own consulting firm, Sentry Hill Partners. He will serve on the audit and governance committees. His financial and operational expertise is expected to bolster Aprea's efforts in advancing its mutant p53 reactivator oncology programs, particularly APR-246, which is in clinical development for various cancers.
Aprea Therapeutics (NASDAQ: APRE) announced the promotion of Gregory S. Wessels to Chief Commercial Officer. This move is timely as the company approaches significant milestones in its frontline MDS program and continues developing eprenetapopt. Wessels brings extensive oncology experience from Bristol-Myers Squibb. Additionally, independent directors Scott Rocklage, Ph.D., and Jonathan Hepple, Ph.D., will step down from the Board after nearly a decade. The company has received multiple FDA designations for eprenetapopt, its lead candidate targeting mutant p53, crucial for cancer therapy.
